Nanofibers as drug-delivery systems for infection control in dentistry

References

• Vieira Colombo AP, Magalhães CB, Hartenbach FARR, et al. Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance. Microb Pathog. 2015;94:27–34.
   PubMed Web of Science ®Google Scholar
• Wang D, Haapasalo M, Gao Y, et al. Antibiofilm peptides against biofilms on titanium and hydroxyapatite surfaces. Bioact Mater. 2018;3:418–425.
   PubMed Web of Science ®Google Scholar
• Wang Z, de la Fuente-nunez C, Shen Y, et al. Treatment of oral multispecies biofilms by an anti-biofilm peptide. PLoS One. 2015;10:e0132512.
   PubMed Web of Science ®Google Scholar
• Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013;69:137–143.
   PubMed Web of Science ®Google Scholar
• Bottino MC, Kamocki K, Yassen GH, et al. Bioactive nanofibrous scaffolds for regenerative endodontics. J Dent Res. 2013;92:963–969.
   PubMed Web of Science ®Google Scholar
• Wang L, Hu C, Shao L. The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine. 2017;12:1227–1249.
   PubMed Web of Science ®Google Scholar
• Albuquerque MT, Valera MC, Moreira CS, et al. Effects of ciprofloxacin-containing scaffolds on enterococcus faecalis biofilms. J Endod. 2015;41:710–714.
   PubMed Web of Science ®Google Scholar
• Chaturvedi TP, Srivastava R, Srivastava AK, et al. Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis - A clinical evaluation. J Clin Diagnostic Res. 2013;7:2339–2342.
   PubMedGoogle Scholar
• Viana JFC, Carrijo J, Freitas CG, et al. Antifungal nanofibers made by controlled release of sea animal derived peptide. Nanoscale. 2015;7:6238–6246.
   PubMed Web of Science ®Google Scholar
• Samprasit W, Rojanarata T, Akkaramongkolporn P, et al. Fabrication and in vitro/in vivo performance of mucoadhesive electrospun nanofiber mats containing α-mangostin. AAPS PharmSciTech. 2015;16:1140–1152.
   PubMed Web of Science ®Google Scholar
• Freitas RA. Molecular robots and other high-tech possibilities. J Am Dent Assoc. 2000;131:1559–1565.
   PubMed Web of Science ®Google Scholar
• Bapat RA, Joshi CP, Bapat P, et al. The use of nanoparticles as biomaterials in dentistry. Drug Discov Today. 2019;24:85–98.
   PubMed Web of Science ®Google Scholar
• Zafar MS, Alnazzawi AA, Alrahabi M, et al. Nanotechnology and nanomaterials in dentistry. Adv Dent Biomater. 2019;2019:477–505.
   Google Scholar
• Dvir T, Timko BP, Kohane DS, et al. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol. Nature Publishing Group 2011;6: 13–22.
   PubMed Web of Science ®Google Scholar
• Nandi SK, Mahato A, Kundu B, et al. Organic–inorganic micro/nanofiber composites for biomedical applications. Mater Biomed Eng. 2019;2019:21–55.
   Google Scholar
• Beachley V, Wen X. Polymer nanofibrous structures: fabrication, biofunctionalization, and cell interactions. Prog Polym Sci. 2010;35:868–892.
   PubMed Web of Science ®Google Scholar
• Bhardwaj N, Kundu SC. Electrospinning: A fascinating fiber fabrication technique. Biotechnol Adv. 2010;28:325–347.
   PubMed Web of Science ®Google Scholar
• Rivero G, Aldana AA, Abraham GA. Nanocomposite electrospun micro/nanofibers for biomedical applications. Mater Biomed Eng. 2019;2019:89–126.
   Google Scholar
• Albuquerque MTP, Evans JD, Gregory RL, et al. Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm. Clin Oral Investig. 2016;20:387–393.
   PubMed Web of Science ®Google Scholar
• Albuquerque MTP, Ryan SJ, Münchow EA, et al. Antimicrobial effects of novel triple antibiotic paste-mimic scaffolds on actinomyces naeslundii biofilm. J Endod. 2015;41:1337–1343.
   PubMed Web of Science ®Google Scholar
• Shahi RG, Albuquerque MTP, Münchow EA, et al. Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. Odontology. 2017;105:354–363.
   PubMed Web of Science ®Google Scholar
• de Carvalho LD, Peres BU, Maezono H, et al. Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats. J Appl Oral Sci. 2019;27:1–10.
   Web of Science ®Google Scholar
• Grafe T, Graham K, Polymeric nanofibers and nanofiber webs: a new class of nonwovens. Int Nonwovens J. 2003;os-12: 1558925003os – 12.
   Google Scholar
• Pulapura S, Kohn J. Trends in the development of bioresorbable polymers for medical applications. J Biomater Appl. 1992;6:216–250.
   PubMedGoogle Scholar
• Zhou L, He H, Li MC, et al. Grafting polycaprolactone diol onto cellulose nanocrystals via click chemistry: enhancing thermal stability and hydrophobic property. Carbohydr Polym. 2018;189:331–341.
   PubMed Web of Science ®Google Scholar
• Bharadwaz A, Jayasuriya AC, Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration. Mater Sci Eng C. 2020; 110.
   PubMed Web of Science ®Google Scholar
• Tao O, Kort-Mascort J, Lin Y, et al. The applications of 3D printing for craniofacial tissue engineering. Micromachines. 2019;10: 480.
   Web of Science ®Google Scholar
• Jauregui C, Yoganarasimha S, Madurantakam P. Mesenchymal stem cells derived from healthy and diseased human gingiva support osteogenesis on electrospun polycaprolactone scaffolds. Bioengineering. 2018;5(1):8.
   Google Scholar
• Goonoo N, Jeetah R, Bhaw-Luximon A, et al. Polydioxanone-based bio-materials for tissue engineering and drug/gene delivery applications. Eur J Pharm Biopharm. 2015;97: 371–391.
   PubMed Web of Science ®Google Scholar
• Ray JA, Doddi N, Regula D, et al. Polydioxanone (PDS), a novel monofilament synthetic absorbable suture. Surg Gynecol Obstet. 1981;153:497–507.
   PubMedGoogle Scholar
• Albuquerque MT, Valera MC, Nakashima M, et al. Tissue-engineering-based strategies for regenerative endodontics. J Dent Res. 2014;93:1222–1231.
   PubMed Web of Science ®Google Scholar
• Balagangadharan K, Dhivya S, Selvamurugan N. Chitosan based nanofibers in bone tissue engineering. Int J Biol Macromol. 2017;104:1372–1382.
   PubMed Web of Science ®Google Scholar
• Vasconcelos DP, Fonseca AC, Costa M, et al. Macrophage polarization following chitosan implantation. Biomaterials. 2013;34:9952–9959.
   PubMed Web of Science ®Google Scholar
• Miller RJ, Chan CY, Rastogi A, et al. Combining electrospun nanofibers with cell-encapsulating hydrogel fibers for neural tissue engineering. J Biomater Sci Polym Ed. 2018;94:1625–1642.
   Web of Science ®Google Scholar
• Mousavi SA, Ghotaslou R, Kordi S, et al. Antibacterial and antifungal effects of chitosan nanoparticles on tissue conditioners of complete dentures. Int J Biol Macromol. 2018;118:881–885.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Jin F, Wu Z, et al. O-acylation of chitosan nanofibers by short-chain and long-chain fatty acids. Carbohydr Polym. 2017;177:203–209.
   PubMed Web of Science ®Google Scholar
• Koosha M, Mirzadeh H. Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers. J Biomed Mater Res A. 2015;103:3081–3093.
   PubMed Web of Science ®Google Scholar
• Bhattacharya M, Seong W-J. Carbon nanotube-based materials—Preparation, biocompatibility, and applications in dentistry. Nanobiomater Clin Dent. 2019;2019:41–76.
   Google Scholar
• Kim HW, Kim HE. Nanofiber generation of hydroxyapatite and fluor-hydroxyapatite bioceramics. J Biomed Mater Res - Part B Appl Biomater. 2006;77:323–328.
   PubMed Web of Science ®Google Scholar
• Ranjbar M, Pardakhty A, Tahmipour B, et al. Novel CaO/polylactic acid nanoscaffold as dental resin nanocomposites and the investigation of physicochemical properties. Luminescence. 2019;34:360–367.
   PubMed Web of Science ®Google Scholar
• Peres BU, Manso AP, Carvalho LD, et al. Experimental composites of polyacrilonitrile-electrospun nanofibers containing nanocrystal cellulose. Dent Mater. 2019;35:e286–e297.
   PubMed Web of Science ®Google Scholar
• Boda SK, Almoshari Y, Wang H, et al. Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration. Acta Biomater. 2019;85:282–293.
   PubMed Web of Science ®Google Scholar
• Elsayed NA, Zada S, Allam NK. Mineralization of electrospun gelatin/CaCO 3 composites: A new approach for dental applications. Mater Sci Eng C. 2019;100:655–664.
   PubMed Web of Science ®Google Scholar
• Mohammadian F, Eatemadi A. Drug loading and delivery using nanofibers scaffolds. Artif. Cells, Nanomed Biotechnol. 2017;45:881–888.
   PubMed Web of Science ®Google Scholar
• García-López E, Olvera-Trejo D, Velásquez-García LF. 3D printed multiplexed electrospinning sources for large-scale production of aligned nanofiber mats with small diameter spread. Nanotechnology. 2017;28:425302.
   PubMed Web of Science ®Google Scholar
• Hosseini FS, Enderami SE, Hadian A, et al. Efficient osteogenic differentiation of the dental pulp stem cells on β-glycerophosphate loaded polycaprolactone/polyethylene oxide blend nanofibers. J Cell Physiol. 2019;234:13951–13958.
   PubMed Web of Science ®Google Scholar
• Alipour M, Aghazadeh M, Akbarzadeh A, et al. Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds Artif. Cells, Nanomed Biotechnol. 2019;47:3431–3437.
   PubMed Web of Science ®Google Scholar
• Hokmabad VR, Davaran S, Aghazadeh M, et al. Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering. Front Chem Sci Eng. 2019;13:108–119.
   Web of Science ®Google Scholar
• Kaushik SN, Kim B, Walma AM, et al. Biomimetic microenvironments for regenerative endodontics. Biomater Res. 2016;20:14.
   PubMedGoogle Scholar
• Bottino MC, Münchow EA, Albuquerque MTP, et al. Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier. J Biomed Mater Res - Part B Appl Biomater. 2017;105:2085–2092.
   PubMed Web of Science ®Google Scholar
• Dadras Chomachayi M, Solouk A, Akbari S, et al. Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: thyme essential oil and doxycycline monohydrate release study. J Biomed Mater Res A. 2018;106:1092–1103.
   PubMed Web of Science ®Google Scholar
• Ramírez-Agudelo R, Scheuermann K, Gala-García A, et al. Hybrid nanofibers based on poly-caprolactone/gelatin/hydroxyapatite nanoparticles-loaded Doxycycline: effective anti-tumoral and antibacterial activity. Mater Sci Eng C. 2018;83:25–34.
   PubMed Web of Science ®Google Scholar
• Pitts NB, Zero DT, Marsh PD, et al. Dental caries. Nat Rev Dis Prim. 2017;3:17030.
   PubMed Web of Science ®Google Scholar
• Frencken JE, Sharma P, Stenhouse L, et al. Global epidemiology of dental caries and severe periodontitis – a comprehensive review. J Clin Periodontol. 2017;44:S94–S105.
   PubMed Web of Science ®Google Scholar
• Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet. 2007;369:51–59.
   PubMed Web of Science ®Google Scholar
• Cheng L, Zhang K, Weir MD, et al. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries. Nanomedicine. 2015;10: 627–641.
   PubMed Web of Science ®Google Scholar
• Samprasit W, Kaomongkolgit R, Sukma M, et al. Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention. Carbohydr Polym. 2015;117:933–940.
   PubMed Web of Science ®Google Scholar
• Esteban-Tejeda L, Cabal B, Torrecillas R, et al. Antimicrobial activity of submicron glass fibres incorporated as a filler to a dental sealer. Biomed Mater. 2016;11(4):045014.
   Web of Science ®Google Scholar
• Dieste O, Quintero F, Pou J, et al. Influence of the working conditions on nanofiber diameters obtained by Laser Spinning. Appl Phys A Mater Sci Process. 2011;104:1217–1222.
   Web of Science ®Google Scholar
• Gutierrez-Orozco F, Thomas-Ahner JM, Berman-Booty LD, et al. Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice. Mol Nutr Food Res. 2014;58:1226–1238.
   PubMed Web of Science ®Google Scholar
• Blokland A, Watt RG, Tsakos G, et al. Traumatic dental injuries and socioeconomic position - findings from the Children’s Dental Health Survey 2013. Community Dent Oral Epidemiol. 2016;44:586–591.
   PubMed Web of Science ®Google Scholar
• He L, Zhong J, Gong Q, et al. Treatment of necrotic teeth by apical revascularization: meta-analysis. Sci Rep. 2017;7(1): 13941.
   Web of Science ®Google Scholar
• Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. J Endod. 2007;33:377–390.
   PubMed Web of Science ®Google Scholar
• Nagata JY, Soares AJ, Souza-Filho FJ, et al. Microbial evaluation of traumatized teeth treated with triple antibiotic paste or calcium hydroxide with 2% chlorhexidine gel in pulp revascularization. J Endod. 2014;40:778–783.
   PubMed Web of Science ®Google Scholar
• Adnan S, Ullah R. Top-cited articles in regenerative endodontics: a bibliometric analysis. J Endod. 2018;44:1650–1664.
   PubMed Web of Science ®Google Scholar
• Simon SR, Tomson PL, Berdal A. Regenerative endodontics: regeneration or repair? J Endod. 2014;40:S70–5.
   PubMed Web of Science ®Google Scholar
• Kim SG, Malek M, Sigurdsson A, et al. Regenerative endodontics: a comprehensive review. Int Endod J. 2018;51:1367–1388.
   Web of Science ®Google Scholar
• Sampaio-Maia B, Caldas IM, Pereira ML, et al. The oral microbiome in health and its implication in oral and systemic diseases. Adv Appl Microbiol. 2016;97:171–210.
   PubMed Web of Science ®Google Scholar
• Murray PE. Platelet-rich plasma and platelet-rich fibrin can induce apical closure more frequently than blood-clot revascularization for the regeneration of immature permanent teeth: a meta-analysis of clinical efficacy. Front Bioeng Biotechnol. 2018;6:139.
   PubMed Web of Science ®Google Scholar
• Arruda MEF, Neves MAS, Diogenes A, et al. Infection control in teeth with apical periodontitis using a triple antibiotic solution or calcium hydroxide with chlorhexidine: a randomized clinical trial. J Endod. 2018;44:1474–1479.
   PubMed Web of Science ®Google Scholar
• Abbaszadegan A, Dadolahi S, Gholami A, et al. Antimicrobial and cytotoxic activity of cinnamomum zeylanicum, calcium hydroxide, and triple antibiotic paste as root canal dressing materials. J Contemp Dent Pr. 2016;17:105–113.
   PubMedGoogle Scholar
• Hoshino E, Kurihara-Ando N, Sato I, et al. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J. 1996;29:125–130.
   PubMed Web of Science ®Google Scholar
• Porter MLA, Münchow EA, Albuquerque MTP, et al. Effects of novel 3-dimensional antibiotic-containing electrospun Scaffolds on dentin discoloration. J Endod. 2016;42:106–112.
   PubMed Web of Science ®Google Scholar
• Arslan H, Akcay M, Cakir M, et al. Comparison of bond strength of self-etch adhesive to pulp chamber dentin after placement of calcium hydroxide and various antibiotic pastes. Acta Odontol Scand. 2015;73:226–231.
   PubMed Web of Science ®Google Scholar
• Villarreal-Gómez LJ, Cornejo-Bravo JM, Vera-Graziano R, et al. Electrospinning as a powerful technique for biomedical applications: a critically selected survey. J Biomater Sci Polym Ed. 2016;27:157–176.
   PubMed Web of Science ®Google Scholar
• Siqueira JF Jr. Endodontic infections: concepts, paradigms, and perspectives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:281–293.
   PubMed Web of Science ®Google Scholar
• Fouad AF. Microbiological aspects of traumatic injuries. Dent Traumatol. 2019;35:324–332.
   PubMed Web of Science ®Google Scholar
• Murad CF, Sassone LM, Faveri M, et al. Microbial diversity in persistent root canal infections investigated by checkerboard DNA-DNA hybridization. J Endod. 2014;40:899–906.
   PubMed Web of Science ®Google Scholar
• Palasuk J, Kamocki K, Hippenmeyer L, et al. Bimix antimicrobial scaffolds for regenerative endodontics. J Endod. 2014;40:1879–1884.
   PubMed Web of Science ®Google Scholar
• Wright MEE, Wong AT, Levitt D, et al. Influence of ciprofloxacin-based additives on the hydrolysis of nanofiber polyurethane membranes. J Biomed Mater Res A. 2018;106:1211–1222.
   PubMed Web of Science ®Google Scholar
• Ricucci D, Siqueira JF Jr, Loghin S, et al. Pulp and apical tissue response to deep caries in immature teeth: A histologic and histobacteriologic study. J Dent. 2017;56:19–32.
   PubMed Web of Science ®Google Scholar
• Albuquerque MTP, Nagata J, Bottino MC. Antimicrobial efficacy of triple antibiotic–eluting polymer nanofibers against multispecies biofilm. J Endod. 2017;43:S51–S56.
   PubMed Web of Science ®Google Scholar
• Althumairy RI, Teixeira FB, Diogenes A. Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla. J Endod. 2014;40:521–525.
   PubMed Web of Science ®Google Scholar
• Karczewski A, Feitosa SA, Hamer EI, et al. Clindamycin-modified triple antibiotic nanofibers: a stain-free antimicrobial intracanal drug delivery system. J Endod. 2018;44:155–162.
   PubMed Web of Science ®Google Scholar
• Kinane DF, Stathopoulou PG, Papapanou PN, Periodontal diseases. Nat Rev Dis Primers. 2017; 3. Nature Publishing Group.
   Web of Science ®Google Scholar
• Meyle J, Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontol. 2000;2015(69):7–17.
   Google Scholar
• Hasturk H, Kantarci A. Activation and resolution of periodontal inflammation and its systemic impact. Periodontol. 2000;2015(69):255–273.
   Google Scholar
• Carrizales-Sepúlveda EF, Ordaz-Farías A, Vera-Pineda R, et al. Periodontal disease, systemic inflammation and the risk of cardiovascular disease. Heart Lung Circ. 2018;27: 1327–1334.
   PubMed Web of Science ®Google Scholar
• Jepsen K, Jepsen S. Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis. Periodontol 2000. 2016;71:82–112.
   PubMed Web of Science ®Google Scholar
• Szulc M, Zakrzewska A, Zborowski J. Local drug delivery in periodontitis treatment: A review of contemporary literature. Dent Med Probl. 2018;55:333–342.
   PubMed Web of Science ®Google Scholar
• Chen X, Wu G, Feng Z, et al. Advanced biomaterials and their potential applications in the treatment of periodontal disease. Crit Rev Biotechnol. 2016;36(4):760–775.
   PubMed Web of Science ®Google Scholar
• Schulz S, Porsch M, Grosse I, et al. Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. Arch Oral Biol. 2019;99:169–176.
   PubMed Web of Science ®Google Scholar
• Makkawi H, Hoch S, Burns E, et al. Porphyromonas gingivalis stimulates TLR2-PI3K signaling to escape immune clearance and induce bone resorption independently of MyD88. Front Cell Infect Microbiol. 2017;7:359.
   Web of Science ®Google Scholar
• Zupančič Š, Preem L, Kristl J, et al. Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens. Eur J Pharm Sci. 2018;122:347–358.
   PubMed Web of Science ®Google Scholar
• Dias AM, da Silva FG, Monteiro APDF, et al. Polycaprolactone nanofibers loaded oxytetracycline hydrochloride and zinc oxide for treatment of periodontal disease. Mater Sci Eng C. 2019;103:109798.
   PubMed Web of Science ®Google Scholar
• Zupančič Š, Casula L, Rijavec T, et al. Sustained release of antimicrobials from double-layer nanofiber mats for local treatment of periodontal disease, evaluated using a new micro flow-through apparatus. J Control Release. 2019;316:223–235.
   PubMed Web of Science ®Google Scholar
• Tekce M, Ince G, Gursoy H, et al. Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: A 1-year follow-up study. J Clin Periodontol. 2015;42:363–372.
   PubMed Web of Science ®Google Scholar
• ZupančičŠ, Rijavec T, Lapanje A, et al. Nanofibers with incorporated autochthonous bacteria as potential probiotics for local treatment of periodontal disease. Biomacromolecules. 2018;19:4299–4306.
   PubMed Web of Science ®Google Scholar
• Bottino MC, Thomas V. Membranes for periodontal regeneration-a materials perspective. Front Oral Biol. 2015;17:90–100.
   PubMedGoogle Scholar
• Wang Y, Jiang Y, Zhang Y, et al. Dual functional electrospun core-shell nanofibers for anti-infective guided bone regeneration membranes. Mater Sci Eng C. 2019;98:134–139.
   PubMed Web of Science ®Google Scholar
• Carcuac O, Derks J, Abrahamsson I, et al. Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial. J Clin Periodontol. 2017;44:1294–1303.
   PubMed Web of Science ®Google Scholar
• Wang M, Tang T. Surface treatment strategies to combat implant-related infection from the beginning. J Orthop Transl. 2019;17:42–54.
   PubMed Web of Science ®Google Scholar
• Telles DR, Karki N, Marshall MW. Oral Fungal Infections: diagnosis and Management. Dent Clin North Am. 2017;61:319–349.
   PubMedGoogle Scholar
• Salvatori O, Puri S, Tati S, et al. Innate immunity and saliva in candida albicans -mediated oral diseases. J Dent Res. 2016;95:365–371.
   PubMed Web of Science ®Google Scholar
• MA Parecid B. Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans. Braz Oral Res. 2014;28:1806-83242014000100258.
   Web of Science ®Google Scholar
• Tonglairoum P, Ngawhirunpat T, Rojanarata T, et al. Fabrication of mucoadhesive chitosan coated polyvinylpyrrolidone/cyclodextrin/clotrimazole sandwich patches for oral candidiasis. Carbohydr Polym. 2015;132:173–179.
   PubMed Web of Science ®Google Scholar