Development challenges and opportunities in aerosol drug delivery systems in non-invasive ventilation in adults

References

• Maselli DJ, Keyt H, Restrepo MI. Inhaled antibiotic therapy in chronic respiratory diseases. Int J Mol Sci. 2017 May 16;18:5.
   Web of Science ®Google Scholar
• Reddel HK, Bateman ED, Becker A, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015 Sep;46(3):622–639.
   PubMed Web of Science ®Google Scholar
• Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Gold executive summary. Am J Respir Crit Care Med. 2017 Mar 1;195(5):557–582.
   PubMed Web of Science ®Google Scholar
• Osadnik CR, Tee VS, Carson-Chahhoud KV, et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017 Jul 13;7:CD004104.
   PubMed Web of Science ®Google Scholar
• Kallet RH, Diaz JV. The physiologic effects of noninvasive ventilation. Respir Care. 2009 Jan;54(1):102–115.
   PubMed Web of Science ®Google Scholar
• Ehrmann S, Roche-Campo F, Sferrazza Papa GF, et al. Aerosol therapy during mechanical ventilation: an international survey. Intensive Care Med. 2013 Jun;39(6):1048–1056.
   PubMed Web of Science ®Google Scholar
• Laube BL, Janssens HM, de Jongh FH, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J. 2011 Jun;37(6):1308–1331.
   PubMed Web of Science ®Google Scholar
• Ghazanfari T, Elhissi AM, Ding Z, et al. The influence of fluid physicochemical properties on vibrating-mesh nebulization. Int J Pharm. 2007 Jul 18;339(1–2):103–111.
   PubMed Web of Science ®Google Scholar
• Dhand R. Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv. 2008 Mar;21(1):45–60.
   PubMed Web of Science ®Google Scholar
• Dhand R. Aerosol therapy in patients receiving noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv. 2012 Apr;25(2):63–78.
   PubMed Web of Science ®Google Scholar
• Fink J, Ari A. Aerosol delivery to intubated patients. Expert Opin Drug Deliv. 2013 Aug;10(8):1077–1093.
   PubMed Web of Science ®Google Scholar
• Dugernier J, Ehrmann S, Sottiaux T, et al. Aerosol delivery during invasive mechanical ventilation: a systematic review. Crit Care. 2017 Oct 21;21(1):264.
   PubMed Web of Science ®Google Scholar
• Fauroux B, Itti E, Pigeot J, et al. Optimization of aerosol deposition by pressure support in children with cystic fibrosis: an experimental and clinical study. Am J Respir Crit Care Med. 2000 Dec;162(6):2265–2271.
   PubMed Web of Science ®Google Scholar
• Galindo-Filho VC, Brandao DC, Ferreira RC, et al. Noninvasive ventilation coupled with nebulization during asthma crises: a randomized controlled trial. Respir Care. 2013 Feb;58(2):241–249.
   PubMed Web of Science ®Google Scholar
• Branconnier MP, Hess DR. Albuterol delivery during noninvasive ventilation. Respir Care. 2005 Dec;50(12):1649–1653.
   PubMedGoogle Scholar
• Hassan A, Salah ER, Abdelrahman MM, et al. In-vitro/in-vivo comparison of inhaled salbutamol dose delivered by jet nebulizer, vibrating mesh nebulizer and metered dose inhaler with spacer during non-invasive ventilation. Exp Lung Res. 2017 Feb;43(1):19–28.
   PubMed Web of Science ®Google Scholar
• Ari A, Fink JB, Dhand R. Inhalation therapy in patients receiving mechanical ventilation: an update. J Aerosol Med Pulm Drug Deliv. 2012 Dec;25(6):319–332.
   PubMed Web of Science ®Google Scholar
• Michotte JB, Jossen E, Roeseler J, et al. In vitro comparison of five nebulizers during noninvasive ventilation: analysis of inhaled and lost doses. J Aerosol Med Pulm Drug Deliv. 2014 Dec;27(6):430–440.
   PubMedGoogle Scholar
• Abdelrahim ME, Plant P, Chrystyn H. In-vitro characterisation of the nebulised dose during non-invasive ventilation. J Pharm Pharmacol. 2010 Aug;62(8):966–972.
   PubMed Web of Science ®Google Scholar
• Saeed H, Ali AMA, Elberry AA, et al. Modeling and optimization of nebulizers’ performance in non-invasive ventilation using different fill volumes: comparative study between vibrating mesh and jet nebulizers. Pulm Pharmacol Ther. 2018;50:62–71.
   PubMed Web of Science ®Google Scholar
• Rabea H, Ali AM, Salah ER, et al. Modelling of in-vitro and in-vivo performance of aerosol emitted from different vibrating mesh nebulisers in non-invasive ventilation circuit. Eur J Pharm Sci. 2017 Jan;15(97):182–191.
   Google Scholar
• Hess D, Fisher D, Williams P, et al. Medication nebulizer performance. Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest. 1996;110(2):498–505.
   PubMed Web of Science ®Google Scholar
• Sutherasan Y, Ball L, Raimondo P, et al. Effects of ventilator settings, nebulizer and exhalation port position on albuterol delivery during non-invasive ventilation: an in-vitro study. BMC Pulm Med. 2017 Jan 10;17(1):9.
   PubMedGoogle Scholar
• Alonso-Inigo JM, Almela A, Albert A, et al. Active humidification with Boussignac CPAP: in vitro study of a new method. Respir Care. 2013 Apr;58(4):647–654.
   PubMed Web of Science ®Google Scholar
• Restrepo RD, Walsh BK. Humidification during invasive and noninvasive mechanical ventilation: 2012. Respir Care. 2012 May;57(5):782–788.
   PubMed Web of Science ®Google Scholar
• Branson RD, Gentile MA. Is humidification always necessary during noninvasive ventilation in the hospital? Respir Care. 2010 Feb;55(2):209–216.
   PubMed Web of Science ®Google Scholar
• Michotte JB, Staderini E, Le PD, et al. In vitro comparison of a vibrating mesh nebulizer operating in inspiratory synchronized and continuous nebulization modes during noninvasive ventilation. J Aerosol Med Pulm Drug Deliv. 2016 Aug;29(4):328–336.
   PubMed Web of Science ®Google Scholar
• Chatmongkolchart S, Schettino GP, Dillman C, et al. In vitro evaluation of aerosol bronchodilator delivery during noninvasive positive pressure ventilation: effect of ventilator settings and nebulizer position. Crit Care Med. 2002 Nov;30(11):2515–2519.
   PubMed Web of Science ®Google Scholar
• Calvert LD, Jackson JM, White JA, et al. Enhanced delivery of nebulised salbutamol during non-invasive ventilation. J Pharm Pharmacol. 2006 Nov;58(11):1553–1557.
   PubMed Web of Science ®Google Scholar
• Dai B, Kang J, Sun LF, et al. Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv. 2014 Apr;27(2):125–132.
   PubMed Web of Science ®Google Scholar
• Peng Y, Dai B, Hu C-X, et al. Which nebulizer position should be avoided? An extended study of aerosol delivery and ventilator performance during noninvasive positive pressure ventilation. Respiration. 2018;95(3):145–153.
   PubMed Web of Science ®Google Scholar
• Abdelrahim ME, Plant PK, Chrystyn H. The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients. Int J Pharm. 2011 Nov 28;420(2):313–318.
   PubMedGoogle Scholar
• Chatburn RL, McPeck M. A new system for understanding nebulizer performance. Respir Care. 2007;52(8):1037–1050.
   PubMed Web of Science ®Google Scholar
• Harvey CJ, O’Doherty MJ, Page CJ, et al. Comparison of jet and ultrasonic nebulizer pulmonary aerosol deposition during mechanical ventilation. Eur Respir J. 1997 Apr 01;10(4):905–909.
   PubMed Web of Science ®Google Scholar
• Harb HS, Elberry AA, Rabea H, et al. Performance of large spacer versus nebulizer T-piece in single-limb noninvasive ventilation. Respir Care. 2018 Aug 7;63:1360–1369.
   PubMed Web of Science ®Google Scholar
• Michotte JB, Staderini E, Aubriot AS, et al. Pulmonary drug delivery following continuous vibrating mesh nebulization and inspiratory synchronized vibrating mesh nebulization during noninvasive ventilation in healthy volunteers. J Aerosol Med Pulm Drug Deliv. 2018 Feb;31(1):33–41.
   PubMed Web of Science ®Google Scholar
• Reychler G, Leal T, Roeseler J, et al. Effect of continuous positive airway pressure combined to nebulization on lung deposition measured by urinary excretion of amikacin. Respir Med. 2007;101(10):2051–2055.
   PubMed Web of Science ®Google Scholar
• Newman S, Bennett WD, Biddiscombe M, et al. Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv. 2012 Dec;25(Suppl 1):S10–S28.
   PubMedGoogle Scholar
• Fleming J, Bailey DL, Chan HK, et al. Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv. 2012 Dec;25(Suppl 1):S29–S51.
   PubMedGoogle Scholar
• Franca EE, Dornelas de Andrade AF, Cabral G, et al. Nebulization associated with bi-level noninvasive ventilation: analysis of pulmonary radioaerosol deposition. Respir Med. 2006 Apr;100(4):721–728.
   PubMed Web of Science ®Google Scholar
• Maccari JG, Teixeira C, Savi A, et al. Nebulization during spontaneous breathing, CPAP, and bi-level positive-pressure ventilation: a randomized analysis of pulmonary radioaerosol deposition. Respir Care. 2014;59(4):479–484.
   Google Scholar
• Pollack CV Jr., Fleisch KB, Dowsey K. Treatment of acute bronchospasm with beta-adrenergic agonist aerosols delivered by a nasal bilevel positive airway pressure circuit. Ann Emerg Med. 1995 Nov;1(5):552–557.
   Google Scholar
• Parkes SN, Bersten AD. Aerosol kinetics and bronchodilator efficacy during continuous positive airway pressure delivered by face mask. Thorax. 1997 Feb;52(2):171–175.
   PubMed Web of Science ®Google Scholar
• Brandão DC, Lima VM, Filho VG, et al. Reversal of bronchial obstruction with bi-level positive airway pressure and nebulization in patients with acute asthma. J Asthma. 2009;46(4):356–361.
   PubMed Web of Science ®Google Scholar
• Nava S, Karakurt S, Rampulla C, et al. Salbutamol delivery during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized, controlled study. Intensive Care Med. 2001 Oct;27(10):1627–1635.
   PubMed Web of Science ®Google Scholar
• Hess DR. Aerosol therapy during noninvasive ventilation or high-flow nasal cannula. Respir Care. 2015;60(6):880–891.
   PubMed Web of Science ®Google Scholar
• Dugernier J, Hesse M, Vanbever R, et al. SPECT-CT comparison of lung deposition using a system combining a vibrating-mesh nebulizer with a valved holding chamber and a conventional jet nebulizer: a randomized cross-over study. Pharm Res. 2017 Feb;34(2):290–300.
   PubMed Web of Science ®Google Scholar
• Geller DE. Aerosol antibiotics in cystic fibrosis. Respir Care. 2009;54(5):658–670.
   PubMed Web of Science ®Google Scholar
• Saeed H, Mohsen M, Eldin AS, et al. Effects of fill volume and humidification on aerosol delivery during single-limb noninvasive ventilation. Respir Care. 2018 Nov;63(11):1370–1378.
   PubMedGoogle Scholar
• Saeed H, Mohsen M, Fink JB, et al. Fill volume, humidification and heat effects on aerosol delivery and fugitive emissions during noninvasive ventilation. J Drug Deliv Sci Tec. 2017;39:372–378.
   Web of Science ®Google Scholar
• Mukhopadhyay A, Dela Pena E, Wadden B, et al. Effects of inhalational bronchodilator treatment during noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbations. J Crit Care. 2009 Aug;12(3):474.
   Google Scholar
• Gupta D, Nath A, Agarwal R, et al. A prospective randomized controlled trial on the efficacy of noninvasive ventilation in severe acute asthma. Resp Care. 2010;55(5):536–543.
   PubMed Web of Science ®Google Scholar
• Galindo-Filho VC, Ramos ME, Rattes CS, et al. Radioaerosol pulmonary deposition using mesh and jet nebulizers during noninvasive ventilation in healthy subjects. Respir Care. 2015;60(9):1238–1246.
   PubMed Web of Science ®Google Scholar
• Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017 Aug;50(2).
   PubMed Web of Science ®Google Scholar
• Ari A. Aerosol therapy in pulmonary critical care. Respir Care. 2015 Jun;60(6):858–874.
   PubMed Web of Science ®Google Scholar
• Hindle M, Longest PW. Evaluation of enhanced condensational growth (ECG) for controlled respiratory drug delivery in a mouth-throat and upper tracheobronchial model. Pharm Res. 2010 Sep;27(9):1800–1811.
   PubMed Web of Science ®Google Scholar
• Tian G, Longest PW, Su G, et al. Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways. Ann Biomed Eng. 2011 Mar;39(3):1136–1153.
   PubMed Web of Science ®Google Scholar
• Longest PW, Hindle M. Numerical model to characterize the size increase of combination drug and hygroscopic excipient nanoparticle aerosols. Aerosol Sci Technol. 2011 Jan 1;45(7):884–899.
   PubMed Web of Science ®Google Scholar
• Walenga RL, Longest PW, Kaviratna A, et al. Aerosol drug delivery during noninvasive positive pressure ventilation: effects of intersubject variability and excipient enhanced growth. J Aerosol Med Pulm Drug Deliv. 2017 Jun;30(3):190–205.
   PubMed Web of Science ®Google Scholar
• Longest PW, Golshahi L, Hindle M. Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components. Ann Biomed Eng. 2013 Jun;41(6):1217–1232.
   PubMed Web of Science ®Google Scholar
• Harvey CJ, O’Doherty MJ, Page CJ, et al. Effect of a spacer on pulmonary aerosol deposition from a jet nebuliser during mechanical ventilation. Thorax. 1995 Jan;50(1):50–53.
   PubMed Web of Science ®Google Scholar
• Hussein RRS, Ali MA, Salem HF, et al. In vitro/in vivo correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients. Pharm Dev Technol. 2017 Nov;22(7):871–880.
   PubMed Web of Science ®Google Scholar
• Dugernier J, Reychler G, Wittebole X, et al. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Ann Intensive Care. 2016 Dec;6(1):73.
   PubMedGoogle Scholar
• O’Riordan TG, Palmer LB, Smaldone GC. Aerosol deposition in mechanically ventilated patients. Optimizing nebulizer delivery. Am J Respir Crit Care Med. 1994 Jan;149(1):214–219.
   PubMed Web of Science ®Google Scholar
• Bassetti M, Luyt CE, Nicolau DP, et al. Characteristics of an ideal nebulized antibiotic for the treatment of pneumonia in the intubated patient. Ann Intensive Care. 2016;6(1):35.
   PubMed Web of Science ®Google Scholar
• Miller DD, Amin MM, Palmer LB, et al. Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med. 2003 Aug;2(10):1205–1209.
   Google Scholar