Silicon dioxide and titanium dioxide particles found in human tissues

References

• Austin, J. H., R. W. Rinehart, and E. Ball. 1972. “A Colorimetric Method for the Microdetermination of Silicon in the Presence of Excess Phosphorus.” Microchemical Journal 17 (6): 670–676. doi:10.1016/0026-265X(72)90135-X.
   Web of Science ®Google Scholar
• Bergna, H. E. 2006. “Silicic Acids and Colloidal Silica.” In Colloidal Silica: Fundamentals and Applications, edited by HE Bergna and WO Roberts, 37–41. London: Taylor & Francis Group.
   Google Scholar
• Böckmann, J., H. Lahl, T. Eckert, and B. Unterhalt. 2000. “Blood Levels of Titanium before and after Oral Administration of Titanium Dioxide.” Pharmazie 55 (2): 140–143.
   PubMed Web of Science ®Google Scholar
• Bouwmeester, H., I. Lynch, H. J. Marvin, K. A. Dawson, M. Berges, D. Braguer, H. J. Byrne, et al. 2011. “Minimal Analytical Characterization of Engineered Nanomaterials Needed for Hazard Assessment in Biological Matrices.” Nanotoxicology 5 (1): 1–11. doi:10.3109/17435391003775266.
   PubMed Web of Science ®Google Scholar
• Carlisle, E. M., and W. Mertz. 1986. 7-Silicon. Trace Elements in Human and Animal Nutrition. 5th ed, 373–390. San Diego: Academic Press.
   Google Scholar
• Chen, W. H., Y. W. Liu, H. J. Wang, E. Hnizdo, Y. Sun, L. P. Su, X. Zhang, et al. 2012. “Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study.” PLoS Medicine 9 (4): e1001206. doi:10.1371/journal.pmed.1001206.
   PubMed Web of Science ®Google Scholar
• Crosera, E., A. Prodi, M. Mauro, M. Pelin, C. Florio, F. Bellomo, G. Adami, et al. 2015. “Titanium Dioxide Nanoparticle Penetration into the Skin and Effects on HaCaT Cells.” International Journal of Environmental Research and Public Health 12 (8): 9282–9297. doi:10.3390/ijerph120809282.
   PubMed Web of Science ®Google Scholar
• Dekkers, S., P. Krystek, R. Peters, D. Lankveld, B. Bokkers, P. van Hoeven-Arentzen, H. Bouwmeester, and A. G. Oomen. 2011. “Presence and Risks of Nanosilica in Food Products.” Nanotoxicology 5 (3): 393–405. doi:10.3109/17435390.2010.519836.
   PubMed Web of Science ®Google Scholar
• EU Official Journal of the European Union. 2008a. Commission Directive 2008/84/EC of 27 August 2008 Laying Down Specific Purity Criteria on Food Additive Other Than Colours and Sweeteners. Official Journal of the European Union L253.
   Google Scholar
• EU Official Journal of the European Union. 2008b. Regulation (Ec) No. 1333/2008 of the European Parliament and of the Council of 16 December 2008 on Food Additives. Official Journal of the European Union L354: 16–33.
   Google Scholar
• European Commission. 1994. “European Parliament and Council Directive 94/36/EC of 30 June 1994 on Colours in Foodstuffs.” Official Journal of the European Communities L237: 13–29.
   Google Scholar
• Evans, G. R., D. T. Netscher, M. A. Schusterman, S. S. Kroll, G. L. Robb, G. P. Reece, and M. J. Miller. 1996. “Silicon Tissue Assays: A Comparison of Nonaugmented Cadaveric and Augmented Patient Levels.” Plastic and Reconstructive Surgery 97 (6): 1207–1214. doi:10.1097/00006534-199605000-00016.
   PubMed Web of Science ®Google Scholar
• Frisken, K. W., G. W. Dandie, S. Lugowski, and G. Jordan. 2002. “A Study of Titanium Release into Body Organs following the Insertion of Single Threaded Screw Implants into the Mandibles of Sheep.” Australian Dental Journal 47 (3): 214–217. doi:10.1111/j.1834-7819.2002.tb00331.x.
   PubMed Web of Science ®Google Scholar
• Fruijtier-Polloth, C. 2012. “The Toxicological Mode of Action and the Safety of Synthetic Amorphous Silica-a Nanostructured Material.” Toxicology 294: 61–79.
   PubMed Web of Science ®Google Scholar
• Hardy, A., D. Benford, T. Halldorsson, M. J. Jeger, H. K. Knutsen, S. More, H. Naegeli, et al. 2018. “Guidance on Risk Assessment of the Application of Nanoscience and Nanotechnologies in the Food and Feed Chain: Part 1, Human and Animal Health.” EFSA Journal 16: 5327. doi:10.2903/j.efsa.2018.5327.
   PubMed Web of Science ®Google Scholar
• Heringa, M. B., R. J. B. Peters, R. L. A. W. Bleys, M. K. van der Lee, P. C. Tromp, P. C. E. van Kesteren, J. C. H. van Eijkeren, A. K. Undas, A. G. Oomen, and H. Bouwmeester. 2018. “Detection of Titanium Particles in Human Liver and Spleen and Possible Health Implications.” Particle and Fibre Toxicology 15 (1): 15. doi:10.1186/s12989-018-0251-7.
   PubMedGoogle Scholar
• Jones, K., J. Morton, I. Smith, K. Jurkschat, A. H. Harding, and G. Evans. 2015. “Human in Vivo and in Vitro Studies on Gastrointestinal Absorption of Titanium Dioxide Nanoparticles.” Toxicology Letters 233 (2): 95–101. doi:10.1016/j.toxlet.2014.12.005.
   PubMed Web of Science ®Google Scholar
• Jovanovic, B. 2015. “Critical Review of Public Health Regulations of Titanium Dioxide, a Human Food Additive.” Integrated Environmental Assessment 11: 10–20.
   PubMed Web of Science ®Google Scholar
• Laborda, F., E. Bolea, and J. Jimenez-Lamana. 2014. “Single Particle Inductively Coupled Plasma Mass Spectrometry: A Powerful Tool for Nanoanalysis.” Analytical Chemistry 86 (5): 2270–2278. doi:10.1021/ac402980q.
   PubMed Web of Science ®Google Scholar
• Lim, J. H., P. Sisco, T. K. Mudalige, G. Sanchez-Pomales, P. C. Howard, and S. W. Linder. 2015. “Detection and Characterization of SiO2 and TiO2 Nanostructures in Dietary Supplements.” Journal of Agricultural and Food Chemistry 63 (12): 3144–3152. doi:10.1021/acs.jafc.5b00392.
   PubMed Web of Science ®Google Scholar
• Locci, E., I. Pilia, R. Piras, S. Pili, G. Marcias, P. Cocco, F. De Giorgio, et al. 2019. “Particle Background Levels in Human Tissues – PABALIHT Project. Part I: A Nanometallic Study of Metal-Based Micro- and Nanoparticles in Liver and Kidney in an Italian Population Group.” Journal of Nanoparticle Research 21 (3): 45. doi:10.1007/s11051-019-4480-y.
   Web of Science ®Google Scholar
• Maynard, A. D., R. J. Aitken, T. Butz, V. Colvin, K. Donaldson, G. Oberdorster, M. A. Philbert, et al. 2006. “Safe Handling of Nanotechnology.” Nature 444 (7117): 267–269. doi:10.1038/444267a.
   PubMed Web of Science ®Google Scholar
• Mojsiewicz-Pienkowska, K., and J. Lukasiak. 2003. “Analytical Fractionation of Silicon Compounds in Foodstuffs.” Food Control 14: 153–162.
   Web of Science ®Google Scholar
• Morfeld, P., D. Taeger, H. Mitura, A. Bosch, A. Nordone, R. Vormberg, R. McCunney, and R. Merget. 2014. “Cross-Sectional Study on Respiratory Morbidity in Workers after Exposure to Synthetic Amorphous Silica at Five German Production Plants Exposure Assessment and Exposure Estimates.” Journal of Occupational and Environmental Medicine 56 (1): 72–78. doi:10.1097/JOM.0000000000000055.
   PubMed Web of Science ®Google Scholar
• Mueller, N. C., and B. Nowack. 2008. “Exposure Modeling of Engineered Nanoparticles in the Environment.” Environmental Science and Technology 42: 4447–4453. doi:10.1021/es7029637.
   PubMed Web of Science ®Google Scholar
• Napierska, D., L. Thomassen, D. Lison, J. Martens, and P. Hoet. 2010. “The Nanosilica Hazard: Another Variable Entity.” Particle and Fibre Toxicology 7 (1): 39. doi:10.1186/1743-8977-7-39.
   PubMed Web of Science ®Google Scholar
• National Research Council. 2005. Mineral Tolerance of Animals: Second Revised Edition. Washington.
   Google Scholar
• Pelclova, D., T. Navratil, T. Kacerova, B. Zamostna, Z. Fenclova, S. Vlckova, and P. Kacer. 2019. “NanoTiO2 Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO2 is Absorbed in Humans.” Nanomaterials 9 (6): 888. doi:10.3390/nano9060888.
   Web of Science ®Google Scholar
• Pele, L. C., V. Thoree, S. F. Bruggraber, D. Koller, R. P. Thompson, M. C. Lomer, and J. J. Powell. 2015. “Pharmaceutical/Food Grade Titanium Dioxide Particles Are Absorbed into the Bloodstream of Human Volunteers.” Particle and Fibre Toxicology 12 (1): 26. doi:10.1186/s12989-015-0101-9.
   PubMedGoogle Scholar
• Peters, R. J. B., A. K. Undas, J. Memelink, G. van Bemmel, S. Munniks, H. Bouwmeester, P. Nobels, W. Schuurmans, and M. van der Lee. 2018. “Development and Validation of a Method for the Detection of Titanium Dioxide Particles in Human Tissue with Single Particle ICP-MS.” Current Trends in Analytical and Bioanalytical Chemistry 2: 74–84. doi:10.36959/525/442.
   Google Scholar
• Peters, R. J. B., G. van Bemmel, N. B. L. Milani, G. C. T. den Hertog, A. K. Undas, M. van der Lee, and H. Bouwmeester. 2018. “Detection of Nanoparticles in Dutch Surface Waters.” Science of the Total Environment 621: 210–218. doi:10.1016/j.scitotenv.2017.11.238.
   PubMed Web of Science ®Google Scholar
• Peters, R. J. B., Z. H. Rivera, G. van Bemmel, H. J. P. Marvin, S. Weigel, and H. Bouwmeester. 2014. “Development and Validation of Single Particle ICP-MS for Sizing and Quantitative Determination of Nano-Silver in Chicken Meat.” Analytical and Bioanalytical Chemistry 406 (16): 3875–3885. doi:10.1007/s00216-013-7571-0.
   PubMed Web of Science ®Google Scholar
• Peters, R., Z. Herrera-Rivera, A. Undas, M. van der Lee, H. Marvin, H. Bouwmeester, and S. Weigel. 2015. “Single Particle ICP-MS Combined with a Data Evaluation Tool as a Routine Technique for the Analysis of Nanoparticles in Complex Matrices.” Journal of Analytical Atomic Spectrometry 30 (6): 1274–1285. doi:10.1039/C4JA00357H.
   Web of Science ®Google Scholar
• Peters, R. J. B, G. van Bemmel, Z. Herrera-Rivera, H. P. F. G. Helsper, H. J. P. Marvin, S. Weigel, P. C. Tromp, A. G. Oomen, A. G. Rietveld, and H. Bouwmeester. 2014. “Characterization of Titanium Dioxide Nanoparticles in Food Products: Analytical Methods to Define Nanoparticles.” Journal of Agricultural and Food Chemistry 62 (27): 6285–6293. doi:10.1021/jf5011885.
   PubMed Web of Science ®Google Scholar
• Peters, R., E. Kramer, A. G. Oomen, Z. E. Herrera Rivera, G. Oegema, P. C. Tromp, R. Fokkink, et al. 2012. “Presence of Nano-Sized Silica during in Vitro Digestion of Foods Containing Silica as a Food Additive.” ACS Nano 6 (3): 2441–2451. doi:10.1021/nn204728k.
   PubMed Web of Science ®Google Scholar
• Rompelberg, C., M. B. Heringa, G. van Donkersgoed, J. Drijvers, A. Roos, S. Westenbrink, R. Peters, G. van Bemmel, W. Brand, and A. G. Oomen. 2016. “Oral Intake of Added Titanium Dioxide and Its Nanofraction from Food Products, Food Supplements and Toothpaste by the Dutch Population.” Nanotoxicology 10 (10): 1404–1414. doi:10.1080/17435390.2016.1222457.
   PubMed Web of Science ®Google Scholar
• Ryu, H. J., N. W. Seong, B. J. So, H. S. Seo, J. H. Kim, J. S. Hong, M. K. Park, et al. 2014. “Evaluation of Silica Nanoparticle Toxicity after Topical Exposure for 90 Days.” International Journal of Nanomedicine 9: 127–136.
   PubMed Web of Science ®Google Scholar
• Sarmiento-Gonzalez, A., J. Encinar, J. M. Marchante-Gayon, and A. Sanz-Medel. 2009. “Titanium Levels in the Organs and Blood of Rats with a Titanium Implant, in the Absence of Wear, as Determined by Double-Focusing ICP-MS.” Analytical and Bioanalytical Chemistry 393: 335–343. doi:10.1007/s00216-008-2449-2.
   PubMed Web of Science ®Google Scholar
• Sepeur, S., N. Laryea, S. Goedicke, and F. Grobeta. Hannover: Vincentz Network, 2008.
   Google Scholar
• Shi, H., R. Magaye, V. Castranova, and J. Zhao. 2013. “Titanium Dioxide Nanoparticles: A Review of Current Toxicological Data.” Particle and Fibre Toxicology 10 (1): 15. doi:10.1186/1743-8977-10-15.
   PubMed Web of Science ®Google Scholar
• Sohal, I. S., Y. K. Cho, K. S. O’Fallon, P. Gaines, P. Demokritou, and D. Bello. 2018. “Dissolution Behavior and Biodurability of Ingested Engineered Nanomaterials in the Gastrointestinal Environment.” ACS Nano 12 (8): 8115–8128. doi:10.1021/acsnano.8b02978.
   PubMed Web of Science ®Google Scholar
• Sugibayashi, K., H. Todo, and E. Kimura. 2008. “Safety Evaluation of Titanium Dioxide Nanoparticles by Their Absorption and Elimination Profiles.” The Journal of Toxicological Sciences 33 (3): 293–298. doi:10.2131/jts.33.293.
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration. 2002. “Code of Federal Regulations Title 21-Food and Drugs Part 73, Listing of color additives exempt from certification.” 21CFR73.2575.
   Google Scholar
• van der Zande, M., R. Vandebriel, M. Groot, E. Kramer, Z. Herrera Rivera, K. Rasmussen, J. S. Ossenkoppele, et al. 2014. “Sub-Chronic Toxicity Study in Rats Orally Exposed to Nanostructured Silica.” Particle and Fibre Toxicology 11 (1): 8. doi:10.1186/1743-8977-11-8.
   PubMedGoogle Scholar
• van Kesteren, P. C. E., F. Cubadda, H. Bouwmeester, J. C. H. van Eijkeren, S. Dekkers, W. H. de Jong, and A. G. Oomen. 2015. “Novel Insights into the Risk Assessment of the Nanomaterial Synthetic Amorphous Silica, Additive E551, in Food.” Nanotoxicology 9 (4): 442–452. doi:10.3109/17435390.2014.940408.
   PubMed Web of Science ®Google Scholar
• Van Rossem, T. M., H. P. Fransen, J. Verkaik-Kloosterman, E. J. M. Buurma-Rethans, and M. C. Ocke. 2011. Dutch National Food Consumption Survey 2007–2010. Diet of children and adults 7 to 69 years. RIVM-Report 350050006, Bilthoven; 2011.
   Google Scholar
• Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. Von Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Products.” Environmental Science and Technology 46 (4): 2242–2250. doi:10.1021/es204168d.
   PubMed Web of Science ®Google Scholar
• WHO. 1974. Toxicological Evaluation of Some Food Additives Including Anticaking Agents, Antimicrobials, Antioxidants, Emulsifiers and Thickening Agents. Geneva: WHO.
   Google Scholar
• WHO. 1982. Environmental Health Criteria 24: Titanium. Geneva: WHO.
   Google Scholar
• Younes, M., G. Aquilina, L. Castle, K. H. Engel, P. Fowler, F. J. Frutos Fernandez, R. Geurtler, et al. 2019. “Scientific Opinion on the Proposed Amendment of the EU Specifications for Titanium Dioxide (E 171) with Respect to the Inclusion of Additional Parameters Related to Its Particle Size Distribution.” EFSA Journal 17: 5760. doi:10.2903/j.efsa.2019.5760.
   Web of Science ®Google Scholar
• Yukawa, M., K. Amano, M. Suzuki-Yasumoto, and M. Terai. 1980. “Distribution of Trace Elements in the Human Body Determined by Neutron Activation Analysis.” Archives of Environmental Health: An International Journal 35 (1): 36–44. doi:10.1080/00039896.1980.10667459.
   PubMedGoogle Scholar