Use of XyCAM RI for Noninvasive Visualization and Analysis of Retinal Blood Flow Dynamics During Clinical Investigations

References

• Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901.
   PubMed Web of Science ®Google Scholar
• Fan N, Wang P, Tang L, et al. Ocular Blood Flow and Normal Tension Glaucoma. Biomed Res Int. 2015;2015(308505–308505). DOI:10.1155/2015/308505
   Google Scholar
• Schuman JS. Measuring Blood Flow: so What? JAMA Ophthalmol. 2015;133:1052–1053.
   PubMed Web of Science ®Google Scholar
• Shiga Y, Omodaka K, Kunikata H, et al. Waveform Analysis of Ocular Blood Flow and the Early Detection of Normal Tension Glaucoma. Invest Ophthalmol Vis Sci. 2013;54(7699–7706). DOI:10.1167/iovs.13-12930
   PubMedGoogle Scholar
• Jia Y, Bailey ST, Wilson DJ, et al. Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration. Ophthalmology. 2014;121(7):1435-1444. DOI:10.1016/j.ophtha.2014.01.034.
   Web of Science ®Google Scholar
• Mori K, Gehlbach PL, Ito YN, et al. Decreased arterial dye-filling and venous dilation in the macular choroid associated with age-related macular degeneration. Retina. 2005;25:430–437.
   PubMed Web of Science ®Google Scholar
• Pemp B, Schmetterer L. Ocular blood flow in diabetes and age-related macular degeneration. Canadian Jophthalmol. 2008;43(295–301). DOI:10.3129/i08-049
   Google Scholar
• Harris A, Ciulla TA, Chung HS, et al. Regulation of Retinal and Optic Nerve Blood Flow. Arch Ophtalmol. 1998;116(1491–1495). DOI:10.1001/archopht.116.11.1491
   Google Scholar
• Frost S, Kanagasingam Y, Sohrabi H, et al. Retinal vascular biomarkers for early detection and monitoring of Alzheimer’s disease. Transl Psychiatry. 2013;3(e233). DOI:10.1038/tp.2012.150
   PubMedGoogle Scholar
• Cheung CY-L, Ong YT, Ikram MK, et al. Microvascular network alterations in the retina of patients with Alzheimer’s disease. Alzheimer’s & Dementia. 2014;10(2):135–142.
   PubMed Web of Science ®Google Scholar
• Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health. 2014;2(2):e106-e116.
   PubMed Web of Science ®Google Scholar
• Tham Y-C, Li X, Wong TY, et al. Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: a Systematic Review and Meta-Analysis. Ophthalmology. 2014;121(11):2081–2090.
   Web of Science ®Google Scholar
• Gupta P, Zhao D, Guallar E, et al. Prevalence of Glaucoma in the United States: the 2005–2008 National Health and Nutrition Examination Survey. Invest Ophthalmol Vis Sci. 2016;57:2905–2913-2905–2913.
   Web of Science ®Google Scholar
• Varma R, Lee PP, Goldberg I, et al. An assessment of the health and economic burdens of glaucoma. Am J Ophthalmol. 2011;152(4):515–522.
   Web of Science ®Google Scholar
• Killer HE, Pircher A. Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis. Eye. 2018;32(5):924–930.
   PubMed Web of Science ®Google Scholar
• Flammer J. The vascular concept of glaucoma. Surv Ophthalmol. 1994;38:S3–S6.
   PubMedGoogle Scholar
• Hood DC, De Moraes CG. Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields. Invest Ophthalmol Vis Sci. 2018;59(788–791). DOI:10.1167/iovs.17-23713
   Google Scholar
• Wang DL, Raza AS, De Moraes CG, et al. Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses. Transl Vis Sci Technol. 2015;4(6):4.
   PubMed Web of Science ®Google Scholar
• Schwartz R, Loewenstein A. Early detection of age related macular degeneration: current status. Int J Retina Vitreous. 2015;1(1). DOI:10.1186/s40942-015-0022-7
   PubMedGoogle Scholar
• London A, Benhar I, Schwartz M. The retina as a window to the brain—from eye research to CNS disorders. Nat Rev Neurol. 2013;9(1):44–53.
   PubMed Web of Science ®Google Scholar
• Zafar S, McCormick J, Giancardo L, et al. Retinal Imaging for Neurological Diseases: “A Window into the Brain”.. Int Ophthalmol Clin. 2019;59:137–154.
   PubMedGoogle Scholar
• Cabrera Debuc D, Somfai GM, Koller A. Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases. Am J Physiol Heart Circ Physiol. 2017;312:H201–H212.
   PubMed Web of Science ®Google Scholar
• Berisha F, Feke GT, Trempe CL, et al. Retinal abnormalities in early Alzheimer’s disease. Invest Ophthalmol Vis Sci. 2007;48(2285–2289). DOI:10.1167/iovs.06-1029
   PubMedGoogle Scholar
• Koronyo Y, Salumbides BC, Black KL, et al. Disease in the Retina: imaging Retinal Aβ Plaques for Early Diagnosis and Therapy Assessment. Neurodegen Dis. 2012;10(285–293). DOI:10.1159/000335154
   PubMedGoogle Scholar
• Feke GT, Hyman BT, Stern RA, et al. Retinal blood flow in mild cognitive impairment and Alzheimer’s disease. Alzheimers Dement. 2015;1(144–151). DOI:10.1016/j.dadm.2015.01.004
   Google Scholar
• Snyder PJ, Alber J, Alt C, et al. Retinal imaging in Alzheimer’s and neurodegenerative diseases. Alzheimer’s Dementia. 2020. DOI:10.1002/alz.12179.
   Web of Science ®Google Scholar
• Alber J, Goldfarb D, Thompson LI, et al. Developing retinal biomarkers for the earliest stages of Alzheimer’s disease: what we know, what we don’t, and how to move forward. Alzheimer’s Dementia. 2020;16(229–243). DOI:10.1002/alz.12006
   PubMedGoogle Scholar
• Maram J, Srinivas S, Sadda SR. Evaluating ocular blood flow. Indian J Ophthalmol. 2017;65(337–346). DOI:10.4103/ijo.IJO_330_17
   PubMedGoogle Scholar
• Stern MD. Laser Doppler velocimetry in blood and multiply scattering fluids: theory. Appl Opt. 1985;24(1968). DOI:10.1364/ao.24.001968
   PubMedGoogle Scholar
• Grinvald A, Bonhoeffer T, Vanzetta I, et al. High-resolution functional optical imaging: from the neocortex to the eye. Ophthalmol Clin North Am. 2004;17:53–67. doi:10.1016/j.ohc.2003.12.003
   Google Scholar
• Sugiyama T, Araie M, Riva CE, et al. Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 2010;88(723–729). DOI:10.1111/j.1755-3768.2009.01586.x
   Google Scholar
• Spaide RF, Klancnik JM Jr., Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:45–50. .
   PubMed Web of Science ®Google Scholar
• Briers JD, Fercher AF. Retinal blood-flow visualization by means of laser speckle photography. Invest Ophthalmol Vis Sci. 1982;22:255–259.
   PubMed Web of Science ®Google Scholar
• Fercher AF, Briers JD. Flow visualization by means of single-exposure speckle photography. Opt Commun. 1981;37:326–330.
   Web of Science ®Google Scholar
• Cheng H, Luo Q, Zeng S, et al. Modified laser speckle imaging method with improved spatial resolution. J Biomed Opt. 2003;8:559–564.
   PubMed Web of Science ®Google Scholar
• Murari K, Li N, Rege A, et al. Contrast-enhanced imaging of cerebral vasculature with laser speckle. App Opt. 2007;46:5340–5346.
   Google Scholar
• Rege A, Senarathna J, Li N, et al. Anisotropic processing of laser speckle images improves spatiotemporal resolution. IEEE Trans Biomed Eng. 2012;59:1272–1280.
   PubMed Web of Science ®Google Scholar
• Duncan DD, Kirkpatrick SJ. Proc SPIE 6858: optics in Tissue Engineering and Regenerative Medicine II. p. 685802.
   Google Scholar
• Bandyopadhyay R, Gittings A, Suh S, et al. Speckle-visibility spectroscopy: a tool to study time-varying dynamics. Rev Sci Instrum. 2005;76:0931101–0931111.
   Web of Science ®Google Scholar
• Duncan DD, Kirkpatrick SJ. Can laser speckle flowmetry be made a quantitative tool? Journal of the Optical Society of America. 2008;25:2088–2094.
   Web of Science ®Google Scholar
• Le TM, Paul JS, Ong SH. Laser Speckle Imaging for Blood Flow Analysis. In: Pham T, editors. Computational Biology. Applied Bioinformatics and Biostatistics in Cancer Research. Springer, New York, NY. 2009. https://doi.org/10.1007/978-1-4419-0811-7_11
   Google Scholar
• Ramirez-San-Juan JC, Ramos-García R, Guizar-Iturbide I, et al. Impact of velocity distribution assumption on simplified laser speckle imaging equation. Opt Express. 2008;16:3197–3203.
   PubMed Web of Science ®Google Scholar
• Parthasarathy AB, Tom WJ, Gopal A, et al. Robust flow measurement with multi-exposure speckle imaging. Opt Exp. 2008;16:1975–1989.
   PubMed Web of Science ®Google Scholar
• Rege A, Murari K, Seifert A, et al. Multi exposure laser speckle contrast imaging of the angiogenic microenvironment. J Biomed Opt. 2011;16:05600601–05600610.
   Web of Science ®Google Scholar
• Cho K-A, Rege A, Jing Y, et al. Portable, non-invasive video imaging of retinal blood flow dynamics. Sci Rep. 2020;10(20236). DOI:10.1038/s41598-020-76407-5.
   Google Scholar
• Kunikata H, Nakazawa T. Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease. Asia Pac J Ophthalmol (Phila). 2016;5(151–158). DOI:10.1097/apo.0000000000000160
   Google Scholar
• Rege A, Murari K, Li N, et al. in Proc 32nd Ann Intl Conf Engr Med Biol Soc (EMBC). 1978–1981.
   Google Scholar
• Vinnett A, Asanad S, Cho K-A, et al. OCT Angiography vs Laser Speckle Contrast Imaging: correlation between Static and Dynamic Measurements of Peripapillary Blood Flow in Glaucoma, Glaucoma Suspect, and Healthy Eyes. Invest Ophthalmol Vis Sci. 2020;61:617. [cited 2021 Mar 15]. Available from: https://iovs.arvojournals.org/article.aspx?articleid=2770120
   Web of Science ®Google Scholar
• Rege A, Liu Y, Jing Y, et al. Non-invasive, non-mydriatic imaging of retinal blood flow over multiple fields of view. Invest Ophthalmol Vis Sci. 2018;59:5878.
   Web of Science ®Google Scholar
• Kalarn S, Cho K-A, Vinnett, A, et al. Repeatability and Reproducibility of the XyCAM RI Across Multiple Operators. Invest Ophthalmol Vis Sci. 2020;61:5321.
   Web of Science ®Google Scholar
• Rege A, Cunningham SI, Liu Y, et al. Noninvasive Assessment of Retinal Blood Flow Using a Novel Handheld Laser Speckle Contrast Imager. Transl Vis Sci Technol. 2018;7(7–7). DOI:10.1167/tvst.7.6.7
   PubMedGoogle Scholar
• Kalarn S, Cho K-A, Thompson G, et al. Non-Invasive Blood-Flow Measurement in the Glaucomatous Optic Nerve Head using the XyCAM RI Retinal Imaging System. Invest Ophthalmol Vis Sci. 2019;60:5616.
   Web of Science ®Google Scholar
• Cho K-A Wu Y, Lee W-H, et al. Assessment of Blood Flow Information in Diabetic Eyes using the XyCAM RI. Invest Ophthalmol Vis Sci. 2020;61:1736.
   Web of Science ®Google Scholar
• Cabrera Debuc D, Cho K-A, Wu Y, et al. Volumetric Blood Flow Changes in the Retina During Mild Cognitive Impairment: early Results. Invest Ophthalmol Vis Sci. 2020;61:1853.
   Web of Science ®Google Scholar
• Guan K, Hudson C, Flanagan JG. Variability and repeatability of retinal blood flow measurements using the Canon laser blood flowmeter. Microvasc Res. 2003;65:145–151.
   PubMed Web of Science ®Google Scholar
• Chhablani J, Bartsch DU, Cheng L, et al. Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager. Graefe’s Arch Clin Exp Ophthalmol. 2013;251(2665–2670). DOI:10.1007/s00417-013-2360-1
   Google Scholar
• Aizawa N, Yokoyama Y, Chiba N,et al. Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma. Clin Ophthalmol. 2011;5:1171–1176. doi:10.2147/OPTH.S22093
   Google Scholar
• Shiga Y, Kunikata H, Aizawa N, et al. Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma. Curr Eye Res. 2016;41(1447–1453). DOI:10.3109/02713683.2015.1127974
   PubMedGoogle Scholar
• Maeda K, Ishikawa F, Ohguro H. Ocular blood flow levels and visual prognosis in a patient with nonischemic type central retinal vein occlusion. Clin Ophthalmol. 2009;3:489–491.
   PubMedGoogle Scholar
• Matsumoto M, Suzuma K, Fukazawa Y, et al. Retinal blood flow levels measured by Laser Speckle Flowgraphy in central retinal vein occlusion as a predictive factor for ischemia and visual loss. Invest Ophthalmol Vis Sci. 2013;54:5126.
   Web of Science ®Google Scholar
• Nitta F, Kunikata H, Aizawa N, et al. The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. Clin Ophthalmol. 2014;8(1119–1127). DOI:10.2147/OPTH.S62022
   PubMedGoogle Scholar