References
- Seeman NC. DNA in a material world. Nature. 2003;421(6921):427–431.
- Yang JJ, Jiang Q, He L, et al. Self-assembled double-bundle DNA tetrahedron for efficient antisense delivery. ACS Appl Mater Interfaces. 2018;10(28):23693–23699. https://doi.org/https://doi.org/10.1021/acsami.8b07889
- Pinheiro AV, Han DR, Shih WM, et al. Challenges and opportunities for structural DNA nanotechnology. Nat Nanotechnol. 2011;6(12):763–772. https://doi.org/https://doi.org/10.1038/nnano.2011.187
- Raniolo S, Croce S, Thomsen RP, et al. Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries. Nanoscale. 2019;11(22):10808–10818. https://doi.org/https://doi.org/10.1039/C9NR02006C
- Zhang J, Wang Z, Gao Y, et al. Simple self-assembled targeting DNA nano sea urchin as a multivalent drug carrier. ACS Appl Bio Mater. 2020;3(7):4514–4521. https://doi.org/https://doi.org/10.1021/acsabm.0c00462
- Li J, Pei H, Zhu B, et al. Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. ACS Nano. 2011;5(11):8783–8789. https://doi.org/https://doi.org/10.1021/nn202774x
- Schuller VJ, Heidegger S, Sandholzer N, et al. Cellular immunostimulation by CpG-sequence-coated DNA origami structures. ACS Nano. 2011;5(12):9696–9702. https://doi.org/https://doi.org/10.1021/nn203161y
- Qu Y, Yang J, Zhan P, et al. Self-assembled DNA dendrimer nanoparticle for efficient delivery of immunostimulatory CpG motifs. ACS Appl Mater Interfaces. 2017;9(24):20324–20329. https://doi.org/https://doi.org/10.1021/acsami.7b05890
- Xie N, Huang J, Yang X, et al. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sensors. 2016;1(12):1445–1452. https://doi.org/https://doi.org/10.1021/acssensors.6b00593
- Zhou WJ, Liang WB, Li DX, et al. Dual-color encoded DNAzyme nanostructures for multiplexed detection of intracellular metal ions in living cells. Biosens Bioelectron. 2016;85:573–579.
- Li C, Xue C, Wang J, et al. Oriented tetrahedron-mediated protection of catalytic DNA molecular-scale detector against in vivo degradation for intracellular miRNA detection. Anal Chem. 2019;91(18):11529–11536. https://doi.org/https://doi.org/10.1021/acs.analchem.9b00860
- Xue C, Wang L, Huang H, et al. Stimuli-induced upgrade of nuclease-resistant DNA nanostructure composed of a single molecular beacon for detecting mutant genes. ACS Sens. 2021;6(11):4029–4037. https://doi.org/https://doi.org/10.1021/acssensors.1c01423
- Wang W, Gao Y, Wang W, et al. Ultrasensitive electrochemical detection of cancer-related point mutations based on surface-initiated three-dimensionally self-assembled DNA nanostructures from only two palindromic probes. Anal Chem. 2022;94(2):1029–1036. https://doi.org/https://doi.org/10.1021/acs.analchem.1c03991
- Du Y, Jiang Q, Beziere N, et al. DNA-Nanostructure-Gold-Nanorod hybrids for enhanced in vivo optoacoustic imaging and photothermal therapy. Adv Mater. 2016;28(45):10000–10007. https://doi.org/https://doi.org/10.1002/adma.201601710
- Wang P, Rahman MA, Zhao Z, et al. Visualization of the cellular uptake and trafficking of DNA origami nanostructures in cancer cells. J Am Chem Soc. 2018;140(7):2478–2484. https://doi.org/https://doi.org/10.1021/jacs.7b09024
- Xu J, Z-S W, Wang Z, et al. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs. Biomaterials. 2017;120:57–65.
- Xue C, Zhang SX, Ouyang CH, et al. Target-induced catalytic assembly of Y-shaped DNA and its application for in situ imaging of microRNAs. Angew Chem Int Ed. 2018;57(31):9739–9743. https://doi.org/https://doi.org/10.1002/anie.201804741
- Yang Z, Zhang S, Zhao H, et al. Branched DNA junction-enhanced isothermal circular strand displacement polymerization for intracellular imaging of microRNAs. Anal Chem. 2018;90(23):13891–13899. https://doi.org/https://doi.org/10.1021/acs.analchem.8b03063
- Xue C, Zhang S, Li C, et al. Y-shaped backbone-rigidified triangular DNA scaffold-directed stepwise movement of a DNAzyme walker for sensitive microRNA imaging within living cells. Anal Chem. 2019;91(24):15678–15685. https://doi.org/https://doi.org/10.1021/acs.analchem.9b03784
- Liu R, Zhang SB, Zheng TT, et al. Intracellular nonenzymatic in situ growth of three-dimensional DNA nanostructures for imaging specific biomolecules in living cells. ACS Nano. 2020;14(8):9572–9584. https://doi.org/https://doi.org/10.1021/acsnano.9b09995
- Gao Y, Zhang S, Wu C, et al. Self-protected DNAzyme walker with a circular bulging DNA shield for amplified imaging of miRNAs in living cells and mice. ACS Nano. 2021;15(12):19211–19224. https://doi.org/https://doi.org/10.1021/acsnano.1c04260
- Li C, Zhang J, Gao Y, et al. Nonenzymatic autonomous assembly of cross-linked network structures from only two palindromic DNA components for intracellular fluorescence imaging of miRNAs. ACS Sens. 2022;7(2):601–611. https://doi.org/https://doi.org/10.1021/acssensors.1c02504
- Xue C, Niu H, Hu S, et al. Visually predicting microRNA-regulated tumor metastasis by intracellularly 3D counting of fluorescent spots based on in situ growth of DNA flares. J Adv Res. 2022, https://doi.org/https://doi.org/10.1016/j.jare.2022.03.001
- Zhang B, Tian T, Xiao D, et al. Facilitating in situ tumor imaging with a tetrahedral DNA framework-enhanced hybridization chain reaction probe. Adv Funct Mater. 2022;32(16):2109728. https://doi.org/https://doi.org/10.1002/adfm.202109728
- Chen Y-J, Groves B, Muscat RA, et al. DNA nanotechnology from the test tube to the cell. Nat Nanotechnol. 2015;10(9):748–760. https://doi.org/https://doi.org/10.1038/nnano.2015.195
- Zhang C-Y, Yeh H-C, Kuroki MT, et al. Single-quantum-dot-based DNA nanosensor. Nat Mater. 2005;4(11):826–831. https://doi.org/https://doi.org/10.1038/nmat1508
- Sun SJ, Yang SL, Hu XM, et al. Combination of immunomagnetic separation with aptamer-mediated double rolling circle amplification for highly sensitive circulating tumor cell detection. ACS Sens. 2020;5(12):3870–3878. https://doi.org/https://doi.org/10.1021/acssensors.0c01082
- Sun S, Xu H, Yang Y, et al. Intracellular in situ assembly of palindromic DNA hydrogel for predicting malignant invasion and preventing tumorigenesis. Chem Eng J. 2022;428:131150.
- Xue C, Huang H, Wang L, et al. Swelling of serum-stable DNA nanoparticles upon target-induced conformational rearrangement of sensing probes for the signal-on detection of cancer-related genes. Anal Chem. 2022;94(6):2749–2756. https://doi.org/https://doi.org/10.1021/acs.analchem.1c03598
- Liu JB, Song LL, Liu SL, et al. A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy. Nano Lett. 2018;18(6):3328–3334. https://doi.org/https://doi.org/10.1021/acs.nanolett.7b04812
- Mou Q, Ma Y, Pan G, et al. DNA trojan horses: self-assembled floxuridine-containing DNA polyhedra for cancer therapy. Angew Chem Int Ed. 2017;56(41):12528–12532. https://doi.org/https://doi.org/10.1002/anie.201706301
- Zhang SX, Chen C, Xue C, et al., Ribbon of DNA lattice on gold nanoparticles for selective drug delivery to cancer cells. Angew Chem Int Ed. 2020;59(34): 14584–14592. https://doi.org/https://doi.org/10.1002/anie.202005624,
- Xue C, Zhang SB, Yu X, et al. Periodically ordered, nuclease-resistant DNA nanowires decorated with cell-specific aptamers as selective theranostic agents. Angew Chem Int Edit. 2020;59(40):17540–17547.
- Xue C, Hu S, Gao Z-H, et al., Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs. Nat Commun. 2021;12(1): 2928. https://doi.org/https://doi.org/10.1038/s41467-021-23250-5
- Ma W, Yang Y, Zhu J, et al. Biomimetic nanoerythrosome‐coated aptamer–DNA tetrahedron/maytansine conjugates: pH‐responsive and targeted cytotoxicity for HER2‐positive breast cancer. Adv Mater.2022;2109609.https://doi.org/https://doi.org/10.1002/adma.202109609
- Gao Y, Li Q, Zhang J, et al. Bead-string-shaped DNA nanowires with intrinsic structural advantages and their potential for biomedical applications. ACS Appl Mater Interfaces. 2020;12(3):3341–3353. https://doi.org/https://doi.org/10.1021/acsami.9b16249
- Ouyang C, Zhang S, Xue C, et al., Precision guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in vivo. J Am Chem Soc. 2020;142(3): 1265–1277. https://doi.org/https://doi.org/10.1021/jacs.9b09782
- Li J, Fan CH, Pei H, et al. Smart drug delivery nanocarriers with self-assembled DNA nanostructures. Adv Mater. 2013;25(32):4386–4396. https://doi.org/https://doi.org/10.1002/adma.201300875
- Xia ZW, Wang P, Liu XW, et al. Tumor-penetrating peptide-modified DNA tetrahedron for targeting drug delivery. Biochemistry. 2016;55(9):1326–1331. https://doi.org/https://doi.org/10.1021/acs.biochem.5b01181
- Arap W, Pasqualini R, Ruoslahti EJS. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 1998;279(5349):377–380. https://doi.org/https://doi.org/10.1126/science.279.5349.377
- Schaffert DH, Okholm AH, Sørensen RS, et al. Intracellular delivery of a planar DNA origami structure by the transferrin-receptor internalization pathway. Small. 2016;12(19):2634–2640. https://doi.org/https://doi.org/10.1002/smll.201503934
- Setyawati MI, Kutty RV, Leong DT. DNA nanostructures carrying stoichiometrically definable antibodies. Small. 2016;12(40):5601–5611.
- Sudimack J, Lee RJ. Targeted drug delivery via the folate receptor. Adv Drug Del Rev. 2000;41(2):147–162.
- Lee H, Lytton-Jean AKR, Chen Y, et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol. 2012;7(6):389–393. https://doi.org/https://doi.org/10.1038/nnano.2012.73
- Raniolo S, Vindigni G, Ottaviani A, et al. Selective targeting and degradation of doxorubicin-loaded folate-functionalized DNA nanocages. Nanomed Nanotechnol Biol Med. 2018;14(4):1181–1190. https://doi.org/https://doi.org/10.1016/j.nano.2018.02.002
- Raniolo S, Vindigni G, Unida V, et al. Entry, fate and degradation of DNA nanocages in mammalian cells: a matter of receptors. Nanoscale. 2018;10(25):12078–12086. https://doi.org/https://doi.org/10.1039/C8NR02411A
- Wu C, Han D, Chen T, et al. Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy. J Am Chem Soc. 2013;135(49):18644–18650. https://doi.org/https://doi.org/10.1021/ja4094617
- Zhu GZ, Zheng J, Song EQ, et al. Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics. Proc Natl Acad Sci U S A. 2013;110(20):7998–8003. https://doi.org/https://doi.org/10.1073/pnas.1220817110
- Zhu G, Hu R, Zhao Z, et al. Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications. J Am Chem Soc. 2013;135(44):16438–16445. https://doi.org/https://doi.org/10.1021/ja406115e
- Charoenphol P, Bermudez H. Aptamer-targeted DNA nanostructures for therapeutic delivery. Mol Pharm. 2014;11(5):1721–1725.
- Li Q, Zhao D, Shao X, et al. Aptamer-modified tetrahedral DNA nanostructure for tumor-targeted drug delivery. ACS Appl Mater Interfaces. 2017;9(42):36695–36701. https://doi.org/https://doi.org/10.1021/acsami.7b13328
- Vindigni G, Raniolo S, Iacovelli F, et al. AS1411 aptamer linked to DNA nanostructures diverts its traffic inside cancer cells and improves its therapeutic efficacy. Pharmaceutics. 2021;13(10):1671. https://doi.org/https://doi.org/10.3390/pharmaceutics13101671
- Chang M, Yang C-S, Huang D-M. Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy. ACS Nano. 2011;5(8):6156–6163.
- Torchilin VP. Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. Annu Rev Biomed Eng. 2006;8(1):343–375.
- Won Y-W, Lim KS, Kim Y-H. Intracellular organelle-targeted non-viral gene delivery systems. J Control Release. 2011;152(1):99–109.
- Wang Y, Wei G, Zhang X, et al. Multistage targeting strategy using magnetic composite nanoparticles for synergism of photothermal therapy and chemotherapy. Small. 2018;14(12):1702994. https://doi.org/https://doi.org/10.1002/smll.201702994
- Jing Y, Xiong X, Ming Y, et al. A multifunctional micellar nanoplatform with pH-triggered cell penetration and nuclear targeting for effective cancer therapy and inhibition to lung metastasis. Adv Healthc Mater. 2018;7(7):1700974. https://doi.org/https://doi.org/10.1002/adhm.201700974
- Li WQ, Wang Z, Hao S, et al. Mitochondria-targeting polydopamine nanoparticles to deliver doxorubicin for overcoming drug resistance. ACS Appl Mater Interfaces. 2017;9(20):16793–16802. https://doi.org/https://doi.org/10.1021/acsami.7b01540
- Sakhrani NM, Padh H. Organelle targeting: third level of drug targeting. Drug Des Devel Ther. 2013;7:585–599.
- Yasuhara N, Takeda E, Inoue H, et al. Importin α/β-mediated nuclear protein import is regulated in a cell cycle-dependent manner. Exp Cell Res. 2004;297(1):285–293. https://doi.org/https://doi.org/10.1016/j.yexcr.2004.03.010
- Chen WH, Luo GF, Zhang XZ. Recent advances in subcellular targeted cancer therapy based on functional materials. Adv Mater. 2019;31(3):1802725. https://doi.org/https://doi.org/10.1002/adma.201802725
- Wang G-H, Chen H, Cai -Y-Y, et al. Efficient gene vector with size changeable and nucleus targeting in cancer therapy. Mater Sci Eng C. 2018;90:568–575.
- Z-Y L, Liu Y, J-J H, et al. Stepwise-acid-active multifunctional mesoporous silica nanoparticles for tumor-specific nucleus-targeted drug delivery. ACS Appl Mater Interfaces. 2014;6(16):14568–14575. https://doi.org/https://doi.org/10.1021/am503846p
- Han -S-S, Z-Y L, Zhu J-Y, et al. Dual-pH sensitive charge-reversal polypeptide micelles for tumor-triggered targeting uptake and nuclear drug delivery. Small. 2015;11(21):2543–2554. https://doi.org/https://doi.org/10.1002/smll.201402865
- Wang H-Y, Chen J-X, Sun Y-X, et al. Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei. J Control Release. 2011;155(1):26–33. https://doi.org/https://doi.org/10.1016/j.jconrel.2010.12.009
- Wang H-Y, Li C, Yi W-J, et al. Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate. Bioconjugate Chem. 2011;22(8):1567–1575. https://doi.org/https://doi.org/10.1021/bc2001177
- Tkachenko AG, Xie H, Coleman D, et al. Multifunctional gold nanoparticle−peptide complexes for nuclear targeting. J Am Chem Soc. 2003;125(16):4700–4701. https://doi.org/https://doi.org/10.1021/ja0296935
- Herce HD, Garcia AE. Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes. Proc Natl Acad Sci U S A . 2007;104( 52):20805–20810. doi:https://doi.org/10.1073/pnas.0706574105.
- Chan MS, Lo PK. Nanoneedle-assisted delivery of site-selective peptide-functionalized DNA nanocages for targeting mitochondria and nuclei. Small. 2014;10(7):1255–1260. .
- Shalek Alex K, Robinson Jacob T, Karp Ethan S, et al. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci U S A. 2010;107( 5):1870–1875. doi:https://doi.org/10.1073/pnas.0909350107.
- Shalek AK, Gaublomme JT, Wang L, et al. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012;12(12):6498–6504. https://doi.org/https://doi.org/10.1021/nl3042917
- Liang L, Li J, Li Q, et al., Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells. Angew Chem Int Ed. 2014;53(30):7745–7750. https://doi.org/https://doi.org/10.1002/anie.201403236
- Zanta Maria A, Belguise-Valladier P, Behr J-P. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A . 1999;96( 1):91–96. doi:https://doi.org/10.1073/pnas.96.1.91.
- Kumar MD, Dravid A, Kumar A, et al. Gene therapy as a potential tool for treating neuroblastoma—a focused review. Cancer Gene Ther. 2016;23(5):115–124. https://doi.org/https://doi.org/10.1038/cgt.2016.16
- Pearson S, Jia H, Kandachi K. China approves first gene therapy. Nat Biotechnol. 2004;22(1):3–4.
- Chen K, Guo L, Zhang J, et al. A gene delivery system containing nuclear localization signal: increased nucleus import and transfection efficiency with the assistance of RanGAP1. Acta Biomater. 2017;48:215–226.
- Wang W, Li W, Ma N, et al. Non-viral gene delivery methods. Curr Pharm Biotechnol. 2013;14(1):46–60.
- Soniat M, Chook Yuh M. Nuclear localization signals for four distinct karyopherin-β nuclear import systems. Biochem J. 2015;468(3):353–362.
- Chen K, Chen Q, Wang K, et al. Synthesis and characterization of a PAMAM-OH derivative containing an acid-labile β-thiopropionate bond for gene delivery. Int J Pharm. 2016;509(1):314–327. https://doi.org/https://doi.org/10.1016/j.ijpharm.2016.05.060
- Biswas A, Joo K-I, Liu J, et al. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano. 2011;5(2):1385–1394. https://doi.org/https://doi.org/10.1021/nn1031005
- Li N, Yang H, Yu Z, et al. Nuclear-targeted siRNA delivery for long-term gene silencing. Chem Sci. 2017;8(4):2816–2822. https://doi.org/https://doi.org/10.1039/C6SC04293G
- Wong C, Stylianopoulos T, Cui J, et al. Multistage nanoparticle delivery system for deep penetration into tumor tissue Proc Natl Acad Sci U S A. 2011;108( 6):2426–2431. doi:https://doi.org/10.1073/pnas.1018382108.
- Qiu LP, Chen T, Ocsoy I, et al. A cell-targeted, size-photocontrollable, nuclear-uptake nanodrug delivery system for drug-resistant cancer therapy. Nano Lett. 2015;15(1):457–463. https://doi.org/https://doi.org/10.1021/nl503777s
- Zhang L, Abdullah R, Hu X, et al., Engineering of bioinspired, size-controllable, self-degradable cancer-targeting DNA nanoflowers via the incorporation of an artificial sandwich base. J Am Chem Soc. 2019;141(10):4282–4290. https://doi.org/https://doi.org/10.1021/jacs.8b10795
- Li D, Qiao Z, Yu Y, et al. In situ fluorescence activation of DNA–silver nanoclusters as a label-free and general strategy for cell nucleus imaging. Chem Commun. 2018;54(9):1089–1092. https://doi.org/https://doi.org/10.1039/C7CC08228B
- Yeh H-C, Sharma J, Han JJ, et al. A DNA−silver nanocluster probe that fluoresces upon hybridization. Nano Lett. 2010;10(8):3106–3110. https://doi.org/https://doi.org/10.1021/nl101773c
- Yeh H-C, Sharma J, Shih I-M, et al. A fluorescence light-up Ag nanocluster probe that discriminates single-nucleotide variants by emission color. J Am Chem Soc. 2012;134(28):11550–11558. https://doi.org/https://doi.org/10.1021/ja3024737
- Qian R, Ding L, Ju H. Switchable fluorescent imaging of intracellular telomerase activity using telomerase-responsive mesoporous silica nanoparticle. J Am Chem Soc. 2013;135(36):13282–13285.
- Liu X, Wei M, Liu Y, et al. Label-free detection of telomerase activity in urine using telomerase-responsive porous anodic alumina nanochannels. Anal Chem. 2016;88(16):8107–8114. https://doi.org/https://doi.org/10.1021/acs.analchem.6b01817
- Wang ZJ, Guo WL, Kuang X, et al. Nanopreparations for mitochondria targeting drug delivery system: current strategies and future prospective. Asian J Pharm Sci. 2017;12(6):498–508. https://doi.org/https://doi.org/10.1016/j.ajps.2017.05.006
- Galley HF. Bench-to-bedside review: targeting antioxidants to mitochondria in sepsis. Crit Care. 2010;14(4):230.
- Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol. 2008;9(8):616–627.
- Lu P, Bruno BJ, Rabenau M, et al. Delivery of drugs and macromolecules to the mitochondria for cancer therapy. J Control Release. 2016;240:38–51.
- Fulda S, Galluzzi L, Kroemer G. Targeting mitochondria for cancer therapy. Nat Rev Drug Discovery. 2010;9(6):447–464.
- Hu QL, Gao M, Feng GX, et al. Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics. Angew Chem Int Ed. 2014;53(51):14225–14229. https://doi.org/https://doi.org/10.1002/anie.201408897
- Battogtokh G, Choi YS, Kang DS, et al. Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives. Acta Pharm Sin B. 2018;8(6):862–880. https://doi.org/https://doi.org/10.1016/j.apsb.2018.05.006
- Yamada Y, Satrialdi H, Hibino, et al. Power of mitochondrial drug delivery systems to produce innovative nanomedicines. Adv Drug Del Rev. 2020;154-155:187–209.
- Battogtokh G, Cho YY, Lee JY, et al. Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment. Front Pharmacol. 2018;9:922.
- Yan JQ, Chen J, Zhang N, et al., Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis. J Mat Chem B. 2020;8(3): 492–503. . https://doi.org/https://doi.org/10.1039/C9TB02266J
- James AM, Blaikie FH, Smith RAJ, et al. Specific targeting of a DNA-alkylating reagent to mitochondria. Eur J Biochem. 2003;270(13):2827–2836. https://doi.org/https://doi.org/10.1046/j.1432-1033.2003.03660.x.
- Han M, Vakili MR, Soleymani Abyaneh H, et al. Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells. Mol Pharm. 2014;11(8):2640–2649. https://doi.org/https://doi.org/10.1021/mp500038g
- Millard M, Gallagher JD, Olenyuk BZ, et al. A selective mitochondrial-targeted chlorambucil with remarkable cytotoxicity in breast and pancreatic cancers. J Med Chem. 2013;56(22):9170–9179. https://doi.org/https://doi.org/10.1021/jm4012438
- Wu S, Cao Q, Wang X, et al. Design, synthesis and biological evaluation of mitochondria targeting theranostic agents. Chem Commun. 2014;50(64):8919–8922. https://doi.org/https://doi.org/10.1039/C4CC03296A
- Chen W-H, X-D X, Luo G-F, et al. Dual-targeting pro-apoptotic peptide for programmed cancer cell death via specific mitochondria damage. Sci Rep. 2013;3(1):3468. https://doi.org/https://doi.org/10.1038/srep03468
- Zhang S, Yang L, Ling X, et al. Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer. Acta Biomater. 2015;28:160–170.
- Wang H, Xu W. Mito-methyl coumarin, a novel mitochondria-targeted drug with great antitumor potential was synthesized. Biochem Biophys Res Commun. 2017;489(1):1–7.
- Bielski ER, Zhong Q, Brown M, et al. Effect of the conjugation density of triphenylphosphonium cation on the mitochondrial targeting of poly(amidoamine) dendrimers. Mol Pharm. 2015;12(8):3043–3053. https://doi.org/https://doi.org/10.1021/acs.molpharmaceut.5b00320
- Cho DY, Cho H, Kwon K, et al. Triphenylphosphonium-conjugated poly(ε-caprolactone)-based self-assembled nanostructures as nanosized drugs and drug delivery carriers for mitochondria-targeting synergistic anticancer drug delivery. Adv Funct Mater. 2015;25(34):5479–5491. https://doi.org/https://doi.org/10.1002/adfm.201501422
- Khatun Z, Choi YS, Kim YG, et al. Bioreducible poly(ethylene glycol)–triphenylphosphonium conjugate as a bioactivable mitochondria-targeting nanocarrier. Biomacromolecules. 2017;18(4):1074–1085. https://doi.org/https://doi.org/10.1021/acs.biomac.6b01324
- Zhao J, Li Z, Shao Y, et al., Spatially selective imaging of mitochondrial microRNAs via optically programmable strand displacement reactions. Angew Chem. 2021;133(33): 18081–18085. . https://doi.org/https://doi.org/10.1002/ange.202105696
- Liu Z, Pei H, Zhang L, et al., Mitochondria-targeted DNA nanoprobe for real-time imaging and simultaneous quantification of Ca2+ and pH in neurons. ACS Nano. 2018;12(12): 12357–12368. . https://doi.org/https://doi.org/10.1021/acsnano.8b06322
- Li F, Liu Y, Dong Y, et al., Dynamic assembly of DNA nanostructures in living cells for mitochondrial interference. J Am Chem Soc. 2022;144(10): 4667–4677.https://doi.org/https://doi.org/10.1021/jacs.2c00823
- Wang L XX, Yao YB, Yao, et al. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials. 2011;32(24):5673–5687. https://doi.org/https://doi.org/10.1016/j.biomaterials.2011.04.029
- Jiang L, Li L, He XD, et al. Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response. Biomaterials. 2015;52:126–139.
- Fernández-Carneado J, Van Gool M, Martos V, et al. Highly efficient, nonpeptidic oligoguanidinium vectors that selectively internalize into mitochondria. J Am Chem Soc. 2005;127(3):869–874. https://doi.org/https://doi.org/10.1021/ja044006q
- Yousif LF, Stewart KM, Horton KL, et al. Mitochondria-penetrating peptides: sequence effects and model cargo transport. ChemBioChem. 2009;10(12):2081–2088. https://doi.org/https://doi.org/10.1002/cbic.200900017
- Javadpour MM, Juban MM, W-CJ L, et al. De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem. 1996;39(16):3107–3113. https://doi.org/https://doi.org/10.1021/jm9509410
- Agemy L, Friedmann-Morvinski D, Kotamraju VR, et al. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc Natl Acad Sci U S A . 2011;108(42):17450–17455 doi:https://doi.org/10.1073/pnas.1114518108. https://doi.org/https://doi.org/10.1073/pnas.1114518108
- Chan MS, Tam DY, Dai Z, et al. Mitochondrial delivery of therapeutic agents by amphiphilic DNA nanocarriers. Small. 2016;12(6):770–781. https://doi.org/https://doi.org/10.1002/smll.201503051
- Yamada Y, Harashima H. Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Del Rev. 2008;60(13):1439–1462.
- Flierl A, Jackson C, Cottrell B, et al. Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid. Mol Ther. 2003;7(4):550–557. https://doi.org/https://doi.org/10.1016/S1525-0016(03)00037-6
- Seibel P, Trappe J, Villani G, et al. Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Res. 1995;23(1):10–17. https://doi.org/https://doi.org/10.1093/nar/23.1.10
- Vestweber D, Schatz G. DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature. 1989;338(6211):170–172.
- Weissig V, D’Souza GGM, Torchilin VP. DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J Control Release. 2001;75(3):401–408.
- D’Souza GGM, Rammohan R, Cheng S-M, et al. DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release. 2003;92(1):189–197. https://doi.org/https://doi.org/10.1016/S0168-3659(03)00297-9
- D’Souza GGM, Boddapati SV, Weissig V. Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion. 2005;5(5):352–358.
- Srivastava S, Moraes CT. Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease. Hum Mol Genet. 2001;10(26):3093–3099.
- Mukhopadhyay A, Ni L, Yang CS, et al. Bacterial signal peptide recognizes HeLa cell mitochondrial import receptors and functions as a mitochondrial leader sequence. Cell Mol Life Sci. 2005;62(16):1890–1899. https://doi.org/https://doi.org/10.1007/s00018-005-5178-0
- Yousif LF, Stewart KM, Kelley SO. Targeting mitochondria with organelle-specific compounds: strategies and applications. ChemBioChem. 2009;10(12):1939–1950.
- Kawamura E, Maruyama M, Abe J, et al. Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids. 2020;20:687–698.
- Yamada Y, Munechika R, Satrialdi S, et al. Mitochondrial delivery of an anticancer drug via systemic administration using a mitochondrial delivery system that inhibits the growth of drug-resistant cancer engrafted on mice. J Pharm Sci. 2020;109(8):2493–2500. https://doi.org/https://doi.org/10.1016/j.xphs.2020.04.020
- Raouane M, Desmaële D, Urbinati G, et al. Lipid conjugated oligonucleotides: a useful strategy for delivery. Bioconjugate Chem. 2012;23(6):1091–1104. https://doi.org/https://doi.org/10.1021/bc200422w
- Langecker M, Arnaut V, List J, et al. DNA nanostructures interacting with lipid bilayer membranes. Acc Chem Res. 2014;47(6):1807–1815. https://doi.org/https://doi.org/10.1021/ar500051r
- Chan Y-HM, van Lengerich B, Boxer SG. Lipid-anchored DNA mediates vesicle fusion as observed by lipid and content mixing. Biointerphases. 2008;3(2):FA17–FA21.
- Czogalla A, Petrov EP, Kauert DJ, et al. Switchable domain partitioning and diffusion of DNA origami rods on membranes. Faraday Discuss. 2013;161:31–43. https://doi.org/https://doi.org/10.1039/C2FD20109G
- Johnson-Buck A, Jiang S, Yan H, et al. DNA–cholesterol barges as programmable membrane-exploring agents. ACS Nano. 2014;8(6):5641–5649. https://doi.org/https://doi.org/10.1021/nn500108k
- Conway JW, Madwar C, Edwardson TG, et al. Dynamic behavior of DNA cages anchored on spherically supported lipid bilayers. J Am Chem Soc. 2014;136(37):12987–12997. https://doi.org/https://doi.org/10.1021/ja506095n
- Langecker M, Arnaut V, Martin Thomas G, et al. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science. 2012;338(6109):932–936. https://doi.org/https://doi.org/10.1126/science.1225624
- Burns JR, Stulz E, Howorka S. Self-assembled DNA nanopores that span lipid bilayers. Nano Lett. 2013;13(6):2351–2356.
- Suzuki Y, Endo M, Yang Y, et al. Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface. J Am Chem Soc. 2014;136(5):1714–1717. https://doi.org/https://doi.org/10.1021/ja4109819
- Tian J, Ding L, Ju H, et al. A multifunctional nanomicelle for real‐time targeted imaging and precise near‐infrared cancer therapy. Angew Chem. 2014;126(36):9698–9703. https://doi.org/https://doi.org/10.1002/ange.201405490
- Lee H, Dam DHM, Ha JW, et al. Enhanced human epidermal growth factor receptor 2 degradation in breast cancer cells by lysosome-targeting gold nanoconstructs. ACS Nano. 2015;9(10):9859–9867. https://doi.org/https://doi.org/10.1021/acsnano.5b05138
- Ma WJ, Zhang YX, Zhang YX, et al., An intelligent DNA nanorobot with in vitro enhanced protein lysosomal degradation of HER2. Nano Lett. 2019;19(7): 4505–4517. https://doi.org/https://doi.org/10.1021/acs.nanolett.9b01320
- Lubke T, Lobel P, Sleat DE. Proteomics of the lysosome. Biochim Et Biophysica Acta-Molecular Cell Res. 2009;1793(4):625–635.https://doi.org/https://doi.org/10.1016/j.bbamcr.2008.09.018
- Dominska M, Dykxhoorn DM. Breaking down the barriers: siRNA delivery and endosome escape. J Cell Sci. 2010;123(8):1183–1189.
- Sharma A, Vaghasiya K, Ray E, et al. Lysosomal targeting strategies for design and delivery of bioactive for therapeutic interventions. J Drug Targeting. 2018;26(3):208–221. https://doi.org/https://doi.org/10.1080/1061186X.2017.1374390
- Li CC, Luo SS, Wang J, et al. Nuclease-resistant signaling nanostructures made entirely of DNA oligonucleotides. Nanoscale. 2021;13(15):7034–7051. https://doi.org/https://doi.org/10.1039/D1NR00197C
- Ge Z, Gu H, Li Q, et al. Concept and development of framework nucleic acids. J Am Chem Soc. 2018;140(51):17808–17819. https://doi.org/https://doi.org/10.1021/jacs.8b10529
- Wang Y, Li Y, Gao S, et al. Tetrahedral framework nucleic acids can alleviate taurocholate-induced severe acute pancreatitis and its subsequent multiorgan injury in mice. Nano Lett. 2022;22(4):1759–1768. https://doi.org/https://doi.org/10.1021/acs.nanolett.1c05003
- Du Y, Peng P, Li T. DNA logic operations in living cells utilizing lysosome-recognizing framework nucleic acid nanodevices for subcellular imaging. ACS Nano. 2019;13(5):5778–5784.
- Walsh AS, Yin H, Erben CM, et al. DNA cage delivery to mammalian cells. ACS Nano. 2011;5(7):5427–5432. https://doi.org/https://doi.org/10.1021/nn2005574
- Pei H, Liang L, Yao G, et al. Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors. Angewandte Chemie (International Ed. in English). 2012;51(36):9020–9024. https://doi.org/https://doi.org/10.1002/anie.201202356
- Li H, Zhou X, Yao D, et al. pH-responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system. Chem Commun. 2018;54(28):3520–3523. https://doi.org/https://doi.org/10.1039/C8CC00440D
- Mahlknecht G, Maron R, Mancini M, et al. Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(20):8170–8175. https://doi.org/https://doi.org/10.1073/pnas.1302594110
- Loibl S, Gianni L. HER2-positive breast cancer. Lancet. 2017;389(10087):2415–2429.
- Yarden Y. Biology of HER2 and its importance in breast cancer. Oncology. 2001;61(suppl 2):1–13.
- Bang Y-J, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–697. https://doi.org/https://doi.org/10.1016/S0140-6736(10)61121-X
- Sawaki A, Ohashi Y, Omuro Y, et al. Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the trastuzumab for gastric cancer (ToGA) study. Gastric Cancer. 2012;15(3):313–322. https://doi.org/https://doi.org/10.1007/s10120-011-0118-1
- Zhang Y, Leonard M, Shu Y, et al. Overcoming tamoxifen resistance of human breast cancer by targeted gene silencing using multifunctional pRNA nanoparticles. ACS Nano. 2017;11(1):335–346. https://doi.org/https://doi.org/10.1021/acsnano.6b05910
- Zhang Q, Park E, Kani K, et al. Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling. Proc Natl Acad Sci. 2012;109(33):13237–13242.
- Petrizzo A, Conte C, Tagliamonte M, et al. Functional characterization of biodegradable nanoparticles as antigen delivery system. J Exp Clin Cancer Res. 2015;34(1):114. https://doi.org/https://doi.org/10.1186/s13046-015-0231-9
- Niazi JH, Verma SK, Niazi S, et al. In vitro HER2 protein-induced affinity dissociation of carbon nanotube-wrapped anti-HER2 aptamers for HER2 protein detection. Analyst. 2015;140(1):243–249. https://doi.org/https://doi.org/10.1039/C4AN01665C
- Kwon S, Duarte JN, Li Z, et al. Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chem Biol. 2018;13(10):2973–2980. https://doi.org/https://doi.org/10.1021/acschembio.8b00653
- Kroemer G, Jäättelä M. Lysosomes and autophagy in cell death control. Nat Rev Cancer. 2005;5(11):886–897.
- Chen T, Wu CS, Jimenez E, et al. DNA micelle flares for intracellular mRNA imaging and gene therapy. Angew Chem Int Ed. 2013;52(7):2012–2016. https://doi.org/https://doi.org/10.1002/anie.201209440
- Leung K, Chakraborty K, Saminathan A, et al. A DNA nanomachine chemically resolves lysosomes in live cells. Nat Nanotechnol. 2019;14(2):176–183.