Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris

References

• Nguyen CM, Beroukhim K, Danesh MJ, et al. The psychosocial impact of acne, vitiligo, and psoriasis: a review. Clin Cosmet Investig Dermatol. 2016;9:383–392.
   PubMed Web of Science ®Google Scholar
• Moradi TS, Makrantonaki E, Ganceviciene R, et al. Acne vulgaris. Nat Rev Dis Primers. 2015;1(1):15029.
   PubMedGoogle Scholar
• Bhat YJ, Latief I, Hassan I. Update on etiopathogenesis and treatment of Acne. Indian J Dermatol Venereol Leprol. 2017;83(3):298–306.
   PubMed Web of Science ®Google Scholar
• Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patients. Int J Womens Dermatol. 2018;4(2):56–71.
   PubMedGoogle Scholar
• WHO. WHO model prescribing information. Geneva: World Health Organization; 1997. p. 65.
   Google Scholar
• Raza K, Talwar V, Setia A, et al. Acne: an understanding of the disease and its impact on life Int. J Drug Dev Res. 2012;4(2):14–20.
   Google Scholar
• Cooper AJ, Harris VR. Modern management of acne. Med J Aust. 2017;206(1):41–45.
   PubMed Web of Science ®Google Scholar
• Amichai B, Grunwald MH. Isotretinoin in dermatology. J Dermatolog Treat. 2000;11(4):219–240.
   Web of Science ®Google Scholar
• Khalil NY, Darwish IA, Al-Qahtani AA. Isotretinoin. Profiles Drug Subst Excip Relat Methodol. 2020;45:119–157.
   PubMedGoogle Scholar
• Webster GFM. Isotretinoin: mechanism of action and patient selection. Semin Cutan Med Surg. 2015;34(5 Suppl):S86–8.
   PubMedGoogle Scholar
• Hirsch RJ, Shalita AR. Isotretinoin dosing: past, present, and future trends. Semin Cutan Med Surg. 2001;20(3):162–165.
   PubMed Web of Science ®Google Scholar
• Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009;1(3):162–169.
   PubMedGoogle Scholar
• Gurbuz A, Ozhan G, Gungor S, et al. Colloidal carriers of isotretinoin for topical acne treatment: skin uptake, ATR-FTIR and in vitro cytotoxicity studies. Arch Dermatol Res. 2015;307(7):607–615.
   PubMed Web of Science ®Google Scholar
• Raza K, Singh B, Singal P, et al. Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids Surf B Biointerfaces. 2013;105:67–74.
   PubMed Web of Science ®Google Scholar
• Liu J, Hu W, Chen H, et al. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm. 2007;328(2):191–195.
   PubMed Web of Science ®Google Scholar
• Zeichner JA. Inflammatory acne treatment: review of current and New Topical therapeutic options. J Drugs Dermatol. 2016;15(1 Suppl 1):s11–6.
   PubMedGoogle Scholar
• Silva EL, Carneiro G, De Araújo LA, et al. Solid lipid nanoparticles loaded with retinoic acid and lauric acid as an alternative for topical treatment of Acne Vulgaris. J Nanosci Nanotechnol. 2015;15(1):792–799.
   PubMed Web of Science ®Google Scholar
• Kaminska EC. Treatment of acne and acne-related scarring with fixed combination clindamycin phosphate and benzoyl peroxide gel (1.2%/3.75%) and tretinoin gel microsphere 0.06% in an Asian American transgender female. SAGE Open Med Case Rep. 2020;8:1–4.
   Web of Science ®Google Scholar
• Tan HH. Topical antibacterial treatments for acne vulgaris: comparative review and guide to selection. Am J Clin Dermatol. 2004;5(2):79–84.
   PubMed Web of Science ®Google Scholar
• Greydanus DE, Azmeh R, Cabral MD, et al. Acne in the first three decades of life: an update of a disorder with profound implications for all decades of life. Dis Mon. 2021;67(4):101103.
   PubMed Web of Science ®Google Scholar
• Abdel-Naser MB, Zouboulis CC. Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris. Expert Opin Pharmacother. 2008;9(16):2931–2937.
   PubMed Web of Science ®Google Scholar
• Waugh J, Noble S, Scott LJ. Adapalene: a review of its use in the treatment of acne vulgaris. Drugs. 2004;64(13):1465–1478.
   PubMed Web of Science ®Google Scholar
• Webster G. Mechanism-based treatment of acne vulgaris: the value of combination therapy. J Drugs Dermatol. 2005;4(3):281–288.
   PubMedGoogle Scholar
• Sharma G, Dhankar G, Thakur K, et al. Benzyl benzoate-loaded microemulsion for topical applications: enhanced dermatokinetic profile and better delivery promises. AAPS PharmSciTech. 2016;17(5):1221–1231.
   PubMed Web of Science ®Google Scholar
• Raza K, Singh B, Singla N, et al. Nano-lipoidal carriers of isotretinoin with anti-aging potential: formulation, characterization and biochemical evaluation. J Drug Target. 2013;21(5):435–442.
   PubMed Web of Science ®Google Scholar
• Raza K, Singh B, Singla S, et al. Nanocolloidal carriers of isotretinoin: antimicrobial activity against Propionibacterium acnes and dermatokinetic modeling. Mol Pharm. 2013;10(5):1958–1963.
   PubMed Web of Science ®Google Scholar
• Patel R, Prabhu P. Nanocarriers as versatile delivery systems for effective management of acne. Int J Pharm. 2020;579:119140.
   PubMed Web of Science ®Google Scholar
• Gupta S, Wairkar S, Bhatt LK. Isotretinoin and α-tocopherol acetate-loaded solid lipid nanoparticle topical gel for the treatment of acne. J Microencapsul. 2020;37(8):557–565.
   PubMed Web of Science ®Google Scholar
• Amer SS, Nasr M, Mamdouh W, et al. Insights on the use of nanocarriers for acne alleviation. Curr Drug Deliv. 2019;16(1):18–25.
   PubMed Web of Science ®Google Scholar
• Kahraman E, Özhan G, Özsoy Y, et al. Polymeric micellar nanocarriers of benzoyl peroxide as potential follicular targeting approach for acne treatment. Colloids Surf B Biointerfaces. 2016;146:692–699.
   PubMed Web of Science ®Google Scholar
• Ioele G, Cione E, Risoli A, et al. Accelerated photostability study of tretinoin and isotretinoin in liposome formulations. Int J Pharm. 2005;293(1–2):251–260.
   PubMedGoogle Scholar
• Diniz DGA, Alves CPI, Castro NC, et al. Isotretinoin-containing liposomes: obtention, characterization and in vitro cytotoxicity on leukemia cells. Appl Cancer Res. 2008;28:106-111.
   Google Scholar
• Song H, Geng H, Ruan J, et al. Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. Nanoscale Res Lett. 2011;6(1):354–354. DOI:10.1186/1556-276X-6-354.
   PubMedGoogle Scholar
• Sharma G, Goyal H, Thakur K, et al. Novel elastic membrane vesicles (EMVs) and ethosomes-mediated effective topical delivery of aceclofenac: a new therapeutic approach for pain and inflammation. Drug Deliv. 2016;23(8):3135–3145.
   PubMed Web of Science ®Google Scholar
• Sharma G, Thakur K, Setia A, et al. Fabrication of acyclovir-loaded flexible membrane vesicles (FMVs): evidence of preclinical efficacy of antiviral activity in murine model of cutaneous HSV-1 infection. Drug Deliv Transl Res. 2017;7(5):683–694.
   PubMed Web of Science ®Google Scholar
• Negi P, Singh B, Sharma G, et al. Enhanced topical delivery of lidocaine via ethosomes-based hydrogel: ex-vivo and in-vivo evaluation. J Nanopharm Drug Deliv. 2014;2:1–10.
   Google Scholar
• WHO. The international pharmacopoeia. Geneva: World Health Organization Geneva; 2003. p. 71–74.
   Google Scholar
• Chuang G, Yeh A-I. Rheological characteristics and texture attributes of glutinous rice cakes (mochi). J Food Eng. 2006;74(3):314–323.
   Web of Science ®Google Scholar
• Bhatia A, Bhushan S, Singh B, et al. Studies on tamoxifen encapsulated in lipid vesicles: effect on the growth of human breast cancer MCF-7 cells. J Liposome Res. 2009;19(3):169–172.
   PubMed Web of Science ®Google Scholar
• Sharma G, Saini MK, Thakur K, et al. Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. Nanomedicine (Lond). 2017;12(6):615–638.
   PubMed Web of Science ®Google Scholar
• Yang D, Pornpattananangkul D, Nakatsuji T, et al. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009;30(30):6035–6040.
   PubMed Web of Science ®Google Scholar
• McBride MC, Karl Malcolm R, David WA, et al. Persistence of antimicrobial activity through sustained release of triclosan from pegylated silicone elastomers. Biomaterials. 2009;30(35):6739–6747.
   PubMed Web of Science ®Google Scholar
• Tzellos T, Zampeli V, Makrantonaki E, et al. Treating acne with antibiotic-resistant bacterial colonization. Expert Opin Pharmacother. 2011;12(8):1233–1247.
   PubMed Web of Science ®Google Scholar
• Schoop VM, Mirancea N, Fusenig NE. Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts. J Invest Dermatol. 1999;112(3):343–353.
   PubMed Web of Science ®Google Scholar
• Van Meerloo J, Kaspers GJ, Cloos J. Cell sensitivity assays: the MTT assay. Methods Mol Biol. 2011;731:237–245.
   PubMedGoogle Scholar
• Langehanenberg P, Kemper B, Dirksen D, et al. Autofocusing in digital holographic phase contrast microscopy on pure phase objects for live cell imaging. Appl Opt. 2008;47(19):D176.
   PubMed Web of Science ®Google Scholar
• Thakur K, Sharma G, Singh B, et al. Nano-engineered lipid-polymer hybrid nanoparticles of fusidic acid: an investigative study on dermatokinetics profile and MRSA-infected burn wound model. Drug Deliv Transl Res. 2019;9(4):748–763.
   PubMed Web of Science ®Google Scholar
• Yano K, Masaoka Y, Kataoka M, et al. Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes. J Pharm Sci. 2010;99(3):1336–1345.
   PubMed Web of Science ®Google Scholar
• Sharma G, Devi N, Thakur K, et al. Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model. Drug Deliv Transl Res. 2018;8(8):398–413.
   PubMedGoogle Scholar
• ICH. Stability testing of new drug substances and products. Q1A(R2) 2003.
   Google Scholar
• Raza K, Singh B, Lohan S, et al. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. Int J Pharm. 2013;456(1):65–72.
   PubMed Web of Science ®Google Scholar
• Raza K, Shareef MA, Singal P, et al. Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation. J Liposome Res. 2014;24(4):290–296.
   PubMed Web of Science ®Google Scholar
• Sharma G, Kamboj S, Thakur K, et al. Delivery of thermoresponsive-tailored mixed micellar nanogel of lidocaine and prilocaine with improved dermatokinetic profile and therapeutic efficacy in Topical Anaesthesia. AAPS PharmSciTech. 2017;18(3):790–792.
   PubMed Web of Science ®Google Scholar
• Neumann F, Elger W. The effect of a new antiandrogenic steroid, 6-chloro-17-HYDROXY-1alpha, 2alpha-methylenepregna-4,6-diene-3,20-dione acetate (cyproterone acetate) on the sebaceous glands of mice. J Invest Dermatol. 1966;46(6):561–572.
   PubMed Web of Science ®Google Scholar
• Jensen BK, L.a M, Kachevsky V, et al. The negligible systemic availability of retinoids with multiple and excessive topical application of isotretinoin 0.05% gel (Isotrex) in patients with acne vulgaris. J Am Acad Dermatol. 1991;24(3):425–428.
   PubMed Web of Science ®Google Scholar
• Tran PH, Tran TT, Lee BJ. Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles. Int J Pharm. 2013;455(1–2):235–240.
   PubMedGoogle Scholar
• Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods. 2000;44(1):235–249.
   PubMed Web of Science ®Google Scholar
• Jindal N, Mehta SK. Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: optimization of formulation and in vitro evaluation. Colloids Surf B Biointerfaces. 2015;129:100–106.
   PubMed Web of Science ®Google Scholar
• Sharifi R, Pasalar P, Kamalinejad M, et al. The effect of silymarin (Silybum marianum) on human skin fibroblasts in an in vitro wound healing model. Pharm Biol. 2013;51(3):298–303.
   PubMed Web of Science ®Google Scholar
• Ihara S, Motobayashi Y. Wound closure in foetal rat skin. Development. 1992;114(3):573–582.
   PubMed Web of Science ®Google Scholar
• Jiang YZ, Tong YJ, Xiao TQ, et al. Exploring the three-dimensional structure of dermal tissues of normal skin and scar in rat with synchrotron radiation X-ray imaging technology. Zhonghua Shao Shang Za Zhi. 2012;28(1):5–8.
   PubMedGoogle Scholar