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Article

Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles

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Article: 1379861 | Received 18 May 2017, Accepted 10 Sep 2017, Published online: 05 Oct 2017

References

  • WHO. Obesity: preventing and managing. The global epidemic. 2000. (WHO Technical Report Sseries 894); p. 268.
  • WHO. Fact sheet: Obesity and overweight. WHO Media centre website. 2016. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/
  • Ota T. Chemokine systems link obesity to insulin resistance. Diabetes Metab J. 2013 Jun;37(3):165–172. PubMed PMID: 23807918; PubMed Central PMCID: PMC3689012.
  • Brown WV, Fujioka K, Wilson PW, et al. Obesity: why be concerned. Am J Med. 2009;122(4 Suppl 1):S4–S11.
  • Machova L, Cizek L, Koutna J, et al. The impact of obesity on cardiovascular disease mortality in the District Sumperk, Czech Republic. Int J Public Health. 2007;52(4):255–258. PubMed PMID: 18030957.
  • Karagozian R, Derdak Z, Baffy G. Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism. 2014 May;63(5):607–617. PubMed PMID: 24629562.
  • Hurt RT, Edakkanambeth Varayil J, Ebbert JO. New pharmacological treatments for the management of obesity. Curr Gastroenterol Rep. 2014;16(6):394. PubMed PMID: 24828101.
  • Rodgers RJ, Tschop MH, Wilding JP. Anti-obesity drugs: past, present and future. Dis Model Mech. 2012 Sep 5;5:621–626. PubMed PMID: 22915024; PubMed Central PMCID: PMC3424459.
  • Lee DR, Lee YS, Choi BK, et al. Roots extracts of Adenophora triphylla var. japonica improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice. Asian Pac J Trop Med. 2015 Nov;8(11):898–906. PubMed PMID: 26614988.
  • Jo YH, Choi KM, Liu Q, et al. Anti-obesity effect of 6,8-diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata fruits in high-fat diet-induced obese mice. Nutrients. 2015 Dec 15;7(12):10480–10490. PubMed PMID: 26694457; PubMed Central PMCID: PMC4690096.
  • Jeong YJ, Sohn EH, Jung YH, et al. Anti-obesity effect of Crinum asiaticum var. japonicum baker extract in high-fat diet-induced and monogenic obese mice. Biomed Pharmacother. 2016 Aug;82:35–43. PubMed PMID: 27470336.
  • Huang TW, Chang CL, Kao ES, et al. Effect of hibiscus sabdariffa extract on high fat diet-induced obesity and liver damage in hamsters. Food Nutr Res. 2015;59:29018. PubMed PMID: 26475512; PubMed Central PMCID: PMC4608971.
  • Choi BK, Park SB, Lee DR, et al. Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pac J Trop Med. 2016 Jul;9(7):635–643. PubMed PMID: 27393090.
  • Liu J, Lee J, Salazar Hernandez MA, et al. Treatment of obesity with celastrol. Cell. 2015 May 21;161(5):999–1011. PubMed PMID: 26000480; PubMed Central PMCID: PMC4768733.
  • Qin L, Ou-Yang L-B. Anti-obesity effect of glycyrrhizin on obese rats and its mechanism. Cent Pharm. 2010;8:204–208.
  • Xie W, Zhang Y, Wang N, et al. Novel effects of macrostemonoside A, a compound from Allium macrostemon Bung, on hyperglycemia, hyperlipidemia, and visceral obesity in high-fat diet-fed C57BL/6 mice. Eur J Pharmacol. 2008;599(1–3):159–165.
  • Cheng J, Zhou ZW, Sheng HP, et al. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther. 2015;9:33–78. PubMed PMID: 25552899; PubMed Central PMCID: PMC4277126.
  • Xiao-Xu G, Xian-Jun M, Ji-Hai L. Study on functions of active polysaccharide from Schisandra Chinensis (Turcz) Baill in reducing weight and fat. Sci Technol Food Ind. 2008;29:248–251.
  • Wei-Wei L, Jin Y, Li-Hua W, et al. Effect of hawthorn leaf flavonids on lipid metabolism in hyperlipidemia rats. Health Res. 2010;8:8–11.
  • Zhang WL, Zhu L, Jiang JG. Active ingredients from natural botanicals in the treatment of obesity. Obes Rev. 2014 Dec;15(12):957–967. PubMed PMID: 25417736.
  • Kim KS, Lee DS, Bae GS, et al. The inhibition of JNK MAPK and NF-kappaB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect. Eur J Pharmacol. 2013 Dec 05;721(1–3):267–276. PubMed PMID: 24076326.
  • Jin ZL, Gao N, Zhang JR, et al. The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:9–14. PubMed PMID: 24614095.
  • Liu P, Hu Y, Guo DH, et al. Potential antidepressant properties of Radix Polygalae (Yuan Zhi). Phytomedicine. 2010 Aug;17(10):794–799. PubMed PMID: 20541923.
  • The State Commission of Chinese Pharmacopoeia. Pharmacopoeia of People’s Republic of China, part I. Beijing: Chemical Industry Press; 2010.
  • Lee H, Kang R, Yoon Y. SH21B, an anti-obesity herbal composition, inhibits fat accumulation in 3T3-L1 adipocytes and high fat diet-induced obese mice through the modulation of the adipogenesis pathway. J Ethnopharmacol. 2010 Feb 17;127(3):709–717. PubMed PMID: 19963057.
  • Lee JH, Kim T, Lee JJ, et al. The herbal medicine KBH-1 inhibits fat accumulation in 3T3-L1 adipocytes and reduces high fat diet-induced obesity through regulation of the AMPK pathway. PLoS One. 2015;10(12):e0142041. PubMed PMID: 26649747; PubMed Central PMCID: PMC4674115.
  • Lee JH, Lee JJ, Cho WK, et al. KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats. BMC Complement Altern Med. 2016 Sep 13;16:355–367. PubMed PMID: 27618865; PubMed Central PMCID: PMC5020448.
  • Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):73–83. PubMed PMID: 23768554.
  • Robles Alonso V, Guarner F. Linking the gut microbiota to human health. Br J Nutr. 2013 Jan;109(Suppl 2):S21–S26. PubMed PMID: 23360877.
  • Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207–214. PubMed PMID: 22699609; PubMed Central PMCID: PMC3564958.
  • Jin Y, Zeng Z, Wu Y, et al. Oral exposure of mice to carbendazim induces hepatic lipid metabolism disorder and gut microbiota dysbiosis. Toxicological Sci. 2015 Sep;147(1):116–126. PubMed PMID: 26071454.
  • Lin H, An Y, Hao F, et al. Correlations of fecal metabonomic and microbiomic changes induced by high-fat diet in the pre-obesity state. Sci Rep. 2016 Feb 26;6:21618. PubMed PMID: 26916743; PubMed Central PMCID: PMC4768318.
  • Everard A, Lazarevic V, Derrien M, et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes. 2011;60(11):2775–2786.
  • Clarke SF, Murphy EF, Nilaweera K, et al. The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes. 2012 May–Jun;3(3):186–202. PubMed PMID: 22572830; PubMed Central PMCID: PMC3427212.
  • Mai V, McCrary QM, Sinha R, et al. Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers. Nutr J. 2009;21(8):49–59.
  • Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011 May 12;473(7346):174–180. PubMed PMID: 21508958; PubMed Central PMCID: PMC3728647.
  • Chakraborti CK. New-found link between microbiota and obesity. World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):110–119. PubMed PMID: 26600968; PubMed Central PMCID: PMC4644874.
  • Moreno-Indias I, Cardona F, Tinahones FJ, et al. Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus. Front Microbiol. 2014;5(190):1–10. PubMed PMID: 24808896; PubMed Central PMCID: PMC4010744.
  • Graham C, Mullen A, Whelan K. Obesity and the gastrointestinal microbiota: a review of associations and mechanisms. Nutr Rev. 2015 Jun;73(6):376–385. PubMed PMID: 26011912.
  • Zebisch K, Voigt V, Wabitsch M, et al. Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem. 2012 Jun 01;425(1):88–90. PubMed PMID: 22425542.
  • Shackelford CYNTHIA, Long G, Wolf JEFFREY, et al. Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies. Toxicol Pathol. 2002;30(1):93–96.
  • Garber M, Grabherr MG, Guttman M, et al. Computational methods for transcriptome annotation and quantification using RNA-seq. Nat Methods. 2011 Jun;8(6):469–477. PubMed PMID: 21623353.
  • Shin J, Lee S, Go MJ, et al. Analysis of the mouse gut microbiome using full-length 16S rRNA amplicon sequencing. Sci Rep. 2016 Jul 14;6:29681. PubMed PMID: 27411898; PubMed Central PMCID: PMC4944186.
  • Marmugi A, Ducheix S, Lasserre F, et al. Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology. 2012 Feb;55(2):395–407. PubMed PMID: 21932408.
  • Million M, Lagier JC, Yahav D, et al. Gut bacterial microbiota and obesity. Clinical Microbiol Infection. 2013 Apr;19(4):305–313. PubMed PMID: 23452229.
  • Saito T, Nishida M, Saito M, et al. The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate-activated protein kinase activity and lipogenic gene expression in high-fat diet-fed obese mice. Nutr Res. 2016 Oct;36(10):1090–1097. PubMed PMID: 27865350.
  • Echeverria F, Ortiz M, Valenzuela R, et al. Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: relationship to tissue development and aging. Prostaglandins Leukot Essent Fatty Acids. 2016 Nov;114:28–34. PubMed PMID: 27926461.
  • Ip E, Farrell GC, Robertson G, et al. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology. 2003 Jul;38(1):123–132. PubMed PMID: 12829994.
  • Rakhshandehroo M, Sanderson LM, Matilainen M, et al. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res. 2007;2007:26839. PubMed PMID: 18288265; PubMed Central PMCID: PMC2233741.
  • Dwyer JR, Donkor J, Zhang P, et al. Mouse lipin-1 and lipin-2 cooperate to maintain. PNAS. 2012.
  • Kang HW, Wei J, Cohen DE. Regulation of lipid and glucose metabolism by phosphatidylcholine transfer protein. Trends Endocrinol Metab. 2010 Jul;21(7):449–456. PubMed PMID: 20338778; PubMed Central PMCID: PMC2897958.
  • Wang J, Mitsche MA, Lutjohann D, et al. Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 2015 Feb;56(2):319–330. PubMed PMID: 25378657; PubMed Central PMCID: PMC4306686.
  • Kamisuki S, Mao Q, Abu-Elheiga L, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28;16(8):882–892. PubMed PMID: 19716478.
  • Zhu X, Bian H, Gao X. The potential mechanisms of berberine in the treatment of nonalcoholic fatty liver disease. Molecules. 2016 Oct 14;21(10). PubMed PMID: 27754444. DOI:10.3390/molecules21101336
  • Nukitrangsan N, Iwasaki H, Okabe T, et al. Effect of Peucedanum japonicum Thunb on the expression of obesity-related genes in mice on a high-fat diet. J Oleo Sci. 2011;60(10):527–536.
  • Olteanu S, Kandel-Kfir M, Shaish A, et al. Lack of interleukin-1alpha in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice. Digestive Liver Dis. 2014 May;46(5):433–439. PubMed PMID: 24582082.
  • Szabo G, Csak T. Inflammasomes in liver diseases. J Hepatol. 2012 Sep;57(3):642–654. PubMed PMID: 22634126.
  • Negrin KA, Roth Flach RJ, DiStefano MT, et al. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PloS One. 2014;9(9):e107265. PubMed PMID: 25216251; PubMed Central PMCID: PMC4162604.
  • Osborn O, Brownell SE, Sanchez-Alavez M, et al. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine. 2008 Oct;44(1):141–148. PubMed PMID: 18723371; PubMed Central PMCID: PMC3063393.
  • Trigueros L, Peña S, Ugidos AV, et al. Food ingredients as anti-obesity agents. Crit Rev Food Sci Nutr. 2013;53(9):585–587.
  • Patterson E, Ryan PM, Cryan JF, et al. Gut microbiota, obesity and diabetes. Postgrad Med J. 2016 May;92(1087):286–300. PubMed PMID: 26912499.
  • Wong JM, de Souza R, Kendall CW, et al. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006 Mar;40(3):235–243. PubMed PMID: 16633129.
  • Semova I, Carten JD, Stombaugh J, et al. Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. Cell Host Microbe. 2012 Sep 13;12(3):277–288. PubMed PMID: 22980325; PubMed Central PMCID: PMC3517662.
  • Clarke SF, Murphy EF, O’Sullivan O, et al. Targeting the microbiota to address diet-induced obesity: a time dependent challenge. PLoS One. 2013;8(6):e65790. PubMed PMID: 23762426; PubMed Central PMCID: PMC3676335.
  • Looft T, Johnson TA, Allen HK, et al. In-feed antibiotic effects on the swine intestinal microbiome. Proc Natl Acad Sci USA. 2012 Jan 31;109(5):1691–1696. PubMed PMID: 22307632; PubMed Central PMCID: PMC3277147.
  • Kameyama K, Itoh K. Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice. Microbes Env. 2014;29(4):427–430. PubMed PMID: 25283478; PubMed Central PMCID: PMC4262368.
  • Kim KA, Gu W, Lee IA, et al. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One. 2012;7(10):e47713. PubMed PMID: 23091640; PubMed Central PMCID: PMC3473013.
  • Evans CC, LePard KJ, Kwak JW, et al. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One. 2014;9(3):e92193. PubMed PMID: 24670791; PubMed Central PMCID: PMC3966766.