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Review

Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application

, , , & ORCID Icon
Pages 31-54 | Received 16 Jun 2022, Accepted 22 Nov 2022, Published online: 15 Dec 2022

References

  • Roberts MS, Cheruvu HS, Mangion SE, et al. Topical drug delivery: history, percutaneous absorption, and product development. Adv Drug Deliv Rev. 2021 Oct;177:113929.
  • Haque T, Talukder MMU. Chemical enhancer: a simplistic way to modulate barrier function of the stratum corneum. Adv Pharm Bull. 2018 Jun;8(2):169–179.
  • Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008 Nov;26(11):1261–1268.
  • Rawat S, Vengurlekar S, Rakesh B, et al. Transdermal delivery by iontophoresis. Indian J Pharm Sci. 2008 Jan;70(1):5–10.
  • Polat BE, Hart D, Langer R, et al. Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends. J Control Release. 2011 Jun 30;152(3):330–348.
  • Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev. 2004 Mar 27;56(5):581–587.
  • Sklar LR, Burnett CT, Waibel JS, et al. Laser assisted drug delivery: a review of an evolving technology. Lasers Surg Med. 2014 Apr;46(4):249–262.
  • Manstein D, Herron GS, Sink RK, et al., Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426–438.
  • Bodendorf MO, Grunewald S, Wetzig T, et al. Fractional laser skin therapy. J Dtsch Dermatol Ges. 2009 Apr;7(4):301–308.
  • Waibel JS, Rudnick A, Shagalov DR, et al. Update of ablative fractionated lasers to enhance cutaneous topical drug delivery. Adv Ther. 2017 Aug;34(8):1840–1849.
  • Menon GK. New insights into skin structure: scratching the surface. Adv Drug Deliv Rev. 2002 Nov 1;54(Suppl 1):S3–17.
  • Haedersdal M, Sakamoto FH, Farinelli WA, et al. Fractional CO(2) laser-assisted drug delivery. Lasers Surg Med. 2010 Feb;42(2):113–122.
  • Haak CS, Farinelli WA, Tam J, et al. Fractional laser-assisted delivery of methyl aminolevulinate: impact of laser channel depth and incubation time. Lasers Surg Med. 2012 Dec;44(10):787–795.
  • Haedersdal M, Sakamoto FH, Farinelli WA, et al. Pretreatment with ablative fractional laser changes kinetics and biodistribution of topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL). Lasers Surg Med. 2014 Aug;46(6):462–469.
  • Bachhav YG, Summer S, Heinrich A, et al. Effect of controlled laser microporation on drug transport kinetics into and across the skin. J Control Release. 2010 Aug 17;146(1):31–36.
  • Oni G, Brown SA, Kenkel JM. Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model? Lasers Surg Med. 2012 Feb;44(2):168–174.
  • Bachhav YG, Heinrich A, Kalia YN. Using laser microporation to improve transdermal delivery of diclofenac: increasing bioavailability and the range of therapeutic applications. Eur J Pharm Biopharm. 2011 Aug;78(3):408–414.
  • Erlendsson AM, Taudorf EH, Eriksson AH, et al. Ablative fractional laser alters biodistribution of ingenol mebutate in the skin. Arch Dermatol Res. 2015 Aug;307(6):515–522.
  • Taudorf EH, Lerche CM, Vissing A-C, et al. Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation. Expert Opin Drug Deliv. 2015 Jul;12(7):1059–1069.
  • Taudorf EH, Lerche CM, Erlendsson AM, et al. Fractional laser-assisted drug delivery: laser channel depth influences biodistribution and skin deposition of methotrexate. Lasers Surg Med. 2016 Jul;48(5):519–529.
  • Nguyen HX, Banga AK. Delivery of methotrexate and characterization of skin treated by fabricated PLGA microneedles and fractional ablative laser. Pharm Res. 2018 Feb 21;35(3):68.
  • Kakar P, Li Z, Li Y, et al. Laser facilitates week-long sustained transdermal drug delivery at high doses. J Control Release. 2020 Jan 7;319:428–437. DOI:10.1016/j.jconrel.2020.01.011
  • Yu J, Bachhav YG, Summer S, et al. Using controlled laser-microporation to increase transdermal delivery of prednisone. J Control Release. 2010 Nov 20;148(1):e71–3.
  • Chen X, Shah D, Kositratna G, et al. Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology. J Control Release. 2012 Apr 10;159(1):43–51.
  • Chen X, Kositratna G, Zhou C, et al. Micro-fractional epidermal powder delivery for improved skin vaccination. J Control Release. 2014 Oct 28;192:310–316.
  • Haak CS, Bhayana B, Farinelli WA, et al. The impact of treatment density and molecular weight for fractional laser-assisted drug delivery. J Control Release. 2012 Nov 10;163(3):335–341.
  • Wenande E, Olesen UH, Boesen MR, et al. Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin. Drug Deliv. 2018 Nov;25(1):1877–1885.
  • Wenande E, Olesen UH, Nielsen MM, et al. Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake. Expert Opin Drug Deliv. 2017 Mar;14(3):307–317.
  • Wenande E, Tam J, Bhayana B, et al. Laser-assisted delivery of synergistic combination chemotherapy in in vivo skin. J Control Release. 2018 Apr 10;275:242–253. DOI:10.1016/j.jconrel.2018.02.019.
  • Kale M, Kipping T, Banga AK. Modulated delivery of donepezil using a combination of skin microporation and iontophoresis. Int J Pharm. 2020 Nov 15;589:119853. DOI:10.1016/j.ijpharm.2020.119853.
  • Bachhav YG, Heinrich A, Kalia YN. Controlled intra- and transdermal protein delivery using a minimally invasive Erbium:YAG fractional laser ablation technology. Eur J Pharm Biopharm. 2013 Jun;84(2):355–364.
  • Lee W-R, Shen S-C, Chen W-Y, et al. Noninvasive delivery of siRNA and plasmid DNA into skin by fractional ablation: erbium:YAG laser versus CO(2) laser. European Journal of Pharmaceutics and Biopharmaceutics. 2014 Apr;86(3):315–323.
  • Lee WR, Shen SC, Sung CT, et al. Is the fractional laser still effective in assisting cutaneous macromolecule delivery in barrier-deficient skin? Psoriasis and atopic dermatitis as the disease models. Pharm Res. 2018 Apr 26;35(7):128.
  • Song Y, Hemmady K, Puri A, et al. Transdermal delivery of human growth hormone via laser-generated micropores. Drug Deliv Transl Res. 2018 Apr;8(2):450–460.
  • Hendel K, Hansen ACN, Bik L, et al. Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging. Drug Deliv. 2021 Dec;28(1):1141–1149.
  • Hendel KK, Bagger C, Olesen UH, et al. Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging. Drug Deliv. 2019 Dec;26(1):244–251.
  • Rosenberg LK, Bagger C, Janfelt C, et al. A comparison of human and porcine skin in laser-assisted drug delivery of chemotherapeutics. Lasers Surg Med. 2021 Jan;53(1):162–170.
  • Yu J, Kalaria DR, Kalia YN. Erbium:YAG fractional laser ablation for the percutaneous delivery of intact functional therapeutic antibodies. J Control Release. 2011 Nov 30;156(1):53–59.
  • Christensen RL, Omland SH, Persson DP, et al. Topical delivery of nivolumab, a therapeutic antibody, by fractional laser and pneumatic injection. Lasers Surg Med. 2021 Jan;53(1):154–161.
  • Christensen RL, Hendel KK, Persson DP, et al. Topical delivery of PD-1 inhibitors with laser-assisted passive diffusion and active intradermal injection: investigation of cutaneous pharmacokinetics and biodistribution patterns. Lasers Surg Med. 2022 Jan;54(1):170–181.
  • Li Z, Cao Y, Li Y, et al. Vaccine delivery alerts innate immune systems for more immunogenic vaccination. JCI Insight. 2021 Apr 8;6(7). DOI:10.1172/jci.insight.144627.
  • Bansal A, Gamal W, Menon IJ, et al. Laser-assisted skin delivery of immunocontraceptive rabies nanoparticulate vaccine in poloxamer gel. Eur J Pharm Sci. 2020 Dec 1;155:105560. DOI:10.1016/j.ejps.2020.105560.
  • Joshi D, Gala RP, Uddin MN, et al. Novel ablative laser mediated transdermal immunization for microparticulate measles vaccine. Int J Pharm. 2021 Sep 5;606:120882. DOI:10.1016/j.ijpharm.2021.120882.
  • Engelke L, Winter G, Engert J. Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery. Eur J Pharm Biopharm. 2018 Jul;128:119–130.
  • Lee WR, Hsiao CY, Huang TH, et al. Low-fluence laser-facilitated platelet-rich plasma permeation for treating MRSA-infected wound and photoaging of the skin. Int J Pharm. 2021 Feb 15;595:120242. DOI:10.1016/j.ijpharm.2021.120242.
  • Vora D, Kim Y, Banga AK. Development and evaluation of a heparin gel for transdermal delivery via laser-generated micropores. Ther Deliv. 2021 Feb;12(2):133–144.
  • Oni G, Lequeux C, Cho M-J, et al. Transdermal delivery of adipocyte-derived stem cells using a fractional ablative laser. Aesthet Surg J. 2013 Jan;33(1):109–116.
  • Yu J, Dubey S, Kalia YN. Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation. Expert Opin Drug Deliv. 2018 Jun;15(6):559–566.
  • Olesen UH, Mogensen M, Haedersdal M. Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography. Lasers Med Sci. 2017 Apr;32(3):679–684.
  • Erlendsson AM, Doukas AG, Farinelli WA, et al. Fractional laser-assisted drug delivery: active filling of laser channels with pressure and vacuum alteration. Lasers Surg Med. 2016 Feb;48(2):116–124.
  • Meesters AA, Nieboer MJ, Almasian M, et al. Drug penetration enhancement techniques in ablative fractional laser assisted cutaneous delivery of indocyanine green. Lasers Surg Med. 2019 Oct;51(8):709–719.
  • Singhal M, Del Rio-Sancho S, Sonaje K, et al. Fractional laser ablation for the cutaneous delivery of triamcinolone acetonide from cryomilled polymeric microparticles: creating intraepidermal drug depots. Mol Pharm. 2016 Feb 1;13(2):500–511.
  • Gou S, Del Rio-Sancho S, Singhal M, et al. Er:YAG fractional laser ablation for cutaneous co-delivery of pentoxifylline and d-alpha-tocopherol succinate: a new approach for topical treatment of radiation-induced skin fibrosis. Eur J Pharm Sci. 2019 Jul 1;135:22–31. DOI:10.1016/j.ejps.2019.05.007.
  • Olesen UH, Clergeaud G, Lerche CM, et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro. Lasers Surg Med. 2019 Jan;51(1):79–87.
  • Bhattaccharjee SA, Murnane KS, Banga AK. Transdermal delivery of breakthrough therapeutics for the management of treatment-resistant and post-partum depression. Int J Pharm. 2020 Dec 15;591:120007. DOI:10.1016/j.ijpharm.2020.120007.
  • Cao Y, Kakar P, Hossen MN, et al. Sustained epidermal powder drug delivery via skin microchannels. J Control Release. 2017 Mar 10;249:94–102. DOI:10.1016/j.jconrel.2017.01.030.
  • Weiss R, Hessenberger M, Kitzmuller S, et al. Transcutaneous vaccination via laser microporation. J Control Release. 2012 Sep 10;162(2):391–399.
  • Olesen UH, Clergeaud G, Hendel KK, et al. Enhanced and sustained cutaneous delivery of vismodegib by ablative fractional laser and microemulsion formulation. J Invest Dermatol. 2020 Oct;140(10):2051–2059.
  • Andrews SN, Jeong E, Prausnitz MR. Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum. Pharm Res. 2013 Apr;30(4):1099–1109.
  • Ko D-Y, Jeon S-Y, Kim K-H, et al. Fractional erbium: YAG laser-assisted photodynamic therapy for facial actinic keratoses: a randomized, comparative, prospective study. J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1529–1539.
  • Haak CS, Christiansen K, Erlendsson AM, et al. Ablative fractional laser enhances MAL-induced PpIX accumulation: impact of laser channel density, incubation time and drug concentration. J Photochem Photobiol B. 2016 Jun;159:42–48.
  • Wang JV, Griffin TD. Fractional ablative laser-assisted photodynamic therapy as field treatment for actinic keratoses: our anecdotal experience. Skinmed. 2020;18(4):214–216.
  • Choi JH, Shin EJ, Jeong KH, et al. Comparative analysis of the effects of CO2 fractional laser and sonophoresis on human skin penetration with 5-aminolevulinic acid. Lasers Med Sci. 2017 Nov;32(8):1895–1900.
  • Choi S-H, Kim T-H, Song K-H. Efficacy of iontophoresis-assisted ablative fractional laser photodynamic therapy with short incubation time for the treatment of actinic keratosis: 12-month follow-up results of a prospective, randomised, comparative trial. Photodiagnosis Photodyn Ther. 2017 Jun;18:105–110.
  • Song HS, Jung S-E, Jang YH, et al. Fractional carbon dioxide laser-assisted photodynamic therapy for patients with actinic keratosis. Photodermatol Photoimmunol Photomed. 2015 Nov;31(6):296–301.
  • Pires MTF, Pereira AD, Duraes SMB, et al. Laser-assisted MAL-PDT associated with acoustic pressure wave ultrasound with short incubation time for field cancerization treatment: a left-right comparison. Photodiagnosis Photodyn Ther. 2019 Dec;28:216–220.
  • Paasch U, Said T. Treating field cancerization by ablative fractional laser and indoor daylight: assessment of efficacy and tolerability. J Drugs Dermatol. 2020 Apr 1;19(4):425–427.
  • Tian T, Luo Y, Jiang T, et al. Clinical effect of ablative fractional laser-assisted topical anesthesia on human skin: a randomized pilot study. J Cosmet Laser Ther. 2016 Nov;18(7):409–412.
  • Meesters AA, Bakker MM, de Rie MA, et al. Fractional CO2 laser assisted delivery of topical anesthetics: a randomized controlled pilot study. Lasers Surg Med. 2016 Feb;48(2):208–211.
  • Meesters AA, Nieboer MJ, Kezic S, et al. Parameters in fractional laser assisted delivery of topical anesthetics: role of laser type and laser settings. Lasers Surg Med. 2018 Oct;50(8):813–818.
  • Issa MC, Torreao PS, Boechat M, et al. Early investigations in drug delivery of onabotulinum toxin A using combined fractional ablative laser with impact ultrasound vs. injections of onabotulinum toxin A for palmar hyperhidrosis: a right-left comparison trial. Br J Dermatol. 2018 Nov;179(5):1168–1169.
  • Park JH, Chun JY, Lee JH. Laser-assisted topical corticosteroid delivery for the treatment of keloids. Lasers Med Sci. 2017 Apr;32(3):601–608.
  • AbdEl‐Dayem DH, Nada HA, Hanafy NS, et al. Laser-assisted topical steroid application versus steroid injection for treating keloids: a split side study. J Cosmet Dermatol. 2021 Jan;20(1):138–142.
  • Artzi O, Sprecher E, Koren A, et al. Fractional ablative CO2 laser followed by topical application of sodium stibogluconate for treatment of active cutaneous leishmaniasis: a randomized controlled trial. Acta Derm Venereol. 2019 Jan 1;99(1):53–57.
  • Hilerowicz Y, Koren A, Mashiah J, et al. Fractional ablative carbon dioxide laser followed by topical sodium stibogluconate application: a treatment option for pediatric cutaneous leishmaniasis. Pediatr Dermatol. 2018 May;35(3):366–369.
  • Ma G, Wu P, Lin X, et al. Fractional carbon dioxide laser-assisted drug delivery of topical timolol solution for the treatment of deep infantile hemangioma: a pilot study. Pediatr Dermatol. 2014 May-Jun;31(3):286–291.
  • Wenande E, Hendel K, Mogensen M, et al. Efficacy and safety of laser-assisted combination chemotherapy: an explorative imaging-guided treatment with 5-fluorouracil and cisplatin for basal cell carcinoma. Lasers Surg Med. 2021 Jan;53(1):119–128.
  • Fredman G, Wenande E, Hendel K, et al. Efficacy and safety of laser-assisted combination chemotherapy: a follow-up study of treatment with 5-fluorouracil and cisplatin for basal cell carcinoma. Lasers Surg Med. 2022 Jan;54(1):113–120.
  • Lee DW, Ahn HH, Kye YC, et al. Clinical experience of ingenol mebutate gel for the treatment of Bowen’s disease. J Dermatol. 2018 Apr;45(4):425–430.
  • Zech NH, Murtinger M, Uher P. Pregnancy after ovarian superovulation by transdermal delivery of follicle-stimulating hormone. Fertil Steril. 2011 Jun 30;95(8):2784–2785.
  • Bauer M, Lackner E, Matzneller P, et al. Phase I study to assess safety of laser-assisted topical administration of an anti-TNF biologic in patients with chronic plaque-type psoriasis. Front Med (Lausanne). 2021;8:712511.
  • Badawi AM, Osman MA. Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma. Clin Cosmet Investig Dermatol. 2018;11:13–20.
  • Cavalie M, Sillard L, Montaudie H, et al. Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther. 2015 Mar-Apr;28(2):74–78.
  • Waibel JS, Wulkan AJ, Shumaker PR. Treatment of hypertrophic scars using laser and laser assisted corticosteroid delivery. Lasers Surg Med. 2013 Mar;45(3):135–140.
  • Tawfik AA, Fathy M, Badawi A, et al. Topical 5 fluorouracil cream vs combined 5 fluorouracil and fractional erbium YAG laser for treatment of severe hypertrophic scars. Clin Cosmet Investig Dermatol. 2019;12:173–180.
  • Issa MC, Pires M, Silveira P, et al. Transepidermal drug delivery: a new treatment option for areata alopecia? J Cosmet Laser Ther. 2015 Feb;17(1):37–40.
  • Salah M, Samy N, Fawzy MM, et al. The effect of the fractional carbon dioxide laser on improving minoxidil delivery for the treatment of androgenetic alopecia. J Lasers Med Sci. 2020;11(1):29–36.
  • Genina EA, Bashkatov AN, Dolotov LE, et al. Transcutaneous delivery of micro- and nanoparticles with laser microporation. J Biomed Opt. 2013 Nov;18(11):111406.
  • Banzhaf CA, Wind BS, Mogensen M, et al. Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy. Lasers Surg Med. 2016 Feb;48(2):157–165.
  • Banzhaf CA, Thaysen-Petersen D, Bay C, et al. Fractional laser-assisted drug uptake: impact of time-related topical application to achieve enhanced delivery. Lasers Surg Med. 2017 Apr;49(4):348–354.
  • Lee YI, Kim S, Kim J, et al. Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy. J Cosmet Dermatol. 2021 Jun;20(6):1774–1781.
  • Nguyen HX, Banga AK. Effect of ablative laser on in vitro transungual delivery. Int J Pharm. 2018 Jun 15;544(2):402–414.
  • Guan X-H, Xu T-H, Chen X, et al. Fractionated carbon dioxide (CO2) laser treatment contributes to trans-nail penetration of rhodamine B and changes of cytokine microenvironment. Lasers Med Sci. 2021 Oct;36(8):1619–1623.
  • Yang C-H, Tsai M-T, Shen S-C, et al. Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography. Biomed Opt Express. 2014 Nov 1;5(11):3949–3959.
  • Ortner VK, Nguyen N, Brewer JR, et al. Fractional CO 2 laser ablation leads to enhanced permeation of a fluorescent dye in healthy and mycotic nails—An imaging investigation of laser–tissue effects and their impact on ungual drug delivery. Lasers Surg Med. 2022 Apr 22;54(6):861–874.
  • Suh JH, Lee SK, Kim MS, et al. Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. J Dermatolog Treat. 2020 Jun;31(4):410–414.
  • Shehadeh W, Matz H, Ellenbogen E, et al. Pulse-dye laser followed by betamethasone-calcipotriol and fractional ablative CO2-laser-assisted delivery for nail psoriasis. Dermatologic Surg. 2021 Apr 1;47(4):e111–e116.
  • Gaudana R, Ananthula HK, Parenky A, et al. Ocular drug delivery. AAPS J. 2010 Sep;12(3):348–360.
  • Patel A, Cholkar K, Agrahari V, et al. Ocular drug delivery systems: an overview. World J Pharmacol. 2013;2(2):47–64.
  • Falavarjani KG, Nguyen QD. Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature. Eye (Lond). 2013 Jul;27(7):787–794.
  • Patane MA, Cohen A, From S, et al. Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial. Clin Ophthalmol. 2011;5:633–643.
  • Thakur Singh RR, Tekko I, McAvoy K, et al. Minimally invasive microneedles for ocular drug delivery. Expert Opin Drug Deliv. 2017 Apr;14(4):525–537.
  • Figueroa M, Schocket LS, DuPont J, et al. Effect of laser treatment for dry age related macular degeneration on foveolar choroidal haemodynamics. Br J Ophthalmol. 2004 Jun;88(6):792–795.
  • Tiwari NN, Sachdev GS, Ramamurthy S, et al. Comparative analysis of visual outcomes and ocular aberrations following wavefront optimized and topography-guided customized femtosecond laser in situ keratomileusis for myopia and myopic astigmatism: a contralateral eye study. Indian J Ophthalmol. 2018 Nov;66(11):1558–1561.
  • Chen H, Hyatt T, Afshari N. Visual and refractive outcomes of laser cataract surgery. Curr Opin Ophthalmol. 2014 Jan;25(1):49–53.
  • Thakur RRS, Adwan S, Tekko I, et al. Laser irradiation of ocular tissues to enhance drug delivery. Int J Pharm. 2021 Mar 1;596:120282. DOI:10.1016/j.ijpharm.2021.120282.
  • Zaman RT, Gopal A, Starr K, et al. Micro-patterned drug delivery device for light-activated drug release. Lasers Surg Med. 2012 Jan;44(1):30–48.

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