The effects of genotype × phenotype interactions on silver nanoparticle toxicity in organotypic cultures of murine tracheal epithelial cells

References

• Alessandrini, F., A. Vennemann, S. Gschwendtner, A. U. Neumann, M. Rothballer, T. Seher, M. Wimmer, et al. 2017. “Pro-Inflammatory Versus Immunomodulatory Effects of Silver Nanoparticles in the Lung: The Critical Role of Dose.” Nanomaterials (Basel, Switzerland) 7 (10): 300. doi:10.3390/nano7100300.
   Google Scholar
• Alsaleh, N. B., and J. M. Brown. 2018. “Immune Responses to Engineered Nanomaterials: Current Understanding and Challenges.” Current Opinion in Toxicology 10: 8–14. doi:10.1016/j.cotox.2017.11.011.
   PubMedGoogle Scholar
• Bachler, G., N. Von Goetz, and K. Hungerbuhler. 2013. “A Physiologically Based Pharmacokinetic Model for Ionic Silver and Silver Nanoparticles.” International Journal of Nanomedicine 8: 3365–3382. doi:10.2147/IJN.S46624.
   PubMed Web of Science ®Google Scholar
• Borok, Z., J. A. Whitsett, P. B. Bitterman, V. J. Thannickal, D. N. Kotton, S. D. Reynolds, M. A. Krasnow, et al. 2011. “Cell Plasticity in Lung Injury and Repair: Report from an NHLBI Workshop, April 19–20, 2010.” Proceedings of the American Thoracic Society 8 (3): 215–222. doi:10.1513/pats.201012-067CB.
   PubMedGoogle Scholar
• Burden, N., C. Mahony, B. P. Müller, C. Terry, C. Westmoreland, and I. Kimber. 2015. “Aligning the 3Rs with New Paradigms in the Safety Assessment of Chemicals.” Toxicology 330: 62–66. doi:10.1016/j.tox.2015.01.014.
   PubMed Web of Science ®Google Scholar
• Campbell, C. D., K. Mohajeri, M. Malig, F. Hormozdiari, B. Nelson, G. Du, K. M. Patterson, et al. 2014. “Whole-Genome Sequencing of Individuals from a Founder Population Identifies Candidate Genes for Asthma.” PLoS One 9 (8): e104396 doi:10.1371/journal.pone.0104396.
   PubMed Web of Science ®Google Scholar
• Choo, W., C. Park, S. Jung, B. Moon, H. Ahn, J. Ryu, K.-S. Kim, Y. Lee, I. Yu, and S. Oh. 2016. “ Long-Term Exposures to Low Doses of Silver Nanoparticles Enhanced In Vitro Malignant Cell Transformation in Non-tumorigenic BEAS-2B Cells.” Toxicology In Vitro : An International Journal Published in Association with BIBRA 37: 41–49. doi:10.1016/j.tiv.2016.09.003.
   PubMed Web of Science ®Google Scholar
• Chuang, H.-C., T.-C. Hsiao, C.-K. Wu, H.-H. Chang, C.-H. Lee, C.-C. Chang, T.-J. Cheng, and Taiwan. 2013. “Allergenicity and Toxicology of Inhaled Silver Nanoparticles in Allergen-Provocation Mice Models.” International Journal of Nanomedicine 8: 4495–4506. doi:10.2147/IJN.S52239.
   PubMed Web of Science ®Google Scholar
• Cronholm, P., H. L. Karlsson, J. Hedberg, T. A. Lowe, L. Winnberg, K. Elihn, I. Wallinder, and L. Möller. 2013. “Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison between Nanoparticles and Their Corresponding Metal Ions.” Small (Weinheim an der Bergstrasse, Germany) 9 (7): 970–982. doi:10.1002/smll.201201069.
   PubMed Web of Science ®Google Scholar
• Danilczuk, M., A. Lund, J. Sadlo, H. Yamada, and J. Michalik. 2006. “Conduction Electron Spin Resonance of Small Silver Particles.” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 63 (1): 189–191. doi:10.1016/j.saa.2005.05.002.
   PubMed Web of Science ®Google Scholar
• Dickinson, J. D., Y. Alevy, N. P. Malvin, K. K. Patel, S. P. Gunsten, M. J. Holtzman, T. S. Stappenbeck, and S. L. Brody. 2016. “IL13 Activates Autophagy to Regulate Secretion in Airway Epithelial Cells.” Autophagy 12 (2): 397–409. doi:10.1080/15548627.2015.1056967.
   PubMed Web of Science ®Google Scholar
• Donaldson, K., V. Stone, A. Clouter, L. Renwick, and W. Macnee. 2001. “Ultrafine Particles.” Occupational and Environmental Medicine 58 (3): 211–216, 199. doi:10.1136/oem.58.3.211.
   PubMed Web of Science ®Google Scholar
• Elenkov, I. J. 2004. “Glucocorticoids and the Th1/Th2 Balance.” Annals of the New York Academy of Sciences 1024: 138–146. doi:10.1196/annals.1321.010.
   PubMed Web of Science ®Google Scholar
• Flynn, A. N., O. A. Itani, T. O. Moninger, and M. J. Welsh. 2009. “Acute Regulation of Tight Junction Ion Selectivity in Human Airway Epithelia.” Proceedings of the National Academy of Sciences of the United States of America 106 (9): 3591–3596. doi:10.1073/pnas.0813393106.
   PubMed Web of Science ®Google Scholar
• Gereda, J. E., D. Y. M. Leung, A. Thatayatikom, J. E. Streib, M. R. Price, M. D. Klinnert, and A. H. Liu. 2000. “Relation between House-Dust Endotoxin Exposure, Type 1 T-Cell Development, and Allergen Sensitisation in Infants at High Risk of Asthma.” The Lancet 355 (9216): 1680–1683. doi:10.1016/S0140-6736(00)02239-X.
   PubMed Web of Science ®Google Scholar
• Gliga, A. R., S. Skoglund, I. Wallinder, B. Fadeel, and H. L. Karlsson. 2014. “Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release.” Particle and Fibre Toxicology 11: 11–17. doi:10.1186/1743-8977-11-11.
   PubMed Web of Science ®Google Scholar
• Goss, C. H., S. A. Newsom, J. S. Schildcrout, L. Sheppard, and J. D. Kaufman. 2004. “Effect of Ambient Air Pollution on Pulmonary Exacerbations and Lung Function in Cystic Fibrosis.” American Journal of Respiratory and Critical Care Medicine 169 (7): 816–821. doi:10.1164/rccm.200306-779OC.
   PubMed Web of Science ®Google Scholar
• Haddad, J. J., and C. S. Fahlman. 2002. “Redox- and Oxidant-Mediated Regulation of Interleukin-10: An anti-Inflammatory, Antioxidant Cytokine?” Biochemical and Biophysical Research Communications 297 (2): 163–176. doi:10.1016/S0006-291X(02)02094-6.
   PubMed Web of Science ®Google Scholar
• Hallstrand, T. S., T. L. Hackett, W. A. Altemeier, G. Matute-Bello, P. M. Hansbro, and D. A. Knight. 2014. “Airway Epithelial Regulation of Pulmonary Immune Homeostasis and Inflammation.” Clinical Immunology (Orlando, Fla.) 151 (1): 1–15. doi:10.1016/j.clim.2013.12.003.
   PubMed Web of Science ®Google Scholar
• Horani, A., J. D. Dickinson, and S. L. Brody. 2013. “Applications of Mouse Airway Epithelial Cell Culture for Asthma Research.” Methods in Molecular Biology (Clifton, N.J.) 1032: 91–107. doi:10.1007/978-1-62703-496-8_7.
   PubMedGoogle Scholar
• Huh, D., B. D. Matthews, A. Mammoto, M. Montoya-Zavala, H. Y. Hsin, and D. E. Ingber. 2010. “Reconstituting Organ-Level Lung Functions on a Chip.” Science (New York, N.Y.) 328 (5986): 1662–1668. doi:10.1126/science.1188302.
   PubMed Web of Science ®Google Scholar
• Jeannet, N., M. Fierz, M. Kalberer, H. Burtscher, and M. Geiser. 2015. “Nano Aerosol Chamber for in-Vitro Toxicity (NACIVT) Studies.” Nanotoxicology 9 (1): 34–42. doi:10.3109/17435390.2014.886739.
   PubMed Web of Science ®Google Scholar
• Jeannet, N., M. Fierz, S. Schneider, L. Künzi, N. Baumlin, M. Salathe, H. Burtscher, and M. Geiser. 2015. “Acute Toxicity of Silver and Carbon Nanoaerosols to Normal and Cystic Fibrosis Human Bronchial Epithelial Cells.” Nanotoxicology 10: 1–13. doi:10.3109/17435390.2015.1049233.
   Web of Science ®Google Scholar
• Juarez-Moreno, K., E. B. Gonzalez, N. Giron-Vazquez, R. A. Chavez-Santoscoy, J. D. Mota-Morales, L. L. Perez-Mozqueda, M. R. Garcia-Garcia, A. Pestryakov, and N. Bogdanchikova. 2017. “Comparison of Cytotoxicity and Genotoxicity Effects of Silver Nanoparticles on Human Cervix and Breast Cancer Cell Lines.” Human & Experimental Toxicology 36 (9): 931–948. doi:10.1177/0960327116675206.
   PubMed Web of Science ®Google Scholar
• Judson, R. S., K. A. Houck, R. J. Kavlock, T. B. Knudsen, M. T. Martin, H. M. Mortensen, D. M. Reif, et al. 2010. “In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project.” Environmental Health Perspectives 118 (4): 485–492. doi:10.1289/ehp.0901392.
   PubMed Web of Science ®Google Scholar
• Judson, R. S., R. J. Kavlock, R. W. Setzer, E. A. Hubal, M. T. Martin, T. B. Knudsen, K. A. Houck, R. S. Thomas, B. A. Wetmore, and D. J. Dix. 2011. “Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment.” Chemical Research in Toxicology 24 (4): 451–462. doi:10.1021/tx100428e.
   PubMed Web of Science ®Google Scholar
• Kato, T., S. Tada-Oikawa, K. Takahashi, K. Saito, L. Wang, A. Nishio, R. Hakamada-Taguchi, S. Kawanishi, and K. Kuribayashi. 2006. “Endocrine Disruptors That Deplete Glutathione Levels in APC Promote Th2 Polarization in Mice Leading to the Exacerbation of Airway Inflammation.” European Journal of Immunology 36 (5): 1199–1209. doi:10.1002/eji.200535140.
   PubMed Web of Science ®Google Scholar
• Kim, H., M. Kim, S. Lee, S. Oh, and K. Chung. 2011. “Genotoxic Effects of Silver Nanoparticles Stimulated by Oxidative Stress in Human Normal Bronchial Epithelial (BEAS-2B) Cells.” Mutation Research 726 (2): 129–135. doi:10.1016/j.mrgentox.2011.08.008.
   PubMed Web of Science ®Google Scholar
• Kim, J., E. Kuk, K. Yu, J.-H. Kim, S. Park, H. Lee, S. Kim, et al. 2007. “Antimicrobial Effects of Silver Nanoparticles.” Nanomedicine : Nanotechnology, Biology, and Medicine 3 (1): 95–101. doi:10.1016/j.nano.2006.12.001.
   PubMed Web of Science ®Google Scholar
• Kim, E., J. Lee, J. Kim, G. Lee, K. Ahn, J. Park, and I. Yu. 2015. “Case Study on Risk Evaluation of Silver Nanoparticle Exposure from Antibacterial Sprays Containing Silver Nanoparticles.” Journal of Nanomaterials 2015: 1–8. doi:10.1155/2015/346586.
   Web of Science ®Google Scholar
• Kim, H., D. Shin, Y. Park, C. Park, S. Oh, and K. Chung. 2014. “Silver Nanoparticles Induce p53-Mediated Apoptosis in Human Bronchial Epithelial (BEAS-2B) Cells.” The Journal of Toxicological Sciences 39 (3): 401–412. doi:10.2131/jts.39.401.
   PubMed Web of Science ®Google Scholar
• Kimura, T., H. Kawabe, C. Jiang, W. Zhang, Y. Y. Xiang, C. Lu, M. W. Salter, N. Brose, W. Y. Lu, and D. Rotin. 2011. “Deletion of the Ubiquitin Ligase Nedd4L in Lung Epithelia Causes Cystic Fibrosis-Like Disease.” Proceedings of the National Academy of Sciences of the United States of America 108 (8): 3216–3221. doi:10.1073/pnas.1010334108.
   PubMed Web of Science ®Google Scholar
• Krause, S., J. Behrends, A. Borowski, J. Lohrmann, S. Lang, D. Myrtek, T. Lorenzen, J. C. Virchow, W. Luttmann, and K. Friedrich. 2006. “Blockade of Interleukin-13-Mediated Cell Activation by a Novel Inhibitory Antibody to Human IL-13 Receptor alpha1.” Molecular Immunology 43 (11): 1799–1807. doi:10.1016/j.molimm.2005.11.001.
   PubMed Web of Science ®Google Scholar
• Krewski, D., M. E. Andersen, E. Mantus, and L. Zeise. 2009. “Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment.” Risk Analysis : An Official Publication of the Society for Risk Analysis 29 (4): 474–479. doi:10.1111/j.1539-6924.2008.01150.x.
   PubMed Web of Science ®Google Scholar
• Lee, J., M. Kwon, J. Ji, C. Kang, K. Ahn, J. Han, and I. Yu. 2011. “Exposure Assessment of Workplaces Manufacturing Nanosized TiO2 and Silver.” Inhalation Toxicology 23 (4): 226–236. doi:10.3109/08958378.2011.562567.
   PubMed Web of Science ®Google Scholar
• Lee, V., R. S. Mcmahan, X. Hu, X. Gao, E. M. Faustman, W. C. Griffith, T. J. Kavanagh, D. L. Eaton, J. K. Mcguire, and W. C. Parks. 2015. “Amphiphilic Polymer-Coated CdSe/ZnS Quantum Dots Induce Pro-Inflammatory Cytokine Expression in Mouse Lung Epithelial Cells and Macrophages.” Nanotoxicology 9 (3): 336–343. doi:10.3109/17435390.2014.930532.
   PubMed Web of Science ®Google Scholar
• Lee, J., J. Mun, J. Park, and I. Yu. 2012. “A Health Surveillance Case Study on Workers Who Manufacture Silver Nanomaterials.” Nanotoxicology 6 (6): 667–669. doi:10.3109/17435390.2011.600840.
   PubMed Web of Science ®Google Scholar
• Lerner, C. A., I. K. Sundar, and I. Rahman. 2016. “Mitochondrial Redox System, Dynamics, and Dysfunction in Lung Inflammaging and COPD.” The International Journal of Biochemistry & Cell Biology 81 (Pt B): 294–306. doi:10.1016/j.biocel.2016.07.026.
   PubMed Web of Science ®Google Scholar
• Long, Y. M., L. G. Hu, X. T. Yan, X. C. Zhao, Q. F. Zhou, Y. Cai, and G. B. Jiang. 2017. “Surface Ligand Controls Silver Ion Release of Nanosilver and Its Antibacterial Activity Against Escherichia coli.” International Journal of Nanomedicine 12: 3193–3206. doi:10.2147/IJN.S132327.
   PubMed Web of Science ®Google Scholar
• Ma, R., C. Levard, S. M. Marinakos, Y. Cheng, J. Liu, M. F. Michel, G. E. Brown, and G. V. Lowry. 2012. “Size-Controlled Dissolution of Organic-Coated Silver Nanoparticles.” Environmental Science & Technology 46 (2): 752–759. doi:10.1021/es201686j.
   PubMed Web of Science ®Google Scholar
• Macpherson, J. C., SaA. Comhair, S. C. Erzurum, D. F. Klein, M. F. Lipscomb, M. S. Kavuru, M. K. Samoszuk, and S. L. Hazen. 2001. “Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species.” Journal of Immunology (Baltimore, Md. : 1950) 166 (9): 5763–5772. doi:10.4049/jimmunol.166.9.5763.
   PubMed Web of Science ®Google Scholar
• MacRedmond, R. E., G. K. Singhera, S. J. Wadsworth, S. Attridge, M. Bahzad, K. Williams, H. O. Coxson, S. R. White, and D. R. Dorscheid. 2014. “Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.” J Steroids Horm Sci 5. doi:10.4172/2157-7536.1000134.
   PubMedGoogle Scholar
• Matsui, H., S. H. Randell, S. W. Peretti, C. W. Davis, and R. C. Boucher. 1998. “Coordinated Clearance of Periciliary Liquid and Mucus from Airway Surfaces.” The Journal of Clinical Investigation 102 (6): 1125–1131. doi:10.1172/JCI2687.
   PubMed Web of Science ®Google Scholar
• Melgert, B. N., D. S. Postma, I. Kuipers, M. Geerlings, M. A. Luinge, B. W. A. Strate, HaM. Kerstjens, W. Timens, and M. N. Hylkema. 2005. “Female Mice Are More Susceptible to the Development of Allergic Airway Inflammation than Male Mice.” Clinical Experimental Allergy 35 (11): 1496–1503. doi:10.1111/j.1365-2222.2005.02362.x.
   PubMed Web of Science ®Google Scholar
• Meng, Q., Z. Peng, L. Chen, J. Si, Z. Dong, and Y. Xia. 2010. “Nuclear Factor-κB Modulates Cellular Glutathione and Prevents Oxidative Stress in Cancer Cells .” Cancer Letters 299 (1): 45–53. doi:10.1016/j.canlet.2010.08.002.
   PubMed Web of Science ®Google Scholar
• Metzger, R. J., O. D. Klein, G. R. Martin, and M. A. Krasnow. 2008. “The Branching Programme of Mouse Lung Development.” Nature 453 (7196): 745–750. doi:10.1038/nature07005.
   PubMed Web of Science ®Google Scholar
• Molfino, N. A., and A. J. Coyle. 2008. “Gene-Environment Interactions in Chronic Obstructive Pulmonary Disease.” International Journal of Chronic Obstructive Pulmonary Disease 3 (3): 491–497. doi:10.2147/copd.s2528.
   PubMedGoogle Scholar
• Nam, J. H., K. W. Park, E. S. Park, Y. B. Lee, H. G. Lee, H. H. Baik, Y. S. Kim, S. Maeng, J. Park, and B. K. Jin. 2012. “ Interleukin-13/-4-Induced Oxidative Stress Contributes to Death of Hippocampal Neurons in aβ1-42-Treated Hippocampus In Vivo .” Antioxidants & Redox Signaling 16 (12): 1369–1383. doi:10.1089/ars.2011.4175.
   PubMed Web of Science ®Google Scholar
• Ostedgaard, L. S., T. O. Moninger, J. D. Mcmenimen, N. M. Sawin, C. P. Parker, I. M. Thornell, L. S. Powers, et al. 2017. “Gel-Forming Mucins Form Distinct Morphologic Structures in Airways.” Proceedings of the National Academy of Sciences of the United States of America 114 (26): 6842–6847. doi:10.1073/pnas.1703228114.
   PubMed Web of Science ®Google Scholar
• Parker, J. C., S. Thavagnanam, G. Skibinski, J. Lyons, J. Bell, L. G. Heaney, and M. D. Shields. 2013. “Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model.” PLoS One 8 (5): e61023doi:10.1371/journal.pone.0061023.
   PubMed Web of Science ®Google Scholar
• Park, J., B. Kwak, E. Bae, J. Lee, Y. Kim, K. Choi, and J. Yi. 2009. “Characterization of Exposure to Silver Nanoparticles in a Manufacturing Facility.” Journal of Nanoparticle Research 11 (7): 1705–1712. doi:10.1007/s11051-009-9725-8.
   Web of Science ®Google Scholar
• Park, J. J., B. A. Weldon, S. Hong, T. Workman, W. C. Griffith, J. H. Park, and E. M. Faustman. 2018. “Characterization of 3D Embryonic C57BL/6 and a/J Mouse Midbrain Micromass in Vitro Culture Systems for Developmental Neurotoxicity Testing.” Toxicol In Vitro 48: 33–44. doi:10.1016/j.tiv.2017.12.009.
   PubMed Web of Science ®Google Scholar
• Petecchia, L., F. Sabatini, C. Usai, E. Caci, L. Varesio, and G. A. Rossi. 2012. “Cytokines Induce Tight Junction Disassembly in Airway Cells via an EGFR-Dependent MAPK/ERK1/2-Pathway.” Laboratory Investigation; a Journal of Technical Methods and Pathology 92 (8): 1140–1148. doi:10.1038/labinvest.2012.67.
   PubMed Web of Science ®Google Scholar
• Pope, C. A. 2000. “Epidemiology of Fine Particulate Air Pollution and Human Health: biologic Mechanisms and Who’s at Risk??” Environmental Health Perspectives 108 Suppl 4 (Suppl 4): 713–723. doi:10.1289/ehp.108-1637679.
   PubMedGoogle Scholar
• Quadros, M. E., and L. C. Marr. 2010. “Environmental and Human Health Risks of Aerosolized Silver Nanoparticles.” Journal of the Air & Waste Management Association (1995) 60 (7): 770–781. doi:10.3155/1047-3289.60.7.770.
   PubMedGoogle Scholar
• Quadros, M. E., and L. C. Marr. 2011. “Silver Nanoparticles and Total Aerosols Emitted by Nanotechnology-Related Consumer Spray Products.” Environmental Science & Technology 45 (24): 10713–10719. doi:10.1021/es202770m.
   PubMed Web of Science ®Google Scholar
• Rock, J. R., C. E. Barkauskas, M. J. Cronce, Y. Xue, J. R. Harris, J. Liang, P. W. Noble, and B. L. M. Hogan. 2011. “Multiple Stromal Populations Contribute to Pulmonary Fibrosis Without Evidence for Epithelial to Mesenchymal Transition.” Proceedings of the National Academy of Sciences 108 (52): E1475–E1483. doi:10.1073/pnas.1117988108.
   PubMed Web of Science ®Google Scholar
• Schindelin, J., I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, et al. 2012. “Fiji: An Open-Source Platform for Biological-Image Analysis.” Nature Methods 9 (7): 676–682. doi:10.1038/nmeth.2019.
   PubMed Web of Science ®Google Scholar
• Schlinkert, P., E. Casals, M. Boyles, U. Tischler, E. Hornig, N. Tran, J. Zhao, et al. 2015. “The Oxidative Potential of Differently Charged Silver and Gold Nanoparticles on Three Human Lung Epithelial Cell Types.” Journal of Nanobiotechnology 13: 1. doi:10.1186/s12951-014-0062-4.
   PubMed Web of Science ®Google Scholar
• Scoville, D. K., D. Botta, K. Galdanes, S. C. Schmuck, C. C. White, P. L. Stapleton, T. K. Bammler, et al. 2017. “Genetic Determinants of Susceptibility to Silver Nanoparticle-Induced Acute Lung Inflammation in Mice .” FASEB Journal : official Publication of the Federation of American Societies for Experimental Biology 31 (10): 4600–4611. doi:10.1096/fj.201700187R.
   PubMed Web of Science ®Google Scholar
• Scoville, D. K., C. C. White, D. Botta, L. A. Mcconnachie, M. E. Zadworny, S. C. Schmuck, X. Hu, et al. 2015. “Susceptibility to Quantum Dot Induced Lung Inflammation Differs Widely Among the Collaborative Cross Founder Mouse Strains.” Toxicology and Applied Pharmacology 289 (2): 240–250. doi:10.1016/j.taap.2015.09.019.
   PubMed Web of Science ®Google Scholar
• Shannahan, J. H., X. Lai, P. C. Ke, R. Podila, J. M. Brown, and F. A. Witzmann. 2013. “Silver Nanoparticle Protein Corona Composition in Cell Culture Media.” PLoS One 8 (9): e74001. doi:10.1371/journal.pone.0074001.
   PubMed Web of Science ®Google Scholar
• Soutiere, S. E., C. G. Tankersley, and W. Mitzner. 2004. “Differences in Alveolar Size in Inbred Mouse Strains.” Respiratory Physiology & Neurobiology 140 (3): 283–291. doi:10.1016/j.resp.2004.02.003.
   PubMed Web of Science ®Google Scholar
• Steelant, B., S. F. Seys, L. Van Gerven, M. Van Woensel, R. Farre, P. Wawrzyniak, I. Kortekaas Krohn, et al. 2018. “Histamine and T Helper Cytokine-Driven Epithelial Barrier Dysfunction in Allergic Rhinitis.” The Journal of Allergy and Clinical Immunology 141 (3): 951–963 e8. doi:10.1016/j.jaci.2017.08.039.
   PubMed Web of Science ®Google Scholar
• Sung, J. H., J. H. Ji, K. S. Song, J. H. Lee, K. H. Choi, S. H. Lee, and I. J. Yu. 2011. “Acute Inhalation Toxicity of Silver Nanoparticles.” Toxicology and Industrial Health 27 (2): 149–154. doi:10.1177/0748233710382540.
   PubMed Web of Science ®Google Scholar
• Svensson, C. R., S. S. Ameer, L. Ludvigsson, N. Ali, A. Alhamdow, M. E. Messing, J. Pagels, et al. 2016. “Validation of an Air-Liquid Interface Toxicological Set-up Using Cu, Pd, and Ag Well-Characterized Nanostructured Aggregates and Spheres.” Journal of Nanoparticle Research 18 (4): 86. doi:10.1007/s11051-016-3389-y.
   PubMed Web of Science ®Google Scholar
• Team, R. C. 2018. R: A language and environment for statistical computing [online]. R Foundation for Statistical Computing. https://www.r-project.org.
   Google Scholar
• Usepa 2013. Use of High-Throughput Assays and Computational Tools in the Endocrine Disruptor Screening Program [online]. https://www.epa.gov/endocrine-disruption/use-high-throughput-assays-and-computational-tools-endocrine-disruptor. [Accessed Access Date
   Google Scholar
• Usepa 2017. Reviewing New Chemicals under the Toxic Substances Control Act (TSCA) [online]. https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca/control-nanoscale-materials-under
   Google Scholar
• Utsugi, M., K. Dobashi, Y. Koga, Y. Shimizu, T. Ishizuka, K. Iizuka, J. Hamuro, T. Nakazawa, and M. Mori. 2002. “Glutathione Redox Regulates Lipopolysaccharide-Induced IL-12 Production through p38 Mitogen-Activated Protein Kinase Activation in Human Monocytes: role of Glutathione Redox in IFN-Gamma Priming of IL-12 Production.” Journal of Leukocyte Biology 71 (2): 339–347.
   PubMed Web of Science ®Google Scholar
• Vance, M. E., T. Kuiken, E. P. Vejerano, S. P. Mcginnis, M. F. Hochella, D. Rejeski, and M. S. Hull. 2015. “Nanotechnology in the Real World: Redeveloping the Nanomaterial Consumer Products Inventory.” Beilstein Journal of Nanotechnology 6: 1769–1780. doi:10.3762/bjnano.6.181.
   PubMed Web of Science ®Google Scholar
• Von Mutius, E. 2009. “Gene-Environment Interactions in Asthma.” The Journal of Allergy and Clinical Immunology 123 (1): 3–11; quiz 12-3. doi:10.1016/j.jaci.2008.10.046.
   PubMed Web of Science ®Google Scholar
• Weaver, M., L. Batts, and B. Hogan. 2003. “Tissue Interactions Pattern the Mesenchyme of the Embryonic Mouse Lung.” Developmental Biology 258 (1): 169–184. doi:10.1016/S0012-1606(03)00117-9.
   PubMed Web of Science ®Google Scholar
• Weldon, B. A., E. M. Faustman, G. Oberdörster, T. Workman, W. C. Griffith, C. Kneuer, and I. Yu. 2016. “Occupational Exposure Limit for Silver Nanoparticles: Considerations on the Derivation of a General Health-Based Value.” Nanotoxicology 10 (7): 945–956. doi:10.3109/17435390.2016.1148793.
   PubMed Web of Science ®Google Scholar
• Weldon, B. A., J. J. Park, S. Hong, T. Workman, R. Dills, J. H. Lee, W. C. Griffith, T. J. Kavanagh, and E. M. Faustman. 2018. “Using Primary Organotypic Mouse Midbrain Cultures to Examine Developmental Neurotoxicity of Silver Nanoparticles across Two Genetic Strains.” Toxicology and Applied Pharmacology 354: 215-224. doi:10.1016/j.taap.2018.04.017.
   Google Scholar
• Weldy, C. S., C. C. White, H. W. Wilkerson, T. V. Larson, J. A. Stewart, S. E. Gill, W. C. Parks, and T. J. Kavanagh. 2011. “Heterozygosity in the Glutathione Synthesis Gene Gclm Increases Sensitivity to Diesel Exhaust Particulate Induced Lung Inflammation in Mice.” Inhalation Toxicology 23 (12): 724–735. doi:10.3109/08958378.2011.608095.
   PubMed Web of Science ®Google Scholar
• Wilson, A. G. E. 2011. “Chapter 1. Introduction and Overview.” In New Horizons in Predictive Toxicology. Royal Society of Chemistry.
   Google Scholar
• Yamanaka, K., T. Fujisawa, H. Kusagaya, K. Mori, M. Niwa, K. Furuhashi, M. Kono, E. Hamada, T. Suda, and M. Maekawa. 2018. “IL-13 Regulates IL-17C Expression by Suppressing NF-κB-Mediated Transcriptional Activation in Airway Epithelial Cells .” Biochemical and Biophysical Research Communications 495 (1): 1534–1540. doi:10.1016/j.bbrc.2017.11.207.
   PubMed Web of Science ®Google Scholar
• Yasuo, M., K. Fujimoto, T. Tanabe, H. Yaegashi, K. Tsushima, K. Takasuna, T. Koike, M. Yamaya, and T. Nikaido. 2006. “Relationship Between Calcium-Activated Chloride Channel 1 and MUC5AC in Goblet Cell Hyperplasia Induced by Interleukin-13 in Human Bronchial Epithelial Cells.” Respiration; International Review of Thoracic Diseases 73 (3): 347–359. doi:10.1159/000091391.
   PubMed Web of Science ®Google Scholar
• You, Y., and S. L. Brody. 2013. “Culture and Differentiation of Mouse Tracheal Epithelial Cells.” Methods in Molecular Biology (Clifton, N.J.) 945: 123–143.
   PubMedGoogle Scholar
• You, Y., E. J. Richer, T. Huang, and S. L. Brody. 2002. “Growth and Differentiation of Mouse Tracheal Epithelial Cells: Selection of a Proliferative Population.” American Journal of Physiology. Lung Cellular and Molecular Physiology 283 (6): L1315–L6521. doi:10.1152/ajplung.00169.2002.
   PubMed Web of Science ®Google Scholar
• Zhang, H., X. Wang, M. Wang, L. Li, C. Chang, Z. Ji, T. Xia, and A. E. Nel. 2015. “Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles That Are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression.” Small (Weinheim an der Bergstrasse, Germany) 11 (31): 3797–3805. doi:10.1002/smll.201500251.
   PubMed Web of Science ®Google Scholar