References
- Biswas K, Shaw S, Mishra S, et al. Nanotechnology in Biology and Medicine. 1st ed. 2019. p. 185–192. doi: 10.1201/9780429259333
- Sulakshana G., A.S.R.-W.J.P. Res, Undefined 2015. In vitro evaluation of antifungal activity in three different species of Costus, Wjpr.S3.Ap-South-1.Amazonaws.Com. 4 (2015). https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1441012271.pdf.
- Sharma P, Joshi T, Joshi T, et al. In silico screening of potential antidiabetic phytochemicals from Phyllanthus emblica against therapeutic targets of type 2 diabetes. Journal of Ethnopharmacology. 2020;248:112268. doi: 10.1016/j.jep.2019.112268
- Hajam YA, Kumar R, Reshi MS, … Ishtikhar M. Administration of Costus igneus Nak leaf extract improves diabetic-induced impairment in hepatorenal functions in male albino rats. J King Saud Univ Sci. 2022;34(4):101911. doi:10.1016/j.jksus.2022.101911
- Msopa E, Mwanakasale V. Identification of risk factors of diabetes mellitus in bank employees of selected banks in Ndola town. Diabetes & Metab Syndr: Clin Res Rev. 2019;13(2):1497–1504. doi:10.1016/j.dsx.2018.11.062
- https://www.who.int/health-topics/diabetes#tab=tab_1
- Srivastava S, He F, Huang Y, et al. A brief review on medicinal plants-at-arms against COVID-19. Interdiscip Perspect Infect Dis. 2023;2023:16.
- Ahmed D, Khan MI, Kaithwas G, et al. Molecular docking analysis and antidiabetic activity of Rifabutin against STZ-NA induced diabetes in albino wistar rats. Beni-Suef Univ J Basic Appl Sci. 2017;6:269–284. doi:10.1016/J.BJBAS.2017.04.010
- N. Gupta, T. Gudipati, G.P.-I.J.C.M.A. Sci, undefined 2018, Plant secondary metabolites of pharmacological significance in reference to diabetes mellitus: an update, Researchgate.Net. (n.d.). https://www.researchgate.net/profile/Neha-Gupta-42/publication/325306464_Plant_Secondary_Metabolites_of_Pharmacological_Significance_in_Reference_to_Diabetes_Mellitus_An_Update/links/5ba1da7e45851574f7d58d52/Plant-Secondary-Metabolites-of-Pharmacological-Significance-in-Reference-to-Diabetes-Mellitus-An-Update.pdf (accessed June 2, 2022).
- Hegde P, Rao H, Rao P. A review on Insulin plant (Costus igneus Nak). Pharmacogn Rev. 2014;8:67. doi:10.4103/0973-7847.125536
- M.S. Deogade, A. Wanjari, S.C. Lohakare, Pharmacognostical and Phytochemical study of NE Br leaf Costus igneus Original Article, (n.d.). doi:10.1007/978-3-540
- Joshi BN, Munot H, Hardikar M, et al. Orally active hypoglycemic protein from Costus igneus N. E. Br.: an in vitro and in vivo study. Biochem. Biophys. Res. Commun. 2013;436:278–282. doi:10.1016/J.BBRC.2013.05.093
- Suchitra MR, Srinithya N, Sivakumar R, et al. Inhibitory effect of Costus igneus Linn (Insulin Leaf) on alpha amylase, alpha glucosidase activity to facilitate antihyperglycemic effect in Type 2 Diabetes Mellitus. J Glob Trends Pharm Sci. 2021;12:9782–9786. https://www.jgtps.com/
- Costa IS, Medeiros AF, Piuvezam G, et al. Insulin-like proteins in plant sources: a systematic review. Diabetes Metab Syndr Obes. 2020;13:3421–3431. doi: 10.2147/DMSO.S256883
- Bhat V, Asuti N, Kamat A. M.S.-J. of P., undefined 2010. Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats, Cabdirect.Org. (n.d.). https://www.cabdirect.org/cabdirect/abstract/20103155496 (accessed June 2, 2022).
- Sadrzadeh SH, Nanji AA, Meydani M. Effect of chronic ethanol feeding on plasma and liver α-and γ-tocopherol levels in normal and vitamin E-deficient rats: relationship to lipid peroxidation. Biochem Pharmacol. 1994;47(11):2005–2010. doi:10.1016/0006-2952(94)90075-2
- Anderson D, Phillips BJ, Yu TW, et al. Effects of vitamin C supplementation in human volunteers with a range of cholesterol levels on biomarkers of oxygen radical-generated damage. Pure Appl Chem. 2000;72(6):973–983. doi:10.1351/pac200072060973
- F. Mathew, B.V.-I.J.P.S.R. Res, undefined 2019, A review on medicinal exploration of Costus igneus: the insulin plant, Researchgate.Net. (n.d.). https://www.researchgate.net/profile/Arvind-Singh-21/post/Insulin_plant_Costus_igneus_Does_it_really_work_against_diabetes_How_it_works/attachment/5d24b4ac3843b0b9825a0193/AS%3A778778351509504%401562686636104/download/1.pdf
- Reddy Peasari J, sri Motamarry S, Varma KS, et al. Chromatographic analysis of phytochemicals in Costus igneus and computational studies of flavonoids. Inform Med Unlocked. 2018;13:34–40. doi:10.1016/j.imu.2018.10.004
- Arul B, Kothai R, Josephine A, et al. Hypoglycemic activity of Casearia esculenta roxb. in normal and diabetic albino rats. Orig Artic Iran J Pharm Res. 2006;1:47–51. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=79506 [accessed June 2, 2022].
- Chattopadhyay RR. A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol. 1999;67:367–372. doi:..Rao, M.M. V, Hariprasad, T.P.N., 2021. In silico analysis of a potential antidiabetic phytochemical erythrin against therapeutic targets of diabetes. Silico Pharmacol. 9, 5. doi:10.1007/S40203-020-00065-8
- Bisht S. S.S.-J. of P.S. and Research, undefined 2010. Anti-hyperglycemic and antidyslipidemic potential of Azadirachta indica leaf extract in STZ-induced diabetes mellitus, Citeseer. (n.d.). http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.193.7268&rep=rep1&type=pdf (accessed June 2, 2022).
- Ajiboye BO, Oloyede HOB, Salawu MO. Antihyperglycemic and antidyslipidemic activity of Musa paradisiaca-based diet in alloxan-induced diabetic rats. Food Sci Nutr. 2018;6:137. doi:10.1002/FSN3.538
- Arif R, Ahmad S, Mustafa G, et al. Molecular docking and simulation studies of antidiabetic agents devised from hypoglycemic polypeptide-P of Momordica charantia. Biomed Res Int. 2021;2021:1–15. doi: 10.1155/2021/5561129
- Chevalier S, Burgess SC, Malloy CR, et al. The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism. Diabetes. 2006;55:675–681. doi:10.2337/DIABETES.55.03.06.DB05-1117
- Perry RJ, Camporez JPG, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160:745–758. doi:10.1016/J.CELL.2015.01.012
- Chen C, Zhou S, Meng Q. A molecular docking study of Rhizoma Atractylodis and Rhizoma Atractylodis Macrocephalae herbal pair with respect to type 2 diabetes mellitus. J Tradit Chinese Med Sci. 2018;5:185–198. doi:10.1016/J.JTCMS.2018.05.004
- Kasina SVSK, Baradhi KM. Dipeptidyl Peptidase IV (DPP IV) Inhibitors, (2022) 1–5. https://www.ncbi.nlm.nih.gov/books/NBK542331/ [accessed June 2, 2022].
- E.D. Dixon, A.D. Nardo, T. Claudel, M. Trauner, H. Popper, The role of lipid sensing nuclear receptors (PPARs and LXR) and metabolic lipases in obesity, diabetes and NAFLD, Mdpi.Com. (2021). doi:10.3390/genes12050645
- Hardikar MR, Varma ME, Kulkarni AA, et al. Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus. Phytochemistry. 2016;124:99–107. doi:10.1016/J.PHYTOCHEM.2016.02.001
- Suchitra MR, Srinithya N, Sivakumar R, et al. Inhibitory effect of Costus igneus Linn (Insulin Leaf) on alpha amylase, alpha glucosidase activity to facilitate antihyperglycemic effect in Type 2 diabetes mellitus. J Glob Trends Pharm Sci. 2021;12:9782–9786. https://www.jgtps.com/.
- Kim S, Chen J, Cheng T, et al. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 2021;49:D1388–D1395. doi:10.1093/NAR/GKAA971
- Lipinski CA, Discovery M, Lombardo F, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Elsevier. 1997;23:3–25. https://www.sciencedirect.com/science/article/pii/S0169409X96004231.
- Whirl-Carrillo M, McDonagh EM, Hebert JM, et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92:414–417. doi:10.1038/CLPT.2012.96
- Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46:D1074–D1082. doi:10.1093/NAR/GKX1037
- Banerjee P, Eckert AO, Schrey AK, et al. ProTox-II: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res. 2018;46:W257–W263. doi:10.1093/NAR/GKY318
- Berman HM, Westbrook J, Feng Z, et al. The Protein Data Bank. Nucleic Acids Res. 2000;28:235–242. doi:10.1093/NAR/28.1.235
- Guex N, Peitsch MC. SWISS-MODEL and the Swiss-Pdb Viewer: an environment for comparative protein modeling. Electrophoresis. 1997;18:2714–2723. doi:10.1002/ELPS.1150181505
- Hanwell MD, Curtis DE, Lonie DC, et al. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J. Cheminform. 2012;4:1–17. doi:10.1186/1758-2946-4-17/FIGURES/14
- Kozlovskii I, Popov P. Spatiotemporal identification of druggable binding sites using deep learning. Commun Biol. 2020;31:1–12. doi:10.1038/s42003-020-01350-0
- Wallace AC, Laskowski RA, Thornton JM. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng Des Sel. 1995;8:127–134. doi:10.1093/PROTEIN/8.2.127
- Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera—a visualization system for exploratory research and analysis. J Comput Chem. 2004;25:1605–1612. doi:10.1002/JCC.20084
- Bowers KJ, Chow E, Xu H., R.O.D.-P. of the, undefined 2006. n.d Scalable algorithms for molecular dynamics simulations on commodity clusters, Dl.Acm.Org. https://dl.acm.org/doi/abs/10.11451188455.1188544.
- Martyna GJ, Tobias DJ. M.L.K.-T.J. of chemical physics, undefined 1994, constant pressure molecular dynamics algorithms. Aip Scitation Org. 1994;101:44130. doi:10.1063/1.467468
- Garg S, Anand A, Lamba Y, et al. Molecular docking analysis of selected phytochemicals against SARS-CoV-2 Mpro receptor. Vegetos. 2020;33:766–781. doi:10.1007/S42535-020-00162-1/TABLES/3
- Imran M, Iqbal S, Hussain A, et al. In silico screening, SAR and kinetic studies of naturally occurring flavonoids against SARS CoV-2 main protease. Arab J Chem. 2022;15:103473. doi:10.1016/J.ARABJC.2021.103473
- Kumar Vishwas D. A remedial anti-diabetic insulin plant. Int Res J Mod Eng Technol Sci. 1475;05(05):2582–5208.
- Shinde S, Surwade S, Sharma R. Costus ignus: insulin plant and it’s preparations as remedial approach for diabetes mellitus. Artic Int J Pharm Sci Res. 2022;13:1551. doi:10.13040/IJPSR.0975-8232.13(4).1551-58
- reddy Peasari J, sri Motamarry S, Varma KS, et al. Chromatographic analysis of phytochemicals in Costus igneus and computational studies of flavonoids. Informatics Med Unlocked. 2018;13:34–40. doi:10.1016/J.IMU.2018.10.004
- Khan M, Patujo J, Mushtaq I, et al. Anti-diabetic potential, crystal structure, molecular docking, DFT, and optical-electrochemical studies of new dimethyl and diethyl carbamoyl-N, N′-disubstituted based thioureas. J Mol Struct. 2022;1253:132207. doi:10.1016/J.MOLSTRUC.2021.132207
- Jaradat N, Khasati A, Hawi M, et al. Antidiabetic, antioxidant, and anti-obesity effects of phenylthio-ethyl benzoate derivatives, and molecular docking study regarding α-amylase enzyme. Sci Reports. 2022;121. 12(2022):1–9. doi:10.1038/s41598-022-07188-2
- Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7:17. doi: 10.1038/SREP42717
- Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 1997;23:3–25. doi:10.1016/S0169-409X(96)00423-1
- Lipinski C. Drug discovery today. Technol. 2004a;1(4):337–341.
- Lipinski CA. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discov Today: Technol. 2004b;1:337–341. doi:10.1016/j.ddtec.2004.11.007
- Marondedze E, Govender K. Computational investigation of the binding characteristics of β-amyloid fibrils. Biophysical Chemistry. 2019;256:106281. doi: 10.1016/j.bpc.2019.106281
- Obermeier B, Verma A, Ransohoff RM. The blood–brain barrier. Handbook of clinical neurology. 1st ed. Vol. 133, Elsevier; 2016. Chapter 3.
- Kim MT, Sedykh A, Chakravarti SK, et al. Critical evaluation of human oral bioavailability for pharmaceutical drugs by using various cheminformatics approaches. Pharm Res. 2014;31:1002–1014. doi:10.1007/s11095-013-1222-1
- Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera—a visualization system for exploratory research and analysis. J Comput Chem. 2004;25:1605–1612. doi:10.1002/jcc.20084
- Klaholz BP, Moras D. C-H-O Hydrogen bonds in the nuclear receptor RARc—a potential tool for drug selectivity. Structure. 2002;10:1197–1204. doi:10.1016/S0969-2126(02)00828-6
- Mishra A, Dey S. Molecular docking studies of a cyclic octapeptide-cyclosaplin from sandalwood. Biomolecules. 2019;9(11):740. doi:10.3390/biom9110740
- Imran M, Iqbal S, Hussain A. In silico screening, SAR and kinetic studies of naturally occurring flavonoids against SARS CoV-2 main protease. Arab J Chem. 2022;15(1):103473. doi:10.1016/j.arabjc.2021.103473
- Lakhera S, Devlal K, Ghosh A, et al. Modelling the DFT structural and reactivity study of feverfew and evaluation of its potential antiviral activity against COVID-19 using molecular docking and MD simulations. Chem Pap. 2022;76:2759–2776. doi:10.1007/S11696-022-02067-6
- Kattaru S, Manne Mudhu S, Echambadi Loganathan S, et al. Increased insulin and GLUT2 gene expression and elevated glucokinase activity in β-like cells of islets of langerhans differentiated from human haematopoietic stem cells on treatment with Costus igneus leaf extract. Mol Biol Rep. 2021;48:4477–4485. doi:10.1007/S11033-021-06467-X/FIGURES/5