Phytoconstituents of Butterbur (P. japonicus), their metabolic pathway and ability to modulate bone morphogenic protein (BMP) signaling

References

• Baek HJ, hyung Kim I, Yun PY, Kim YK. 2021. Prognosis of single tooth implants following alveolar ridge preservation with two recombinant human bone morphogenetic protein-2 delivery systems. BMC Oral Health. 21.
   PubMed Web of Science ®Google Scholar
• Belal A, Elkady H, Al-Karmalawy AA, Amin AH, Ghoneim MM, El-Sherbiny M, Al-Serwi RH, Abdou MA, Ibrahim MH, Mehany ABM. 2022. Discovery of some heterocyclic molecules as bone morphogenetic protein 2 (BMP-2)-inducible kinase inhibitors: virtual screening, ADME properties, and molecular docking simulations. Molecules. 27.
   Web of Science ®Google Scholar
• Borlak J, Diener HC, Kleeberg-Hartmann J, Messlinger K, Silberstein S. 2022. Petasites for migraine prevention: New data on mode of action, pharmacology and safety. A narrative review. Front Neurol. 13.
   PubMed Web of Science ®Google Scholar
• Bradford STJ, Ranghini EJ, Grimley E, Lee PH, Dressler GR. 2019. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J Biol Chem. 294.
   Web of Science ®Google Scholar
• Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A. 2011. Bone morphogenetic proteins: A critical review. Cell Signal. 23.
   PubMed Web of Science ®Google Scholar
• Chao YL, Wang TM, Chang HH, Lin LD. 2021. Effects of low-dose rhBMP-2 on peri-implant ridge augmentation in a canine model. J Clin Periodontol. 48.
   PubMed Web of Science ®Google Scholar
• Chen M, Cui Y, Li H, Luan J, Zhou X, Han J. 2019. Icariin promotes the osteogenic action of BMP2 by activating the cAMP signaling pathway. Molecules. 24.
   Web of Science ®Google Scholar
• Choi H, Jeong BC, Kook MS, Koh JT. 2016. Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways. J Biomed Sci. 23.
   Web of Science ®Google Scholar
• Djoumbou-Feunang Y, Fiamoncini J, Gil-de-la-Fuente A, Greiner R, Manach C, Wishart DS. 2019. Biotransformer: A comprehensive computational tool for small molecule metabolism prediction and metabolite identification. J Cheminform. 11.
   PubMed Web of Science ®Google Scholar
• Durbano HW, Halloran D, Nguyen J, Stone V, McTague S, Eskander M, Nohe A. 2020. Aberrant BMP2 signaling in patients diagnosed with osteoporosis. Int J Mol Sci. 21.
   PubMed Web of Science ®Google Scholar
• Ebara S, Nakayama K. 2002. Mechanism for the action of bone morphogenetic proteins and regulation of their activity. Spine (Phila PA 1976). 27.
   PubMed Web of Science ®Google Scholar
• Farghaly TA, Althagafi I, Ibrahim MH, Al-Qurashi NT, Farooq U. 2021. Synthesis under microwaves irradiation, structure elucidation, docking study for inhibiting COVID-19 and DFT calculations of novel azoles incorporated indole moiety. J Mol Struct. 1244.
   Web of Science ®Google Scholar
• Ferrari SL, Abrahamsen B, Napoli N, Akesson K, Chandran M, Eastell R, El-Hajj Fuleihan G, Josse R, Kendler DL, Kraenzlin M, et al. 2018. Diagnosis and management of bone fragility in diabetes: an emerging challenge. Osteop Int. 29.
   Web of Science ®Google Scholar
• Fitzpatrick V, Fourel L, Destaing O, Gilde F, Albigès-Rizo C, Picart C, Boudou T. 2017. Signal mingle: micropatterns of BMP-2 and fibronectin on soft biopolymeric films regulate myoblast shape and SMAD signaling. Sci Rep. 7.
   Web of Science ®Google Scholar
• Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, Salmon RM, Read RJ, ten Dijke P, Morrell NW, Li W. 2022. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 13.
   Web of Science ®Google Scholar
• Guo YF, Su T, Yang M, jun Li C, Guo Q, Xiao Y, Huang Y, Liu Y, Luo XH. 2021. The role of autophagy in bone homeostasis. J Cell Physiol. 236.
   Web of Science ®Google Scholar
• Hiemoriikondo M. 2020. Antioxidant compounds of Petasites japonicus and their preventive effects in chronic diseases: a review. J Clin Biochem Nutr. 67:10–18.
   PubMed Web of Science ®Google Scholar
• Iwamoto Y. 2009. Breeding of Japanese butterbur (Petasites japonicus) by using flowerhead culture. Plant Biotechnol. 26:189–196.
   Web of Science ®Google Scholar
• James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, Ting K, Soo C. 2016. A review of the clinical side effects of bone morphogenetic protein-2. Tissue Eng Part B Rev. 22.
   PubMed Web of Science ®Google Scholar
• Johnell O, Kanis JA. 2006. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteop Int. 17.
   Web of Science ®Google Scholar
• Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD. 2004. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 11:481–488.
   PubMed Web of Science ®Google Scholar
• Kulinowski Ł, Luca SV, Minceva M, Skalicka-Woźniak K. 2022. A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.). J Ethnopharmacol. 293.
   PubMed Web of Science ®Google Scholar
• Lademann F, Hofbauer LC, Rauner M. 2020. The bone morphogenetic protein pathway: The osteoclastic perspective. Front Cell Dev Biol. 8.
   PubMed Web of Science ®Google Scholar
• Lee JS, Jeong M, Park S, Ryu SM, Lee J, Song Z, Guo Y, Choi JH, Lee D, Jang DS. 2019. Chemical constituents of the leaves of butterbur (Petasites japonicus) and their anti-inflammatory effects. Biomolecules. 9.
   Web of Science ®Google Scholar
• Lin S, Svoboda KKH, Feng JQ, Jiang X. 2016. The biological function of type i receptors of bone morphogenetic protein in bone. Bone Res. 4.
   Web of Science ®Google Scholar
• Lowery JW, Pazin D, Intini G, Kokabu S, Chappuis V, Capelo LP, Rosen V. 2011. The role of BMP2 signaling in the skeleton. Crit Rev Eukaryot Gene Expr. 21.
   PubMed Web of Science ®Google Scholar
• Mace PD, Cutfield JF, Cutfield SM. 2006. High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding. Biochem Biophys Res Commun. 351.
   PubMed Web of Science ®Google Scholar
• Miyazono K, Kamiya Y, Morikawa M. 2010. Bone morphogenetic protein receptors and signal transduction. J Biochem. 147:35–51.
   PubMed Web of Science ®Google Scholar
• Mueller TD, Nickel J. 2012. Promiscuity and specificity in BMP receptor activation. FEBS Lett. 586.
   PubMed Web of Science ®Google Scholar
• Nicolin V, de Tommasi N, Nori SL, Costantinides F, Berton F, di Lenarda R. 2019. Modulatory effects of plant polyphenols on bone remodeling: A prospective view from the bench to bedside. Front Endocrinol (Lausanne). 10.
   PubMed Web of Science ®Google Scholar
• Ohte S, Yamazaki H, Takahashi O, Rotinsulu H, Wewengkang DS, Sumilat DA, Abdjul DB, Maarisit W, Kapojos MM, Zhang H, et al. 2021. Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation. Bioorg Med Chem Lett. 35.
   PubMed Web of Science ®Google Scholar
• Okamoto M, Murai J, Yoshikawa H, Tsumaki N. 2006. Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J Bone Miner Res. 21.
   Web of Science ®Google Scholar
• Puel C, Mathey J, Agalias A, Kati-coulibaly S, Mardon J, Obled C, Davicco MJ, Lebecque P, Horcajada MN, Skaltsounis AL, Coxam V. 2006. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 25.
   PubMed Web of Science ®Google Scholar
• Qin S, Ang E, Dai L, Yang X, Ye D, Chen H, Zhou L, Yang M, Teguh D, Tan R, et al. 2015. Natural germacrane sesquiterpenes inhibit osteoclast formation, bone resorption, RANKL-induced NF-κB activation, and IκBα degradation. Int J Mol Sci. 16:26599–26607.
   PubMed Web of Science ®Google Scholar
• Rahman MS, Akhtar N, Jamil HM, Banik RS, Asaduzzaman SM. 2015. TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone Res. 3.
   PubMed Web of Science ®Google Scholar
• Segredo-Morales E, García-García P, Reyes R, Pérez-Herrero E, Delgado A, Évora C. 2018. Bone regeneration in osteoporosis by delivery BMP-2 and PRGF from tetronic–alginate composite thermogel. Int J Pharm. 543.
   PubMedGoogle Scholar
• Tang H, Zhang X, Xue G, Xu F, Wang Q, Yang P, Hong B, Xu Y, Huang Q, Liu J, Zuo Q. 2021. The biology of bone morphogenetic protein signaling pathway in cerebrovascular system. Chin Neurosurg J. 7.
   Google Scholar
• Thangavelu R, Sai Harika M, Raj Kumar T, Siva Sankar Reddy L. 2017. Docking studies of benzimidazole derivatives using HEX 8.0 synthesis and microbial evaluation of amino acid anti metabolites view project anti cancer agents view project. Int J Pharm Sci Res. 8:1677–1688.
   Google Scholar
• Varacallo MA, Fox EJ. 2014. Osteoporosis and its complications. Med Clin North Amer. 98.
   PubMed Web of Science ®Google Scholar
• Wang RN, Green J, Wang Z, Deng Y, Qiao M, Peabody M, Zhang Q, Ye J, Yan Z, Denduluri S, et al. 2014. Bone morphogenetic protein (BMP) signaling in development and human diseases. Genes Dis. 1.
   Google Scholar
• Wang X, Li Z, Wang Z, Liu H, Cui Y, Liu Y, Ren M, Zhan H, Li Z, Wu M, Wang J. 2021. Incorporation of bone morphogenetic protein-2 and osteoprotegerin in 3D-printed Ti6Al4 V scaffolds enhances osseointegration under osteoporotic conditions. Front Bioeng Biotechnol. 9.
   Web of Science ®Google Scholar
• Wang Z, Bao HW, Xu YJ. 2020. Cnidium lactone prevents bone loss in an ovariectomized rat model through the estrogen-α/BMP-2/Smad signaling pathway. J Gene Med. 22.
   Web of Science ®Google Scholar
• Wu AM, Bisignano C, James SL, Abady GG, Abedi A, Abu-Gharbieh E, Alhassan RK, Alipour V, Arabloo J, Asaad M, et al. 2021. Global, regional, and national burden of bone fractures in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2.
   PubMedGoogle Scholar
• Yang J, Shi P, Tu M, Wang Y, Liu M, Fan F, Du M. 2014. Bone morphogenetic proteins: relationship between molecular structure and their osteogenic activity. Food Sci Hum Wellness. 3.
   Google Scholar
• Zhang A, Chen Z, Yu X, Zhang L, Song Q. 2021. Rational derivation of osteogenic peptides from bone morphogenetic protein-2 knuckle epitope by integrating in silico analysis and In vitro assay. Int J Pept Res Ther. 27.
   PubMed Web of Science ®Google Scholar
• Zhao YH, Abraham MH, Le J, Hersey A, Luscombe CN, Beck G, Sherborne B, Cooper I. 2002. Rate-limited steps of human oral absorption and QSAR studies. Pharm Res. 19:1446–1457.
   PubMed Web of Science ®Google Scholar