SLN and NLC for topical, dermal, and transdermal drug delivery

References

• Kovacevic A, Savic S, Vuleta G, et al. Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure. Int J Pharm. 2011 Mar 15;406(1–2):163–172. PubMed PMID: 21219990.
   PubMedGoogle Scholar
• Guimarães KL, Ré MI. Lipid nanoparticles as carriers for cosmetic ingredients: the first (SLN) and the second generation (NLC). nanocosmetics and nanomedicines. Berlin, Heidelberg: Springer Berlin Heidelberg; 2011. p. 101–122.
   Google Scholar
• Pardeike J, Hommoss A, Muller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm. 2009 Jan 21; 366(1–2):170–184. PubMed PMID: 18992314.
   PubMed Web of Science ®Google Scholar
• Battaglia L, Gallarate M. Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery. Expert Opin Drug Deliv. 2012 May;9(5):497–508. PubMed PMID: 22439808.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Shegokar R, Souto EB. Chap 30 Role of excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs). In Grumezescu AM, editor. Nanostructures for novel therapy. Amsterdam: Elsevier; 2017. p. 811–843.
   Google Scholar
• Shrestha H, Bala R, Arora S. Lipid-based drug delivery systems. J Pharm (Cairo). 2014;2014:801820. PubMed PMID: 26556202; PubMed Central PMCID: PMC4590796.
   PubMedGoogle Scholar
• Khosa A, Reddi S, Saha RN. Nanostructured lipid carriers for site-specific drug delivery. Biomed Pharmacothe. 2018 Jul;103:598–613. PubMed PMID: 29677547.
   PubMed Web of Science ®Google Scholar
• Del Pozo-Rodriguez A, Delgado D, Gascon AR, et al. Lipid nanoparticles as drug/gene delivery systems to the retina. J Ocul Pharmacol Ther. 2013 Mar;29(2):173–188. PubMed PMID: 23286300.
   PubMed Web of Science ®Google Scholar
• Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Adv Pharm Bull. 2015 Sep;5(3):305–313. PubMed PMID: 26504751; PubMed Central PMCID: PMC4616893.
   PubMed Web of Science ®Google Scholar
• Muller RH, Shegokar R, Keck CM. 20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications. Curr Drug Discov Technol. 2011 Sep;8(3):207–227. PubMed PMID: 21291409.
   PubMedGoogle Scholar
• Gratieri T, Krawczyk-Santos AP, da Rocha PBR, et al. SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis. Curr Pharm Des. 2017 Nov 14. [ PubMed PMID: 29141535]. DOI:10.2174/1381612823666171115112745
   PubMed Web of Science ®Google Scholar
• Gordillo-Galeano A, Mora-Huertas CE. Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release. Eur J Pharm Biopharm. 2018 Dec;133:285–308. PubMed PMID: 30463794.
   PubMed Web of Science ®Google Scholar
• Vieira R, Severino P, Nalone LA, et al. Sucupira oil-loaded nanostructured lipid carriers (NLC): lipid screening, factorial design, release profile and Cytotoxicity. Molecules. 2020;25:685.
   PubMed Web of Science ®Google Scholar
• Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev. 2004 May 7;56(9):1257–1272. PubMed PMID: 15109768.
   PubMed Web of Science ®Google Scholar
• Joshi MD, Muller RH. Lipid nanoparticles for parenteral delivery of actives. Eur J Pharm Biopharm. 2009 Feb;71(2):161–172; PubMed PMID: 18824097.
   PubMed Web of Science ®Google Scholar
• Carbone C, Teixeira MDC, Sousa MDC, et al. Clotrimazole-loaded mediterranean essential oils NLC: a synergic treatment of candida skin infections. Pharmaceutics. 2019 May 13;11(5). PubMed PMID: 31085997; PubMed Central PMCID: PMCPMC6572383. DOI:10.3390/pharmaceutics11050231
   Web of Science ®Google Scholar
• Teixeira MC, Carbone C, Souto EB. Beyond liposomes: recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery. Prog Lipid Res. 2017 Oct;68:1–11. PubMed PMID: 28778472.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Kovacevic AB, Garcia ML, et al. Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: current evidence from in vitro and in vivo evaluation. Eur J Pharm Biopharm. 2016 Nov;108:235–252. PubMed PMID: 27519829.
   PubMed Web of Science ®Google Scholar
• Severino P, Andreani T, Macedo AS, et al. Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv. 2012;2012:750891. PubMed PMID: 22175030; PubMed Central PMCID: PMC3228282.
   PubMedGoogle Scholar
• Campos JR, Fernandes AR, Sousa R, et al. Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line. Pharm Dev Technol. 2019 Jun;24(5):616–622. PubMed PMID: 30477410.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Mira E, Egea MA, Souto EB, et al. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery. Nanotechnology. 2011 Jan 28;22(4):045101. PubMed PMID: 21169662.
   PubMed Web of Science ®Google Scholar
• Pereira I, Zielinska A, Ferreira NR, et al. Optimization of linalool-loaded solid lipid nanoparticles using experimental factorial design and long-term stability studies with a new centrifugal sedimentation method. Int J Pharm. 2018 Oct 5;549(1–2):261–270. PubMed PMID: 30075252.
   PubMedGoogle Scholar
• Severino P, Santana MH, Souto EB. Optimizing SLN and NLC by 2 (2)full factorial design: effect of homogenization technique. Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1375–1379. PubMed PMID: 24364934.
   PubMed Web of Science ®Google Scholar
• Shimojo AAM, Fernandes ARV, Ferreira NRE, et al. Evaluation of the influence of process parameters on the properties of resveratrol-loaded NLC using 2 (2)full factorial design. Antioxidants (Basel). 2019 Aug 3;8(8). PubMed PMID: 31382599; PubMed Central PMCID: PMCPMC6719996. DOI:10.3390/antiox8080272
   PubMedGoogle Scholar
• Zielinska A, Ferreira NR, Durazzo A, et al. Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (sln) using experimental factorial design and dispersion analysis. Molecules. 2019 Jul 24;24(15). PubMed PMID: 31344802; PubMed Central PMCID: PMCPMC6696006. DOI:10.3390/molecules24152683
   PubMed Web of Science ®Google Scholar
• Zielinska A, Martins-Gomes C, Ferreira NR, et al. Anti-inflammatory and anti-cancer activity of citral: optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer(R). Int J Pharm. 2018 Dec 20;553(1–2):428–440. PubMed PMID: 30385373.
   PubMed Web of Science ®Google Scholar
• Souto EB, Doktorovova S, Campos JR, et al. Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells. Eur J Pharm Sci. 2019 Feb;1(128):27–35. PubMed PMID: 30472221.
   PubMed Web of Science ®Google Scholar
• Silva AM, Martins-Gomes C, Fangueiro JF, et al. Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines. Pharm Dev Technol. 2019 Dec;24(10):1243–1249. PubMed PMID: 31437118.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Souto EB, Silva AM. Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - a systematic review of in vitro data. Eur J Pharm Biopharm. 2014 May;87(1):1–18. PubMed PMID: 24530885.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, AM S, Gaivao I, et al. Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles. J Appl Toxicol. 2014 Apr;34(4):395–403. PubMed PMID: 24243595.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Santos DL, Costa I, et al. Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells. Int J Pharm. 2014 Aug 25;471(1–2):18–27. PubMed PMID: 24836663.
   PubMed Web of Science ®Google Scholar
• Severino P, Pinho SC, Souto EB, et al. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. Colloids Surf B Biointerfaces. 2011 Aug 1;86(1):125–130. PubMed PMID: 21543196.
   PubMed Web of Science ®Google Scholar
• Souto EB, Doktorovova S, Boonme P. Lipid-based colloidal systems (nanoparticles, microemulsions) for drug delivery to the skin: materials and end-product formulations. J Drug Delivery Sci Technol. 2011;21(1):43–54.
   Web of Science ®Google Scholar
• Nikolic S, Keck CM, Anselmi C, et al. Skin photoprotection improvement: synergistic interaction between lipid nanoparticles and organic UV filters. Int J Pharm. 2011 Jul 29;414(1–2):276–284. PubMed PMID: 21600969.
   PubMed Web of Science ®Google Scholar
• Kheradmandnia S, Vasheghani-Farahani E, Nosrati M, et al. Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomed. 2010 Dec;6(6):753–759. PubMed PMID: 20599527.
   PubMed Web of Science ®Google Scholar
• Xia Q, Saupe A, Muller RH, et al. Nanostructured lipid carriers as novel carrier for sunscreen formulations. Int J Cosmet Sci. 2007 Dec;29(6):473–482. PubMed PMID: 18489386.
   PubMedGoogle Scholar
• Shellhammer TH, Rumsey TR, Krochta JM. Viscoelastic properties of edible lipids. J Food Eng. 1997;33(3–4):305–320.
   Web of Science ®Google Scholar
• Montenegro L, Pasquinucci L, Zappala A, et al. Rosemary essential oil-loaded lipid nanoparticles: in vivo topical activity from gel vehicles. Pharmaceutics. 2017 Oct 21;9(4). PubMed PMID: 29065483; PubMed Central PMCID: PMC5750654. DOI:10.3390/pharmaceutics9040048
   Web of Science ®Google Scholar
• Keck CM, Kovacevic A, Muller RH, et al. Formulation of solid lipid nanoparticles (SLN): the value of different alkyl polyglucoside surfactants. Int J Pharm. 2014 Oct 20;474(1–2):33–41. PubMed PMID: 25108048.
   PubMed Web of Science ®Google Scholar
• Souto EB, Anselmi C, Centini M, et al. Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN). Int J Pharm. 2005 May 13;295(1–2):261–268. PubMed PMID: 15848010.
   PubMed Web of Science ®Google Scholar
• Das S, Ng WK, Tan RB. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs? Eur J Pharm Sci. 2012 Aug 30;47(1):139–151. PubMed PMID: 22664358
   PubMed Web of Science ®Google Scholar
• Huang ZR, Hua SC, Yang YL, et al. Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion. Acta Pharmacol Sin. 2008 Sep;29(9):1094–1102. PubMed PMID: 18718178.
   PubMed Web of Science ®Google Scholar
• Aburahma MH, Badr-Eldin SM. Compritol 888 ATO: A multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals. Expert Opin Drug Deliv. 2014 Dec;11(12):1865–1883. PubMed PMID: 25152197.
   PubMed Web of Science ®Google Scholar
• Teeranachaideekul V, Chantaburanan T, Junyaprasert VB. Influence of state and crystallinity of lipid matrix on physicochemical properties and permeation of capsaicin-loaded lipid nanoparticles for topical delivery. J Drug Delivery Sci Technol. 2017;39:300–307.
   Web of Science ®Google Scholar
• Wehrung D, Geldenhuys WJ, Oyewumi MO. Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions. Colloids Surf B Biointerfaces. 2012 Jun 1;94:259–265. PubMed PMID: 22386863.
   PubMed Web of Science ®Google Scholar
• Mendes AI, Silva AC, Catita JA, et al. Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity. Colloids Surf B Biointerfaces. 2013 Nov;1(111):755–763. PubMed PMID: 23954816.
   PubMed Web of Science ®Google Scholar
• Joshi M, Patravale V. Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of Valdecoxib. Drug Dev Ind Pharm. 2006 Sep;32(8):911–918. PubMed PMID: 16954103.
   PubMed Web of Science ®Google Scholar
• Zoubari G, Staufenbiel S, Volz P, et al. Effect of drug solubility and lipid carrier on drug release from lipid nanoparticles for dermal delivery. Eur J Pharm Biopharm. 2017;110(Jan):39–46. PubMed PMID: 27810471.
   PubMed Web of Science ®Google Scholar
• Paudel A, Worku ZA, Meeus J, et al. Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations. Int J Pharm. 2013 Aug 30;453(1):253–284. PubMed PMID: 22820134.
   PubMed Web of Science ®Google Scholar
• Agrawal Y, Petkar KC, Sawant KK. Development, evaluation and clinical studies of acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int J Pharm. 2010 Nov 30;401(1–2):93–102. PubMed PMID: 20858539.
   PubMed Web of Science ®Google Scholar
• Fang JY, Fang CL, Liu CH, et al. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm. 2008 Oct;702:633–640. PubMed PMID: 18577447.
   PubMed Web of Science ®Google Scholar
• Handbook of pharmaceutical excipients. 6th Rowe RC, Sheskey PJ, Quinn ME (Editors) London, UK: Pharmaceutical press and american pharmacists association. 2009; English. (Pharmacy International).
   Google Scholar
• Chantaburanan T, Teeranachaideekul V, Chantasart D, et al. Effect of binary solid lipid matrix of wax and triglyceride on lipid crystallinity, drug-lipid interaction and drug release of ibuprofen-loaded solid lipid nanoparticles (SLN) for dermal delivery. J Colloid Interface Sci. 2017 Oct;15(504):247–256. PubMed PMID: 28551519.
   PubMed Web of Science ®Google Scholar
• Kawadkar J, Pathak A, Kishore R, et al. Formulation, characterization and in vitro-in vivo evaluation of flurbiprofen-loaded nanostructured lipid carriers for transdermal delivery. Drug Dev Ind Pharm. 2013 Apr;39(4):569–578. PubMed PMID: 22639934.
   PubMed Web of Science ®Google Scholar
• Garg A, Singh S. Enhancement in antifungal activity of eugenol in immunosuppressed rats through lipid nanocarriers. Colloids Surf B Biointerfaces. 2011 Oct 15;87(2):280–288. PubMed PMID: 21689909.
   PubMed Web of Science ®Google Scholar
• Pokharkar VB, Shekhawat PB, Dhapte VV, et al. Development and optimization of eugenol loaded nanostructured lipid carriers for periodontal delivery. Int J Pharm Pharm Sci. 2011;3(4):138–143.
   Google Scholar
• Negi LM, Jaggi M, Talegaonkar S. Development of protocol for screening the formulation components and the assessment of common quality problems of nano-structured lipid carriers. Int J Pharm. 2014 Jan 30;461(1–2):403–410. PubMed PMID: 24345574.
   PubMedGoogle Scholar
• Salminen H, Gommel C, Leuenberger BH, et al. Influence of encapsulated functional lipids on crystal structure and chemical stability in solid lipid nanoparticles: towards bioactive-based design of delivery systems. Food Chem. 2016 Jan;1(190):928–937. PubMed PMID: 26213058.
   PubMed Web of Science ®Google Scholar
• McClements DJ, Gumus CE. Natural emulsifiers - biosurfactants, phospholipids, biopolymers, and colloidal particles: molecular and physicochemical basis of functional performance. Adv Colloid Interface Sci. 2016 Aug;234:3–26. PubMed PMID: 27181392.
   PubMed Web of Science ®Google Scholar
• Karn-Orachai K, Smith SM, Phunpee S, et al. The effect of surfactant composition on the chemical and structural properties of nanostructured lipid carriers. J Microencapsul. 2014;31(6):609–618. PubMed PMID: 24861323.
   PubMed Web of Science ®Google Scholar
• Aljuffali IA, Sung CT, Shen FM, et al. Squarticles as a lipid nanocarrier for delivering diphencyprone and minoxidil to hair follicles and human dermal papilla cells. Aaps J. 2014 Jan;16(1):140–150. PubMed PMID: 24307611; PubMed Central PMCID: PMCPMC3889522.
   PubMed Web of Science ®Google Scholar
• Carbone C, Martins-Gomes C, Caddeo C, et al. Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles. Int J Pharm. 2018 Sep 5;548(1):217–226. PubMed PMID: 29966744.
   PubMedGoogle Scholar
• Averina ES, Seewald G, Muller RH, et al. Nanostructured lipid carriers (NLC) on the basis of siberian pine (pinus sibirica) seed oil. Pharmazie. 2010 Jan;65(1):25–31. PubMed PMID: 20187575.
   PubMed Web of Science ®Google Scholar
• Souto EB, Fernandes ARSeverino P, et al. Hybrid antioxidant and antitumor activity of Croton Argyrophyllus Kunth loaded in lipid nanoparticles, Third National Conference on Nanotechnologies and Nanomaterials in the Food Sector and Their Safety Assessment – 18 February 2019, Istituto Superiore di Sanità, Rome, Italy.
   Google Scholar
• Souto EB, Zielinska A, Souto SB, et al. (+)-Limonene 1,2-epoxide-loaded SLN: evaluation of drug release, antioxidant activity and cytotoxicity in HaCaT cell line. Int J Mol Sci. 2020; submitted.
   Web of Science ®Google Scholar
• Zielińska A, Ferreira NR, Feliczak-Guzik A, et al. Release kinetics and stability assessment of monoterpenes-loaded solid lipid nanoparticles (SLN). Pharm Dev Technol. 2020; revised.
   PubMed Web of Science ®Google Scholar
• Souto EB, Mehnert W, Muller RH. Polymorphic behaviour of compritol888 ATO as bulk lipid and as SLN and NLC. J Microencapsul. 2006 Jun;23(4):417–433. PubMed PMID: 16854817.
   PubMed Web of Science ®Google Scholar
• Souto EB, Muller RH. SLN and NLC for topical delivery of ketoconazole. J Microencapsul. 2005 Aug;22(5):501–510. PubMed PMID: 16361193.
   PubMed Web of Science ®Google Scholar
• Tsai MJ, Wu PC, Huang YB, et al. Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting. Int J Pharm. 2012 Feb 28;423(2):461–470. PubMed PMID: 22193056.
   PubMed Web of Science ®Google Scholar
• Teixeira MC, Severino P, Andreani T, et al. d-alpha-tocopherol nanoemulsions: size properties, rheological behavior, surface tension, osmolarity and cytotoxicity. Saudi Pharm J. 2017 Feb;25(2):231–235. PubMed PMID: 28344473; PubMed Central PMCID: PMCPMC5355551.
   PubMed Web of Science ®Google Scholar
• Souto EB, Muller RH. Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes. In Schäfer-Korting M, editor. Handbook of Experimental Pharmacology - Novel Drug Delivery Approaches. Berlin, Germany: Springer Verlag Heidelberg. 2010. Vol. 197. pp. 115–141. ISBN: 978-3642004766.
   Google Scholar
• Souto EB, Doktorovova S. Chapter 6 - solid lipid nanoparticle formulations pharmacokinetic and biopharmaceutical aspects in drug delivery. Methods Enzymol. 2009;464:105–129. PubMed PMID: 19903552.
   PubMed Web of Science ®Google Scholar
• Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007 Jul 10;59(6):478–490. PubMed PMID: 17543416.
   PubMed Web of Science ®Google Scholar
• Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016;44(1):27–40. PubMed PMID: 24813223.
   PubMed Web of Science ®Google Scholar
• Andrade LN, Oliveira DML, Chaud MV, et al. Praziquantel-solid lipid nanoparticles produced by supercritical carbon dioxide extraction: physicochemical characterization, release profile, and cytotoxicity. Molecules. 2019 Oct 28;24(21). PubMed PMID: 31661906. DOI:10.3390/molecules24213881.
   Web of Science ®Google Scholar
• Doktorovova S, Shegokar R, Rakovsky E, et al. Cationic solid lipid nanoparticles (cSLN): structure, stability and DNA binding capacity correlation studies. Int J Pharm. 2011 Nov 28;420(2):341–349. PubMed PMID: 21907778.
   PubMedGoogle Scholar
• Souto EB, Muller RH. Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization. J Microencapsul. 2006 Jun;23(4):377–388. PubMed PMID: 16854814.
   PubMed Web of Science ®Google Scholar
• Bunjes H, Unruh T. Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering. Adv Drug Deliv Rev. 2007 Jul 10;59(6):379–402. PubMed PMID: 17658653.
   PubMed Web of Science ®Google Scholar
• Bunjes H, Steiniger F, Richter W. Visualizing the structure of triglyceride nanoparticles in different crystal modifications. Langmuir. 2007 Mar 27;23(7):4005–4011. PubMed PMID: 17316032.
   PubMed Web of Science ®Google Scholar
• Sharma N, Bhandari S, Deshmukh R, et al. Development and characterization of embelin-loaded nanolipid carriers for brain targeting. Artif Cells Nanomed Biotechnol. 2017 May;45(3):409–413. PubMed PMID: 27012597.
   PubMed Web of Science ®Google Scholar
• Araujo J, Garcia ML, Mallandrich M, et al. Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): in vitro and ex vivo studies. Nanomedicine. 2012 Aug;8(6):1034–1041. PubMed PMID: 22115598.
   PubMed Web of Science ®Google Scholar
• Araujo J, Nikolic S, Egea MA, et al. Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye. Colloids Surf B Biointerfaces. 2011 Nov 1;88(1):150–157. PubMed PMID: 21764568.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Mira E, Nikolic S, Garcia ML, et al. Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen. J Pharm Sci. 2011 Jan;100(1):242–251. PubMed PMID: 20575052.
   PubMed Web of Science ®Google Scholar
• Junyaprasert VB, Teeranachaideekul V, Souto EB, et al. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. Int J Pharm. 2009 Jul 30;377(1–2):207–214. PubMed PMID: 19465098.
   PubMed Web of Science ®Google Scholar
• Yang Y, Corona A 3rd, Schubert B, et al. The effect of oil type on the aggregation stability of nanostructured lipid carriers. J Colloid Interface Sci. 2014 Mar;15(418):261–272. PubMed PMID: 24461844.
   PubMed Web of Science ®Google Scholar
• Schafer-Korting M, Mehnert W, Korting HC. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev. 2007 Jul 10;59(6):427–443. PubMed PMID: 17544165.
   PubMed Web of Science ®Google Scholar
• Radomska-Soukharev A. Stability of lipid excipients in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007 Jul 10;59(6):411–418. PubMed PMID: 17553589.
   PubMed Web of Science ®Google Scholar
• Rangsimawong W, Opanasopit P, Rojanarata T, et al. Skin transport of hydrophilic compound-loaded pegylated lipid nanocarriers: comparative study of liposomes, niosomes, and solid lipid nanoparticles. Biol Pharm Bull. 2016;39(8):1254–1262. PubMed PMID: 27476936.
   PubMed Web of Science ®Google Scholar
• Rangsimawong W, Opanasopit P, Rojanarata T, et al. Terpene-containing PEGylated liposomes as transdermal carriers of a hydrophilic compound. Biol Pharm Bull. 2014;37(12):1936–1943. PubMed PMID: 25297807.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Shegokar R, Martins-Lopes P, et al. Modified rose bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN). Eur J Pharm Sci. 2012 Apr 11;45(5):606–612. PubMed PMID: 22245537.
   PubMed Web of Science ®Google Scholar
• Severino P, Souto EB, Pinho SC, et al. Hydrophilic coating of mitotane-loaded lipid nanoparticles: preliminary studies for mucosal adhesion. Pharm Dev Technol. 2013 May-Jun;18(3):577–581. PubMed PMID: 21958059.
   PubMed Web of Science ®Google Scholar
• Souto EB, Wissing SA, Barbosa CM, et al. Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm. 2004 Jul;58(1):83–90. PubMed PMID: 15207541.
   PubMed Web of Science ®Google Scholar
• Fangueiro JF, Gonzalez-Mira E, Martins-Lopes P, et al. A novel lipid nanocarrier for insulin delivery: production, characterization and toxicity testing. Pharm Dev Technol. 2013 May-Jun;18(3):545–549. PubMed PMID: 21711084.
   PubMed Web of Science ®Google Scholar
• Schubert MA, Harms M, Muller-Goymann CC. Structural investigations on lipid nanoparticles containing high amounts of lecithin. Eur J Pharm Sci. 2006 Feb;27(2–3):226–236. PubMed PMID: 16298113.
   PubMed Web of Science ®Google Scholar
• Schubert MA, Muller-Goymann CC. Characterisation of surface-modified solid lipid nanoparticles (SLN): influence of lecithin and nonionic emulsifier. Eur J Pharm Biopharm. 2005 Sep;61(1–2):77–86. PubMed PMID: 16011893.
   PubMed Web of Science ®Google Scholar
• Jeon HS, Seo JE, Kim MS, et al. A retinyl palmitate-loaded solid lipid nanoparticle system: effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo. Int J Pharm. 2013 Aug 16;452(1–2):311–320. PubMed PMID: 23702002.
   PubMed Web of Science ®Google Scholar
• Gao S, Tian B, Han J, et al. Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema. Int J Nanomedicine. 2019;14:6135–6150. PubMed PMID: 31447556; PubMed Central PMCID: PMCPMC6683961.
   PubMed Web of Science ®Google Scholar
• Silva LA, Andrade LM, de Sa FA, et al. Clobetasol-loaded nanostructured lipid carriers for epidermal targeting. J Pharm Pharmacol. 2016 Jun;68(6):742–750. PubMed PMID: 27061573.
   PubMed Web of Science ®Google Scholar
• Souto EB, Ribeiro AF, Ferreira MI, et al. New nanotechnologies for the treatment and repair of skin burns infections. Int J Mol Sci. 2020;21(2):393. PubMed PMID.
   Web of Science ®Google Scholar
• Barbosa TC, Nascimento LED, Bani C, et al. Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(epsilon-caprolactone) nanocapsules. Toxics. 2019 Sep 22;7(4). PubMed PMID: 31546707. DOI:10.3390/toxics7040051
   PubMed Web of Science ®Google Scholar
• Silva AM, Martins-Gomes C, Coutinho TE, et al. Soft cationic nanoparticles for drug delivery: production and cytotoxicity of solid lipid nanoparticles (SLN). Appl Sci. 2019;9(20):4438.
   Google Scholar
• Souto EB, Almeida AJ, Müller RH, et al. (SLN®, NLC®) for cutaneous drug delivery: structure,protection and skin effects. J Biomed Nanotechnol. 2007;3(4):317–331.
   Web of Science ®Google Scholar
• Ganesan P, Narayanasamy D. Lipid nanoparticles: different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery. Sustainable Chem Pharm. 2017;6:37–56.
   Web of Science ®Google Scholar
• Beloqui A, Solinis MA, Rodriguez-Gascon A, et al. Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomed. 2016 Jan;12(1):143–161. PubMed PMID: 26410277.
   PubMed Web of Science ®Google Scholar
• Mehnert W, Mader K. Solid lipid nanoparticles production, characterization and applications. Adv Drug Deliv Rev. 2001;47(2–3):165–196.
   PubMed Web of Science ®Google Scholar
• Muchow M, Maincent P, Muller RH. Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev Ind Pharm. 2008 Dec;34(12):1394–1405. PubMed PMID: 18665980.
   PubMed Web of Science ®Google Scholar
• Lippacher A, Müller RH, Mäder K. Investigation on the viscoelastic properties of lipid based colloidal drug carriers. Int J Pharm. 2000;196(2):227–230.
   PubMedGoogle Scholar
• Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev. 2002;54:S131–S155.
   PubMed Web of Science ®Google Scholar
• Svilenov H, Tzachev C. Solid lipid nanoparticles - a promising drug delivery system. Nanomedicine. 2014;8:187–237.
   Google Scholar
• Gasco MR. inventor; Google Patents, assignee. Method for producing solid lipid microspheres having a narrow size distribution; 1993.
   Google Scholar
• Trotta M, Debernardi F, Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique. Int J Pharm. 2003;257(1–2):153–160.
   PubMed Web of Science ®Google Scholar
• Quintanar-Guerrero D, Tamayo-Esquivel D, Ganem-Quintanar A, et al. Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres. Eur J Pharm Sci. 2005 Oct;262:211–218. PubMed PMID: 16046105.
   PubMed Web of Science ®Google Scholar
• Schubert M, Müller-Goymann CC. Solvent injection as a new approach for manufacturing lipid nanoparticles – evaluation of the method and process parameters. Eur J Pharm Biopharm. 2003;55(1):125–131.
   PubMed Web of Science ®Google Scholar
• Heurtault B, Saulnier P, Pech B, et al. A novel phase inversion-based process for the preparation of lipid nanocarriers [journal article]. Pharm Res. 2002 June 01;19(6):875–880.
   PubMed Web of Science ®Google Scholar
• Silva AC, Gonzalez-Mira E, Garcia ML, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces. 2011 Aug 1;86(1):158–165. PubMed PMID: 21530187.
   PubMed Web of Science ®Google Scholar
• Lauterbach A, Muller-Goymann CC. Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route. Eur J Pharm Biopharm. 2015 Nov;97(Pt A):152–163. PubMed PMID: 26144664.
   PubMedGoogle Scholar
• Raj R, Mongia P, Ram A, et al. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Artif Cells Nanomed Biotechnol. 2016 Sep;44(6):1434–1439. PubMed PMID: 25919063.
   PubMed Web of Science ®Google Scholar
• Marto J, Sangalli C, Capra P, et al. Development and characterization of new and scalable topical formulations containing N-acetyl-d-glucosamine-loaded solid lipid nanoparticles. Drug Dev Ind Pharm. 2017 Nov;43(11):1792–1800. PubMed PMID: 28581831.
   PubMed Web of Science ®Google Scholar
• Zhang YT, Han MQ, Shen LN, et al. Solid lipid nanoparticles formulated for transdermal aconitine administration and evaluated in vitro and in vivo. J Biomed Nanotechnol. 2015 Feb;11(2):351–361. PubMed PMID: 26349311.
   PubMed Web of Science ®Google Scholar
• Jain S, Mistry MA, Swarnakar NK. Enhanced dermal delivery of acyclovir using solid lipid nanoparticles. Drug Deliv Transl Res. 2011 Oct;1(5):395–406. PubMed PMID: 25788423.
   PubMed Web of Science ®Google Scholar
• Jain AK, Jain A, Garg NK, et al. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf B Biointerfaces. 2014;121:222–229.
   PubMed Web of Science ®Google Scholar
• Butani D, Yewale C, Misra A. Topical Amphotericin B solid lipid nanoparticles: design and development. Colloids Surf B Biointerfaces. 2016 Mar 1;139:17–24. PubMed PMID: 26700229.
   PubMed Web of Science ®Google Scholar
• Melo N, Campos EVR, Franz-Montan M, et al. Characterization of articaine-loaded poly(ε-caprolactone) nanocapsules and solid lipid nanoparticles in hydrogels for topical formulations. J Nanosci Nanotechnol. 2018;18(6):4428–4438.
   PubMed Web of Science ®Google Scholar
• Kurakula M, Ahmed OA, Fahmy UA, et al. Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. J Liposome Res. 2016 Dec;26(4):288–296. PubMed PMID: 26784833.
   PubMed Web of Science ®Google Scholar
• Pokharkar VB, Mendiratta C, Kyadarkunte AY, et al. Skin delivery aspects of benzoyl peroxide-loaded solid lipid nanoparticles for acne treatment. Ther Deliv. 2014 Jun;5(6):635–652. PubMed PMID: 25090278.
   PubMedGoogle Scholar
• Jensen LB, Petersson K, Nielsen HM. In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin. Eur J Pharm Biopharm. 2011 Sep;79(1):68–75. PubMed PMID: 21664463.
   PubMed Web of Science ®Google Scholar
• Puglia C, Offerta A, Tirendi GG, et al. Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv. 2016;23(1):36–40. PubMed PMID: 24735249.
   PubMed Web of Science ®Google Scholar
• Farboud ES, Nasrollahi SA, Tabbakhi Z. Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. Int J Nanomedicine. 2011;6:611–617. PubMed PMID: 21674018; PubMed Central PMCID: PMCPMC3107720.
   PubMed Web of Science ®Google Scholar
• Korkm E, Gokce EH, Ozer O. Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery. Acta Pharm. 2013;63(4):517–529.
   PubMed Web of Science ®Google Scholar
• Joshi SA, Jalalpure SS, Kempwade AA, et al. Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine. J Drug Delivery Sci Technol. 2017;41:444–453.
   Web of Science ®Google Scholar
• Lee MH, Shin GH, Park HJ. Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system. J Appl Polym Sci. 2018;135(11):46004.
   Web of Science ®Google Scholar
• Nayak AP, Tiyaboonchai W, Patankar S, et al. Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment. Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):263–273. PubMed PMID: 20688493.
   PubMed Web of Science ®Google Scholar
• Essaghraoui A, Belfkira A, Hamdaoui B, et al. Improved dermal delivery of cyclosporine a loaded in solid lipid nanoparticles. Nanomaterials (Basel). 2019;9(9):1204. PubMed PMID: 31461853; eng.
   Google Scholar
• Muller RH, Runge SA, Ravelli V, et al. Cyclosporine-loaded solid lipid nanoparticles (SLN): drug-lipid physicochemical interactions and characterization of drug incorporation. Eur J Pharm Biopharm. 2008 Mar;68(3):535–544. PubMed PMID: 17804210.
   PubMed Web of Science ®Google Scholar
• Liu D, Ge Y, Tang Y, et al. Solid lipid nanoparticles for transdermal delivery of diclofenac sodium: preparation, characterization and in vitro studies. J Microencapsul. 2010;27(8):726–734. PubMed PMID: 21034365.
   PubMed Web of Science ®Google Scholar
• Taveira SF, De Santana DC, Araujo LM, et al. Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticles. J Biomed Nanotechnol. 2014 Jul;10(7):1382–1390. PubMed PMID: 24804558.
   PubMed Web of Science ®Google Scholar
• Tupal A, Sabzichi M, Ramezani F, et al. Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. J Microencapsul. 2016 Jun;33(4):372–380. PubMed PMID: 27338131.
   PubMed Web of Science ®Google Scholar
• Garg A, Singh S. Targeting of eugenol-loaded solid lipid nanoparticles to the epidermal layer of human skin. Nanomedicine(Lond). 2014;9(8):1223–1238. PubMed PMID: 23987096.
   PubMed Web of Science ®Google Scholar
• Pradhan M, Singh D, Murthy SN, et al. Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis. Steroids. 2015;101:56–63.
   PubMed Web of Science ®Google Scholar
• Gupta M, Tiwari S, Vyas SP. Influence of various lipid core on characteristics of SLNs designed for topical delivery of fluconazole against cutaneous candidiasis. Pharm Dev Technol. 2013 May-Jun;18(3):550–559. PubMed PMID: 21810069.
   PubMed Web of Science ®Google Scholar
• El-Housiny S, Shams Eldeen MA, El-Attar YA, et al. Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study. Drug Deliv. 2018 Nov;25(1):78–90. PubMed PMID: 29239242; PubMed Central PMCID: PMCPMC6058711.
   PubMed Web of Science ®Google Scholar
• Gupta M, Vyas SP. Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis. Chem Phys Lipids. 2012 May;165(4):454–461. PubMed PMID: 22309657.
   PubMed Web of Science ®Google Scholar
• Andrade LM, de Fatima Reis C, Maione-Silva L, et al. Impact of lipid dynamic behavior on physical stability, in vitro release and skin permeation of genistein-loaded lipid nanoparticles. Eur J Pharm Biopharm. 2014 Sep;88(1):40–47. PubMed PMID: 24816130.
   PubMed Web of Science ®Google Scholar
• Aggarwal N, Goindi S. Preparation and in vivo evaluation of solid lipid nanoparticles of griseofulvin for dermal use. J Biomed Nanotechnol. 2013 Apr;9(4):564–576. PubMed PMID: 23621015.
   PubMed Web of Science ®Google Scholar
• Ghanbarzadeh S, Hariri R, Kouhsoltani M, et al. Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles. Colloids Surf B Biointerfaces. 2015 Dec;1(136):1004–1010. PubMed PMID: 26579567.
   PubMed Web of Science ®Google Scholar
• Montenegro L, Sinico C, Castangia I, et al. Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. Int J Pharm. 2012;434(1–2):169–174.
   PubMed Web of Science ®Google Scholar
• Montenegro L, Panico AM, Santagati LM, et al. Solid lipid nanoparticles loading idebenone ester with pyroglutamic acid: in vitro antioxidant activity and in vivo topical efficacy. Nanomaterials (Basel). 2018 Dec 29;9(1). PubMed PMID: 30597985; PubMed Central PMCID: PMCPMC6359231. DOI:10.3390/nano9010043
   PubMedGoogle Scholar
• Raza K, Singh B, Singal P, et al. Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids Surf B Biointerfaces. 2013 May;1(105):67–74. PubMed PMID: 23357735.
   PubMed Web of Science ®Google Scholar
• Guo D, Dou D, Li X, et al. Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour. Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):255–262. PubMed PMID: 28368657.
   PubMed Web of Science ®Google Scholar
• Gonullu U, Uner M, Yener G, et al. Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery. Acta Pharm. 2015 Mar;65(1):1–13. PubMed PMID: 25781700.
   PubMed Web of Science ®Google Scholar
• Khurana S, Bedi PM, Jain NK. Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam. Chem Phys Lipids. 2013 Oct-Nov;175–176:65–72. PubMed PMID: 23994283.
   PubMed Web of Science ®Google Scholar
• Rostamkalaei SS, Akbari J, Saeedi M, et al. Topical gel of Metformin solid lipid nanoparticles: A hopeful promise as a dermal delivery system. Colloids Surf B Biointerfaces. 2019;175:150–157.
   PubMed Web of Science ®Google Scholar
• Jain S, Jain S, Khare P, et al. Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent. Drug Deliv. 2010 Aug;17(6):443–451. PubMed PMID: 20486871.
   PubMed Web of Science ®Google Scholar
• Madan JR, Khude PA, Dua K. Development and evaluation of solid lipid nanoparticles of mometasone furoate for topical delivery. Int J Pharm Investig. 2014 Apr;4(2):60–64. PubMed PMID: 25006550; PubMed Central PMCID: PMCPMC4083535.
   PubMedGoogle Scholar
• Akbari J, Saeedi M, Morteza-Semnani K, et al. The design of naproxen solid lipid nanoparticles to target skin layers. Colloids Surf B Biointerfaces. 2016 Sep;1(145):626–633. PubMed PMID: 27288817.
   PubMed Web of Science ®Google Scholar
• Mohammadi-Samani S, Zojaji S, Entezar-Almahdi E. Piroxicam loaded solid lipid nanoparticles for topical delivery: preparation, characterization and in vitro permeation assessment. J Drug Delivery Sci Technol. 2018;47:427–433.
   Web of Science ®Google Scholar
• Shrotriya SN, Ranpise NS, Vidhate BV. Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis. Drug Deliv Transl Res. 2017 Feb;7(1):37–52. PubMed PMID: 27981502.
   PubMed Web of Science ®Google Scholar
• Rigon RB, Fachinetti N, Severino P, et al. Skin delivery and in vitro biological evaluation of trans-resveratrol-loaded solid lipid nanoparticles for skin disorder therapies. Molecules. 2016 Jan 20;21(1):E116. PubMed PMID: 26805794; PubMed Central PMCID: PMCPMC6273087.
   PubMed Web of Science ®Google Scholar
• Castro GA, Oliveira CA, Mahecha GA, et al. Comedolytic effect and reduced skin irritation of a new formulation of all-trans retinoic acid-loaded solid lipid nanoparticles for topical treatment of acne. Arch Dermatol Res. 2011 Sep;303(7):513–520. PubMed PMID: 21298279.
   PubMed Web of Science ®Google Scholar
• Silva EL, Carneiro G, De Araujo LA, et al. Solid lipid nanoparticles loaded with retinoic acid and lauric acid as an alternative for topical treatment of acne vulgaris. J Nanosci Nanotechnol. 2015 Jan;15(1):792–799. PubMed PMID: 26328443.
   PubMed Web of Science ®Google Scholar
• Clares B, Calpena AC, Parra A, et al. Nanoemulsions (NEs), liposomes (LPs) and solid lipid nanoparticles (SLNs) for retinyl palmitate: effect on skin permeation. Int J Pharm. 2014 Oct 1;473(1–2):591–598. PubMed PMID: 25102113.
   PubMedGoogle Scholar
• Khameneh B, Halimi V, Jaafari MR, et al. Safranal-loaded solid lipid nanoparticles: evaluation of sunscreen and moisturizing potential for topical applications. Iran J Basic Med Sci. 2015 Jan;18(1):58–63. PubMed PMID: 25810877; PubMed Central PMCID: PMCPMC4366744.
   PubMed Web of Science ®Google Scholar
• Geetha T, Kapila M, Prakash O, et al. Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer. J Drug Target. 2015 Feb;23(2):159–169. PubMed PMID: 25268273.
   PubMed Web of Science ®Google Scholar
• Shrotriya SN, Vidhate BV, Shukla MS. Formulation and development of silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis. J Drug Delivery Sci Technol. 2017;41:164–173.
   Web of Science ®Google Scholar
• Kelidari HR, Saeedi M, Akbari J, et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. Colloids Surf B Biointerfaces. 2015 Apr;1(128):473–479. PubMed PMID: 25797482.
   PubMed Web of Science ®Google Scholar
• Kang JH, Chon J, Kim YI, et al. Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution. Int J Nanomedicine. 2019;14:5381–5396. PubMed PMID: 31409994; PubMed Central PMCID: PMCPMC6645695.
   PubMed Web of Science ®Google Scholar
• Vaghasiya H, Kumar A, Sawant K. Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride. Eur J Pharm Sci. 2013 May 13;49(2):311–322. PubMed PMID: 23557842.
   PubMed Web of Science ®Google Scholar
• Chen YC, Liu DZ, Liu JJ, et al. Development of terbinafine solid lipid nanoparticles as a topical delivery system. Int J Nanomedicine. 2012;7:4409–4418. PubMed PMID: 22923986; PubMed Central PMCID: PMCPMC3423152.
   PubMed Web of Science ®Google Scholar
• Ridolfi DM, Marcato PD, Justo GZ, et al. Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin. Colloids Surf B Biointerfaces. 2012;93:36–40.
   PubMed Web of Science ®Google Scholar
• Pradhan M, Singh D, Singh MR. Influence of selected variables on fabrication of triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. Artif Cells Nanomed Biotechnol. 2016;44(1):392–400. PubMed PMID: 25229831.
   PubMed Web of Science ®Google Scholar
• Nnamani PO, Hansen S, Windbergs M, et al. Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. Int J Pharm. 2014 Dec 30;477(1–2):208–217. PubMed PMID: 25290810.
   PubMed Web of Science ®Google Scholar
• Aditya NP, Patankar S, Madhusudhan B, et al. Arthemeter-loaded lipid nanoparticles produced by modified thin-film hydration: pharmacokinetics, toxicological and in vivo anti-malarial activity. Eur J Pharm Sci. 2010 Aug 11;40(5):448–455. PubMed PMID: 20493255.
   PubMed Web of Science ®Google Scholar
• Kong X, Zhao Y, Quan P, et al. Development of a topical ointment of betamethasone dipropionate loaded nanostructured lipid carrier. Asian J Pharm Sci. 2016;11(2):248–254.
   Web of Science ®Google Scholar
• Yue Y, Zhao D, Yin Q. Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: in vitro and in vivo anesthesia evaluation. Biomed Pharmacother. 2018 Feb;98:813–820. PubMed PMID: 29571251.
   PubMed Web of Science ®Google Scholar
• Lin YK, Huang ZR, Zhuo RZ, et al. Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. Int J Nanomedicine. 2010 Mar 9;5:117–128. PubMed PMID: 20309398; PubMed Central PMCID: PMCPMC2841490.
   PubMed Web of Science ®Google Scholar
• Chen S, Liu W, Wan J, et al. Preparation of coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique. Drug Dev Ind Pharm. 2013 Jan;39(1):20–28. PubMed PMID: 23116283.
   PubMed Web of Science ®Google Scholar
• Nguyen CN, Nguyen TTT, Nguyen HT, et al. Nanostructured lipid carriers to enhance transdermal delivery and efficacy of diclofenac. Drug Deliv Transl Res. 2017 Oct;7(5):664–673. 10.1007/s13346-017-0415-2. PubMed PMID: 28776220.
   PubMed Web of Science ®Google Scholar
• Abdel-Salam FS, Mahmoud AA, Ammar HO, et al. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. J Liposome Res. 2017 Mar;27(1):41–55. PubMed PMID: 26956098.
   PubMed Web of Science ®Google Scholar
• Lin Y-K, Al-Suwayeh SA, Leu Y-L, et al. Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata. Pharm Res. 2013;30(2):435–446.
   PubMed Web of Science ®Google Scholar
• Fan X, Chen J, Shen Q. Docetaxel-nicotinamide complex-loaded nanostructured lipid carriers for transdermal delivery. Int J Pharm. 2013 Dec 31;458(2):296–304. PubMed PMID: 24177313.
   PubMed Web of Science ®Google Scholar
• Mendes IT, Ruela ALM, Carvalho FC, et al. Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil. Colloids Surf B Biointerfaces. 2019 May;1(177):274–281. PubMed PMID: 30763792.
   PubMed Web of Science ®Google Scholar
• Jain A, Mehra NK, Nahar M, et al. Topical delivery of enoxaparin using nanostructured lipid carrier. J Microencapsul. 2013;30(7):709–715. PubMed PMID: 23534492.
   PubMed Web of Science ®Google Scholar
• Han F, Yin R, Che X, et al. Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation. Int J Pharm. 2012 Dec 15;439(1–2):349–357. PubMed PMID: 22989987.
   PubMed Web of Science ®Google Scholar
• Cirri M, Bragagni M, Mennini N, et al. Development of a new delivery system consisting in “drug–in cyclodextrin–in nanostructured lipid carriers” for ketoprofen topical delivery. Eur J Pharm Biopharm. 2012 Jan;80(1):46–53. PubMed PMID: 21839833.
   PubMed Web of Science ®Google Scholar
• Lin WJ, Duh YS. Nanostructured lipid carriers for transdermal delivery of acid labile lansoprazole. Eur J Pharm Biopharm. 2016 Nov;108:297–303. PubMed PMID: 27449633.
   PubMed Web of Science ®Google Scholar
• Bhagurkar AM, Repka MA, Murthy SN. A novel approach for the development of a nanostructured lipid carrier formulation by hot-melt extrusion technology. J Pharm Sci. 2017 Apr;106(4):1085–1091. PubMed PMID: 28040458.
   PubMed Web of Science ®Google Scholar
• Okonogi S, Riangjanapatee P. Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration. Int J Pharm. 2015 Jan 30;478(2):726–735. PubMed PMID: 25479097.
   PubMed Web of Science ®Google Scholar
• Khurana S, Jain NK, Bedi PM. Development and characterization of a novel controlled release drug delivery system based on nanostructured lipid carriers gel for meloxicam. Life Sci. 2013 Nov 13;93(21):763–772. PubMed PMID: 24113071.
   PubMed Web of Science ®Google Scholar
• Singh S, Singh M, Tripathi CB, et al. Development and evaluation of ultra-small nanostructured lipid carriers: novel topical delivery system for athlete’s foot. Drug Deliv Transl Res. 2016 Feb;6(1):38–47. 10.1007/s13346-015-0263-x. PubMed PMID: 26542152.
   PubMed Web of Science ®Google Scholar
• Uprit S, Kumar Sahu R, Roy A, et al. Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia. Saudi Pharm J. 2013 Oct;21(4):379–385. PubMed PMID: 24227958; PubMed Central PMCID: PMCPMC3824938.
   PubMed Web of Science ®Google Scholar
• Kim BS, Na YG, Choi JH, et al. The improvement of skin whitening of phenylethyl resorcinol by nanostructured lipid carriers. Nanomaterials (Basel). 2017 Aug 28;7(9). PubMed PMID: 28846658; PubMed Central PMCID: PMCPMC5618352. DOI:10.3390/nano7090241
   Google Scholar
• Alam S, Aslam M, Khan A, et al. Nanostructured lipid carriers of pioglitazone for transdermal application: from experimental design to bioactivity detail. Drug Deliv. 2016;23(2):601–609. PubMed PMID: 24937378.
   PubMed Web of Science ®Google Scholar
• Zhao J, Piao X, Shi X, et al. Podophyllotoxin-loaded nanostructured lipid carriers for skin targeting: in vitro and in vivo studies. Molecules. 2016 Nov 17;21(11). PubMed PMID: 27869698; PubMed Central PMCID: PMCPMC6274358. DOI:10.3390/molecules21111549
   Web of Science ®Google Scholar
• Chen-yu G, Chun-fen Y, Qi-lu L, et al. Development of a quercetin-loaded nanostructured lipid carrier formulation for topical delivery. Int J Pharm. 2012 Jul 1;430(1–2):292–298. PubMed PMID: 22486962.
   PubMed Web of Science ®Google Scholar
• Lee SG, Jeong JH, Kim SR, et al. Topical formulation of retinyl retinoate employing nanostructured lipid carriers. J Pharm Invest. 2012;42(5):243–250.
   Google Scholar
• Chauhan MK, Sharma PK. Optimization and characterization of rivastigmine nanolipid carrier loaded transdermal patches for the treatment of dementia. Chem Phys Lipids. 2019 Nov;224:104794. PubMed PMID: 31361985.
   PubMed Web of Science ®Google Scholar
• Chen H, Wang Y, Zhai Y, et al. Development of a ropivacaine-loaded nanostructured lipid carrier formulation for transdermal delivery. Colloids Surf A Physicochem Eng Asp. 2015;465:130–136.
   Web of Science ®Google Scholar
• Kovacs A, Berko S, Csanyi E, et al. Development of nanostructured lipid carriers containing salicyclic acid for dermal use based on the quality by design method. Eur J Pharm Sci. 2017 Mar;1(99):246–257. PubMed PMID: 28012940.
   PubMed Web of Science ®Google Scholar
• Elnaggar YS, El-Massik MA, Abdallah OY. Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles. Int J Nanomedicine. 2011;6:3195–3205. PubMed PMID: 22238508; PubMed Central PMCID: PMCPMC3254264.
   PubMed Web of Science ®Google Scholar
• Shamma RN, Aburahma MH. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. Int J Nanomedicine. 2014;9:5449–5460. PubMed PMID: 25473283; PubMed Central PMCID: PMCPMC4251754.
   PubMed Web of Science ®Google Scholar
• Savic V, Ilic T, Nikolic I, et al. Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: formulation characterization and assessment of dermal delivery compared to referent ointment. Int J Pharm. 2019 Oct;5(569):118624. PubMed PMID: 31419461.
   PubMed Web of Science ®Google Scholar
• Gaba B, Fazil M, Khan S, et al. Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride. Bull Faculty Pharm Cairo Univ. 2015;53(2):147–159.
   Google Scholar
• Chen Y, Zhou L, Yuan L, et al. Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers. Int J Nanomedicine. 2012;7:3023–3032. PubMed PMID: 22787398; PubMed Central PMCID: PMCPMC3392146.
   PubMed Web of Science ®Google Scholar
• Santos GA, Angelo T, Andrade LM, et al. The role of formulation and follicular pathway in voriconazole cutaneous delivery from liposomes and nanostructured lipid carriers. Colloids Surf B Biointerfaces. 2018 Oct;1(170):341–346. PubMed PMID: 29940500.
   PubMed Web of Science ®Google Scholar
• Song SH, Lee KM, Kang JB, et al. Improved skin delivery of voriconazole with a nanostructured lipid carrier-based hydrogel formulation. Chem Pharm Bull (Tokyo). 2014;62(8):793–798. PubMed PMID: 25087631.
   PubMed Web of Science ®Google Scholar
• Bikkad ML, Nathani AH, Mandlik SK, et al. Halobetasol propionate-loaded solid lipid nanoparticles (SLN) for skin targeting by topical delivery. J Liposome Res. 2014 Jun;24(2):113–123. PubMed PMID: 24131382.
   PubMed Web of Science ®Google Scholar
• Montenegro L, Sinico C, Castangia I, et al. Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. Int J Pharm. 2012 Sep 15;434(1–2):169–174. PubMed PMID: 22659127.
   PubMed Web of Science ®Google Scholar
• Harde H, Agrawal AK, Katariya M, et al. Development of a topical adapalene-solid lipid nanoparticle loaded gel with enhanced efficacy and improved skin tolerability [10.1039/C5RA06047H]. RSC Adv. 2015;5(55):43917–43929.
   Web of Science ®Google Scholar
• Waghule T, Rapalli VK, Singhvi G, et al. Voriconazole loaded nanostructured lipid carriers based topical delivery system: qbD based designing, characterization, in-vitro and ex-vivo evaluation. J Drug Delivery Sci Technol. 2019;52:303–315.
   Web of Science ®Google Scholar
• Moghddam SM, Ahad A, Aqil M, et al. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using box-behnken design approach. Artif Cells Nanomed Biotechnol. 2017 May;45(3):617–624. PubMed PMID: 27050533.
   PubMed Web of Science ®Google Scholar
• Jain A, Garg NK, Jain A, et al. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne. Drug Dev Ind Pharm. 2016;42(6):897–905.
   PubMed Web of Science ®Google Scholar
• Chen H, Chang X, Du D, et al. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release. 2006 Jan 10;110(2):296–306. PubMed PMID: 16325954.
   PubMed Web of Science ®Google Scholar
• Souto EB, Wissing SA, Barbosa CM, et al. Comparative study between the viscoelastic behaviors of different lipid nanoparticle formulations. J Cosmet Sci. 2004 Sep-Oct;55(5):463–471. PubMed PMID: 15608996.
   PubMed Web of Science ®Google Scholar
• Shrotriya SN, Ranpise NS, Vidhate BV. Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis. Drug Deliv Transl Res. 2017 Feb 01;7(1):37–52.
   PubMed Web of Science ®Google Scholar
• Souto EB, Dias-Ferreira J, Oliveira J, et al. Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach. Int J Mol Sci. 2019;20:5659.
   Google Scholar
• Raj R, Mongia P, Ram A, et al. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Artif Cells Nanomed Biotechnol. 2016 Aug 17;44(6):1434–1439.
   PubMed Web of Science ®Google Scholar
• Akbari J, Saeedi M, Morteza-Semnani K, et al. The design of naproxen solid lipid nanoparticles to target skin layers. Colloids Surf B Biointerfaces. 2016;145:626–633.
   PubMed Web of Science ®Google Scholar
• Bikkad ML, Nathani AH, Mandlik SK, et al. Halobetasol propionate-loaded solid lipid nanoparticles (SLN) for skin targeting by topical delivery. J Liposome Res. 2014 Jun 01;24(2):113–123.
   PubMed Web of Science ®Google Scholar
• Zhao J, Piao X, Shi X, et al. Podophyllotoxin-loaded nanostructured lipid carriers for skin targeting: in vitro and in vivo studies. Molecules. 2016;21(11):1549. PubMed PMID: 27869698; eng.
   Web of Science ®Google Scholar
• Chen S, Liu W, Wan J, et al. Preparation of Coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique. Drug Dev Ind Pharm. 2013 Jan 01;39(1):20–28.
   PubMed Web of Science ®Google Scholar
• Rocha KAD, Krawczyk-Santos AP, Andrade LM, et al. Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate. Int J Pharm. 2017 Oct 5;531(1):292–298. PubMed PMID: 28859937.
   PubMed Web of Science ®Google Scholar
• Guo D, Dou D, Li X, et al. Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour. Artif Cells Nanomed Biotechnol. 2018 Feb 17;46(2):255–262.
   PubMed Web of Science ®Google Scholar
• Lee MH, Shin GH, Park HJ. Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system. J Appl Polym Sci. 2018;135(11):46004.
   Web of Science ®Google Scholar
• Gaur PK, Mishra S, Verma A, et al. Ceramide–palmitic acid complex based curcumin solid lipid nanoparticles for transdermal delivery: pharmacokinetic and pharmacodynamic study. J Exp Nanosci. 2016 Jan 02;11(1):38–53.
   Web of Science ®Google Scholar
• Chauhan MK, Sharma PK. Optimization and characterization of rivastigmine nanolipid carrier loaded transdermal patches for the treatment of dementia. Chem Phys Lipids. 2019 Nov 01;224: 104794.
   PubMed Web of Science ®Google Scholar
• Yue Y, Zhao D, Yin Q. Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: in vitro and in vivo anesthesia evaluation. Biomed Pharmacother. 2018 Feb 01;98: 813–820.
   PubMed Web of Science ®Google Scholar