990
Views
0
CrossRef citations to date
0
Altmetric
Review Article

The efficacy and adverse events of arsenic trioxide for the patients with myelodysplastic syndrome: a systematic review and component network meta-analysis

ORCID Icon, , , &
Article: 2274149 | Received 14 Apr 2023, Accepted 16 Oct 2023, Published online: 31 Oct 2023

References

  • Bokorová R, Fuchs O, Myslivcova D, et al. Arsenic trioxide upregulates cereblon mRNA expression and potentiates sensitivity of SKM-1 and MDS-L cells to lenalidomide. Blood. 2019;134(Supplement_1):5397. doi:10.1182/blood-2019-126443
  • Vey N, Bosly A, Guerci A, et al. Arsenic trioxide in patients with myelodysplastic syndromes: a phase II multicenter study. J Clin Oncol. 2006 Jun;24(16):2465–2471. doi:10.1200/JCO.2005.03.9503
  • Schiller GJ, Slack J, Hainsworth JD, et al. Phase II multicenter study of arsenic trioxide in patients with myelodysplastic syndromes. J Clin Oncol. 2006 Jun;24(16):2456–2464. doi:10.1200/JCO.2005.03.7903
  • Zandberg DP, Huang TY, Ke X, et al. Treatment and outcomes for chronic myelomonocytic leukemia compared to myelodysplastic syndromes in older adults. Haematologica . 2013 Apr;98(4):584–590. doi:10.3324/haematol.2012.062547
  • Gangat N, Patnaik MM, Begna K, et al. Primary myelodysplastic syndromes: The Mayo Clinic experience With 1000 patients. Mayo Clin Proc. 2015 Dec;90(12):1623–1638. doi:10.1016/j.mayocp.2015.08.022
  • Sterne JAC, Savovic J, Page MJ, et al. Rob 2: a revised tool for assessing risk of bias in randomised trials. Br Med J. 2019 Aug;366:l4898. doi:10.1136/bmj.l4898
  • Rucker G, Petropoulou M, Schwarzer G. Network meta-analysis of multicomponent interventions. Biom J. 2020 May;62(3):808–821. doi:10.1002/bimj.201800167
  • Shim SR, Kim SJ, Lee J, et al. Network meta-analysis: application and practice using R software. Epidemiol Health. 2019;41:e2019013. doi:10.4178/epih.e2019013
  • Rucker G, Schmitz S, Schwarzer G. Component network meta-analysis compared to a matching method in a disconnected network: A case study. Biom J. 2021;63(2):447–461. doi:10.1002/bimj.201900339
  • Kropf PL, Shameem R, Pancari PA, et al. Improved survival for MDS/CMML patients treated with the combination of decitabine (DAC) and arsenic trioxide (ATO) in a phase II adaptive three arm randomization study: DAC alone Vs. DAC +/-Carboplatin or ATO. Blood [Conference Abstract]. 2016;128(22):3170. doi:10.1182/blood.V128.22.3170.3170
  • Wei W, Zhou F, Zhang Y, et al. A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes. Leukemia Res. 2012;36(6):715–719. doi:10.1016/j.leukres.2011.12.023
  • Bu YW. The clinical research of arsenic trioxide combined with thalidomide in the treatment of patients with intermediate-1 MDS. J Jining Med Univ. 2016;39(04):245–247.
  • Zeng YJ, Liang ZY, Peng GR, et al. Turmeric enhanced the efficacy of arsenic trioxide combining with thalidomide for patients with myelodysplastic syndrome. Jiangxi J Trad Chinese Med. 2021;52(11):31–33.
  • Zeng ZY. Efficacy and safety of Arsenious Acid and Thalidomide in the treatment of myelodysplastic syndrome. Contemp Med. 2018;24(11):76–78.
  • Chen QW, Zhang L, Lu JH, et al. The clinical observation of arsenic trioxide combined with Jianpibushenjiedu Fomula for elderly patients with MDS-RAEB. Liaon J Trad Chinese Med. 2011;38(9):1841–1843.
  • Dang HB. The analysis of thalidomide combinded with arsenic trioxide for 38 patients with myelodysplastic syndrome. Chongqing Med. 2014;43(14):1791–1793.
  • Deng LL. Efficacy analysis of arsenic trioxide combining with thalidomide for patients with intermediate risk-1 myelodysplastic syndrome. Diet Health. 2018;5(39):78.
  • Guo SL. Applicating arsenic trioxide for the treatment of myelodysplastic syndrome-refractory anemia with excess blasts. China Pract Med. 2012;7(24):195–196.
  • Guo TJ, Gong JM, Wu BJ, et al. Clinical observation on arsenic trioxide combined with cytarabine in the treatment of 38 patients with myelodysplastic syndrome. China Med Herald. 2012;9(9):80–1,4.
  • Huang PC, Si YH, Mo SY. Effect of arsenic trioxide combined with thalidomide in the treatment of myelodysplastic syndrome. Guide China Med. 2020;18(14):77–78.
  • Li HY. Comparative analysis of arsenic trioxide and HAG for the treatment of myelodysplastic syndrome. J North Pharm. 2017;14(02):174–175.
  • Li HM, Liu LN, Mei ZY, et al. Analysis of effect of ultra-low dose of decitabine and arsenic acid in treatment of myelodysplastic syndrome. J Med Forum. 2018;39(1):1–26.
  • Li SM. Clinical trial of arsenic trioxide in the treatment of patients with middle and high risk myelodysplastic syndrome. Chin J Clin Pharmacol. 2017;33(23):2364–2367.
  • Li YQ, Liang ZW, Luo GZ. Compound Zaofan pill combined with low dose cytarabine, arsenic trioxide treatment syndrome randomized controlled trial of abnormal comprehensive geriatric bone marrow hyperplasia. J Pract Tradition Chin Intern. 2013;27(06):102–104.
  • Liang YN LISL. Efficacy analysis of arsenic trioxide plus thalidomide for myelodysplastic syndrome. J Med Theor Pract. 2013;26(17):2312–2313.
  • Liang YN, Qin YL. Analysis of the clinical effect of arsenious acid combine with thalidomide for treating myelodysplastic syndrome. J Yanan Univers(Med Sci). 2015;13(2):32–34.
  • Liu H. The clinical value of As2O3+ Ara-c in treating the patients with MDS. J Hunan Norm Univer(Med Sci). 2016;13(6):20–23.
  • Liu WX, He T, Wang T, et al. The clinical efficacy observation of patients with myelodysplastic syndrome treated by arsenic trioxide combining with thalidomide. China Health Care Nutrition. 2013;10:589–590.
  • Luo ZY. Combination treatment of arsenic trioxide and thalidomide for patients with myelodysplastic syndrome: efficacy and adverse events. Contempor Med. 2017;23(03):33–34.
  • Su JM, Zhang C, Rong TJ, et al. Combination treatment of arsenic trioxide and thalidomide for patients with myelodysplastic syndrome. Shanxi Med J. 2017;46(05):559–562.
  • Sun F, Gao MJ, Yong YL. The 30 instances clinical observation of “Bushen Jiedu Recipe” and arsenious acid in treating myelodysplastic syndrome. Liaon J Tradition Chin Med. 2014;41(8):1656–1658.
  • Tian Y. Clinical study on myelodysplastic syndrome. China Clin Practl Med. 2010;04(5):32–33.
  • Wang FY. Combination of thalidomide, calcitriol and andarsenic trioxide in the treatment of myelodysplastic syndrome. Hainan Med J. 2009;20(11):42–44.
  • Wang GJ, Tian Y. Effect of arsenious acid combined with thalidomide on patients with myelodysplastic syndromes. J Med Forum. 2018;39(7):55–57.
  • Wang GY, Ma HH, Zhao JS. Clinical value study about the combining application of arsenic trioxide and thalidomide for 85 cases with myelodysplastic syndrome. Cardiovas Diseas J Integrat Trad Chin Wester Med(Electron). 2019;7(26):187–188.
  • Wang JX, Zhang QR. The regulative effect of arsenic trioxide plus thalidomide for myelodysplastic syndrome. Modern J Integrat Tradition Chin Western Med . 2013;22(24):2679–2681.
  • Wu CN, Song GC, Zhang J. Efficacy of arsenic trioxide in the treatment of elderly patients with high risk of bone marrow hyperplasia syndrome. Sichuan Med J. 2017;38(01):66–68.
  • Yang HP, Zhao XQ, Hu M. Arsenic trioxide associated with large-dose ascorbic acid, thalidomide in treatment of 20 patients with myelodysplastic syndrome. J Hen Univ Sci Techn (Med Sci). 2011;29(04):280–282.
  • Yu SM. An explorative research of patients with myelodysplastic syndrome treated by thalidomide, arsenic trioxide and Rocaltrol. Guide China Med. 2017;15(08):68–69.
  • Zhang J, Xu JG. Comparison of between arsenic trioxide and HAG regimen in the treatment of myelodysplastic syndrome. Sichuan Med J. 2012;33(10):1793–1795.
  • Zhang QR, Chen LS, Wang JX, et al. Effects of arsenic trioxide plus thalidomide on immune function in patients with myelodysplastic syndrome. Clinic Med China. 2013;29(12):1243–1246.
  • Zhang QR, Chen LS, Zhang GH, et al. The efficacy observation of the regimen majoritve with arsenic trioxide for elderly high risk patients with myelodysplastic syndrome. Chin J Clinic (Electron Edit). 2011;5(16):4895–4896.
  • Zhao XQ, Wu YL, Yang HP. Clinical analysis of thalidomide, arsenic trioxide and calcitriol treating myelodysplastic syndrome]. Chinese J. Trauma Disabil Med. 2016;24(18):17–18.
  • Zhao XQ, Yang HP. Exploration and analysis of the therapeutic value of arsenic trioxide combined with thalidomide for patients with myelodysplastic syndrome. J ShanDong First Med Univers ShanDong Academ Med Sci. 2017;38(04):414–415.
  • Zhong JW, Luo C, Zhao CF, et al. Effect observation of thalidomide combined with arsenious acid in the treatment of myelodysplastic syndrome. Chinese J Pharmacoepidemiol. 2017;26(4):234–236.
  • Zhu CX. Investigate the effect of arsenic trioxide combined with thalidomide in the treatment of myelodysplastic syndrome. China Foreig Med Treatm. 2020;39(13):99–101.
  • Zuo AL. A combination of arsenic trioxide and CAG for patients with myelodysplastic syndrome. Tianjin Med J. 2010;38(11):1007–1008.
  • Zhang YZ, Xie SY, Sun Y. Effects of decitabine combined with arsenic trioxide regimen on immune function in patients with myelodysplastic syndrome undergoing chemotherapy. Contemp Med. 2022;28(13):148–150.
  • Greenberg PL, Stone RM, Al-Kali A, et al. Myelodysplastic syndromes, version 2.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2017;15(1):60–87. doi:10.6004/jnccn.2017.0007
  • Zhang ZN. Diagnosis and efficacy criteria of hematological disease (version 2). Yang CL, editor. Beijing: China Science Publishing and Media Ltd; 1998.
  • Cheson BD, Bennett JM, Kantarjian H, et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood. 2000 Dec;96(12):3671–3674.
  • Cheson BD, Greenberg PL, Bennett JM, Lowenberg B, Wijermans PW, Nimer SD. Clinical application and proposal for modification of the international working group (IWG) response criteria in myelodysplasia. Blood 2006 Jul 108(2):419–425. doi:10.1182/blood-2005-10-4149
  • Burnett AK, Milligan D, Prentice AG, et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer. 2007 Mar;109(6):1114–1124. doi:10.1002/cncr.22496
  • Wei G, Ni W, Chiao JW, et al. A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome. J Hematol Oncol. 2011;14(4):46. doi:10.1186/1756-8722-4-46
  • Xie M, Jiang Q, Li L, et al. HAG (Homoharringtonine, Cytarabine, G-CSF) regimen for the treatment of acute Myeloid Leukemia and Myelodysplastic syndrome: A meta-analysis with 2,314 participants. PLoS One. 2016;11(10):e0164238.
  • Hua HY, Gao HQ, Sun AN, et al. Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM–1 human myelodysplastic syndrome cell line. Mol Med Rep. 2016;14(5):4180–4186. doi:10.3892/mmr.2016.5779
  • Huang L, Liu Z, Jiang H, et al. Decitabine shows synergistic effects with arsenic trioxide against myelodysplastic syndrome cells via endoplasmic reticulum stress-related apoptosis. J Investig Med. 2019 Oct;67(7):1067–1075. doi:10.1136/jim-2018-000953
  • Wu X, Hu Z, Nizzero S, et al. Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity. J Control Release. 2017 Dec;268:92–101. doi:10.1016/j.jconrel.2017.10.012
  • Galimberti S, Guerrini F, Salvi F, et al. Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study. J Hematol Oncol. 2012 Sep;5:53. doi:10.1186/1756-8722-5-53
  • Shao X, Lu R, Guan X, et al. [Effects of arsenic trioxide on Id4 methylation status in bone marrow mononuclear cells and its clinical efficacy for myelodysplastic syndrome]. Zhonghua Xue Ye Xue Za Zhi. 2014 Mar;35(3):247–250.
  • Zhou QB, Zhu QZ, Wang HZ, et al. Traditional Chinese medicine containing arsenic treated MDS patients effectively through Regulating Aberrant Hypomethylation. Evid Base Complem Altern Med. 2020;2020:7469809.
  • Hollow SE, Johnstone TC. Realgar and arsenene nanomaterials as arsenic-based anticancer agents. Curr Opin Chem Biol. 2023 Feb;72:102229. doi:10.1016/j.cbpa.2022.102229