Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice

References

• Aureli, F., M. Ciprotti, M. D’Amato, E. do Nascimento da Silva, S. Nisi, D. Passeri, A. Sorbo, et al. 2020. “Determination of Total Silicon and SiO(2) Particles Using an ICP-MS Based Analytical Platform for Toxicokinetic Studies of Synthetic Amorphous Silica.” Nanomaterials (Basel, Switzerland) 10 (5): 888. doi:10.3390/nano10050888.
   Google Scholar
• Bettini, S., E. Boutet-Robinet, C. Cartier, C. Coméra, E. Gaultier, J. Dupuy, N. Naud, et al. 2017. “Food-Grade TiO2 Impairs Intestinal and Systemic Immune Homeostasis, Initiates Preneoplastic Lesions and Promotes Aberrant Crypt Development in the Rat Colon.” Scientific Reports 7: 40373. doi:10.1038/srep40373.
   PubMed Web of Science ®Google Scholar
• Bolyen, E., J. R. Rideout, M. R. Dillon, N. A. Bokulich, C. C. Abnet, G. A. Al-Ghalith, H. Alexander, et al. 2019. “Reproducible, Interactive, Scalable and Extensible Microbiome Data Science Using QIIME 2.” Nature Biotechnology 37 (8): 852–857. doi:10.1038/s41587-019-0209-9.
   PubMed Web of Science ®Google Scholar
• Boudard, D., F. Aureli, B. Laurent, N. Sturm, A. Raggi, E. Antier, L. Lakhdar, et al. 2019. “Chronic Oral Exposure to Synthetic Amorphous Silica (NM-200) Results in Renal and Liver Lesions in Mice.” Kidney International Reports 4 (10): 1463–1471. doi:10.1016/j.ekir.2019.06.007.
   PubMed Web of Science ®Google Scholar
• Chen, L., J. Liu, Y. Zhang, G. Zhang, Y. Kang, A. Chen, X. Feng, and L. Shao. 2018. “The Toxicity of Silica Nanoparticles to the Immune System.” Nanomedicine (London, England) 13 (15): 1939–1962. doi:10.2217/nnm-2018-0076.
   PubMed Web of Science ®Google Scholar
• De Jong, W. H., E. De Rijk, A. Bonetto, W. Wohlleben, V. Stone, A. Brunelli, E. Badetti, A. Marcomini, I. Gosens, and F. R. Cassee. 2019. “Toxicity of Copper Oxide and Basic Copper Carbonate Nanoparticles after Short-Term Oral Exposure in Rats.” Nanotoxicology 13 (1): 50–72. doi:10.1080/17435390.2018.1530390.
   PubMed Web of Science ®Google Scholar
• Dekkers, S., H. Bouwmeester, P. M. J. Bos, R. J. B. Peters, A. G. Rietveld, and A. G. Oomen. 2013. “Knowledge Gaps in Risk Assessment of Nanosilica in Food: Evaluation of the Dissolution and Toxicity of Different Forms of Silica.” Nanotoxicology 7 (4): 367–377. doi:10.3109/17435390.2012.662250.
   PubMed Web of Science ®Google Scholar
• Dekkers, S., P. Krystek, R. J. B. Peters, D. P. K. Lankveld, B. G. H. Bokkers, P. H. van Hoeven-Arentzen, H. Bouwmeester, and A. G. Oomen. 2011. “Presence and Risks of Nanosilica in Food Products.” Nanotoxicology 5 (3): 393–405. doi:10.3109/17435390.2010.519836.
   PubMed Web of Science ®Google Scholar
• Downs, T. R., M. E. Crosby, T. Hu, S. Kumar, A. Sullivan, K. Sarlo, B. Reeder, et al. 2012. “Silica Nanoparticles Administered at the Maximum Tolerated Dose Induce Genotoxic Effects through an Inflammatory Reaction While Gold Nanoparticles Do Not.” Mutation Research/Genetic Toxicology and Environmental Mutagenesis 745 (1–2): 38–50. doi:10.1016/j.mrgentox.2012.03.012.
   PubMed Web of Science ®Google Scholar
• Fabjan, E. S., P. Nadrah, A. Ajdovec, M. Tomšič, G. Dražić, M. Mazaj, N. Z. Logar, et al. 2020. “Colorimetric Cutoff Indication of Relative Humidity Based on Selectively Functionalized Mesoporous Silica.” Sensors and Actuators B Chemistry 316 (April): 128–138.
   Google Scholar
• Fu, C., T. Liu, L. Li, H. Liu, D. Chen, and F. Tang. 2013. “The Absorption, Distribution, Excretion and Toxicity of Mesoporous Silica Nanoparticles in Mice following Different Exposure Routes.” Biomaterials 34 (10): 2565–2575. doi:10.1016/j.biomaterials.2012.12.043.
   PubMed Web of Science ®Google Scholar
• Guichard, Y., M. A. Maire, S. Sébillaud, C. Fontana, C. Langlais, J. C. Micillino, C. Darne, et al. 2015. “Genotoxicity of Synthetic Amorphous Silica Nanoparticles in Rats following Short-Term exposure. Part 2: intratracheal instillation and intravenous injection.” Environ Mol Mutagen 56 (2): 228–244. doi:10.1002/em.21928.
   PubMed Web of Science ®Google Scholar
• Hadipour Moghaddam, S. P., R. Mohammadpour, and H. Ghandehari. 2019. “In Vitro and In Vivo Evaluation of Degradation, Toxicity, Biodistribution, and Clearance of Silica Nanoparticles as a Function of Size, Porosity, Density, and Composition.” Journal of Controlled Release: Official journal of the Controlled Release Society 311–312: 1–15. doi:10.1016/j.jconrel.2019.08.028.
   PubMed Web of Science ®Google Scholar
• Hadrup, N., K. Aimonen, M. Ilves, H. Lindberg, R. Atluri, N. M. Sahlgren, N. R. Jacobsen, et al. forthcoming. “Pulmonary Toxicity of Synthetic Amorphous Silica – Effects of Porosity and Copper Oxide Doping.” Submitted to Nanotoxicology.
   Web of Science ®Google Scholar
• Holian, A., R. F. Hamilton, Z. Wu, S. Deb, K. L. Trout, Z. Wang, R. Bhargava, and S. Mitra. 2019. “Lung Deposition Patterns of MWCNT Vary with Degree of Carboxylation.” Nanotoxicology 13 (2): 143–159. doi:10.1080/17435390.2018.1530392.
   PubMed Web of Science ®Google Scholar
• Husain, M., A. T. Saber, C. Guo, N. R. Jacobsen, K. A. Jensen, C. L. Yauk, A. Williams, et al. 2013. “Pulmonary Instillation of Low Doses of Titanium Dioxide Nanoparticles in Mice Leads to Particle Retention and Gene Expression Changes in the Absence of Inflammation.” Toxicology and Applied Pharmacology 269 (3): 250–262. doi:10.1016/j.taap.2013.03.018.
   PubMed Web of Science ®Google Scholar
• Ilves, M., J. Palomäki, M. Vippola, M. Lehto, K. Savolainen, T. Savinko, and H. Alenius. 2014. “Topically Applied ZnO Nanoparticles Suppress Allergen Induced Skin Inflammation but Induce Vigorous IgE Production in the Atopic Dermatitis Mouse Model.” Particle and Fibre Toxicology 11 (1): 38. doi:10.1186/s12989-014-0038-4.
   PubMedGoogle Scholar
• Juère, E., G. Del Favero, F. Masse, D. Marko, A. Popat, J. Florek, R. Caillard, et al. 2020. “Gastro-protective Protein-Silica Nanoparticles Formulation for Oral Drug Delivery: In Vitro Release, Cytotoxicity and Mitochondrial Activity.” European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 151: 171–180. doi:10.1016/j.ejpb.2020.03.015.
   PubMed Web of Science ®Google Scholar
• Kettiger, H., D. Sen Karaman, L. Schiesser, J. M. Rosenholm, and J. Huwyler. 2015. “Comparative Safety Evaluation of Silica-Based Particles.” Toxicology In Vitro 30 (1 Pt B): 355–363. doi:10.1016/j.tiv.2015.09.030.
   PubMed Web of Science ®Google Scholar
• Kim, J. H., C. S. Kim, R. M. C. Ignacio, D. H. Kim, M. E. J. Sajo, E. H. Maeng, X. F. Qi, et al. 2014. “Immunotoxicity of Silicon Dioxide Nanoparticles with Different Sizes and Electrostatic Charge.” International Journal of Nanomedicine 9: 183–193.
   PubMed Web of Science ®Google Scholar
• Kim, M., J. H. Park, H. Jeong, J. Hong, W. S. Choi, B. H. Lee, and C. Y. Park. 2017. “An Evaluation of the In Vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration.” Scientific Reports 7 (1): 1–8. doi:10.1038/s41598-017-08843-9.
   PubMedGoogle Scholar
• Kwon, J. Y., P. Koedrith, and Y. R. Seo. 2014. “Current Investigations into the Genotoxicity of Zinc Oxide and Silica Nanoparticles in Mammalian Models in Vitro and in Vivo: Carcinogenic/Genotoxic Potential, Relevant Mechanisms and Biomarkers, Artifacts, and Limitations.” International Journal of Nanomedicine 9: 271–286.
   PubMed Web of Science ®Google Scholar
• Landsiedel, R., L. Ma-Hock, T. Hofmann, M. Wiemann, V. Strauss, S. Treumann, W. Wohlleben, S. Gröters, K. Wiench, and B. van Ravenzwaay. 2014. “Application of Short-Term Inhalation Studies to Assess the Inhalation Toxicity of Nanomaterials.” Particle and Fibre Toxicology 11: 16. doi:10.1186/1743-8977-11-16.
   PubMed Web of Science ®Google Scholar
• Li, L., T. Liu, C. Fu, L. Tan, X. Meng, and H. Liu. 2015. “Biodistribution, Excretion, and Toxicity of Mesoporous Silica Nanoparticles after Oral Administration Depend on Their Shape.” Nanomedicine: Nanotechnology, Biology, and Medicine 11 (8): 1915–1924. doi:10.1016/j.nano.2015.07.004.
   PubMed Web of Science ®Google Scholar
• Liang, C. L., Q. Xiang, W. M. Cui, J. Fang, N. N. Sun, X. P. Zhang, Y. N. Li, H. Yang, Z. Yu, and X. D. Jia. 2018. “Subchronic Oral Toxicity of Silica Nanoparticles and Silica Microparticles in Rats.” Biomedical and Environmental Sciences: BES 31 (3): 197–207. doi:10.3967/bes2018.025.
   PubMed Web of Science ®Google Scholar
• Liljenström, C., D. Lazarevic, and G. Finnveden. 2013. Silicon-based nanomaterials in a life-cycle perspective, including a case study on self-cleaning coatings. ISBN 978-91-7501-942-0.
   Google Scholar
• Lin, Y. S., and C. L. Haynes. 2010. “CH2-Hemolysis and Size Different MSN.” Journal of the American Chemical Society 132 (13): 4834–4842. doi:10.1021/ja910846q.
   PubMed Web of Science ®Google Scholar
• Lindberg, H. K., G. C.-M. Falck, J. Catalán, A. J. Koivisto, S. Suhonen, H. Järventaus, E. M. Rossi, et al. 2012. “Genotoxicity of Inhaled Nanosized TiO(2) in Mice.” Mutation Research 745 (1–2): 58–64. doi:10.1016/j.mrgentox.2011.10.011.
   PubMed Web of Science ®Google Scholar
• Maser, E., M. Schulz, U. G. Sauer, M. Wiemann, L. Ma-Hock, W. Wohlleben, A. Hartwig, and R. Landsiedel. 2015. “In Vitro and in Vivo Genotoxicity Investigations of Differently Sized Amorphous SiO2 Nanomaterials.” Mutation Research. Genetic Toxicology and Environmental Mutagenesis 794: 57–74. doi:10.1016/j.mrgentox.2015.10.005.
   PubMed Web of Science ®Google Scholar
• Maurer-Jones, M. A., Y. S. Lin, and C. L. Haynes. 2010. “Functional Assessment of Metal Oxide Nanoparticle Toxicity in Immune Cells.” ACS Nano 4 (6): 3363–3373. doi:10.1021/nn9018834.
   PubMed Web of Science ®Google Scholar
• Morfeld, P., A. Bosch, K. Weber, M. Heinemann, and N. Krueger. 2017. “Synthetic Amorphous Silica in Food: Findings about “Liver Fibrosis “and Other Study-Related Findings in Van der Zande et al. (2014) are Questionable.” EC Pharmacology and Toxicology 3.2: 49–61.
   Google Scholar
• Murugadoss, S., D. Lison, L. Godderis, S. Van Den Brule, J. Mast, F. Brassinne, N. Sebaihi, and P. H. Hoet. 2017. “Toxicology of Silica Nanoparticles: An Update.” Archives of Toxicology 91 (9): 2967–3010. doi:10.1007/s00204-017-1993-y.
   PubMed Web of Science ®Google Scholar
• Nagpal, R., S. Wang, L. C. Solberg Woods, O. Seshie, S. T. Chung, C. A. Shively, T. C. Register, S. Craft, D. A. McClain, and H. Yadav. 2018. “Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-Human Primate, and Human Feces.” Frontiers in Microbiology 9: 2897. doi:10.3389/fmicb.2018.02897.
   PubMed Web of Science ®Google Scholar
• OECD. 2014. Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453: Second Edition, OECD Series on Testing and Assessment, No. 116. Paris: OECD Publishing.
   Google Scholar
• OECD. 2016. Test No. 474: Mammalian Erythrocyte Micronucleus Test, OECD Guidelines for the Testing of Chemicals, Section 4. Paris: OECD Publishing.
   Google Scholar
• Pfuhler, S., T. R. Downs, A. J. Allemang, Y. Shan, and M. E. Crosby. 2017. “Weak Silica Nanomaterial-Induced Genotoxicity Can Be Explained by Indirect DNA Damage as Shown by the OGG1-Modified Comet Assay and Genomic Analysis.” Mutagenesis 32 (1): 5–12. doi:10.1093/mutage/gew064.
   PubMed Web of Science ®Google Scholar
• Roth, G. A., M. D. P. S. Peña, N. M. Neu-Baker, S. Tahiliani, and S. A. Brenner. 2015. “Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping.” Journal of Visualized Experiments (106): e53317. doi:10.3791/53317.
   PubMed Web of Science ®Google Scholar
• Sahlgren, N. M., R. Atluri, O. Aguerre-Chariol, Y. Kembouche, P. A. Clausen, and K. A. Jensen. forthcoming. “Physicochemical Characteristics of Mesoporous Silica with and without CuO-Doping and Their Dissolution in Artificial Lung Fluids.”
   Google Scholar
• Talamini, L., M. B. Violatto, Q. Cai, M. P. Monopoli, K. Kantner, Ž. Krpetić, A. Perez-Potti, et al. 2017. “Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles.” ACS Nano 11 (6): 5519–5529. doi:10.1021/acsnano.7b00497.
   PubMed Web of Science ®Google Scholar
• Tao, Z., B. B. Toms, J. Goodisman, and T. Asefa. 2009. “Mesoporosity and Functional Group Dependent Endocytosis and Cytotoxicity of Silica Nanomaterials.” Chemical Research in Toxicology 22 (11): 1869–1880. doi:10.1021/tx900276u.
   PubMed Web of Science ®Google Scholar
• Tarantini, A., R. Lanceleur, A. Mourot, M. T. Lavault, G. Casterou, G. Jarry, K. Hogeveen, and V. Fessard. 2015. “Toxicity, Genotoxicity and Proinflammatory Effects of Amorphous Nanosilica in the Human Intestinal Caco-2 Cell Line.” Toxicology In Vitro: Vitro 29 (2): 398–407. doi:10.1016/j.tiv.2014.10.023.
   PubMed Web of Science ®Google Scholar
• Tassinari, R., G. Di Felice, C. Butteroni, B. Barletta, S. Corinti, F. Cubadda, F. Aureli, et al. 2020. “Hazard Identification of Pyrogenic Synthetic Amorphous Silica (NM-203) after Sub-Chronic Oral Exposure in Rat: A Multitarget Approach.” Food and Chemical Toxicology 137: 111168. doi:10.1016/j.fct.2020.111168.
   PubMed Web of Science ®Google Scholar
• van der Zande, M., R. J. Vandebriel, M. J. Groot, E. Kramer, Z. E. Herrera Rivera, K. Rasmussen, J. S. Ossenkoppele, et al. 2014. “Sub-Chronic Toxicity Study in Rats Orally Exposed to Nanostructured Silica.” Particle and Fibre Toxicology 11 (1): 8. doi:10.1186/1743-8977-11-8.
   PubMedGoogle Scholar
• Vance, M. E., T. Kuiken, E. P. Vejerano, S. P. McGinnis, M. F. Hochella, D. Rejeski, M. S. Hull, and M. S. Hull. 2015. “Nanotechnology in the Real World: Redeveloping the Nanomaterial Consumer Products Inventory.” Beilstein Journal of Nanotechnology 6: 1769–1780. doi:10.3762/bjnano.6.181.
   PubMed Web of Science ®Google Scholar
• Walczak, A. P., E. Kramer, P. J. M. Hendriksen, R. Helsdingen, M. van der Zande, I. M. C. M. Rietjens, and H. Bouwmeester. 2015. “In Vitro Gastrointestinal Digestion Increases the Translocation of Polystyrene Nanoparticles in an in Vitro Intestinal co-Culture Model.” Nanotoxicology 9 (7): 886–894. doi:10.3109/17435390.2014.988664.
   PubMed Web of Science ®Google Scholar
• Wen, C. -J., L. -W. Zhang, S. A. Al-Suwayeh, T. -C. Yen, and J. -Y. Fang. 2012. “Theranostic Liposomes Loaded with Quantum Dots and Apomorphine for Brain Targeting and Bioimaging.” International Journal of Nanomedicine 7: 1599–1611. doi:10.2147/IJN.S29369.
   PubMed Web of Science ®Google Scholar
• Yoshida, T., Y. Yoshioka, H. Takahashi, K. Misato, T. Mori, T. Hirai, K. Nagano, et al. 2014. “Intestinal Absorption and Biological Effects of Orally Administered Amorphous Silica Particles.” Nanoscale Research Letters 9 (1): 532–537. doi:10.1186/1556-276X-9-532.
   PubMedGoogle Scholar
• Yu, T., K. Greish, L. D. McGill, A. Ray, and H. Ghandehari. 2012. “Influence of Geometry, Porosity, and Surface Characteristics of Silica Nanoparticles on Acute Toxicity: Their Vasculature Effect and.” ACS Nano 6 (3): 2289–2301. doi:10.1021/nn2043803.
   PubMed Web of Science ®Google Scholar
• Yun, J. -W., S. -H. Kim, J. -R. You, W. H. Kim, J. -J. Jang, S. -K. Min, H. C. Kim, et al. 2015. “Comparative Toxicity of Silicon Dioxide, Silver and Iron Oxide Nanoparticles after Repeated Oral Administration to Rats.” Journal of Applied Toxicology: JAT 35 (6): 681–693. doi:10.1002/jat.3125.
   PubMed Web of Science ®Google Scholar