An overview of experiments with lead-containing nanoparticles performed by the Ekaterinburg nanotoxicological research team

References

• Ab Latif, W., A. Ara, and J. A. Usmani. 2015. “Lead Toxicity: A Review.” Interdisciplinary Toxicology 8 (2): 55–64.
   PubMedGoogle Scholar
• Abadin, H., A. Ashizawa, Y.-W. Stevens, F. Llados, G. Diamond, G. Sage, M. Citra, A. Quinones, S. J. Bosch, and S. G. Swarts. 2007. Toxicological Profile for Lead. Atlanta, GA: Agency for Toxic Substances and Disease Registry (US).
   Google Scholar
• Adeyemi, O. O., O. K. Yemitan, and A. E. Taiwo. 2006. “Neurosedative and Muscle-Relaxant Activities of Ethyl Acetate Extract of Baphianitida Nitida AFZEL.” Journal of Ethnopharmacology 106 (3): 312–316. doi:10.1016/j.jep.2005.11.035.
   PubMed Web of Science ®Google Scholar
• Al Naggar, Y. 2016. “Effects of Metal and Metal Oxide Nanoparticles on Honey Bees (Apis millefera L.).” J Aquat Pollut Toxicol 1: 1.
   Google Scholar
• Al Naggar, Y., K. Dsabour, S. Masry, A. Sadek, E. Naiem, and J. P. Giesy. 2018. “Sublethal Effects of Chronic Exposure to CdO or PbO Nanoparticles or Their Binary Mixture on the Honey Bee (Apis Millefera L.).” Environmental Science and Pollution Research International. doi:10.1007/s11356-018-3314-2..
   PubMed Web of Science ®Google Scholar
• Aleksiichuk, V., S. Omelchuk, L. Sokurenko, R. Kaminsky, O. Kovalchuk, and Y. Chaikovsky. 2018. “The Influence of Lead Nanoparticles on the Morpho-Functional Changes of Rat Liver during the Postexposure Period.” Microscopy Research and Technique 81 (7): 781–788. doi:10.1002/jemt.23036.
   PubMed Web of Science ®Google Scholar
• Amiri, A., M. Mohammadi, and M. Shabani. 2016. “Synthesis and Toxicity Evaluation of Lead Oxide (PbO) Nanoparticles in Rats.” Electronic Journal of Biology 12 (2): 110–114.
   Google Scholar
• Assi, M. A., M. N. M. Hezmee, A. W. Haron, M. Y. Sabri, and M. A. Rajion. 2016. “The Detrimental Effects of Lead on Human and Animal Health.” Veterinary World 9 (6): 660–671.
   PubMed Web of Science ®Google Scholar
• Bushueva, T., I. Minigalieva, V. Panov, A. Kuznetsova, A. Naumova, V. Shur, E. Shishkina, et al. 2019. “More Data on in Vitro Assessment of Comparative and Combined Toxicity of Metal Oxide Nanoparticles.” Food and Chemical Toxicology 133 (2019): 110753. doi:10.1016/j.fct.2019.110753.
   PubMedGoogle Scholar
• Dumková, J., T. Smutná, L. Vrlíková, P. Le Coustumer, Z. Večeřa, B. Dočekal, P. Mikuška, et al. 2017. “Sub-Chronic Inhalation of Lead Oxide Nanoparticles Revealed Their Broad Distribution and Tissue-Specific Subcellular Localization in Target Organs.” Particle and Fibre Toxicology 14 (1): 55. doi:10.1186/s12989-017-0236-y.
   PubMedGoogle Scholar
• Elder, A., R. Gelein, V. Silva, T. Feikert, L. Opanashuk, J. Carter, R. Potter, et al. 2006. “Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System.” Environmental Health Perspectives 114 (8): 1172–1178. doi:10.1289/ehp.9030.
   PubMed Web of Science ®Google Scholar
• Fernandez, S. P., C. Wasowski, L. M. Loscalzo, R. E. Granger, G. A. Johnston, A. C. Paladini, and M. Marder. 2006. “Central Nervous System Depressant Action of Flavonoid Glycosides.” European Journal of Pharmacology 539: 168–176.
   PubMed Web of Science ®Google Scholar
• Fiorim, J., R. F. Ribeiro Júnior, E. A. Silveira, A. S. Padilha, M. V. A. Vescovi, H. C. de Jesus, I. Stefanon, et al. 2011. “Low-Level Lead Exposure Increases Systolic Arterial Pressure and Endothelium-Derived Vasodilator Factors in Rat Aortas.” PLoS One. 6 (2): e17117. doi:10.1371/journal.pone.0017117.
   PubMed Web of Science ®Google Scholar
• Flora, G., D. Gupta, and A. Tiwari. 2012. “Toxicity of Lead: A Review with Recent Updates.” Interdisciplinary Toxicology 5 (2): 47–58. doi:10.2478/v10102-012-0009-2.
   PubMedGoogle Scholar
• García-Lestón, J., J. Méndez, E. Pásaro, and B. Laffon. 2010. “Genotoxic Effects of Lead: An Updated Review.” Environment International 36 (6): 623–636. doi:10.1016/j.envint.2010.04.011.
   PubMed Web of Science ®Google Scholar
• Gerstner Garcés, J. B., and R. I. Manotas Artuz. 2012. “Lead Poisoning Due to Bullets Lodged in the Human Body.” Colombia Medica 43 (3): 230–234.
   PubMedGoogle Scholar
• Gidlow, D. A. 2015. “Lead Toxicity.” Occupational Medicine 65 (5): 348–356. doi:10.1093/occmed/kqv018.
   PubMed Web of Science ®Google Scholar
• Glenn, B. S., K. Bandeen-Roche, B.-K. Lee, V. M. Weaver, A. C. Todd, and B. S. Schwartz. 2006. “Changes in Systolic Blood Pressure Associated with Lead in Blood and Bone.” Epidemiology 17 (5): 538–544. doi:10.1097/01.ede.0000231284.19078.4b.
   PubMed Web of Science ®Google Scholar
• Glenn, B. S., W. F. Stewart, J. M. Links, A. C. Todd, and B. S. Schwartz. 2003. “The Longitudinal Association of Lead with Blood Pressure.” Epidemiology 14 (1): 30–36. doi:10.1097/00001648-200301000-00011.
   PubMed Web of Science ®Google Scholar
• Glenn, B. S., W. F. Stewart, B. S. Schwartz, and J. Bressler. 2001. “Relation of Alleles of the Sodium-Potassium Adenosine Triphosphatase Alpha 2 Gene with Blood Pressure and Lead Exposure.” American Journal of Epidemiology 153 (6): 537–545. doi:10.1093/aje/153.6.537.
   PubMed Web of Science ®Google Scholar
• IPCS. 1991. Principles and Methods for the Assessment of Nephrotoxicity Associated With Exposure to Chemicals. Geneva, Switzerland: World Health Organization, International Programme on Chemical Safety.
   Google Scholar
• IPCS. 1995. Inorganic Lead. Geneva, Switzerland: World Health Organization, International Programme on Chemical Safety.
   Google Scholar
• Kao, Y.-Y., T.-J. Cheng, D.-M. Yang, C.-T. Wang, Y.-M. Chiung, and P.-S. Liu. 2012. “Demonstration of an Olfactory Bulb–Brain Translocation Pathway for ZnO Nanoparticles in Rodent Ells in Vitro and in Vivo.” Journal of Molecular Neuroscience 48 (2): 464–471. doi:10.1007/s12031-012-9756-y.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., T. D. Degtyareva, I. I. Minigalieva, L. I. Privalova, S. V. Kuzmin, O. S. Yeremenko, E. P. Kireyeva, et al. 2011. “Sub-Chronic Systemic Toxicity and Bio-Accumulation of Fe3O4 Nano- and Microparticles following Repeated Intraperitoneal Administration to Rats.” International Journal of Toxicology 30 (1): 59–67. doi:10.1177/1091581810385149.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., I. A. Minigalieva, V. G. Panov, L. I. Privalova, A. N. Varaksin, V. B. Gurvich, M. P. Sutunkova, et al. 2015. “Some Patterns of Metallic Nanoparticles’ Combined Subchronic Toxicity as Exemplified by a Combination of Nickel and Manganese Oxide Nanoparticles.” Food and Chemical Toxicology 86: 351–364. doi:10.1016/j.fct.2015.11.012.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., V. G. Panov, I. A. Minigalieva, A. N. Varaksin, L. I. Privalova, T. V. Slyshkina, S. V. Grebenkina, et al. 2015. “Further Development of the Theory and Mathematical Description of Combined Toxicity: An Approach to Classifying Types of Action of Three-Factorial Combinations (a Case Study of Manganese-Chromium-Nickel Subchronic Intoxication).” Toxicology 334: 33–44. doi:10.1016/j.tox.2015.05.005.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., L. I. Privalova, V. Gurvich, O. Makeyev, V. Shur, Y. Beikin, M. Sutunkova, et al. 2013. “Comparative in Vivo Assessment of Some Adverse Bio-Effects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors.” International Journal of Molecular Sciences 14 (2): 2449–2483. doi:10.3390/ijms14022449.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., L. I. Privalova, S. V. Kuzmin, T. D. Degtyareva, M. P. Sutunkova, O. S. Yeremenko, I. A. Minigalieva, et al. 2010. “Some Peculiarities of Pulmonary Clearance Mechanisms in Rats after Intratracheal Instillation of Magnetite (Fe3O4) Suspensions with Different Particle Sizes in the Nanometer and Micrometer Ranges: Are we Defenseless against Nanoparticles?” International Journal of Occupational and Environmental Health 16 (4): 508–524. doi:10.1179/oeh.2010.16.4.508.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B. A., L. I. Privalova, S. V. Kuzmin, V. B. Gurvich, M. P. Sutunkova, E. P. Kireyeva, I. A. Minigalieva, et al. 2012. “An Approach to Tentative Reference Levels Setting for Nanoparticles in the Workroom Air Based on Comparing Their Toxicity with That of Their Micrometric Counterparts: A Case Study of Iron Oxide Fe3O4.” ISRN Nanotechnology 2012: 1–12. doi:10.5402/2012/143613.
   Google Scholar
• Katsnelson, B. A., V. G. Panov, A. N. Varaksin, I. A. Minigalieva, L. I. Privalova, and M. P. Sutunkova. 2016. “Changes in the Dose-Response Relationship of One Toxicant under Simultaneous Exposure to Another Toxicant.” Dose-response 14 (4): 1–9. doi:10.1177/1559325816672935.
   Web of Science ®Google Scholar
• Katsnelson, B. A, L. I. Privalova, M. P. Sutunkova, I. A. Minigalieva, V. B. Gurvich, V. Y. Shur, E. V. Shishkina, et al. 2017., “Experimental Research into Metallic and Metal Oxide Nanoparticle Toxicity in Vivo.” In Bioactivity of Engineered Nanoparticles, edited by B. Yan, H. Zhou, and J. Gardea-Torresdey, 259–319. Singapore, Singapore: Springer.
   Google Scholar
• Khalil, A. T., M. Ovais, I. Ullah, M. Ali, S. A. Jan, Z. K. Shinwari, M. Maaza, et al. 2020. “Bioinspired Synthesis of Pure Massicot Phase Lead Oxide Nanoparticles and Assessment of Their Biocompatibility, Cytotoxicity and in-Vitro Biological Properties.” Arabian Journal of Chemistry 13 (1): 916–931. doi:10.1016/j.arabjc.2017.08.009.
   Web of Science ®Google Scholar
• Klinova, S. V., I. A. Minigalieva, L. I. Privalova, I. E. Valamina, O. H. Makeyev, E. A. Shuman, A. A. Korotkov, et al. 2020. “Further Verification of Some Postulates of the Combined Toxicity Theory: New Animal Experimental Data on Separate and Joint Adverse Effects of Lead and Cadmium.” Food and Chemical Toxicology 136: 110971. doi:10.1016/j.fct.2019.110971.
   PubMed Web of Science ®Google Scholar
• Lasagna-Reeves, C., D. Gonzalez-Romero, M. A. Barria, I. Olmedo, A. Clos, V. M. Sadagopa Ramanujam, A. Urayama, et al. 2010. “Bioaccumulation and Toxicity of Gold Nanoparticles after Repeated Administration in Mice.” Biochemical and Biophysical Research Communications 393 (4): 649–655. doi:10.1016/j.bbrc.2010.02.046.
   PubMed Web of Science ®Google Scholar
• Minigalieva, I. A., T. Bushueva, E. Fröhlich, C. Meindl, K. Öhlinger, V. Panov, A. Varaksin, et al. 2017. “Are in Vivo and in Vitro Assessments of Comparative and Combined Toxicity of the Same Metallic Nanoparticles Compatible, or Contradictory, or Both? A Juxtaposition of Data Obtained in Some Experiments with NiO and Mn3O4 Nanoparticles.” Food and Chemical Toxicology 109 (1): 393–404. doi:10.1016/j.fct.2017.09.032.
   PubMedGoogle Scholar
• Minigalieva, I. A., B. A. Katsnelson, V. G. Panov, L. I. Privalova, A. N. Varaksin, V. B. Gurvich, M. P. Sutunkova, et al. 2017a. “In Vivo Toxicity of Copper Oxide, Lead Oxide and Zinc Oxide Nanoparticles Acting in Different Combinations and Its Attenuation with a Complex of Innocuous Bio-Protectors.” Toxicology 380 (2017): 72–93. doi:10.1016/j.tox.2017.02.007.
   PubMedGoogle Scholar
• Minigalieva, I. A., B. A. Katsnelson, V. G. Panov, L. I. Privalova, A. N. Varaksin, V. B. Gurvich, M. P. Sutunkova, et al. 2017b. “Experimental Study and Mathematical Modeling of Toxic Metals Combined Action as a Scientific Foundation for Occupational and Environmental Health Risk Assessment (a Synthesis of Results Obtained by the Ekaterinburg Research Team, Russia).” Toxicology Reports 4: 194–201. doi:10.1016/j.toxrep.2017.04.002.
   PubMed Web of Science ®Google Scholar
• Minigalieva, I. A., B. A. Katsnelson, L. I. Privalova, V. B. Gurvich, V. G. Panov, A. N. Varaksin, O. H. Makeyev, et al. 2014. “Toxicodynamic and Toxicokinetic Descriptors of Combined Chromium (VI) and Nickel Toxicity.” International Journal of Toxicology 33 (6): 498–505.
   PubMed Web of Science ®Google Scholar
• Minigalieva, I. A., B. A. Katsnelson, L. I. Privalova, M. Sutunkova, V. Gurvich, V. Shur, E. Shishkina, et al. 2015. “Attenuation of Combined Nickel (II) Oxide and Manganese (II, III) Oxide Nanoparticles’ Adverse Effects with a Complex of Bioprotectors.” International Journal of Molecular Sciences 16 (9): 22555–22583. doi:10.3390/ijms160922555.
   PubMed Web of Science ®Google Scholar
• Minigalieva, I. A., B. A. Katsnelson, L. I. Privalova, M. Sutunkova, V. Gurvich, V. Shur, E. Shishkina, et al. 2018. “Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors.” International Journal of Molecular Sciences 19 (3): 837. doi:10.3390/ijms19030837.
   Web of Science ®Google Scholar
• Miri, A., M. Sarani, A. Hashemzadeh, Z. Mardani, and M. Darroudi. 2018. “Biosynthesis and Cytotoxic Activity of Lead Oxide Nanoparticles.” Green Chemistry Letters and Reviews 11 (4): 567–572. doi:10.1080/17518253.2018.1547926.
   Web of Science ®Google Scholar
• Navas-Acien, A., E. Guallar, E. K. Silbergeld, and S. J. Rothenberg. 2007. “Lead Exposure and Cardiovascular Disease–a Systematic Review.” Environmental Health Perspectives 115 (3): 472–482. doi:10.1289/ehp.9785.
   PubMed Web of Science ®Google Scholar
• Oberdörster, G., Z. Sharp, V. Atudorei, A. Elder, R. Gelein, W. Kreyling, C. Cox, et al. 2004. “Translocation of Inhaled Ultrafine Particle to the Brain.” Inhalation Toxicology 16 (6–7): 437–445. doi:10.1080/08958370490439597.
   PubMed Web of Science ®Google Scholar
• Oszlánczi, G., A. Papp, A. Szabó, L. Nagymajtényi, A. Sápi, Z. Kónya, E. Paulik, et al. 2011. “Nervous System Effects in Rats on Subacute Exposure by Lead-Containing Nanoparticles via the Airways.” Inhalation Toxicology 23 (4): 173–181. doi:10.3109/08958378.2011.553248.
   PubMed Web of Science ®Google Scholar
• Panov, V. G., B. A. Katsnelson, A. N. Varaksin, L. I. Privalova, E. P. Kireyeva, M. P. Sutunkova, I. E. Valamina, et al. 2015. “Further Development of Mathematical Description for Combined (a Case Study of Lead–Fluoride Combination.” Toxicology Reports 2: 297–307. doi:10.1016/j.toxrep.2015.02.002.
   PubMed Web of Science ®Google Scholar
• Panov, V. G., I. A. Minigalieva, T. Bushueva, E. Fröhlich, C. Meindl, M. Absenger-Novak, V. Shur, et al. 2020. “Some Peculiarities in the Dose-Dependence of Separate and Combined in Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles with Special Attention to Hormesis Manifestations.” Dose-Response 18 (1): 1–14. doi:10.1177/1559325816672935.
   Web of Science ®Google Scholar
• Privalova, L. I., B. A. Katsnelson, N. Loginova, V. Gurvich, V. Shur, I. Valamina, O. Makeyev, et al. 2014. “Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors.” International Journal of Molecular Sciences 15 (7): 12379–12406. doi:10.3390/ijms150712379.
   PubMed Web of Science ®Google Scholar
• Privalova, L. I., B. A. Katsnelson, M. P. Sutunkova, I. A. Minigalieva, V. B. Gurvich, O. H. Makeyev, V. Y. Shur, et al. 2017. “Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles That Can Pollute Workplace and Ambient Air (a Summary of Authors’ Experimental Results).” Journal of Environmental Protection 08 (08): 844–866. doi:10.4236/jep.2017.88053.
   Google Scholar
• Privalova, L. I., B. A. Katsnelson, A. N. Varaksin, V. G. Panov, and S. L. Balesin. 2016. “The Pulmonary Phagocytosis Response to Separate and Combined Impacts of Manganese (IV) and Chromium (VI) Containing Particulates.” Toxicology 370: 78–85. doi:10.1016/j.tox.2016.09.016.
   PubMed Web of Science ®Google Scholar
• Rylova, M. L. 1964. Methods of Investigating Long-Term Effects of Noxious Environmental Agents in Animal Experiments. Leningrad, Russia: Meditsina.
   Google Scholar
• Sadauskas, E., H. Wallin, M. Stoltenberg, U. Vogel, P. Doering, A. Larsen, G. Danscher, et al. 2007. “Kupffer Cells Are Central in the Removal of Nanoparticles from the Organism.” Particle and Fibre Toxicology 4 (1): 10–16., doi:10.1186/1743-8977-4-10.
   PubMedGoogle Scholar
• Shaikh, S. M., S. K. Shyama, and P. V. Desai. 2015. “Absorption, LD50 and Effects of CoO, MgO and PbO Nanoparticles on Mice mus musculus.” IOSR Journal of Environmental Science, Toxicology and Food Technology 9 (2): 32–38.
   Google Scholar
• Sutunkova, M. P., B. A. Katsnelson, L. I. Privalova, V. B. Gurvich, L. K. Konysheva, V. Y. Shur, E. V. Shishkina, et al. 2016. “On the Contribution of the Phagocytosis and the Solubilization to the Iron Oxide Nanoparticles Retention in and Elimination from Lungs under Long-Term Inhalation Exposure.” Toxicology 363–364 (1): 19–28. doi:10.1016/j.tox.2016.07.006.
   PubMedGoogle Scholar
• Sutunkova, M. P., L. I. Privalova, I. A. Minigalieva, V. B. Gurvich, V. G. Panov, and B. A. Katsnelson. 2018. “The Most Important Inferences from the Ekaterinburg Nanotoxicology Team’s Animal Experiments Assessing Adverse Health Effects of Metallic and Metal Oxide Nanoparticles.” Toxicology Reports 5: 363–376. doi:10.1016/j.toxrep.2018.03.008.
   PubMed Web of Science ®Google Scholar
• Sutunkova, M. P., S. N. Solovyeva, I. N. Chernyshov, S. V. Klinova, V. B. Gurvich, V. Y. Shur, E. V. Shishkina, et al. 2020. “Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles.” International Journal of Molecular Sciences 21 (3): 690. doi:10.3390/ijms21030690.
   Web of Science ®Google Scholar
• Sutunkova, M. P., S. N. Solovyeva, B. A. Katsnelson, V. B. Gurvich, L. I. Privalova, I. A. Minigalieva, T. V. Slyshkina, et al. 2017. “A Paradoxical Rat Organism’s Response to a Long-Term Inhalation of Silica-Containing Submicron (Predominantly, Nanoscale) Particles of an Actual Industrial Aerosol at Realistic Exposure Levels.” Toxicology 384: 59–68. doi:10.1016/j.tox.2017.04.010.
   PubMed Web of Science ®Google Scholar
• Sutunkova, M. P., S. N. Solovyeva, I. A. Minigalieva, V. B. Gurvich, I. E. Valamina, O. H. Makeyev, V. Y. Shur, et al. 2019. “Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles.” International Journal of Molecular Sciences 20 (7): 1778. doi:10.3390/ijms20071778.
   PubMed Web of Science ®Google Scholar
• Taylor, M. P., P. J. Davies, L. J. Kristensen, and J. L. Csavina. 2014. “Licenced to Pollute but Not to Poison: The Ineffectiveness of Regulatoryauthorities at Protecting Public Health from Atmospheric Arsenic, Lead and Other Contaminants Resulting from Mining and Smelting Operations.” Aeolian Research 14: 22–35. doi:10.1016/j.aeolia.2014.03.003.
   Web of Science ®Google Scholar
• Tong, S., Y. E. von Schirnding, and T. Prapamontol. 2000. “Environmental Lead Exposure: A Public Health Problem of Global Dimensions.” Bulletin of the World Health Organization 78 (9): 1068–1077.
   PubMed Web of Science ®Google Scholar
• Varaksin, A. N., B. A. Katsnelson, V. G. Panov, L. I. Privalova, E. P. Kireyeva, I. E. Valamina, O. Y. Beresneva, et al. 2014. “Some Considerations concerning the Theory of Combined Toxicity: A Case Study of Subchronic Experimental Intoxication with Cadmium and Lead.” Food and Chemical Toxicology 64: 144–156. doi:10.1016/j.fct.2013.11.024.
   PubMed Web of Science ®Google Scholar
• WHO. 2010. Childhood Lead Poisoning. Geneva, Switzerland: WHO Document Production Services.
   Google Scholar