Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles

References

• Ali, M. R. K., Y. Wu, T. Han, X. Zhang, H. Xiao, Y. Tang, R. Wu, F. M. Fernández, and M. A. El-Sayed. 2016. “Simultaneous Time-Dependent Surface-Enhanced Raman Spectroscopy, Metabolomics, and Proteomics Reveal Cancer Cell Death Mechanisms Associated with Gold Nanorod Photothermal Therapy.” Journal of the American Chemical Society 138: 15434–15442. doi: 10.1021/jacs.6b08787
   PubMed Web of Science ®Google Scholar
• Alkilany, A., and C. Murphy. 2010. “Toxicity and Cellular Uptake of Gold Nanoparticles: What We Have Learned so Far?” Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology 12 (7): 2313–2333. doi: 10.1007/s11051-010-9911-8
   PubMed Web of Science ®Google Scholar
• Cho, W.-S., M. Cho, J. Jeong, M. Choi, B. S. Han, H.-S. Shin, J. Hong, B. H. Chung, J. Jeong, and M.-H. Cho. 2010. “Size-Dependent Tissue Kinetics of PEG-Coated Gold Nanoparticles.” Toxicology and Applied Pharmacology 245: 116–123. doi: 10.1016/j.taap.2010.02.013
   PubMed Web of Science ®Google Scholar
• Connor, E. E., J. Mwamuka, A. Gole, C. J. Murphy, and M. D. Wyatt. 2005. “Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity.” Small 1: 325327. doi: 10.1002/smll.200400093
   Web of Science ®Google Scholar
• Di Pasqua, A. J., R. E. Mishler, II, Y.-L. Ship, J. C. Dabrowiak, and T. Asefa. 2009. “Preparation of Antibody-Conjugated Gold Nanoparticles.” Materials Letters 63: 1876–1879. doi: 10.1016/j.matlet.2009.05.070
   Web of Science ®Google Scholar
• Dona, A. C., B. Jiménez, H. Schäfer, E. Humpfer, M. Spraul, M. R. Lewis, J. T. Pearce, E. Holmes, J. C. Lindon, and J. K. Nicholson. 2014. “Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping.” Analalytical Chemistry 86: 9887–9894. doi: 10.1021/ac5025039
   PubMed Web of Science ®Google Scholar
• Du, S., K. Kendall, P. Toloueinia, Y. Mehrabadi, G. Gupta, and J. Newton. 2012. “Aggregation and Adhesion of Gold Nanoparticles in Phosphate Buffered Saline.” Journal of Nanoparticle Research 14: 758. doi: 10.1007/s11051-012-0758-z
   Web of Science ®Google Scholar
• Ellis, S. M., and H. S. Steyn. 2003. “Practical Significance (Effect Sizes) Versus or in Combination with Statistical Significance (p-Values).” Management Dynamics 12 (4): 51–53.
   Google Scholar
• Elthon, T. E., and C. R. Stewart. 1984. “Effects of the Proline Analog L-Thiazolidine-4-Carboxylic Acid on Proline Metabolism.” Plant Physiology 74: 213–218. doi: 10.1104/pp.74.2.213
   PubMed Web of Science ®Google Scholar
• Fraga, S., H. Faria, M. E. Soares, J. A. Duarte, L. Soares, E. Pereira, C. Costa-Pereira, J. P. Teixeira, M. De Lourdes Bastos, and H. Carmo. 2013. “Influence of the Surface Coating on the Cytotoxicity, Genotoxicity and Uptake of Gold Nanoparticles in Human HepG2 Cells.” Journal of Applied Toxicology 33: 1111–1119. doi: 10.1002/jat.2865
   PubMed Web of Science ®Google Scholar
• Gao, W., K. Xu, L. Ji, and B. Tang. 2011. “Effect of Gold Nanoparticles on Glutathione Depletion Induced Hydrogen Peroxide Generation and Apoptosis in HL7702 Cells.” Toxicology Letters 205: 86–95. doi: 10.1016/j.toxlet.2011.05.1018
   PubMed Web of Science ®Google Scholar
• Ghosh, D., D. Sarkar, A. Girigoswami, and N. Chattopadhyay. 2011. “A Fully Standardised Method of Synthesis of Gold Nanoparticles of Desired Dimension in the Range 15 nm - 60 nm.” Journal of Nanoscience and Nanotechnology 11: 1141–1146. doi: 10.1166/jnn.2011.3090
   PubMed Web of Science ®Google Scholar
• Gioria, S., J. L. Vicente, P. Barboro, R. La Spina, G. Tomasi, P. Urbán, A. Kinsner-Ovaskainen, R. François, and H. Chassaigne. 2016. “A Combined Proteomics and Metabolomics Approach to Assess the Effect of Gold Nanoparticles In Vitro.” Nanotoxicology 10: 736–748. doi: 10.3109/17435390.2015.1121412
   PubMed Web of Science ®Google Scholar
• Goodman, C. M., C. D. McCusker, T. Yilmaz, and V. M. Rotello. 2004. “Toxicity of Gold Nanoparticles Functionalised with Cationic and Anionic Side Chains.” Bioconjugate Chemistry 15: 897–900. doi: 10.1021/bc049951i
   PubMed Web of Science ®Google Scholar
• Haiss, W., N. T. Thanh, J. Aveyard, and D. G. Fernig. 2007. “Determination of Size and Concentration of Gold Nanoparticles from UV-Vis Spectra.” Analytical Chemistry 79 (11): 4215–4221. doi: 10.1021/ac0702084
   PubMed Web of Science ®Google Scholar
• Hikosakaa, K., J. Kima, M. Kajita, A. Kanayamaa, and Y. Miyamoto. 2008. “Platinum Nanoparticles Have an Activity Similar to Mitochondrial NADH: Ubiquinone Oxidoreductase.” Colloids and Surfaces B: Biointerfaces 66: 195–200. doi: 10.1016/j.colsurfb.2008.06.008
   PubMed Web of Science ®Google Scholar
• Huang, X., I. H. El-Sayed, X. Yi, and M. A. El-Sayed. 2005. “Gold Nanoparticles: Catalyst for the Oxidation of NADH to NAD+.” Journal of Photochemistry and Photobiology B: Biology 81: 76–83. doi: 10.1016/j.jphotobiol.2005.05.010
   PubMed Web of Science ®Google Scholar
• Lasagna-Reeves, C., D. Gonzalez-Romero, M. A. Barria, I. Olmedo, A. Clos, V. M. Sadagopa Ramanujam, A. Urayama, L. Vergara, M. J. Kogan, and C. Soto. 2010. “Bioaccumulation and Toxicity of Gold Nanoparticles after Repeated Administration in Mice.” Biochemical and Biophysical Research Communications 393: 649–655. doi: 10.1016/j.bbrc.2010.02.046
   PubMed Web of Science ®Google Scholar
• Lee, H., M.-Y. Lee, S. H. Bhang, B.-S. Kim, Y. S. Kim, J. H. Ju, K. S. Kim, and S. K. Hahn. 2014. “Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis.” ACS Nano 8 (5): 4790–4798. doi: 10.1021/nn500685h
   PubMed Web of Science ®Google Scholar
• Li, J. J., D. Hartono, C.-N. Ong, B.-H. Bay, and L.-Y. L. Yung. 2010. “Autophagy and Oxidative Stress Associated with Gold Nanoparticles.” Biomaterials 31 (23): 5996–6003. doi: 10.1016/j.biomaterials.2010.04.014
   PubMed Web of Science ®Google Scholar
• Liu, D. C., A. P. Raphael, D. Sundh, J. E. Grice, H. P. Soyer, M. S. Roberts, and T. W. Prow. 2012. “The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences.” Journal of Nanomaterials 2012: 1–8. doi: 10.1155/2012/721706
   Google Scholar
• Mukherjee, P., R. Bhattacharya, P. Wang, L. Wang, S. Basu, J. A. Nagy, A. Atala, D. Mukhopadhyay, and S. Soker. 2005. “Antiangiogenic Properties of Gold Nanoparticles.” Clinical Cancer Research 11 (9): 3530–3534. doi: 10.1158/1078-0432.CCR-04-2482
   PubMed Web of Science ®Google Scholar
• Pillai, G. 2014. “Nanomedicines for Cancer Therapy: An Update of FDA Approved and Those under Various Stages Development.” SOJ Pharmacy and Pharmaceutical Sciences 1: 1–13. doi: 10.15226/2374-6866/1/2/00109
   Google Scholar
• Rambanapasi, C., J. R. Zeevaart, H. Buntting, C. Bester, D. Kotze, R. Hayeshi, and A. Grobler. 2016. “Bioaccumulation and Subchronic Toxicity of 14 Nm Gold Nanoparticles in Rats.” Molecules 21: 763. doi: 10.3390/molecules21060763
   PubMed Web of Science ®Google Scholar
• Rani, M., L. Moudgil, B. Singh, A. Kaushal, A. Mittal, G. S. S. Saini, S. K. Tripathi, G. Singh, and A. Kaura. 2016. “Understanding the Mechanism of Replacement of Citrate from the Surface of Gold Nanoparticles by Amino Acids: A Theoretical and Experimental Investigation and Their Biological Application.” RSC Advances 6 (21): 17373–17383. doi: 10.1039/C5RA26502A
   Web of Science ®Google Scholar
• Reinecke, Reinecke, C. J., G. Koekemoer, F. H. van der Westhuizen, R. Louw, J. Z. Lindeque, L. J. Mienie, and I. Smuts. 2012. “Metabolomics of Urinary Organic Acids in Respiratory Chain Deficiencies in Children.” Metabolomics 8 (2): 264–283. doi: 10.1007/s11306-011-0309-0
   Web of Science ®Google Scholar
• Sadik, O. A., N. Du, V. Kariuki, V. Okello, and V. Bushlyar. 2014. “Current and Emerging Technologies for the Characterisation of Nanomaterials.” ACS Sustainable Chemistry & Engineering 2: 1707–1716. doi: 10.1021/sc500175v
   Web of Science ®Google Scholar
• Schymanski, E. L., J. Jeon, R. Gulde, K. Fenner, M. Ruff, H. P. Singer, and J. Hollender. 2014. “Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence.” Environmental Science & Technology 48: 2097–2098. doi: 10.1021/es5002105
   PubMed Web of Science ®Google Scholar
• Tsai, C.-S., T.-B. Yu, and C.-T. Chen. 2005. “Gold Nanoparticle-Based Competitive Colorimetric Assay for Detection of Protein-Protein Interactions.” Chemical Communications 34: 4273–4275. doi: 10.1039/B507237A
   Web of Science ®Google Scholar
• Taute, C. J. F., and J. Z. Lindeque. 2016. “Advancing Metabolomics Research and Biomarker Application with Nanotechnology.” Current Metabolomics 4: 86–96. doi: 10.2174/2213235X04666160130002922
   Web of Science ®Google Scholar
• Warrack, B. M., S. Hnatyshyn, K. H. Ott, M. D. Reily, M. Sanders, H. Zhang, and D. M. Drexler. 2009. “Normalization Strategies for Metabonomic Analysis of Urine Samples.” Journal of Chromatography B 877: 547–552. doi: 10.1016/j.jchromb.2009.01.007
   PubMed Web of Science ®Google Scholar
• Xu, B., M. Chen, X. Ji, Z. Mao, X. Zhang, X. Wang, and Y. Xia. 2014. “Metabolic Profiles Delineate Potential Role of Glycine in Gold Nanorod-Induced Disruption of Mitochondria and Blood-Testis Barrier Factors in TM-4 Cells.” Nanoscale 6: 8265–8273. doi: 10.1039/C4NR01035C
   PubMed Web of Science ®Google Scholar
• Zhang, L., L. Wang, Y. Hu, Z. Liu, Y. Tian, X. Wu, Y. Zhao, H. Tang, C. Chen, and Y. Wang. 2013. “Selective Metabolic Effects of Gold Nanorods on Normal and Cancer Cells and Their Application in Anticancer Drug Screening.” Biomaterials 34: 7117–7126. doi: 10.1016/j.biomaterials.2013.05.043
   PubMed Web of Science ®Google Scholar
• Zhang, X., M. R. Servos, and J. Liu. 2012. “Surface Science of DNA Adsorption onto Citrate-Capped Gold Nanoparticles.” Langmuir: The ACS Journal of Surfaces and Colloids 28 (8): 3896–3902. doi: 10.1021/la205036p
   PubMed Web of Science ®Google Scholar