Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 8: Alternatives to Animal Models in Toxicology
Submit an article Journal homepage
125
Views
2
CrossRef citations to date
0
Altmetric
Foreword

Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems

Elisa Giovannettia Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, Amsterdam, The Netherlands;b Cancer Pharmacology Lab, Fondazione Pisana per La Scienza, Pisa, ItalyCorrespondence[email protected]
View further author information
&
Godefridus Petersa Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, Amsterdam, The Netherlands;c Department of Biochemistry, Medical University of Gdansk, Gdansk, PolandView further author information
Pages 867-868 | Received 04 Dec 2020, Accepted 07 Jun 2021, Published online: 30 Jun 2021

References

  • Kasteel EEJ, Westerink RHS. Refining in vitro and in silico neurotoxicity approaches by accounting for interspecies and interindividual differences in toxicodynamics. Expert Opin Drug Metab Toxicol. 2021 Feb 14: 1–11. DOI:10.1080/17425255.2021.1885647.
  • Burnett SD, Blanchette AD, Chiu WA, et al. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk characterization. Expert Opin Drug Metab Toxicol. 2021 Mar 8: 1–16. DOI:10.1080/17425255.2021.1894122.
  • Supadmanaba IGP, Comandatore A, Morelli L, et al. Organotypic-liver slide culture systems to explore the role of extracellular vesicles in pancreatic cancer metastatic behavior and guide new therapeutic approaches. Expert Opin Drug Metab Toxicol. 2021 May 21: 1–10. DOI:10.1080/17425255.2021.1925646.
  • Tcheremenskaia O, Benigni R. Towards regulatory acceptance and improving the prediction confidence of in silico approaches: a case study of genotoxicity. Expert Opin Drug Metab Toxicol. 2021 Jun 3: 1–19. DOI:10.1080/17425255.2021.1938540.
  • Breen M, Ring CL, Kreutz A, et al. High-throughput PBTK models for in vitro to in vivo extrapolation. Expert Opin Drug Metab Toxicol. 2021 May 31: 1–19. DOI:10.1080/17425255.2021.1935867.
  • Liang X, Lai Y. Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance. Expert Opin Drug Metab Toxicol. 2021 Apr 1: 1–18. DOI:10.1080/17425255.2021.1912012.
  • Sung JH. Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs. Expert Opin Drug Metab Toxicol. 2021 Apr 5: 1–18. DOI:10.1080/17425255.2021.1908996.
  • Mapanao AK, Che PP, Sarogni P, et al. Tumor grafted - chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation. Expert Opin Drug Metab Toxicol. 2021 Feb 10: 1–22. DOI:10.1080/17425255.2021.1879047.
  • Tukker AM, Westerink RHS. Novel test strategies for in vitro seizure liability assessment. Expert Opin Drug Metab Toxicol. 2021 Feb 17: 1–14. DOI:10.1080/17425255.2021.1876026.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.