Organ-specific toxicity of magnetic iron oxide-based nanoparticles

References

• Ahmad, F., X. Liu, Y. Zhou, H. Yao, F. Zhao, Z. Ling, and C. Xu. 2016. “Assessment of Thyroid Endocrine System Impairment and Oxidative Stress Mediated by Cobalt Ferrite (CoFe2 O4) Nanoparticles in Zebrafish Larvae.” Environmental Toxicology 31 (12): 2068–2080. doi:10.1002/tox.22206.
   PubMed Web of Science ®Google Scholar
• Akilo, O. D., Y. E. Choonara, A. M. Strydom, L. C. Du Toit, P. Kumar, G. Modi, and V. Pillay. 2016. “An in Vitro Evaluation of a Carmustine-Loaded Nano-co-Plex for Potential Magnetic-Targeted Intranasal Delivery to the Brain.” International Journal of Pharmaceutics 500 (1–2): 196–209. doi:10.1016/j.ijpharm.2016.01.043.
   PubMed Web of Science ®Google Scholar
• Akter, M., M. T. Sikder, M. M. Rahman, A. K. M. Ullah, F. B. Hossain, S. Banik, T. Hosokawa, et al. 2018. “A Systematic Review on Silver Nanoparticles-Induced Cytotoxicity: Physicochemical Properties and Perspectives.” Journal of Advanced Research 9: 1–16. doi:10.1016/j.jare.2017.10.008.
   PubMed Web of Science ®Google Scholar
• Alabi, O. A., A. H. Silva, L. R. P. Purnhagen, G. R. R. Souza, M. L. de, Júnior, F. B. Filippin-Monteiro, M. Dalmina, et al. 2019. “Genetic, Reproductive and Oxidative Damage in Mice Triggered by Co-exposure of Nanoparticles: From a Hypothetical Scenario to a Real Concern.” Science of the Total Environment 660: 1264–1273. doi:10.1016/j.scitotenv.2019.01.036.
   PubMed Web of Science ®Google Scholar
• Alarifi, S., D. Ali, and S. Alkahtani. 2015. “Nanoalumina Induces Apoptosis by Impairing Antioxidant Enzyme Systems in Human Hepatocarcinoma Cells.” International Journal of Nanomedicine 10: 3751–3760. doi:10.2147/IJN.S82050.
   PubMed Web of Science ®Google Scholar
• Almeida, S. O., and M. Budoff. 2019. “Effect of Statins on Atherosclerotic Plaque.” Trends in Cardiovascular Medicine 29 (8): 451–455. doi:10.1016/j.tcm.2019.01.001.
   PubMed Web of Science ®Google Scholar
• Amin, R. M., A. Abdelmonem, T. Verwanger, E. Elsherbini, and B. Krammer. 2014. “Cytotoxicity of Magnetic Nanoparticles on Normal and Malignant Human Skin Cells.” Nano LIFE 04 (01): 1440002. doi:10.1142/S1793984414400029.
   Google Scholar
• Anderson, Lisa J., Mark A. Westwood, Sally Holden, Bernard Davis, Emma Prescott, Beatrix Wonke, John B. Porter, et al. 2004. “Myocardial Iron Clearance during Reversal of Siderotic Cardiomyopathy with Intravenous Desferrioxamine: A Prospective Study Using T2 Cardiovascular Magnetic Resonance.” British Journal of Haematology 127 (3): 348–355. doi:10.1111/j.1365-2141.2004.05202.x.
   PubMed Web of Science ®Google Scholar
• Ansari, S. A. M. K., E. Ficiarà, F. A. Ruffinatti, I. Stura, M. Argenziano, O. Abollino, R. Cavalli, et al. 2019. “Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System.” Materials (Basel) 12 (3): 465. doi:10.3390/ma12030465.
   PubMed Web of Science ®Google Scholar
• Arami, Hamed, Amit P. Khandhar, Asahi Tomitaka, Elaine Yu, Patrick W. Goodwill, Steven M. Conolly, and Kannan M. Krishnan. 2015a. “In Vivo Multimodal Magnetic Particle Imaging (MPI) with Tailored Magneto/Optical Contrast Agents.” Biomaterials 52: 251–261. doi:10.1016/j.biomaterials.2015.02.040.
   PubMed Web of Science ®Google Scholar
• Arami, H., A. P. Khandhar, D. Liggitt, and K. M. Krishnan. 2015b. “In Vivo Delivery, Pharmacokinetics, Biodistribution and Toxicity of Iron Oxide Nanoparticles.” Chemical Society Reviews 44 (23): 8576–8607. doi:10.1039/C5CS00541H.
   PubMed Web of Science ®Google Scholar
• Arias, L. S., J. P. Pessan, A. P. M. Vieira, T. M. T. Lima, A. C. B. Delbem, and D. R. Monteiro. 2018. “Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity.” Antibiotics (Basel) 7 (2): 46. doi:10.3390/antibiotics7020046.
   Web of Science ®Google Scholar
• Askri, D., S. Ouni, S. Galai, J. Arnaud, B. Chovelon, S. G. Lehmann, N. Sturm, et al. 2018a. “Intranasal Instillation of Iron Oxide Nanoparticles Induces Inflammation and Perturbation of Trace Elements and Neurotransmitters, but Not Behavioral Impairment in Rats.” Environmental Science and Pollution Research International 25 (17): 16922–16932. doi:10.1007/s11356-018-1854-0.
   PubMed Web of Science ®Google Scholar
• Askri, D., S. Ouni, S. Galai, B. Chovelon, J. Arnaud, S. G. Lehmann, M. Sakly, et al. 2018b. “Sub-acute Intravenous Exposure to Fe2O3 Nanoparticles does not Alter Cognitive Performances and Catecholamine Levels, but Slightly Disrupts Plasma Iron Level and Brain Iron Content in Rats.” Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS) 50: 73–79. doi:10.1016/j.jtemb.2018.06.006.
   PubMed Web of Science ®Google Scholar
• Askri, D., S. Ouni, S. Galai, B. Chovelon, J. Arnaud, N. Sturm, S. G. Lehmann, et al. 2019a. “Nanoparticles in Foods? A Multiscale Physiopathological Investigation of Iron Oxide Nanoparticle Effects on Rats after an Acute Oral Exposure: Trace Element Biodistribution and Cognitive Capacities.” Food and Chemical Toxicology 127: 173–181. doi:10.1016/j.fct.2019.03.006.
   PubMed Web of Science ®Google Scholar
• Askri, D., V. Cunin, D. Béal, S. Berthier, B. Chovelon, J. Arnaud, W. Rachidi, et al. 2019b. “Investigating the Toxic Effects Induced by Iron Oxide Nanoparticles on Neuroblastoma Cell Line: An Integrative Study Combining Cytotoxic, Genotoxic and Proteomic Tools.” Nanotoxicology 13 (8): 1021–1040. doi:10.1080/17435390.2019.1621399.
   PubMed Web of Science ®Google Scholar
• Askri, D., V. Cunin, S. Ouni, D. Beal, W. Rachidi, M. Sakly, S. Amara, et al. 2019c. “Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics.” International Journal of Molecular Sciences 20 (20): 5186. doi:10.3390/ijms20205186.
   Google Scholar
• Awaad, A. 2015. “Histopathological and Immunological Changes Induced by Magnetite Nanoparticles in the Spleen, Liver and Genital Tract of Mice following Intravaginal Instillation.” Journal of Basic and Applied Zoology 71: 32–47. doi:10.1016/j.jobaz.2015.03.003.
   Google Scholar
• Ayres-de-Campos, D. 2017. Obstetric Emergencies: A Practical Guide, edited by Ayres-de-Campos D, Vol. 1, 94, Chapter 2.1. Switzerland: Springer International Publishing. doi:10.1007/978-3-319-41656-4_2
   Google Scholar
• Baratli, Y., A. L. Charles, V. Wolff, L. B. Tahar, L. Smiri, J. Bouitbir, J. Zoll, et al. 2014. “Age Modulates Fe3O4 Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats.” Biomed Research International 2014: 1–10. doi:10.1155/2014/474081.
   Web of Science ®Google Scholar
• Baroli, B., M. G. Ennas, F. Loffredo, M. Isola, R. Pinna, and M. A. López-Quintela. 2007. “Penetration of Metallic Nanoparticles in Human Full-Thickness Skin.” The Journal of Investigative Dermatology 127 (7): 1701–1712. doi:10.1038/sj.jid.5700733.
   PubMed Web of Science ®Google Scholar
• Behzadi, S., V. Serpooshan, W. Tao, M. A. Hamaly, M. Y. Alkawareek, E. C. Dreaden, D. Brown, et al. 2017. “Cellular Uptake of Nanoparticles: Journey inside the Cell.” Chemical Society Reviews 46 (14): 4218–4244. doi:10.1039/c6cs00636a.
   PubMed Web of Science ®Google Scholar
• Berry, C. C., S. Charles, S. Wells, M. J. Dalby, and A. S. G. Curtis. 2004. “The Influence of Transferrin Stabilised Magnetic Nanoparticles on Human Dermal Fibroblasts in Culture.” International Journal of Pharmaceutics 269 (1): 211–225. doi:10.1016/j.ijpharm.2003.09.042.
   PubMed Web of Science ®Google Scholar
• Blank, F., P. Gerber, B. Rothen-Rutishauser, U. Sakulkhu, J. Salaklang, K. De Peyer, P. Gehr, et al. 2011. “Biomedical Nanoparticles Modulate Specific CD4+ T Cell Stimulation by Inhibition of Antigen Processing in Dendritic Cells.” Nanotoxicology 5 (4): 606–621. doi:10.3109/17435390.2010.541293.
   PubMed Web of Science ®Google Scholar
• Bobo, D., K. J. Robinson, J. Islam, K. J. Thurecht, and S. R. Corrie. 2016. “Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.” Pharmaceutical Research 33 (10): 2373–2387. doi:10.1007/s11095-016-1958-5.
   PubMed Web of Science ®Google Scholar
• Bohnen, M. S., G. Peng, S. H. Robey, C. Terrenoire, V. Iyer, K. J. Sampson, and R. S. Kass. 2017. “Molecular Pathophysiology of Congenital Long QT Syndrome.” Physiological Reviews 97 (1): 89–134. doi:10.1152/physrev.00008.2016.
   PubMed Web of Science ®Google Scholar
• Bostan, H. B., R. Rezaee, M. G. Valokala, K. Tsarouhas, K. Golokhvast, A. M. Tsatsakis, and G. Karimi. 2016. “Cardiotoxicity of Nano-particles.” Life Sciences 165: 91–99. doi:10.1016/j.lfs.2016.09.017.
   PubMed Web of Science ®Google Scholar
• Bourrinet, P., H. H. Bengele, B. Bonnemain, P. Bruno, A. Dencausse, J. M. Idee, M. P. Jacobs, and J. M. Lewis. 2006. “Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent.” Investigative Radiology 41 (3): 313–324. doi:10.1097/01.rli.0000197669.80475.dd.
   PubMed Web of Science ®Google Scholar
• Braet, F., E. Wisse, P. Bomans, P. Frederik, W. Geerts, A. Koster, L. Soon, et al. 2007. “Contribution of High-Resolution Correlative Imaging Techniques in the Study of the Liver Sieve in Three-Dimensions.” Microscopy Research and Technique 70 (3): 230–242. doi:10.1002/jemt.20408.
   PubMed Web of Science ®Google Scholar
• Brohi, Rahim Dad., Li Wang, Hira Sajjad Talpur, Di Wu, Farhan Anwar Khan, Dinesh Bhattarai, Zia-Ur Rehman, F. Farmanullah, and Li-Jun Huo. 2017. “Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review.” Frontiers in Pharmacology 8: 606. doi:10.3389/fphar.2017.00606.
   PubMed Web of Science ®Google Scholar
• Bynoe, M. S., C. Viret, A. Yan, and D. G. Kim. 2015. “Adenosine Receptor Signaling: A Key to Opening the Blood–Brain Door.” Fluids Barriers CNS 12: 20. doi:10.1186/s12987-015-0017-7.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas, Lilian, Angélica González-Maciel, Partha S. Mukherjee, Rafael Reynoso-Robles, Beatriz Pérez-Guillé, Carlos Gayosso-Chávez, Ricardo Torres-Jardón, et al. 2019. “Combustion- and Friction-Derived Magnetic Air Pollution Nanoparticles in Human Hearts.” Environmental Research 176: 108567. doi:10.1016/j.envres.2019.108567.
   PubMed Web of Science ®Google Scholar
• Calderón-Garcidueñas, L., A. Herrera-Soto, N. Jury, B. A. Maher, A. González-Maciel, R. Reynoso-Robles, P. Ruiz-Rudolph, et al. 2020. “Reduced Repressive Epigenetic Marks, Increased DNA Damage and Alzheimer's Disease Hallmarks in the Brain of Humans and Mice Exposed to Particulate Urban Air Pollution.” Environmental Research 183: 109226. doi:10.1016/j.envres.2020.109226.
   PubMed Web of Science ®Google Scholar
• Caro, C., D. Egea-Benavente, R. Polvillo, J. L. Royo, M. P. Leal, and M. L. García-Martín. 2019. “Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in Vivo Applications.” Colloids and Surfaces. B: Biointerfaces 177: 253–259. doi:10.1016/j.colsurfb.2019.01.051.
   PubMed Web of Science ®Google Scholar
• Chahinez, T., R. Rachid, G. Salim, B. Lamia, Z. Ghozala, T. Nadjiba, S. Aya, et al. 2016. “Toxicity of Fe 3 O 4 Nanoparticles on Oxidative Stress Status, Stromal Enzymes and Mitochondrial Respiration and Swelling of Oryctolagus Cuniculus Brain Cortex.” Toxicology and Environmental Health Sciences 8 (5): 349–355. doi:10.1007/s13530-016-0296-7.
   Google Scholar
• Chapel, J. M., M. D. Ritchey, D. Zhang, and G. Wang. 2017. “Prevalence and Medical Costs of Chronic Diseases among Adult Medicaid Beneficiaries.” American Journal of Preventive Medicine 53 (6S2): S143–S154. doi:10.1016/j.amepre.2017.07.019.
   PubMed Web of Science ®Google Scholar
• Choi, H. S., B. I. Ipe, P. Misra, J. H. Lee, M. G. Bawendi, and V. John. 2009. “Frangioni Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots.” Nano Letters 9 (6): 2354–2359. doi:10.1021/nl900872r.
   PubMed Web of Science ®Google Scholar
• Choudhury, Hira, Manisha Pandey, Pei Xin Chin, Yee Lin Phang, Jeng Yuen Cheah, Shu Chien Ooi, Kit-Kay Mak, et al. 2018. “Transferrin Receptors-Targeting Nanocarriers for Efficient Targeted Delivery and Transcytosis of Drugs into the Brain Tumors: A Review of Recent Advancements and Emerging Trends.” Drug Delivery and Translational Research 8 (5): 1545–1563. doi:10.1007/s13346-018-0552-2.
   PubMed Web of Science ®Google Scholar
• Cochran, D. B., P. P. Wattamwar, R. Wydra, J. Z. Hilt, K. W. Anderson, R. E. Eitel, and T. D. Dziubla. 2013. “Suppressing Iron Oxide Nanoparticle Toxicity by Vascular Targeted Antioxidant Polymer Nanoparticles.” Biomaterials 34 (37): 9615–9622. doi:10.1016/j.biomaterials.2013.08.025.
   PubMed Web of Science ®Google Scholar
• Conrad, M., and B. Proneth. 2019. “Broken Hearts: Iron Overload, Ferroptosis and Cardiomyopathy.” Cell Research 29 (4): 263–264. doi:10.1038/s41422-019-0150-y.
   PubMed Web of Science ®Google Scholar
• Corot, C., P. Robert, J. M. Idée, and M. Port. 2006. “Recent Advances in Iron Oxide Nanocrystal Technology for Medical Imaging.” Advanced Drug Delivery Reviews 58 (14): 1471–1504. doi:10.1016/j.addr.2006.09.013.
   PubMed Web of Science ®Google Scholar
• Crist, R. M., S. S. K. Dasa, C. H. Liu, J. D. Clogston, M. A. Dobrovolskaia, and S. T. Stern. 2020. “Challenges in the Development of Nanoparticle‐Based Imaging Agents: Characterization and Biology.” Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology e1665. doi:10.1002/wnan.1665.
   PubMed Web of Science ®Google Scholar
• Cromer Berman, S. M., C. J. W. Kshitiz, I. Orukari, A. Levchenko, J. W. M. Bulte, and P. Walczak. 2013. “Cell Motility of Neural Stem Cells is Reduced after SPIO-Labeling, Which is Mitigated after Exocytosis.” Magnetic Resonance in Medicine 69 (1): 255–262. doi:10.1002/mrm.24216.
   PubMed Web of Science ®Google Scholar
• Crowe, T. P., M. H. W. Greenlee, A. G. Kanthasamy, and W. H. Hsu. 2018. “Mechanism of Intranasal Drug Delivery Directly to the Brain.” Life Sciences 195: 44–52. doi:10.1016/j.lfs.2017.12.025.
   PubMed Web of Science ®Google Scholar
• D’Agata, F., F. A. Ruffinatti, S. Boschi, I. Stura, I. Rainero, O. Abollino, et al. 2018. “Magnetic Nanoparticles in the Central Nervous System: Targeting Principles, Applications and Safety Issues.” Molecules 23 (1): 9. doi:10.3390/molecules230100.
   Web of Science ®Google Scholar
• Dalpiaz, A., and B. Pavan. 2018. “Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?” Pharmaceutics 10 (2): 39. doi:10.3390/pharmaceutics10020039.
   PubMed Web of Science ®Google Scholar
• Dhakshinamoorthy, V., V. Manickam, and E. Perumal. 2017. “Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice.” Neurotoxicity Research 32 (2): 187–203. doi:10.1007/s12640-017-9721-1.
   PubMed Web of Science ®Google Scholar
• Di Bona, K. R., Y. Xu, M. Gray, M. Gray, D. Fair, H. Hayles, L. Milad, et al. 2015. “Short- and Long-Term Effects of Prenatal Exposure to Iron Oxide Nanoparticles: Influence of Surface Charge and Dose on Developmental and Reproductive Toxicity.” International Journal of Molecular Sciences 16 (12): 30251–30268. doi:10.3390/ijms161226231.
   PubMed Web of Science ®Google Scholar
• Di Bona, K. R., Y. Xu, P. A. Ramirez, J. DeLaine, C. Parker, Y. Bao, and J. F. Rasco. 2014. “Surface Charge and Dosage Dependent Potential Developmental Toxicity and Biodistribution of Iron Oxide Nanoparticles in Pregnant CD-1 Mice.” Reproductive Toxicology (Elmsford, N.Y.) 50: 36–42. doi:10.1016/j.reprotox.2014.09.010.
   PubMed Web of Science ®Google Scholar
• Dias, A. M. G. C., A. Hussain, A. S. Marcos, and A. C. Roque. 2011. “A Biotechnological Perspective on the Application of Iron Oxide Magnetic Colloids Modified with Polysaccharides.” Biotechnology Advances 29 (1): 142–155. doi:10.1016/j.biotechadv.2010.10.003.
   PubMed Web of Science ®Google Scholar
• Dixon, S. J., K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, et al. 2012. “Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death.” Cell 149 (5): 1060–1072. doi:10.1016/j.cell.2012.03.042.
   PubMed Web of Science ®Google Scholar
• Drozdov, A. S., V. V. Vinogradov, I. P. Dudanov, and V. V. Vinogradov. 2016. “Leach-Proof Magnetic Thrombolytic Nanoparticles and Coatings of Enhanced Activity.” Scientific Reports 6: 28119. doi:10.1038/srep28119.
   PubMed Web of Science ®Google Scholar
• Drozdov, A. S., K. V. Volodina, V. V. Vinogradov, and V. V. Vinogradov. 2015. “Biocomposites for Wound-Healing Based on Sol–Gel Magnetite.” RSC Advances 5 (101): 82992–82997. doi:10.1039/C5RA16177K.
   Web of Science ®Google Scholar
• Du, B., M. Yu, and J. Zheng. 2018. “Transport and Interactions of Nanoparticles in the Kidneys.” Nature Reviews Materials 3 (10): 358–374. doi:10.1038/s41578-018-0038-3.
   Web of Science ®Google Scholar
• Du, Li-Jing, Kun Xiang, Jia-Hui Liu, Zheng-Mei Song, Yuanfang Liu, Aoneng Cao, and Haifang Wang. 2018. “Intestinal Injury Alters Tissue Distribution and Toxicity of ZnO Nanoparticles in Mice.” Toxicology Letters 295: 74–85. doi:10.1016/j.toxlet.2018.05.038.
   PubMed Web of Science ®Google Scholar
• Du, Rong-Hui, Li-Rong Liang, Cheng-Qing Yang, Wen Wang, Tan-Ze Cao, Ming Li, Guang-Yun Guo, et al. 2020. “Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study.” European Respiratory Journal 55 (5): 2000524. doi:10.1183/13993003.00524-2020.
   PubMed Web of Science ®Google Scholar
• Dwivedi, S., M. A. Siddiqui, N. N. Farshori, M. Ahamed, J. Musarrat, and A. A. Al-Khedhairy. 2014. “Synthesis, Characterization and Toxicological Evaluation of Iron Oxide Nanoparticles in Human Lung Alveolar Epithelial Cells.” Colloids and Surfaces. B, Biointerfaces 122: 209–215. doi:10.1016/j.colsurfb.2014.06.064.
   PubMed Web of Science ®Google Scholar
• Einav, S., and M. Leone. 2019. “Epidemiology of Obstetric Critical Illness.” International Journal of Obstetric Anesthesia 40: 128–139. doi:10.1016/j.ijoa.2019.05.010.
   PubMed Web of Science ®Google Scholar
• Elgharabawy, R. M., D. M. Elgharbawy, and A. M. Emara. 2018. “Activation of the Molecular and Functional Effects of Nrf2 against Chronic Iron Oxide Nanorod Overload-Induced Cardiotoxicity.” Human & Experimental Toxicology 37 (8): 870–885. doi:10.1177/0960327117741751.
   PubMed Web of Science ®Google Scholar
• Engin, A. B., and A. Engin. 2019. “Nanoparticles and Neurotoxicity: Dual Response of Glutamatergic Receptors.” Progress in Brain Research 245: 281–303. doi:10.1016/bs.pbr.2019.03.005.
   PubMed Web of Science ®Google Scholar
• Facciolà, Alessio, Giuseppa Visalli, Sebastiano La Maestra, Manuela Ceccarelli, Francesco D'Aleo, Giuseppe Nunnari, Giovanni Francesco Pellicanò, et al. 2019. “Carbon Nanotubes and Central Nervous System: Environmental Risks, Toxicological Aspects and Future Perspectives.” Environmental Toxicology and Pharmacology 65: 23–30. doi:10.1016/j.etap.2018.11.006.
   PubMed Web of Science ®Google Scholar
• Fahmy, Heba M., Esraa M. Aly, Faten F. Mohamed, Neveen A. Noor, and Anwar A. Elsayed. 2020. “Neurotoxicity of Green-Synthesized Magnetic Iron Oxide Nanoparticles in Different Brain Areas of Wistar Rats.” Neurotoxicology 77: 80–93. doi:10.1016/j.neuro.2019.12.014.
   PubMed Web of Science ®Google Scholar
• Fakhardo, Anna F., Elizaveta I. Anastasova, Sabina R. Gabdullina, Anastasia S. Solovyeva, Valeria B. Saparova, Vladimir V. Chrishtop, Ekaterina D. Koshevaya, et al. 2019. “Toxicity Patterns of Clinically Relevant Metal Oxide Nanoparticles.” ACS Applied Bio Materials 2 (10): 4427–4435. doi:10.1021/acsabm.9b00615.
   Google Scholar
• Fallahi, S., Z. Hooshmandi, and M. Setorki. 2017. “The Effects of Fe4NiO4Zn Nanoparticles on Thyroid Tissue and Serum Level of T3, T4 and TSH.” Journal of Shahrekord University of Medical Sciences 18 (6): 115–124. URL: http://journal.skums.ac.ir/article-1-2699-en.html.
   Google Scholar
• Faust, J. J., W. Zhang, Y. Chen, and D. G. Capco. 2014. “Alpha-Fe(2)O(3) Elicits Diameter-Dependent Effects during Exposure to an in Vitro Model of the Human Placenta.” Cell Biology and Toxicology 30 (1): 31–53. doi:10.1007/s10565-013-9267-9.
   PubMed Web of Science ®Google Scholar
• Feng, Q., Y. Liu, J. Huang, K. Chen, J. Huang, and K. Xiao. 2018. “Uptake Distribution, Clearance, and Toxicity of Iron Oxide Nanoparticles with Different Sizes and Coatings.” Scientific Reports 8: 2082.
   PubMed Web of Science ®Google Scholar
• Fernández-Bertólez, N., C. Costa, F. Brandão, G. Kiliç, J. P. Teixeira, E. Pásaro, B. Laffon, et al. 2018. “Neurotoxicity Assessment of Oleic Acid-Coated Iron Oxide Nanoparticles in SH-SY5Y Cells.” Toxicology 406–407: 81–91. doi:10.1016/j.tox.2018.06.003.
   PubMed Web of Science ®Google Scholar
• Fernández-Bertólez, N., C. Costa, F. Brandão, J. A. Duarte, J. P. Teixeira, E. Pásaro, V. Valdiglesias, et al. 2019. “Evaluation of Cytotoxicity and Genotoxicity Induced by Oleic Acid-Coated Iron Oxide Nanoparticles in Human Astrocytes.” Environmental and Molecular Mutagenesis 60 (9): 816–829. doi:10.1002/em.22323.
   PubMed Web of Science ®Google Scholar
• Fernández-Real, J. M., and M. Manco. 2014. “Effects of Iron Overload on Chronic Metabolic Diseases.” The Lancet. Diabetes & Endocrinology 2 (6): 513–526. doi:10.1016/S2213-8587(13)70174-8.
   PubMed Web of Science ®Google Scholar
• Frtús, Adam, Barbora Smolková, Mariia Uzhytchak, Mariia Lunova, Milan Jirsa, Šárka Kubinová, Alexandr Dejneka, et al. 2020. “Analyzing the Mechanisms of Iron Oxide Nanoparticles Interactions with Cells: A Road from Failure to Success in Clinical Applications.” Journal of Controlled Release: Official Journal of the Controlled Release Society 328: 59–77. doi:10.1016/j.jconrel.2020.08.036.
   PubMed Web of Science ®Google Scholar
• Gabrielsen, J. S., D. J. Lamb, and L. I. Lipshultz. 2018. “Iron and a Man's Reproductive Health: The Good, the Bad, and the Ugly.” Current Urology Reports 19 (8): 60. doi:10.1007/s11934-018-0808-x.
   PubMed Web of Science ®Google Scholar
• Gaharwar, U. S., R. Meena, and P. Rajamani. 2019. “Biodistribution, Clearance and Morphological Alterations of Intravenously Administered Iron Oxide Nanoparticles in Male Wistar Rats.” International Journal of Nanomedicine 14: 9677–9692. doi:10.2147/IJN.S223142.
   PubMed Web of Science ®Google Scholar
• Gazibara, T., T. Pekmezović, A. Popović, M. Paunić, and D. Kisić-Tepavčević. 2018. “Chronic Diseases among University Students: Prevalence, Patterns and Impact on Health-Related Quality of Life.” Vojnosanitetski Pregled 75 (12): 1178–1184. doi:10.2298/VSP160920050G.
   Web of Science ®Google Scholar
• Ghadiri, M., E. Vasheghani‐Farahani, F. Atyabi, F. Kobarfard, F. Mohamadyar‐Toupkanlou, and H. Hosseinkhani. 2017. “Transferrin-Conjugated Magnetic Dextran-Spermine Nanoparticles for Targeted Drug Transport cross Blood–Brain Barrier.” Journal of Biomedical Materials Research. Part A 105 (10): 2851–2864. doi:10.1002/jbm.a.36145.
   PubMed Web of Science ®Google Scholar
• Giannopoulou, I., M. A. Pagida, D. D. Briana, and M. T. Panayotacopoulou. 2018. “Perinatal Hypoxia as a Risk Factor for Psychopathology Later in Life: The Role of Dopamine and Neurotrophins.” Hormones (Athens, Greece) 17 (1): 25–32. doi:10.1007/s42000-018-0007-7.
   PubMedGoogle Scholar
• Gómez-Vallejo, V., M. Puigivila, S. Plaza-García, B. Szczupak, R. Piñol, J. L. Murillo, V. Sorribas, et al. 2018.“ PEG-Copolymer-Coated Iron Oxide Nanoparticles that Avoid the Reticuloendothelial System and Act as Kidney MRI Contrast Agents.” Nanoscale 10 (29): 14153–14164. doi:10.1039/c8nr03084g.
   PubMed Web of Science ®Google Scholar
• Gonnissen, D., Y. Qu, K. Langer, C. Öztürk, Y. Zhao, C. Chen, G. Seebohm, et al. 2016. “Comparison of Cellular Effects of Starch-Coated SPIONs and Poly(Lactic-co-Glycolic Acid) Matrix Nanoparticles on Human Monocytes.” International Journal of Nanomedicine 11: 5221–5236. doi:10.2147/IJN.S106540.
   PubMed Web of Science ®Google Scholar
• González-Maciel, A., R. Reynoso-Robles, R. Torres-Jardón, P. S. Mukherjee, and L. Calderón-Garcidueñas. 2017. “Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer's Disease Development.” Journal of Alzheimer's Disease 59 (1): 189–208. doi:10.3233/JAD-170012.
   PubMed Web of Science ®Google Scholar
• Gu, L., R. H. Fang, M. J. Sailor, and J. H. Park. 2012. “In Vivo Clearance and Toxicity of Monodisperse Iron Oxide Nanocrystals.” ACS Nano 6 (6): 4947–4954. doi:10.1021/nn300456z.
   PubMed Web of Science ®Google Scholar
• Gualdani, R., A. Guerrini, E. Fantechi, F. Tadini-Buoninsegni, M. R. Moncelli, and C. Sangregorio. 2019. “Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Modulate hERG Ion Channel Activity.” Nanotoxicology 13 (9): 1197–1209. doi:10.1080/17435390.2019.1650969.
   PubMed Web of Science ®Google Scholar
• Hamm, B., T. Staks, M. Taupitz, R. Maibauer, A. Speidel, A. Huppertz, T. Frenzel, et al. 1994. “Contrast-Enhanced MR Imaging of Liver and Spleen: First Experience in Humans with a New Superparamagnetic Iron Oxide.” Journal of Magnetic Resonance Imaging 4 (5): 659–668. doi:10.1002/jmri.1880040508.
   PubMed Web of Science ®Google Scholar
• Hanini, A., A. Schmitt, K. Kacem, F. Chau, S. Ammar, and J. Gavard. 2011. “Evaluation of Iron Oxide Nanoparticle Biocompatibility.” International Journal of Nanomedicine 6: 787–794. doi:10.2147/IJN.S17574.
   PubMed Web of Science ®Google Scholar
• Harisinghani, M. G., J. Barentsz, P. F. Hahn, W. M. Deserno, S. Tabatabaei, C. H. van de Kaa, J. de la Rosette, et al. 2003. “Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer.” New England Journal of Medicine 348 (25): 2491–2499. doi:10.1056/NEJMoa022749.
   PubMed Web of Science ®Google Scholar
• Harris, J. M., and R. B. Chess. 2003. “Effect of Pegylation on Pharmaceuticals.” Nature Reviews. Drug Discovery 2 (3): 214–221. doi:10.1038/nrd1033.
   PubMed Web of Science ®Google Scholar
• Hasan, A., M. Morshed, A. Memic, S. Hassan, T. J. Webster, and H. E. Marei. 2018. “Nanoparticles in Tissue Engineering: Applications, Challenges and Prospects.” International Journal of Nanomedicine 13: 5637–5655. doi:10.2147/IJN.S153758.
   PubMed Web of Science ®Google Scholar
• He, Q., Z. Zhang, F. Gao, Y. Li, and J. Shi. 2011. “In Vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation.” Small (Weinheim an Der Bergstrasse, Germany) 7 (2): 271–280. doi:10.1002/smll.201001459.
   PubMed Web of Science ®Google Scholar
• Hossen, S., M. K. Hossain, M. K. Basher, M. N. H. Mia, M. T. Rahman, and M. J. Uddin. 2019. “Smart Nanocarrier-Based Drug Delivery Systems for Cancer Therapy and Toxicity Studies: A Review.” Journal of Advanced Research 15: 1–18. doi:10.1016/j.jare.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Hou, C. C., and J. Q. Zhu. 2017. “Nanoparticles and Female Reproductive System: How Do Nanoparticles Affect Oogenesis and Embryonic Development.” Oncotarget 8 (65): 109799–109817. doi:10.18632/oncotarget.19087.
   PubMedGoogle Scholar
• Hou, W., Y. Xie, X. Song, X. Sun, M. T. Lotze, H. J. Zeh, III, R. Kang, et al. 2016. “Autophagy Promotes Ferroptosis by Degradation of Ferritin.” Autophagy 12 (8): 1425–1428. doi:10.1080/15548627.2016.1187366.
   PubMed Web of Science ®Google Scholar
• Huang, C. C., C. Y. Tsai, H. S. Sheu, K. Y. Chuang, C. H. Su, U. S. Jeng, F. Y. Cheng, et al. 2011. “Enhancing Transversal Relaxation for Magnetite Nanoparticles in MR Imaging Using Gd³+- Chelated Mesoporous Silica Shells.” ACS Nano 5 (5): 3905–3916. doi:10.1021/nn200306g.
   PubMed Web of Science ®Google Scholar
• Huo, T., Y. Jia, C. Yin, X. Luo, J. Zhao, Z. Wang, and P. Lv. 2019. “Iron Dysregulation in Vascular Dementia: Focused on the AMPK/Autophagy Pathway.” Brain Research Bulletin 153: 305–313. doi:10.1016/j.brainresbull.2019.09.006.
   PubMed Web of Science ®Google Scholar
• Hussain, S. M., K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager. 2005. “In Vitro Toxicity of Nanoparticles in BRL 3A Rat Liver Cells.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 19 (7): 975–983. doi:10.1016/j.tiv.2005.06.034.
   PubMed Web of Science ®Google Scholar
• Imam, S. Z., S. M. Lantz-McPeak, E. Cuevas, H. Rosas-Hernandez, S. Liachenko, Y. Zhang, S. Sarkar, et al. 2015. “Iron Oxide Nanoparticles Induce Dopaminergic Damage: In Vitro Pathways and in Vivo Imaging Reveals Mechanism of Neuronal Damage.” Molecular Neurobiology 52 (2): 913–926. doi:10.1007/s12035-015-9259-2.
   PubMed Web of Science ®Google Scholar
• Jacobsen, Tove F., Michael Laniado, Bernard E. Van Beers, Benoit Dupas, Frank P. Boudghène, Ernst Rummeny, Theo H. M. Falke, Peter A. Rinck, David MacVicar, and Bjørg Lundby. 1996. “Oral Magnetic Particles (Ferristene) as a Contrast Medium in Abdominal Magnetic Resonance Imaging.” Academic Radiology 3 (7): 571–580. doi:10.1016/S1076-6332(96)80222-4.
   PubMed Web of Science ®Google Scholar
• Jeng, H. A., and J. Swanson. 2006. “Toxicity of Metal Oxide Nanoparticles in Mammalian Cells.” Journal of Environmental Science and Health. Part A, Toxic/Hazardous Substances & Environmental Engineering 41 (12): 2699–2711. doi:10.1080/10934520600966177.
   PubMed Web of Science ®Google Scholar
• Jensen, V. S., T. Porsgaard, J. Lykkesfeldt, and H. Hvid. 2016. “Rodent Model Choice Has Major Impact on Variability of Standard Preclinical Readouts Associated with Diabetes and Obesity Research.” American Journal of Translational Research 8 (8): 3574–3584.
   PubMed Web of Science ®Google Scholar
• Jiang, Ziyu, Kuizhong Shan, Jie Song, Jingbing Liu, Suresh Rajendran, Arivalagan Pugazhendhi, Joe Antony Jacob, and Baoan Chen. 2019. “Toxic Effects of Magnetic Nanoparticles on Normal Cells and Organs.” Life Sciences 220: 156–161. doi:10.1016/j.lfs.2019.01.056.
   PubMed Web of Science ®Google Scholar
• Jung, E., X. Hui, H. Zhu, A. Zhang, W. Wang, B. Buchholz, and H. Maibach. 2019. “Effect of Iron and Silica Nanoparticles’ Size on in Vitro Human Skin Binding and Penetration.” Toxicology Research and Application 3:1–10. doi:10.1177/2397847319893054.
   Google Scholar
• Karlsson, H. L., J. Gustafsson, P. Cronholm, and L. Möller. 2009. “Size-Dependent Toxicity of Metal Oxide Particles – A Comparison between Nano- and Micrometer Size.” Toxicology Letters 188 (2): 112–118. doi:10.1016/j.toxlet.2009.03.014.
   PubMed Web of Science ®Google Scholar
• Karmakar, A., Q. Zhang, and Y. Zhang. 2014. “Neurotoxicity of Nanoscale Materials.” Journal of Food and Drug Analysis 22 (1): 147–160. doi:10.1016/j.jfda.2014.01.012.
   PubMed Web of Science ®Google Scholar
• Katsnelson, Boris A., Tamara D. Degtyareva, Ilzira I. Minigalieva, Larisa I. Privalova, Sergey V. Kuzmin, Olga S. Yeremenko, Ekaterina P. Kireyeva, et al. 2011. “Subchronic Systemic Toxicity and Bioaccumulation of Fe3O4 Nano- and Microparticles following Repeated Intraperitoneal Administration to Rats.” International Journal of Toxicology 30 (1): 59–68., doi: 10.1016/j.toxrep.2018.03.008.
   PubMed Web of Science ®Google Scholar
• Kazemipour, N., S. Nazifi, M. H. H. Poor, Z. Esmailnezhad, R. E. Najafabadi, and E. Abolghasem. 2018. “Hepatotoxicity and Nephrotoxicity of Quercetin, Iron Oxide Nanoparticles, and Quercetin Conjugated with Nanoparticles in Rats.” Comparative Clinical Pathology 27 (6): 1621–1628. doi:10.1007/s00580-018-2783-5.
   Google Scholar
• Kedziorek, D. A., N. Muja, P. Walczak, J. Ruiz-Cabello, A. A. Gilad, C. C. Jie, and W. Jeff. 2010. “Gene Expression Profiling Reveals Early Cellular Responses to Intracellular Magnetic Labeling with Superparamagnetic Iron Oxide Nanoparticles.” Magnetic Resonance in Medicine 63 (4): 1031–1043. doi:10.1002/mrm.22290.
   PubMed Web of Science ®Google Scholar
• Kermanizadeh, A., N. R. Jacobsen, M. Roursgaard, S. Loft, and P. Møller. 2017. “Hepatic Hazard Assessment of Silver Nanoparticle Exposure in Healthy and Chronically Alcohol Fed Mice.” Toxicological Sciences : An Official Journal of the Society of Toxicology 158 (1): 176–187. doi:10.1093/toxsci/kfx080.
   PubMed Web of Science ®Google Scholar
• Khan, A. R., M. Liu, M. W. Khan, and G. Zhai. 2017. “Progress in Brain Targeting Drug Delivery System by Nasal Route.” Journal of Controlled Release : Official Journal of the Controlled Release Society 268: 364–389. doi:10.1016/j.jconrel.2017.09.001.
   PubMed Web of Science ®Google Scholar
• Kiliç, G., N. Fernández-Bertólez, C. Costa, F. Brandão, J. P. Teixeira, E. Pásaro, B. Laffon, et al. 2017. “Chapter 6 – The Application, Neurotoxicity, and Related Mechanism of Iron Oxide Nanoparticles.” Neurotoxicity of Nanomaterials and Nanomedicine, 127–150. New York, NY: Elsevier. doi:10.1016/B978-0-12-804598-5.00006-4..
   Google Scholar
• Kim, B. G., M. K. Park, P. H. Lee, S. H. Lee, J. Hong, M. M. M. Aung, K. T. Moe, et al. 2020. “Effects of Nanoparticles on Neuroinflammation in a Mouse Model of Asthma.” Respiratory Physiology & Neurobiology 271: 103292. doi:10.1016/j.resp.2019.103292.
   PubMed Web of Science ®Google Scholar
• Kim, J. S., T. J. Yoon, K. N. Yu, K. N. Yu, B. G. Kim, S. J. Park, H. W. Kim, et al. 2006. “Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice.” Toxicological Sciences : An Official Journal of the Society of Toxicology 89 (1): 338–347. doi:10.1093/toxsci/kfj027.
   PubMed Web of Science ®Google Scholar
• Kirschvink, J. L., A. Kobayashi-Kirschvink, and B. J. Woodford. 1992. “Magnetite Biomineralization in the Human Brain.” Proceedings of the National Academy of Sciences of the United States of America 89 (16): 7683–7687. doi:10.1073/pnas.89.16.7683.
   PubMed Web of Science ®Google Scholar
• Knorr, F., A. Patzelt, M. C. Meinke, A. Vogt, U. Blume-Peytavi, E. Rühl, and J. Lademann. 2019. “Interactions of Nanoparticles with Skin.” In Biological Responses to Nanoscale Particles, edited by P. Gehr, and R. Zellner, 329–339. Cham: Springer. doi:10.1007/978-3-030-12461-8_13.
   Google Scholar
• Kodali, V., M. H. Littke, S. C. Tilton, J. G. Teeguarden, L. Shi, C. W. Frevert, W. Wang, et al. 2013. “Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles.” ACS Nano 7 (8): 6997–7010. doi:10.1021/nn402145t.
   PubMed Web of Science ®Google Scholar
• Kolosnjaj-Tabi, J., Y. Javed, L. Lartigue, J. Volatron, D. Elgrabli, I. Marangon, G. Pugliese, et al. 2015. “The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice.” ACS Nano 9 (8): 7925–7939. doi:10.1021/acsnano.5b00042.
   PubMed Web of Science ®Google Scholar
• Kornberg, T. G., T. A. Stueckle, J. A. Antonini, Y. Rojanasakul, V. Castranova, Y. Yang, and L. Wang. 2017. “Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk.” Nanomaterials (Basel) 7 (10): 307. doi:10.3390/nano7100307.
   Google Scholar
• Kumari, M., S. Rajak, S. P. Singh, S. I. Kumari, P. U. Kumar, U. S. N. Murty, M. Mahboob, et al. 2012. “Repeated Oral Dose Toxicity of Iron Oxide Nanoparticles: Biochemical and Histopathological Alterations in Different Tissues of Rats.” Journal of Nanoscience and Nanotechnology 12 (3): 2149–2159. doi:10.1166/jnn.2012.5796.
   PubMed Web of Science ®Google Scholar
• Kumari, M., S. Rajak, S. P. Singh, U. S. N. Murty, M. Mahboob, P. Grover, and M. F. Rahman. 2013. “Biochemical Alterations Induced by Acute Oral Doses of Iron Oxide Nanoparticles in Wistar Rats.” Drug and Chemical Toxicology 36 (3): 296–305. doi:10.3109/01480545.2012.720988.
   PubMed Web of Science ®Google Scholar
• Kunzmann, A., B. Andersson, C. Vogt, N. Feliu, F. Ye, S. Gabrielsson, M. S. Toprak, et al. 2011. “Efficient Internalization of Silica-Coated Iron Oxide Nanoparticles of Different Sizes by Primary Human Macrophages and Dendritic Cells.” Toxicology and Applied Pharmacology 253 (2): 81–93. doi:10.1016/j.taap.2011.03.011.
   PubMed Web of Science ®Google Scholar
• Kwon, D., H. W. Nho, and T. H. Yoon. 2014. “X-Ray and Electron Microscopy Studies on the Biodistribution and Biomodification of Iron Oxide Nanoparticles in Daphnia Magna.” Colloids and Surfaces. B, Biointerfaces 122: 384–389. doi:10.1016/j.colsurfb.2014.07.016.
   PubMed Web of Science ®Google Scholar
• Laffon, B., N. Fernández-Bertólez, C. Costa, F. Brandão, J. P. Teixeira, E. Pásaro, and V. Valdiglesias. 2018. “Cellular and Molecular Toxicity of Iron Oxide Nanoparticles.” Advances in Experimental Medicine and Biology 1048: 199–213. doi:10.1007/978-3-319-72041-8_12.
   PubMed Web of Science ®Google Scholar
• Lanks, C. W., A. I. Musani, and D. W. Hsia. 2019. “Community-Acquired Pneumonia and Hospital-Acquired Pneumonia.” The Medical Clinics of North America 103 (3): 487–501. doi:10.1016/j.mcna.2018.12.008.
   PubMed Web of Science ®Google Scholar
• Laurent, S., S. Dutz, U. O. Häfeli, and M. Mahmoudi. 2011. “Magnetic Fluid Hyperthermia: Focus on Superparamagnetic Iron Oxide Nanoparticles.” Advances in Colloid and Interface Science 166 (1–2): 8–23. doi:10.1016/j.cis.2011.04.003.
   PubMed Web of Science ®Google Scholar
• Lei, C., Y. Sun, D. C. W. Tsang, and D. Lin. 2018. “Environmental Transformations and Ecological Effects of Iron-Based Nanoparticles.” Environmental Pollution (Barking, Essex : 1987) 232: 10–30. doi:10.1016/j.envpol.2017.09.052.
   PubMed Web of Science ®Google Scholar
• Leichtmann-Bardoogo, Y., L. A. Cohen, A. Weiss, B. Marohn, S. Schubert, A. Meinhardt, and E. G. Meyron-Holtz. 2012. “Compartmentalization and Regulation of Iron Metabolism Proteins Protect Male Germ Cells from Iron Overload.” American Journal of Physiology-Endocrinology and Metabolism 302 (12): 1519–1530. doi:10.1152/ajpendo.00007.2012.
   Web of Science ®Google Scholar
• Lewinski, N., V. Colvin, and R. Drezek. 2008. “Cytotoxicity of Nanoparticles.” Small (Weinheim an Der Bergstrasse, Germany) 4 (1): 26–49. doi:10.1002/smll.200700595.
   PubMed Web of Science ®Google Scholar
• Lin, Y., C. Hu, A. Chen, X. Feng, H. Liang, S. Yin, G. Zhang, et al. 2020. “Neurotoxicity of Nanoparticles Entering the Brain via Sensory Nerve-to-Brain Pathways: Injuries and Mechanisms.” Archives of Toxicology 94 (5): 1479–1495. doi:10.1007/s00204-020-02701.
   PubMed Web of Science ®Google Scholar
• Liu, Y., J. Li, K. Xu, J. Gu, L. Huang, L. Zhang, N. Liu, et al. 2018. “Characterization of Superparamagnetic Iron Oxide Nanoparticle-Induced Apoptosis in PC12 Cells and Mouse Hippocampus and Striatum.” Toxicology Letters 292: 151–161. doi:10.1016/j.toxlet.2018.04.033.
   PubMed Web of Science ®Google Scholar
• Maher, B. A., A. González-Maciel, R. Reynoso-Robles, R. Torres-Jardón, and L. Calderón-Garcidueñas. 2020. “Iron-Rich Air Pollution Nanoparticles: An Unrecognised Environmental Risk Factor for Myocardial Mitochondrial Dysfunction and Cardiac Oxidative Stress.” Environmental Research 188: 109816. doi:10.1016/j.envres.2020.109816.
   PubMed Web of Science ®Google Scholar
• Maher, B. A., I. A. Ahmed, V. Karloukovski, D. A. MacLaren, P. G. Foulds, D. Allsop, D. M. A. Mann, et al. 2016. “Magnetite Pollution Nanoparticles in the Human Brain.” Proceedings of the National Academy of Sciences 113 (39): 10797–10801. doi:10.1073/pnas.1605941113.
   PubMed Web of Science ®Google Scholar
• Manickam, V., V. Dhakshinamoorthy, and E. Perumal. 2018. “Iron Oxide Nanoparticles Induces Cell Cycle-Dependent Neuronal Apoptosis in Mice.” Journal of Molecular Neuroscience 64 (3): 352–362. doi:10.1007/s12031-018-1030-5.
   PubMed Web of Science ®Google Scholar
• Manickam, V., V. Dhakshinamoorthy, and E. Perumal. 2019. “Iron Oxide Nanoparticles Affects Behaviour and Monoamine Levels in Mice.” Neurochemical Research 44 (7): 1533–1548. doi:10.1007/s11064-019-02774-9.
   PubMed Web of Science ®Google Scholar
• Masselli, G., and G. Gualdi. 2012. “MR Imaging of the Small Bowel.” Radiology 264 (2): 333–348. doi:10.1148/radiol.12111658.
   PubMed Web of Science ®Google Scholar
• McCulley, L., K. Gelperin, S. Bird, S. Harris, C. Wang, and P. Waldron. 2016. “Reports to FDA of Fatal Anaphylaxis Associated with Intravenous Iron Products.” American Journal of Hematology 91 (12): E496–E497. doi:10.1002/ajh.24531.
   PubMed Web of Science ®Google Scholar
• Mesárošová, M., K. Kozics, A. Bábelová, E. Regendová, M. Pastorek, D. Vnuková, B. Buliaková, et al. 2014. “The Role of Reactive Oxygen Species in the Genotoxicity of Surface-Modified Magnetite Nanoparticles.” Toxicology Letters 226 (3): 303–313. doi:10.1016/j.toxlet.2014.02.025.
   PubMed Web of Science ®Google Scholar
• Mohammadpour, R., M. A. Dobrovolskaia, D. L. Cheney, K. F. Greish, and H. Ghandehari. 2019. “Subchronic and Chronic Toxicity Evaluation of Inorganic Nanoparticles for Delivery Applications.” Advanced Drug Delivery Reviews 144: 112–132. doi:10.1016/j.addr.2019.07.00.
   PubMed Web of Science ®Google Scholar
• Morgan, J., R. Bell, and A. L. Jones. 2020. “Endogenous Doesn't Always Mean Innocuous: A Scoping Review of Iron Toxicity by Inhalation.” Journal of Toxicology and Environmental Health. Part B, Critical Reviews 23 (3): 107–136. doi:10.1080/10937404.2020.1731896.
   PubMed Web of Science ®Google Scholar
• Mou, X., Z. Ali, S. Li, and N. He. 2015. “Applications of Magnetic Nanoparticles in Targeted Drug Delivery System.” Journal of Nanoscience and Nanotechnology 15 (1): 54–62. doi:10.1166/jnn.2015.9585.
   PubMed Web of Science ®Google Scholar
• Mourabit, S., J. A. Fitzgerald, R. P. Ellis, A. Takesono, C. S. Porteus, M. Trznadel, J. Metz, et al. 2019. “New Insights into Organ-Specific Oxidative Stress Mechanisms Using a Novel Biosensor Zebrafish.” Environment International 133 (Pt A): 105138. doi:10.1016/j.envint.2019.105138.
   PubMedGoogle Scholar
• Mulens-Arias, V., J. M. Rojas, L. Sanz-Ortega, Y. Portilla, S. Pérez-Yagüe, and D. F. Barber. 2019. “ Polyethylenimine-coated Superparamagnetic Iron Oxide Nanoparticles Impair In Vitro and In Vivo Angiogenesis .” Nanomedicine : Nanotechnology, Biology, and Medicine 21: 102063. doi:10.1016/j.nano.2019.102063.
   PubMed Web of Science ®Google Scholar
• Mushtaq, G., Khan, J. A., E. Joseph, J. Ebenezer, and A. Kamal Mohammad. 2015. “Nanoparticles, Neurotoxicity and Neurodegenerative Diseases.” Current Drug Metabolism 16 (8): 676–684. doi:10.2174/1389200216666150812122302.
   PubMed Web of Science ®Google Scholar
• Naqvi, S., M. Samim, M. Abdin, F. J. Ahmed, A. N. Maitra, C. K. Prashant, and A. K. Dinda. 2010. “Concentration-Dependent Toxicity of Iron Oxide Nanoparticles Mediated by Increased Oxidative Stress.” International Journal of Nanomedicine 5: 983–989. doi:10.2147/IJN.S13244.
   PubMed Web of Science ®Google Scholar
• Naumenko, V., A. A. Nikitin, K. Kapitanova, P. A. Melnikov, S. S. Vodopyanov, A. Garanina, M. Valikhov, et al. 2019. “Intravital Microscopy Reveals a Novel Mechanism of Nanoparticles Excretion in Kidney.” Journal of Controlled Release: Official Journal of the Controlled Release Society 100: 1–1. doi:10.1016/j.jconrel.2019.06.026.
   Web of Science ®Google Scholar
• Nemmar, A., S. Beegam, P. Yuvaraju, J. Yasin, S. Tariq, S. Attoub, and B. H. Ali. 2016. “Ultrasmall Superparamagnetic Iron Oxide Nanoparticles Acutely Promote Thrombosis and Cardiac Oxidative Stress and DNA Damage in Mice Part.” Particle and Fibre Toxicology 13 (1): 22. doi:10.1186/s12989-016-0132-x.
   PubMedGoogle Scholar
• Ng, S. W., S. G. Norwitz, and E. R. Norwitz. 2019. “The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia.” International Journal of Molecular Sciences 20 (13): 3283. doi:10.3390/ijms20133283.
   Web of Science ®Google Scholar
• Noori, A., K. Parivar, M. Modaresi, M. Messripour, M. H. Yousefi, and R. G. 2011. “Amiri Effect of Magnetic Iron Oxide Nanoparticles on Pregnancy and Testicular Development of Mice Afr.” Journal of Biotechnology 10: 1221–1227. doi:10.1016/J.CLINBIOCHEM.2011.08.796.
   Web of Science ®Google Scholar
• Nosrati, Hamed, Mahsa Tarantash, Shayesteh Bochani, Jalil Charmi, Zahra Bagheri, Mohammadjavad Fridoni, Mohammad-Amin Abdollahifar, et al. 2019. “Glutathione (GSH) Peptide Conjugated Magnetic Nanoparticles as Blood–Brain Barrier Shuttle for Mri-Monitored Brain Delivery of Paclitaxel.” ACS Biomaterials Science & Engineering 5 (4): 1677–1685. doi:10.1021/acsbiomaterials.8b01420.
   Web of Science ®Google Scholar
• Nuzhina, J. V., A. A. Shtil, A. Y. Prilepskii, and V. V. Vinogradov. 2019. “Preclinical Evaluation and Clinical Translation of Magnetite-Based Nanomedicines.” Journal of Drug Delivery Science and Technology 54: 101282. doi:10.1016/j.jddst.2019.101282.
   Web of Science ®Google Scholar
• Oberdörster, G., V. Stone, and K. Donaldson. 2007. “Toxicology of Nanoparticles: A Historical Perspective.” Nanotoxicology 1 (1): 2–25. doi:10.1080/17435390701314761.
   Web of Science ®Google Scholar
• Oliveira, V. R., J. J. Uriarte, B. Falcones, I. Jorba, W. A. Zin, R. Farré, D. Navajas, et al. 2019. “Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles.” Frontiers in Physiology 10: 1047. doi:10.3389/fphys.2019.01047.
   PubMed Web of Science ®Google Scholar
• Onishi, H., T. Murakami, T. Kim, M. Hori, S. Hirohashi, M. Matsuki, Y. Narumi, et al. 2009. “Safety of Ferucarbotran in MR Imaging of the Liver: A Pre- and Postexamination Questionnaire-Based Multicenter Investigation.” Journal of Magnetic Resonance Imaging 29 (1): 106–111. doi:10.1002/jmri.21608.
   PubMed Web of Science ®Google Scholar
• Paik, S. Y., J. S. Kim, S. J. Shin, and S. Ko. 2015. “Characterization, Quantification, and Determination of the Toxicity of Iron Oxide Nanoparticles to the Bone Marrow Cells.” International Journal of Molecular Sciences 16 (9): 22243–22257. doi:10.3390/ijms160922243.
   PubMed Web of Science ®Google Scholar
• Park, E. J., D. H. Choi, Y. Kim, E. W. Lee, J. Song, M. H. Cho, J. H. Kim, et al. 2014. “Magnetic Iron Oxide Nanoparticles Induce Autophagy Preceding Apoptosis through Mitochondrial Damage and ER Stress in RAW264.7 Cells.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 28 (8): 1402–1412. doi:10.1016/j.tiv.2014.07.010.
   PubMed Web of Science ®Google Scholar
• Park, E. J., and K. Park. 2009. “Oxidative Stress and Pro-inflammatory Responses Induced by Silica Nanoparticles In Vivo and In Vitro.” Toxicology Letters 184 (1): 18–25. doi:10.1016/j.toxlet.2008.10.012.
   PubMed Web of Science ®Google Scholar
• Park, E. J., U. Jeong, Y. Kim, B. S. Lee, M. H. Cho, and Y. S. Go. 2017. “Deleterious Effects in Reproduction and Developmental Immunity Elicited by Pulmonary Iron Oxide Nanoparticles.” Environmental Research 152: 503–513. doi:10.1016/j.envres.2016.08.025.
   PubMed Web of Science ®Google Scholar
• Patel, S., S. Jana, R. Chetty, S. Thakore, M. Singh, and R. Devkar. 2019. “Toxicity Evaluation of Magnetic Iron Oxide Nanoparticles Reveals Neuronal Loss in Chicken Embryo.” Drug and Chemical Toxicology 42 (1): 1–8. doi:10.1080/01480545.2017.1413110.
   PubMed Web of Science ®Google Scholar
• Patzelt, A., and J. Lademann. 2020. “Recent Advances in Follicular Drug Delivery of Nanoparticles.” Expert Opinion on Drug Delivery 17 (1): 49–60. doi:10.1080/17425247.2020.1700226.
   PubMed Web of Science ®Google Scholar
• Pedram, M. Z., A. Shamloo, A. Alasty, and E. Ghafar-Zadeh. 2016. “Optimal Magnetic Field for Crossing Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A Computational Approach.” Biosensors 6 (2): 25. doi:10.3390/bios6020025.
   PubMedGoogle Scholar
• Pedro, L., Q. Harmer, E. Mayes, and J. D. Shields. 2019. “Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.” Small 15 (20): 1900224. doi:10.1002/smll.201900224.
   Web of Science ®Google Scholar
• Periasamy, V. S., J. Athinarayanan, M. Alhazmi, K. A. Alatiah, and A. A. Alshatwi. 2016. “Fe3 O4 Nanoparticle Redox System Modulation Via Cell-Cycle Progression and Gene Expression in Human Mesenchymal Stem Cells.” Environmental Toxicology 31 (8): 901–912. doi:10.1002/tox.22098.
   PubMed Web of Science ®Google Scholar
• Peto, M. V. 2010. “Aluminium and Iron in Humans: Bioaccumulation, Pathology, and Removal.” Rejuvenation Research 13 (5): 589–598. doi:10.1089/rej.2009.0995.
   PubMed Web of Science ®Google Scholar
• Petters, C., E. Irrsack, M. Koch, and R. Dringen. 2014. “Uptake and Metabolism of Iron Oxide Nanoparticles in Brain Cells.” Neurochemical Research 39 (9): 1648–1660. doi:10.1007/s11064–014-1380-5.
   PubMed Web of Science ®Google Scholar
• Pilakka-Kanthikeel, S., V. S. R. Atluri, V. Sagar, S. K. Saxena, and M. Nair. 2013. “Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood–Brain Barrier for Neuro-protection Using Magnetic Nano Carriers: An In-Vitro Study.” PLoS One 8 (4): e62241. doi:10.1371/journal.pone.0062241.
   PubMed Web of Science ®Google Scholar
• Pollock, W., L. Rose, and C. L. Dennis. 2010. “Pregnant and Postpartum Admissions to the Intensive Care Unit: A Systematic Review.” Intensive Care Medicine 36 (9): 1465–1474. doi:10.1007/s00134–010-1951-0.
   PubMed Web of Science ®Google Scholar
• Pongrac, I. M., M. Dobrivojević, L. B. Ahmed, M. Babič, M. Šlouf, D. Horák, and S. Gajović. 2016. “Improved Biocompatibility and Efficient Labeling of Neural Stem Cells with Poly(L-Lysine)-Coated Maghemite Nanoparticles.” Beilstein Journal of Nanotechnology 7: 926–936. doi:10.3762/bjnano.7.84.
   PubMed Web of Science ®Google Scholar
• Prilepskii, Artur Y., Anna F. Fakhardo, Andrey S. Drozdov, Vasiliy V. Vinogradov, Ivan P. Dudanov, Alexander A. Shtil, Petr P. Bel'tyukov, et al. 2018. “Urokinase-Conjugated Magnetite Nanoparticles as a Promising Drug Delivery System for Targeted Thrombolysis: Synthesis and Preclinical Evaluation.” ACS Applied Materials & Interfaces 10 (43): 36764–36775. doi:10.1021/acsami.8b14790.
   PubMed Web of Science ®Google Scholar
• Raghupathi, W., and V. Raghupathi. 2018. “An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health.” International Journal of Environmental Research and Public Health 15 (3): 431. doi:10.3390/ijerph15030431.
   PubMed Web of Science ®Google Scholar
• Rahman, I., S. K. Biswas, and P. A. Kirkham. 2006. “Regulation of Inflammation and Redox Signaling by Dietary Polyphenols.” Biochemical Pharmacology 72 (11): 1439–1452. doi:10.1016/j.bcp.2006.07.004.
   PubMed Web of Science ®Google Scholar
• Reddy, U. A., P. Prabhakar, and M. Mahboob. 2017. “Biomarkers of Oxidative Stress for in Vivo Assessment of Toxicological Effects of Iron Oxide Nanoparticles.” Saudi Journal of Biological Sciences 24 (6): 1172–1180. doi:10.1016/j.sjbs.2015.09.029.
   PubMed Web of Science ®Google Scholar
• Remya, N. S., S. Syama, A. Sabareeswaran, and P. V. Mohanan. 2016. “Toxicity, Toxicokinetics and Biodistribution of Dextran Stabilized Iron Oxide Nanoparticles for Biomedical Applications.” International Journal of Pharmaceutics 511 (1): 586–598. doi:10.1016/j.ijpharm.2016.06.119.
   PubMed Web of Science ®Google Scholar
• Richards, J. M. J., C. A. Shaw, N. N. Lang, M. C. Williams, S. I. K. Semple, T. J. MacGillivray, C. Gray, et al. 2012. “In Vivo Mononuclear Cell Tracking Using Superparamagnetic Particles of Iron Oxide: Feasibility and Safety in Humans.” Circulation. Cardiovascular Imaging 5 (4): 509–517. doi:10.1161/CIRCIMAGING.112.972596.
   PubMed Web of Science ®Google Scholar
• Robinson, J. G., K. M. Fox, M. F. Bullano, and S. Grandy,; S. S. Group. 2009. “Atherosclerosis Profile and Incidence of Cardiovascular Events: A Population-Based Survey.” BMC Cardiovascular Disorders 9 (1): 46. doi:10.1186/1471-2261-9-46.
   PubMedGoogle Scholar
• Rojas, J. M., L. Sanz-Ortega, V. Mulens-Arias, L. Gutiérrez, S. Pérez-Yagüe, and D. F. Barber. 2016. “Superparamagnetic Iron Oxide Nanoparticle Uptake Alters M2 Macrophage Phenotype, Iron Metabolism, Migration and Invasion.” Nanomedicine : Nanotechnology, Biology, and Medicine 12 (4): 1127–1138. doi:10.1016/j.nano.2015.11.020.
   PubMed Web of Science ®Google Scholar
• Sadauskas, E., H. Wallin, M. Stoltenberg, U. Vogel, P. Doering, A. Larsen, and G. Danscher. 2007. “Kupffer Cells Are Central in the Removal of Nanoparticles from the Organism.” Particle and Fibre Toxicology 4: 10. doi:10.1186/1743–8977-4-10.
   PubMedGoogle Scholar
• Sadeghi, L., B. V. Yousefi, and H. R. Espanani. 2015. “Toxic Effects of the Fe2O3 Nanoparticles on the Liver and Lung Tissue.” Bratislavske Lekarske Listy 116 (6): 373–378. doi:10.4149/bll_2015_071.
   PubMed Web of Science ®Google Scholar
• Saijo, K., and C. K. Glass. 2011. “Microglial Cell Origin and Phenotypes in Health and Disease.” Nature Reviews. Immunology 11 (11): 775–787. doi:10.1038/nri3086.
   PubMed Web of Science ®Google Scholar
• Salimi, M., S. Sarkar, S. Fathi, A. M. Alizadeh, R. Saber, F. Moradi, and H. Delavari. 2018. “Biodistribution, Pharmacokinetics, and Toxicity of Dendrimer-Coated Iron Oxide Nanoparticles in BALB/c Mice.” International Journal of Nanomedicine 13: 1483–1493. doi:10.2147/IJN.S157293.
   PubMed Web of Science ®Google Scholar
• Sangaiya, P., and R. A. Jayaprakash. 2018. “Review on Iron Oxide Nanoparticles and Their Biomedical Applications.” Journal of Superconductivity and Novel Magnetism 31 (11): 3397–3413. doi:10.1007/s10948-018-4841-2.
   Web of Science ®Google Scholar
• Saraiva, C., C. Praça, R. Ferreira, T. Santos, L. Ferreira, and L. Bernardino. 2016. “Nanoparticle-Mediated Brain Drug Delivery: Overcoming Blood–Brain Barrier to Treat Neurodegenerative Diseases.” Journal of Controlled Release : Official Journal of the Controlled Release Society 235: 34–47. doi:10.1016/j.jconrel.2016.05.044.
   PubMed Web of Science ®Google Scholar
• Schmid, D., V. Micić, S. Laumann, and T. Hofmann. 2015. “Measuring the Reactivity of Commercially Available Zero-Valent Iron Nanoparticles Used for Environmental Remediation with Iopromide.” Journal of Contaminant Hydrology 181: 36–45. doi:10.1016/j.jconhyd.2015.01.006.
   PubMed Web of Science ®Google Scholar
• Schneider, M., F. Stracke, S. Hansen, and U. F. Schaefer. 2009. “Nanoparticles and Their Interactions with the Dermal Barrier.” Dermato-endocrinology 1 (4): 197–206. doi:10.4161/derm.1.4.9501.
   PubMedGoogle Scholar
• Sengul, A. B., and E. Asmatulu. 2020. “Toxicity of Metal and Metal Oxide Nanoparticles: A Review.” Environmental Chemistry Letters 18 (5): 1659–1683. doi:10.1007/s10311-020-01033-6.
   Web of Science ®Google Scholar
• Shabanova, E. M., A. S. Drozdov, A. F. Fakhardo, I. P. Dudanov, M. S. Kovalchuk, and V. V. Vinogradov. 2018. “Thrombin@Fe3O4 Nanoparticles for Use as a Hemostatic Agent in Internal Bleeding.” Scientific Reports 8 (1): 1–10. doi:10.1038/s41598-017-18665-4.
   PubMedGoogle Scholar
• Shabanova, E. M., A. S. Drozdov, V. Ivanovski, I. I. Suvorova, and V. V. Vinogradov. 2016. “Collagenase@ Magnetite: Proteolytic Composite for Magnetically Targeted Minimally Invasive Surgery.” RSC Advances 6 (87): 84354–84362. doi:10.1039/C6RA14711A.
   Web of Science ®Google Scholar
• Shagholani, H., S. M. Ghoreishi, and S. H. Sharifi. 2018. “Conversion of Amine Groups on Chitosan-Coated SPIONs into Carbocyclic Acid and Investigation of Its Interaction with BSA in Drug Delivery Systems.” Journal of Drug Delivery Science and Technology 45: 373–377. doi:10.1016/j.jddst.2018.03.029.
   Web of Science ®Google Scholar
• Sharma, H. S., S. Hussain, J. Schlager, S. F. Ali, and A. Sharma. 2010. “Influence of Nanoparticles on Blood–brain Barrier Permeability and Brain Edema Formation in Rats.” Acta Neurochirurgica. Supplement 106: 359–364. doi:10.1007/978-3-211-98811-4_65.
   PubMedGoogle Scholar
• She, X., B. Lan, H. Tian, and B. Tang. 2020. “Cross Talk between Ferroptosis and Cerebral Ischemia.” Frontiers in Neuroscience 14: 776. doi:10.3389/fnins.2020.00776.
   PubMed Web of Science ®Google Scholar
• Sheida, E., O. Sipailova, S. Miroshnikov, E. Sizova, S. Lebedev, E. Rusakova, and S. Notova. 2017. “The Effect of Iron Nanoparticles on Performance of Cognitive Tasks in Rats.” Environmental Science and Pollution Research International 24 (9): 8700–8710. doi:10.1007/s11356-017-8531-6.
   PubMed Web of Science ®Google Scholar
• Shelat, R., S. Ruchita, and A. Khanna. 2018. “Detailed Toxicity Evaluation of β-Cyclodextrin Coated Iron Oxide Nanoparticles for Biomedical Applications.” International Journal of Biological Macromolecules 110: 357–365. doi:10.1016/j.ijbiomac.2017.09.067.
   PubMed Web of Science ®Google Scholar
• Shen, Y., Z. Huang, X. Liu, J. Qian, J. Xu, X. Yang, A. Sun, et al. 2015. “Iron-Induced Myocardial Injury: An Alarming Side Effect of Superparamagnetic Iron Oxide Nanoparticles.” Journal of Cellular and Molecular Medicine 19 (8): 2032–2035. doi:10.1111/jcmm.12582.
   PubMed Web of Science ®Google Scholar
• Shi, Di, Gujie Mi, Soumya Bhattacharya, Suprabha Nayar, and Thomas J. Webster. 2016. “Optimizing Superparamagnetic Iron Oxide Nanoparticles as Drug Carriers Using an in Vitro Blood–Brain Barrier Model.” International Journal of Nanomedicine 11: 5371–5379. doi:10.2147/IJN.S108333.
   PubMed Web of Science ®Google Scholar
• Shi, M., L. Cheng, Z. Zhang, Z. Liu, and X. Mao. 2015. “Ferroferric Oxide Nanoparticles Induce Prosurvival Autophagy in Human Blood Cells by Modulating the Beclin 1/Bcl-2/VPS34 Complex.” International Journal of Nanomedicine 10: 207–216. doi:10.2147/ijn.s72598.
   PubMed Web of Science ®Google Scholar
• Shi, Y., Y. Li, and T. Coradin. 2020. “Magnetically-Oriented Type I collagen-SiO2@Fe3O4 Rods Composite Hydrogels Tuning Skin Cell Growth.” Colloids and Surfaces. B, Biointerfaces 185: 110597. doi:10.1016/j.colsurfb.2019.110597.
   PubMed Web of Science ®Google Scholar
• Shukla, S., A. Jadaun, V. Arora, R. K. Sinha, N. Biyani, and V. K. Jain. 2015. “In Vitro Toxicity Assessment of Chitosan Oligosaccharide Coated Iron Oxide Nanoparticles.” Toxicology Reports 2: 27–39. doi:10.1016/j.toxrep.2014.11.002.
   PubMed Web of Science ®Google Scholar
• Singh, N., G. J. Jenkins, R. Asadi, and S. H. Doak. 2010. “Potential Toxicity of Superparamagnetic Iron Oxide Nanoparticles (SPION).” Nano Reviews 1 (1): 5358. doi:10.3402/nano.v1i0.5358.
   PubMedGoogle Scholar
• Singh, S. P., M. Kumari, S. I. Kumari, M. F. Rahman, M. Mahboob, and P. Grover. 2013. “Toxicity Assessment of Manganese Oxide Micro and Nanoparticles in Wistar Rats after 28 Days of Repeated Oral Exposure.” Journal of Applied Toxicology : JAT 33 (10): 1165–1179. doi:10.1002/jat.2887.
   PubMed Web of Science ®Google Scholar
• Srivastava, V., D. Gusain, and Y. C. Sharma. 2015. “Critical Review on the Toxicity of Some Widely Used Engineered Nanoparticles.” Industrial & Engineering Chemistry Research 54 (24): 6209–6233. doi:10.1021/acs.iecr.5b01610.
   Web of Science ®Google Scholar
• Sun, Z., M. Worden, Y. Wroczynskyj, V. Yathindranath, J. van Lierop, T. Hegmann, and D. W. Miller. 2014. “Magnetic Field Enhanced Convective Diffusion of Iron Oxide Nanoparticles in an Osmotically Disrupted Cell Culture Model of the Blood–Brain Barrier.” International Journal of Nanomedicine 9: 3013–3026. doi:10.2147/IJN.S62260.
   PubMed Web of Science ®Google Scholar
• Sundarraj, K., V. Manickam, A. Raghunath, M. Periyasamy, M. P. Viswanathan, and E. Perumal. 2017. “Repeated Exposure to Iron Oxide Nanoparticles Causes Testicular Toxicity in Mice.” Environmental Toxicology 32 (2): 594–608. doi:10.1002/tox.22262.
   PubMed Web of Science ®Google Scholar
• Szalay, B., E. Tátrai, G. Nyírő, T. Vezér, and G. Dura. 2012. “Potential Toxic Effects of Iron Oxide Nanoparticles in In Vivo and In Vitro Experiments.” Journal of Applied Toxicology : JAT 32 (6): 446–453. doi:10.1002/jat.1779.
   PubMed Web of Science ®Google Scholar
• Teleanu, D. M., C. Chircov, A. M. Grumezescu, and R. I. Teleanu. 2019. “Neurotoxicity of Nanomaterials: An Up-to-Date Overview.” Nanomaterials (Basel) 9 (1): 96. doi:10.3390/nano9010096.
   PubMedGoogle Scholar
• Terrovitis, John, Matthias Stuber, Amr Youssef, Steve Preece, Michelle Leppo, Eddy Kizana, Michael Schär, et al. 2008. “Magnetic Resonance Imaging Overestimates Ferumoxide-Labeled Stem Cell Survival after Transplantation in the Heart.” Circulation 117 (12): 1555–1562. doi:10.1161/CIRCULATIONAHA.107.732073.
   PubMed Web of Science ®Google Scholar
• Tey, N. P., S. L. Lai, and J. K. Teh. 2016. “The Debilitating Effects of Chronic Diseases among the Oldest Old in China.” Maturitas 94: 39–45. doi:10.1016/j.maturitas.2016.08.016.
   PubMed Web of Science ®Google Scholar
• Thomsen, L. B., T. Linemann, K. M. Pondman, J. Lichota, K. S. Kim, R. J. Pieters, G. M. Visser, et al. 2013. “Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells.” ACS Chemical Neuroscience 4 (10): 1352–1360. doi:10.1021/cn400093z.
   PubMed Web of Science ®Google Scholar
• Toropova, Y. G., A. S. Golovkin, A. B. Malashicheva, D. V. Korolev, A. N. Gorshkov, K. G. Gareev, M. V. Afonin, et al. 2017. “In Vitro Toxicity of FemOn, FemOn-SiO2 Composite, and SiO2-FemOn Core-Shell Magnetic Nanoparticles.” International Journal of Nanomedicine 12: 593–603. doi:10.2147/IJN.S122580.
   PubMed Web of Science ®Google Scholar
• Tsoi, Kim M., Sonya A. MacParland, Xue-Zhong Ma, Vinzent N. Spetzler, Juan Echeverri, Ben Ouyang, Saleh M. Fadel, et al. 2016. “Mechanism of Hard-Nanomaterial Clearance by the Liver.” Nature Materials 15 (11): 1212–1221. doi:10.1038/nmat4718.
   PubMed Web of Science ®Google Scholar
• Tyner, K. M., N. Zheng, S. Choi, X. Xu, P. Zou, W. Jiang, C. Guo, et al. 2017. “How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities.” The AAPS Journal 19 (4): 1071–1083. doi:10.1208/s12248-017-0084-6.
   PubMed Web of Science ®Google Scholar
• Unterweger, H., C. Janko, M. Schwarz, L. Dézsi, R. Urbanics, J. Matuszak, E. Őrfi, et al. 2017. “Non-immunogenic Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles: A Biocompatible, Size-Tunable Contrast Agent for Magnetic Resonance Imaging.” International Journal of Nanomedicine 12: 5223–5238. doi:10.2147/IJN.S138108.
   PubMed Web of Science ®Google Scholar
• Vakili-Ghartavol, R., A. A. Momtazi-Borojeni, Z. Vakili-Ghartavol, H. T. Aiyelabegan, M. R. Jaafari, S. M. Rezayat, and S. A. Bidgoli. 2020. “Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles in Different Tissues.” Artificial Cells, Nanomedicine, and Biotechnology 48 (1): 443–451. doi:10.1080/21691401.2019.1709855.
   PubMed Web of Science ®Google Scholar
• Valdiglesias, Vanessa, Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon, et al. 2015. “Effects of Iron Oxide Nanoparticles: Cytotoxicity, Genotoxicity, Developmental Toxicity, and Neurotoxicity.” Environmental and Molecular Mutagenesis 56 (2): 125–148. doi:10.1002/em.21909.
   PubMed Web of Science ®Google Scholar
• Valdiglesias, V., N. Fernández-Bertólez, G. Kiliç, C. Costa, S. Costa, S. Fraga, M. J. Bessaet, et al. 2016. “Are Iron Oxide Nanoparticles Safe? Current Knowledge and Future Perspectives.” Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS) 38: 53–63. doi:10.1016/j.jtemb.2016.03.017.
   PubMed Web of Science ®Google Scholar
• Van Rooy, I., S. Cakir-Tascioglu, W. E. Hennink, G. Storm, R. M. Schiffelers, and E. Mastrobattista. 2011. “In Vivo Methods to Study Uptake of Nanoparticles into the Brain.” Pharmaceutical Research 28 (3): 456–471. doi:10.1007/s11095-010-0291-7.
   PubMed Web of Science ®Google Scholar
• Varallyay, C. G., G. B. Toth, R. Fu, J. P. Netto, J. Firkins, P. Ambady, and E. A. Neuwelt. 2017. “What Does the Boxed Warning Tell us? Safe Practice of Using Ferumoxytol as an MRI Contrast Agent.” AJNR. American Journal of Neuroradiology 38 (7): 1297–1302. doi:10.3174/ajnr.A5188.
   PubMed Web of Science ®Google Scholar
• Voinov, M. A., J. O. Sosa Pagán, E. Morrison, T. I. Smirnova, and A. I. Smirnov. 2011. “Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity.” Journal of the American Chemical Society 133 (1): 35–41. doi:10.1021/ja104683w.
   PubMed Web of Science ®Google Scholar
• Wang, R., B. Song, J. Wu, Y. Zhang, A. Chen, and L. Shao. 2018. “Potential Adverse Effects of Nanoparticles on the Reproductive System.” International Journal of Nanomedicine 13: 8487–8506. doi:10.2147/IJN.S170723.
   PubMed Web of Science ®Google Scholar
• Wang, B., W. Feng, M. Zhu, Y. Wang, M. Wang, Y. Gu, H. Ouyang, et al. 2009. “Neurotoxicity of Low-Dose Repeatedly Intranasal Instillation of Nano-and Submicron-Sized Ferric Oxide Particles in Mice.” Journal of Nanoparticle Research 11 (1): 41–53. doi:10.1007/s11051-008-9452-6.
   Web of Science ®Google Scholar
• Wang, Jun, Yue Chen, Baoan Chen, Jiahua Ding, Guohua Xia, Chong Gao, Jian Cheng, et al. 2010. “Pharmacokinetic Parameters and Tissue Distribution of Magnetic Fe(3)O(4) Nanoparticles in Mice.” International Journal of Nanomedicine 5: 861–866. doi:10.2147/IJN.S13662.
   PubMed Web of Science ®Google Scholar
• Wang, Y., B. Wang, M. T. Zhu, M. Li, H. J. Wang, M. Wang, H. Ouyang, et al. 2011. “Microglial Activation, Recruitment and Phagocytosis as Linked Phenomena in Ferric Oxide Nanoparticle Exposure.” Toxicology Letters 205 (1): 26–37. doi:10.1016/j.toxlet.2011.05.001.
   PubMed Web of Science ®Google Scholar
• Wáng, Y. X. J., and J. M. Idée. 2017. “A Comprehensive Literatures Update of Clinical Researches of Superparamagnetic Resonance Iron Oxide Nanoparticles for Magnetic Resonance Imaging.” Quantitative Imaging in Medicine and Surgery 7 (1): 88–122. doi:10.21037/qims.2017.02.09.
   PubMed Web of Science ®Google Scholar
• Weissleder, R., D. D. Stark, B. L. Engelstad, B. R. Bacon, C. C. Compton, D. L. White, P. Jacobs, et al. 1989. “Superparamagnetic Iron Oxide: Pharmacokinetics and Toxicity.” AJR. American Journal of Roentgenology 152 (1): 167–173. doi:10.2214/ajr.152.1.167.
   PubMed Web of Science ®Google Scholar
• Wu, J., and J. Sun. 2011. “Investigation on Mechanism of Growth Arrest Induced by Iron Oxide Nanoparticles in PC12 Cells.” Journal of Nanoscience and Nanotechnology 11 (12): 11079–11083. doi:10.1166/jnn.2011.3948.
   PubMed Web of Science ®Google Scholar
• Wu, J., T. Ding, and J. Sun. 2013. “Neurotoxic Potential of Iron Oxide Nanoparticles in the Rat Brain Striatum and Hippocampus.” Neurotoxicology 34: 243–253. doi:10.1016/j.neuro.2012.09.006.
   PubMed Web of Science ®Google Scholar
• Wu, T., H. Xu, X. Liang, and M. Tang. 2019. “Caenorhabditis elegans as a Complete Model Organism for Biosafety Assessments of Nanoparticles.” Chemosphere 221: 708–726. doi:10.1016/j.chemosphere.2019.01.021.
   PubMed Web of Science ®Google Scholar
• Wu, X., Y. Tan, H. Mao, and M. Zhang. 2010. “Toxic Effects of Iron Oxide Nanoparticles on Human Umbilical Vein Endothelial Cells.” International Journal of Nanomedicine 5: 385–399.
   PubMed Web of Science ®Google Scholar
• Xue, Y., J. Wu, and J. Sun. 2012. “Four Types of Inorganic Nanoparticles Stimulate the Inflammatory Reaction in Brain Microglia and Damage Neurons in Vitro.” Toxicology Letters 214 (2): 91–98. doi:10.1016/j.toxlet.2012.08.009.
   PubMed Web of Science ®Google Scholar
• Yan, L., X. Liu, W. X. Liu, X. Q. Tan, F. Xiong, N. Gu, W. Hao, et al. 2015. “Fe2O3 Nanoparticles Suppress Kv1.3 Channels via Affecting the Redox Activity of Kvβ2 Subunit in Jurkat T Cells.” Nanotechnology 26 (50): 505103. doi:10.1088/0957-4484/26/50/505103.
   PubMed Web of Science ®Google Scholar
• Yang, H., C. Sun, Z. Fan, X. Tian, L. Yan, L. Du, Y. Liu, et al. 2012. “Effects of Gestational Age and Surface Modification on Materno-fetal Transfer of Nanoparticles in Murine Pregnancy.” Scientific Reports 2: 847. doi:10.1038/srep00847.
   PubMed Web of Science ®Google Scholar
• Yang, J. X., W. L. Tang, and X. X. Wang. 2010. “Superparamagnetic Iron Oxide Nanoparticles May Affect Endothelial Progenitor Cell Migration Ability and Adhesion Capacity.” Cytotherapy 12 (2): 251–259. doi:10.3109/14653240903446910.
   PubMed Web of Science ®Google Scholar
• Yang, L., H. Kuang, W. Zhang, Z. P. Aguilar, Y. Xiong, W. Lai, H. Xu, et al. 2015. “Size Dependent Biodistribution and Toxicokinetics of Iron Oxide Magnetic Nanoparticles in Mice.” Nanoscale 7 (2): 625–636. doi:10.1039/C4NR05061D.
   PubMed Web of Science ®Google Scholar
• Yang, Y. F., P. J. Chen, and V. H. Liao. 2016. “Nanoscale Zerovalent Iron (nZVI) at Environmentally Relevant Concentrations Induced Multigenerational Reproductive Toxicity in Caenorhabditis elegans.” Chemosphere 150: 615–623. doi:10.1016/j.chemosphere.2016.01.068.
   PubMed Web of Science ®Google Scholar
• Yarjanli, Z., K. Ghaedi, A. Esmaeili, S. Rahgozar, and A. Zarrabi. 2017. “Iron Oxide Nanoparticles May Damage to the Neural Tissue through Iron Accumulation, Oxidative Stress, and Protein Aggregation.” BMC Neuroscience 18 (1): 51. doi:10.1186/s12868-017-0369-9.
   PubMed Web of Science ®Google Scholar
• Ye, D., X. Zhang, Y. Yue, R. Raliya, P. Biswas, S. Taylor, Y. Tai, et al. 2018. “Focused Ultrasound Combined with Microbubble-Mediated Intranasal Delivery of Gold Nanoclusters to the Brain.” Journal of Controlled Release 286: 145–153. doi:10.1016/j.jconrel.2018.07.020.
   PubMed Web of Science ®Google Scholar
• Yildirimer, L., N. T. Thanh, M. Loizidou, and A. M. Seifalian. 2011. “Toxicology and Clinical Potential of Nanoparticles.” Nano Today 6 (6): 585–607. doi:10.1016/j.nantod.2011.10.001.
   PubMed Web of Science ®Google Scholar
• Yousef, M. I., A. A. Abuzreda, and M. K. Abdel-Nabi. 2019. “Cardiotoxicity and Lung Toxicity in Male Rats Induced by Long-Term Exposure to Iron Oxide and Silver Nanoparticles.” Experimental and Therapeutic Medicine 18 (6): 4329–4339. doi:10.3892/etm.2019.8108.
   PubMed Web of Science ®Google Scholar
• Yousefi, B. V., E. Amraeai, H. Salehh, L. Sadeghi, L. Najafi, and M. Fazilati. 2013. “Evaluation of Iron Oxide Nanoparticles Effects on Tissue and Enzymes of Thyroid in Rats.” International Research Journal of Biological Sciences 2: 67–69.
   Google Scholar
• Yun, J. W., S. H. Kim, J. R. You, W. H. Kim, J. J. Jang, S. K. Min, H. C. Kim, et al. 2015. “Comparative Toxicity of Silicon Dioxide, Silver and Iron Oxide Nanoparticles after Repeated Oral Administration to Rats.” Journal of Applied Toxicology : JAT 35 (6): 681–693. doi:10.1002/jat.3125.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. N., W. Poon, A. J. Tavares, I. D. McGilvray, and W. C. W. Chan. 2016. “Nanoparticle-Liver Interactions: Cellular Uptake and Hepatobiliary Elimination.” Journal of Controlled Release : Official Journal of the Controlled Release Society 240: 332–348. doi:10.1016/j.jconrel.2016.01.020.
   PubMed Web of Science ®Google Scholar
• Zhao, H., W. Gu, L. Ye, and H. Yang. 2014. “Biodistribution of PAMAM Dendrimer Conjugated Magnetic Nanoparticles in Mice.” Journal of Materials Science. Materials in Medicine 25 (3): 769–776. doi:10.1007/s10856-013-5104-1.
   PubMed Web of Science ®Google Scholar
• Zhao, S., X. Lin, L. Zhang, L. Sun, J. Li, W. Yang, and Z. Sun. 2012. “The in Vivo Investigation of Fe3O4-Nanoparticles Acute Toxicity in Mice Biomed.” Biomedical Engineering: Applications, Basis and Communications 24 (03): 229–235. doi:10.4015/S1016237212500056.
   Google Scholar
• Zhu, L., Z. Zhou, H. Mao, and L. Yang. 2017. “Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy.” Nanomedicine (London, England) 12 (1): 73–87. doi:10.2217/nnm-2016-0316.
   PubMed Web of Science ®Google Scholar
• Zhu, M. T., B. Wang, Y. Wang, L. Yuan, H. J. Wang, M. Wang, H. Ouyang, et al. 2011. “Endothelial Dysfunction and Inflammation Induced by Iron Oxide Nanoparticle Exposure: Risk Factors for Early Atherosclerosis.” Toxicology Letters 203 (2): 162–171. doi:10.1016/j.toxlet.2011.03.021.
   PubMed Web of Science ®Google Scholar
• Zhu, M. T., Y. Wang, W. Y. Feng, B. Wang, M. Wang, H. Ouyang, and Z. F. Chai. 2010. “Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells.” Journal of Nanoscience and Nanotechnology 10 (12): 8584–8590. doi:10.1166/jnn.2010.2488.
   PubMed Web of Science ®Google Scholar
• Ziv-Polat, O., M. Topaz, T. Brosh, and S. Margel. 2010. “Enhancement of Incisional Wound Healing by Thrombin Conjugated Iron Oxide Nanoparticles.” Biomaterials 31 (4): 741–747. doi:10.1016/j.biomaterials.2009.09.093.
   PubMed Web of Science ®Google Scholar
• Zou, Jinglu, Xin Wang, Ling Zhang, and Jinke Wang. 2015. “Iron Nanoparticles Significantly Affect the in Vitro and in Vivo Expression of Id Genes.” Chemical Research in Toxicology 28 (3): 373–383. doi:10.1021/tx500333q.
   PubMed Web of Science ®Google Scholar