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Review

Transcatheter edge-to-edge mitral valve repair in mitral regurgitation: current status and future prospects

, , , , , , , , , , , & show all
Pages 99-108 | Received 15 Mar 2022, Accepted 30 Jun 2022, Published online: 20 Jul 2022

References

  • Enriquez-Sarano M, Akins CW, Vahanian A. Mitral regurgitation. Lancet. 2009;373(9672):1382–1394.
  • Cork DP, McCullough PA, Mehta HS, et al. Impact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients. ESC Heart Fail. 2020;7(4):1502–1509.
  • Otto CM, Nishimura RA, and Bonow RO, et al. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4): 450–500. DOI:10.1016/j.jacc.2020.11.035.
  • Stolz L, Orban M, and Braun D, et al. Anatomy and outcome of secondary mitral regurgitation subtypes undergoing transcatheter mitral valve edge-to-edge repair. JACC Cardiovasc Interv. 2021;14(1):110–111.
  • Klein AL, Burstow DJ, Tajik AJ, et al. Age-related prevalence of valvular regurgitation in normal subjects: a comprehensive color flow examination of 118 volunteers. J Am Soc Echocardiogr. 1990;3(1):54–63.
  • Alfieri O, Denti P. Alfieri stitch and its impact on mitral clip. Eur J Cardiothorac Surg. 2011;39(6):807–808.
  • Alfieri O, Maisano F, and De Bonis M, et al. The double-orifice technique in mitral valve repair: a simple solution for complex problems. J Thorac Cardiovasc Surg. 2001;122(4):674–681 .
  • Maisano F, Torracca L, and Oppizzi M, et al. The edge-to-edge technique: a simplified method to correct mitral insufficiency. Eur J Cardio-thorac Surg. 1998;13(3):240–245. discussion 245-6.
  • Stone GW, Lindenfeld J, and Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med. 2018;379(24):2307–2318.
  • Obadia JF, Messika-Zeitoun D, and Leurent G, et al. Percutaneous repair or medical treatment for secondary mitral regurgitation. N Engl J Med. 2018;379(24):2297–2306.
  • Asch FM, Grayburn PA, Siegel RJ, et al. Echocardiographic outcomes after transcatheter leaflet approximation in patients with secondary mitral regurgitation: the COAPT trial. J Am Coll Cardiol. 2019;74(24):2969–2979.
  • Feldman T, Kar S, and Rinaldi M, et al. Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort. J Am Coll Cardiol. 2009;54(8):686–694.
  • Doldi PM, Buech J, Orban M, et al. Transcatheter mitral valve repair may increase eligibility for heart transplant listing in patients with end-stage heart failure and severe secondary mitral regurgitation. Int J Cardiol. 2021;338:72–78.
  • Mack MJ, Lindenfeld J, Abraham WT, et al. 3-Year outcomes of transcatheter mitral valve repair in patients with heart failure. J Am Coll Cardiol. 2021;77(8):1029–1040.
  • St Goar FG, Fann JI, Komtebedde J, et al. Endovascular edge-to-edge mitral valve repair: short-term results in a porcine model. Circulation. 2003;108(16):1990–1993.
  • Feldman T, Wasserman HS, Herrmann HC, et al. Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial. J Am Coll Cardiol. 2005;46(11):2134–2140.
  • Mauri L, Garg P, Massaro JM, et al. The EVEREST II Trial: design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation. Am Heart J. 2010;160(1):23–29.
  • Karam N, Stolz L, and Orban M, et al. Impact of right ventricular dysfunction on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. JACC Cardiovasc Imaging. 2021;14(4):768–778.
  • Schnitzler K, Hell M, Geyer M, et al. Complications Following MitraClip Implantation. Curr Cardiol Rep. 2021;23(9):131.
  • Hahn RT, and Kodali SK. State-of-the-art intra-procedural imaging for the mitral and tricuspid PASCAL Repair System. Eur Heart J Cardiovasc Imaging. 2021;23(3): e94–e110. DOI:10.1093/ehjci/jeab040.
  • Asch FM, Little SH, Mackensen GB, et al. Incidence and standardised definitions of mitral valve leaflet adverse events after transcatheter mitral valve repair: the EXPAND study. EuroIntervention. 2021;17(11):e932–e941.
  • Praz F, Braun D, and Unterhuber M, et al. Edge-to-Edge mitral valve repair with extended clip arms: early experience from a Multicenter Observational Study. JACC Cardiovasc Interventions. 2019;12(14):1356–1365.
  • Doldi PM, Brinkmann I, Orban M, et al. Percutaneous edge-to-edge repair of severe mitral regurgitation using the MitraClip XTR versus NTR system. Clin Cardiol. 2021;44(5):708–714.
  • Kar Ats S. Core-Lab adjudicated contemporary clinical outcomes at 1 Year with MitraClip™ (NTR/XTR) system from global EXPAND Study, TCT 2020, Oxtober 16, 2020, TCT Connect 2020 (Online). 2020. https://www.tctmd.com/slide/core-lab-adjudicated-contemporary-clinical-outcomes-1-year-mitracliptm-ntrxtr-system-global
  • Stolz L, Orban M, Braun D, et al. Impact of asymmetric tethering on outcomes after edge-to-edge mitral valve repair for secondary mitral regurgitation. Clin Res Cardiol. 2021. DOI:10.1007/s00392-021-01961-5.
  • Chakravarty T, Makar M, Patel D, et al. Transcatheter edge-to-edge mitral valve repair with the MitraClip G4 system. JACC Cardiovasc Interventions. 2020;13(20):2402–2414.
  • Webb JG, Hensey M, Szerlip M, et al. 1-Year outcomes for transcatheter repair in patients with mitral regurgitation from the CLASP Study. JACC Cardiovasc Interv. 2020;13(20):2344–2357.
  • Grayburn PA, Sannino A, and Packer M. Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials. JACC Cardiovasc Imaging. 2019;12(2):353–362 .
  • Orban M, Karam N, Lubos E, et al. Impact of proportionality of secondary mitral regurgitation on outcome after transcatheter mitral valve repair. JACC Cardiovasc Imaging. 2020;14(4):715–725.
  • Messika-Zeitoun D, Iung B, Armoiry X, et al. Impact of mitral regurgitation severity and left ventricular remodeling on outcome after mitraclip implantation: results from the Mitra-FR trial. JACC Cardiovasc Imaging. 2021;14(4):742–752.
  • Hagendorff A, Knebel F, Helfen A, et al. Disproportionate mitral regurgitation: another myth? A critical appraisal of echocardiographic assessment of functional mitral regurgitation. Int J Cardiovasc Imaging. 2021;37(1):183–196.
  • Orban M, Lüsebrink E, Braun D, et al. Recent advances in patient selection and devices for transcatheter edge-to-edge mitral valve repair in heart failure. Expert Rev Med Devices. 2020;17(2):93–102.
  • Hahn RT, Asch F, Weissman NJ, et al. Impact of tricuspid regurgitation on clinical outcomes: the COAPT trial. J Am Coll Cardiol. 2020;76(11):1305–1314.
  • Brener MI, Grayburn P, Lindenfeld J, et al. Right ventricular–pulmonary arterial coupling in patients with HF secondary MR. JACC Cardiovasc Interv. 2021;14(20):2231–2242.
  • Koell B, Orban M, and Weimann J, et al. Outcomes stratified by adapted inclusion criteria after mitral edge-to-edge repair. J Am Coll Cardiol. 2021;78(24):2408–2421.
  • Mehran R, Rao SV, Bhatt DL, et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. Circulation. 2011;123(23):2736–2747.
  • Asmarats L, Rodriguez-Gabella T, Chamandi C, et al. Infective endocarditis following transcatheter edge-to-edge mitral valve repair: a systematic review. Catheter Cardiovasc Interv. 2018;92(3):583–591.
  • Nickenig G, Estevez-Loureiro R, Franzen O, et al. Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry. J Am Coll Cardiol. 2014;64(9):875–884.
  • Schueler R, Öztürk C, Wedekind JA, et al. Persistence of iatrogenic atrial septal defect after interventional mitral valve repair with the MitraClip system: a note of caution. JACC Cardiovasc Interv. 2015;8(3):450–459.
  • Blazek S, Unterhuber M, Rommel KP, et al. Biventricular physiology of iatrogenic atrial septal defects following transcatheter mitral valve edge-to-edge repair. JACC Cardiovasc Interv. 2021;14(1):54–66.
  • Lurz P, Unterhuber M, and Rommel KP, et al. Iatrogenic atrial septal defects following transcatheter mitral valve repair and implications of interventional closure. JACC Cardiovasc Interv. 2021;14(24):2685–2694.
  • Zannad F, Garcia AA, Anker SD, et al. Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document. Eur J Heart Fail. 2013;15(10):1082–1094.
  • Eliya Y, Averbuch T, Le N, et al. Temporal trends and factors associated with the inclusion of patient-reported outcomes in heart failure randomized controlled trials: a systematic review. J Am Heart Assoc. 2021;10(21):e022353.
  • Arnold SV, Chinnakondepalli KM, Spertus JA, et al. Health status after transcatheter mitral-valve repair in heart failure and secondary mitral regurgitation: COAPT trial. J Am Coll Cardiol. 2019;73(17):2123–2132.
  • Giustino G, Lindenfeld J, Abraham WT, et al. NYHA functional classification and outcomes after transcatheter mitral valve repair in heart failure: the COAPT trial. JACC Cardiovasc Interv. 2020;13(20):2317–2328.
  • Maor E, Raphael CE, Panaich SS, et al. Acute changes in left atrial pressure after mitraclip are associated with improvement in 6-minute walk distance. Circ Cardiovasc Interventions. 2017;10(4). DOI:10.1161/CIRCINTERVENTIONS.116.004856.
  • Reichenspurner H, Schillinger W, Baldus S, et al. Clinical outcomes through 12 months in patients with degenerative mitral regurgitation treated with the MitraClip® device in the ACCESS-Europe Phase I trial. Eur J Cardio-thorac Surg. 2013;44(4):e280–8.
  • Maisano F, Franzen O, Baldus S, et al. Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol. 2013;62(12):1052–1061.
  • Rassaf T, Balzer J, Rammos C, et al. Influence of percutaneous mitral valve repair using the MitraClip® system on renal function in patients with severe mitral regurgitation. Catheter Cardiovasc Interv. 2015;85(5):899–903.
  • Puls M, Lubos E, and Boekstegers P. One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J. 2016;37:8. DOI:10.1093/eurheartj/ehv627.
  • Neuss M, Schau T, Isotani A, et al. Elevated mitral valve pressure gradient after MitraClip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure. JACC Cardiovasc Interv. 2017;10(9):931–939.
  • Koell B, Ludwig S, Weimann J, et al. Long-Term outcomes of patients with elevated mitral valve pressure gradient after mitral valve edge-to-edge repair. JACC Cardiovasc Interv. 2022;15(9):922–934.
  • Yoon SH, Makar M, Kar S, et al. Prognostic value of increased mitral valve gradient after transcatheter edge-to-edge repair for primary mitral regurgitation. JACC Cardiovasc Interv. 2022;15(9):935–945.
  • Hahn RT, Hausleiter J. Transmitral gradients following transcatheter edge-to-edge repair: are mean gradients meaningful? JACC Cardiovasc Interv. 2022;15(9):946–949.
  • Luedike P, Riebisch M, Schindhelm F, et al. Impact of mitral valve repair technologies on predictability of post-delivery residual mitral regurgitation. JACC Cardiovasc Interv. 2021;14(23):2638–2640.
  • Higuchi S, Orban M, Stolz L, et al. Impact of residual mitral regurgitation on survival after transcatheter edge-to-edge repair for secondary mitral regurgitation. JACC Cardiovasc Interv. 2021;14(11):1243–1253.
  • Kar S, Mack MJ, Lindenfeld J, et al. Relationship between residual mitral regurgitation and clinical and quality-of-life outcomes after transcatheter and medical treatments in heart failure: COAPT trial. Circulation. 2021;144(6):426–437.
  • Chhatriwalla AK, Vemulapalli S, Szerlip M, et al. Operator experience and outcomes of transcatheter mitral valve repair in the United States. J Am Coll Cardiol. 2019;74(24):2955–2965.
  • Hensey M, Brown RA, Lal S, et al. Transcatheter mitral valve replacement: an update on current techniques, technologies, and future directions. JACC Cardiovasc Interventions. 2021;14(5):489–500.
  • Wild MG, Kreidel F, and Hell MM, et al. Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience. Eur J Heart Fail. 2022;24(5):899–907.
  • Wang DD, Eng M, Greenbaum A, et al. Predicting LVOT obstruction after TMVR. JACC Cardiovasc Imaging. 2016;9(11):1349–1352.
  • Yoon SH, Bleiziffer S, Latib A, et al. Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement. JACC Cardiovasc Interv. 2019;12(2):182–193.
  • Alperi A, Granada JF, Bernier M, et al. Current status and future prospects of transcatheter mitral valve replacement: JACC state-of-the-art review. J Am Coll Cardiol. 2021;77(24):3058–3078.
  • Urena M, Vahanian A, Brochet E, et al. Current indications for transcatheter mitral valve replacement using transcatheter aortic valves: valve-in-valve, valve-in-ring, and valve-in-mitral annulus calcification. Circulation. 2021;143(2):178–196.
  • Wild MG, Kreidel F, Hell MM, et al. Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience. Eur J Heart Fail. 2022;24(5):899–907.
  • Ludwig S, Ruebsamen N, Deuschl F, et al. Screening for transcatheter mitral valve replacement: a decision tree algorithm. EuroIntervention. 2020;16(3):251–258.
  • Fernández-Peregrina E, Pascual I, Freixa X, et al. Transcatheter edge-to-edge mitral valve repair in patients with mitral annulus calcification. EuroIntervention. 2022;17(16):1300–1309.
  • Nabauer M, Orban M. To replace is to reverse: novel insights into transcatheter mitral valve replacement from multimodality imaging. JACC Cardiovasc Interv. 2020;13(17):2049–2051.
  • Vahanian A, Beyersdorf F, and Praz F, et al.2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021 3(7): 561–632. DOI:10.1093/eurheartj/ehab395.
  • Bonow RO, O’Gara PT, Adams DH, et al. 2020 focused update of the 2017 ACC expert consensus decision pathway on the management of mitral regurgitation. J Am Coll Cardiol. 2020;75(17):2236–2270. 2020.
  • Benito-González T, Carrasco-Chinchilla F, Estévez-Loureiro R, et al. Clinical and echocardiographic outcomes of transcatheter mitral valve repair in atrial functional mitral regurgitation. Int J Cardiol. 2021;345:29–35.
  • Popolo Rubbio A, Testa L, Grasso C, et al. Transcatheter edge-to-edge mitral valve repair in atrial functional mitral regurgitation: insights from the multi-center MITRA-TUNE registry. Int J Cardiol. 2022;349:39–45.

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