Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

References

• Zhang M, Chen H, Huang J, et al. Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 2005;76:2115–10.
   PubMed Web of Science ®Google Scholar
• Mao F, Xiao B, Jiang Z, et al. Anticancer effect of lycium barbarum, polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med Oncol. 2011;28:121–126.
   PubMed Web of Science ®Google Scholar
• Miao Y, Xiao B, Jiang Z, et al. Growth inhibition and cell-cycle arrest of human gastric cancer cells by lycium barbarum polysaccharide. Med Oncol. 2010;27:785–790.
   PubMed Web of Science ®Google Scholar
• Gan L, Hua ZS, Liang YX, et al. Immunomodulation and antitumor activity by a polysaccharide-protein complex from lycium barbarum. Int Immunopharmacol. 2014;4:563–569.
   Google Scholar
• Zhang MH, Wang XY, Wang XM, et al. Inhibition of Lycium barbarumpolysaccharide on transplanted liver cancer in mice. Chin Tradit Herbal Drugs. 2012;43:1142–1146.
   Google Scholar
• Qian Z, Lv X, Tao W, et al. Composition oflycium barbarumpolysaccharides and their apoptosis-inducing effect on human hepatoma SMMC-7721 cells. Food Nutr Res. 2015;59:28696.
   Web of Science ®Google Scholar
• Jin M, Huang Q, Zhao K, et al. Biological activities and potential health benefit effects of polysaccharides isolated from lycium barbarum L. Int J Biol Macromol. 2013;54:16–23.
   PubMed Web of Science ®Google Scholar
• Zhang M, Tang X, Wang F, et al. Characterization of lycium barbarum polysaccharide and its effect on human hepatoma cells. Int J Biol Macromol. 2013;61:270–275.
   PubMed Web of Science ®Google Scholar
• Li W, Li Y, Wang Q, et al. Crude extracts from lycium barbarum suppress srebp-1c expression and prevent diet-induced fatty liver through ampk activation. Biomed Res Int. 2014. DOI:10.1155/2014/196198.
   Web of Science ®Google Scholar
• Dubois M, Gilles KA, Hamilton JK, et al. Colorimetric method for determination of sugars and related substances. Anal Chem. 1955;28:350–356.
   Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
   PubMed Web of Science ®Google Scholar
• Bitter T, Muir H. A modified uronic acid carbazole reaction. Anal Biochem. 1962;4:330–334.
   PubMed Web of Science ®Google Scholar
• Li HS, Sun MN, Xu J, et al. Immunological response in h22 transplanted mice undergoing aconitum coreanum, polysaccharide treatment. Int J Biol Macromol. 2013;55:295–300.
   Web of Science ®Google Scholar
• Luo X, Zheng YY, Wen RY, et al. Effects of ceftriaxone induced intestinal dysbacteriosis on lymphocytes in different tissues in mice. Immunobiology. 2016;221:994–1000.
   Web of Science ®Google Scholar
• J Y S, Luo X, Zhang XJ, et al. Immunosuppressive activity of pogostone on T cells: blocking proliferation via S phase arrest. Int Immunopharmacol. 2015;26:328–337.
   Web of Science ®Google Scholar
• Yang B, Xiao B, Sun T. Antitumor and immunomodulatory activity of astragalus membranaceus, polysaccharides in h22 tumor-bearing mice. Int J Biol Macromol. 2013;62:287–290.
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu J, Yue L, et al. One proteoglycan from the fruiting bodies of chroogomphis rutilus (schaeff.: fr.) o.k. miller: purification and structural features. Carbohydr Polym. 2011;86:1381–1384.
   Web of Science ®Google Scholar
• Liang B, Jin M, Liu H. Water-soluble polysaccharide from dried Lycium barbarum fruits: isolation, structural features and antioxidant activity. Carbohydr Polym. 2011;83:1947–1951.
   Web of Science ®Google Scholar
• Sheng X, Yan J, Meng Y, et al. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology. Food Funct. 2017;8:1020–1027.
   PubMed Web of Science ®Google Scholar
• Chen Z, Kwong HTB, Chan SH. Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L. Int Immunopharmacol. 2008;8:1663–1671.
   PubMed Web of Science ®Google Scholar
• Vermes I, Haanen C, Steffens-Nakken H, et al. A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J Immunol Methods. 1995;184:39–51.
   PubMed Web of Science ®Google Scholar
• Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016;30:105–116.
   PubMed Web of Science ®Google Scholar
• Fang SQ, Wang YT, Wei JX, et al. Beneficial effects of chlorogenic acid on alcohol-induced damage in PC12 cells. Biomed Pharmacother. 2016;79:254–262.
   Web of Science ®Google Scholar
• Giannattasio S, Guaragnella N, Arbini AA, et al. Stress-related mitochondrial components and mitochondrial genome as targets of anticancer therapy. Chem Biol Drug Des. 2013;81:102–112.
   PubMed Web of Science ®Google Scholar
• Dai JQ, Huang YG, He AN. Dihydromethysticin kavalactone induces apoptosis in osteosarcoma cells through modulation of PI3K/Akt pathway, disruption of mitochondrial membrane potential and inducing cell cycle arrest. Int J Clin Exp Patho. 2015;8:4356–4366.
   Web of Science ®Google Scholar
• Berenbaum MC. Immunosuppression by platinum diamines. Brit J Cancer. 1971;25:208–211.
   Web of Science ®Google Scholar
• Sánchezsuárez P, Ostroskywegman P, Gallegoshernández F, et al. DNA damage in peripheral blood lymphocytes in patients during combined chemotherapy for breast cancer. Mutat Res-Fund Mol M. 2008;640(1–2):8–15.
   Web of Science ®Google Scholar
• Harris J, Sengar D, Stewart T, et al. The effect of immunosuppressive chemotherapy on immune function in patients with malignant disease. Cancer. 1976;37:1058–1069.
   PubMed Web of Science ®Google Scholar
• Ozolins TR. Cyclophosphamide and the teratology society: an awkward marriage. Birth Defects Res B Dev Reprod Toxicol. 2010;89:289–299.
   Google Scholar
• Becker MS, Schmezer P, Breuer R, et al. The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression. Cell Death Dis. 2014;5:e1000.
   Web of Science ®Google Scholar
• Hunter AM, Lacasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis. 2007;12:1543–1568.
   PubMed Web of Science ®Google Scholar
• Visconti R, Monica RD, Grieco D. Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword. J Exp Clin Cancer Res. 2016;35:153–doi.
   PubMed Web of Science ®Google Scholar
• Levesque JP, Winkler IG. It takes nerves to recover from chemotherapy. Nat Med. 2013;19:669–671.
   Web of Science ®Google Scholar
• Bo R, Sun Y, Zhou S, et al. Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice. Int J Nanomed. 2017;173:6289–6301.
   Google Scholar
• Peng XM, Huang LJ, Qi CH, et al. Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from Lycium barbarum L. Chin J Chem. 2010;19:1190–1197.
   Google Scholar
• Zhang XR, Qi CH, Cheng JP, et al. Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer. Int Immunopharmacol. 2014;19:132–141.
   PubMed Web of Science ®Google Scholar
• Zhu J, Zhao LH, Zhao XP, et al. Lycium barbarum polysaccharides regulate phenotypic and functional maturation of murine dendritic cells. Cell Biol Int. 2007;31:615–619.
   Web of Science ®Google Scholar
• Ho YS, Yu MS, Yik SY, et al. Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cell Mol Neurobiol. 2009;29:1233–1244.
   PubMed Web of Science ®Google Scholar
• Teng P, Li Y, Cheng W, et al. Neuroprotective effects of Lycium barbarum polysaccharides in lipopolysaccharide-induced BV2 microglial cells. Mol Med Rep. 2013;7:1977–1981.
   Web of Science ®Google Scholar
• Gong H, Shen P, Jin L, et al. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Chin J Inf Tradit Chin Med. 2005;20:155–162.
   Google Scholar
• Xin YF, Wan LL, Peng JL, et al. Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress [J]. Food Chem Toxicol. 2011;49:259–264.
   PubMed Web of Science ®Google Scholar
• Xiao J, Liong EC, Ching YP, et al. Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury. Nutr Diabetes. 2013;3:e81.
   Web of Science ®Google Scholar
• Jia L, Li W, Li J, et al. Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. Sci Rep. 2016;6:36209-doi. DOI:10.1038/srep36209.
   Web of Science ®Google Scholar
• Cai H, Liu F, Zuo P, et al. Practical application of antidiabetic efficacy of lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015;11:383–390.
   PubMed Web of Science ®Google Scholar