7,735
Views
29
CrossRef citations to date
0
Altmetric
Conceptual Review

A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 382-404 | Received 12 Oct 2017, Accepted 10 Jun 2018, Published online: 25 Jun 2018

References

  • Apóstolo, J., Cardoso, D., Marta, L., & Amaral, T. (2011). Efeito da estimulação cognitiva em Idosos. Revista de Enfermagem Referência, 3(5), 193–201. doi: 10.12707/RIII11104
  • Apóstolo, J., Cardoso, D., Paúl, C., Rodrigues, M., & Macedo, M. (2016). Efectos de la estimulación cognitiva sobre las personas mayores en el ámbito comunitario. Enfermería Clínica, 26(2), 111–120. doi: 10.1016/j.enfcli.2015.07.008
  • Apóstolo, J., Cardoso, D., Rosa, A., & Paúl, C. (2014). The effect of cognitive stimulation on nursing home elders: A randomized controlled trial. Journal of Nursing Scholarship, 46(3), 157–166. doi: 10.1111/jnu.12072
  • Apóstolo, J., Carvalho, A., Tavares, C., Cardoso, D., Carvalho, M., & Baptista, T. (2013). The effect of cognitive stimulation on depressive symptomatology and quality of life of elderly people. Journal of Aging and Innovation, 2(3), 82–91.
  • Apóstolo, J., Cooke, R., Bobrowicz-Campos, E., Santana, S., Marcucci, M., Cano, A., … Holland, C. (2017). Predicting risk and outcomes for frail older adults: An umbrella review of frailty screening tools. JBI Database of Systematic Reviews and Implementation Reports, 15(4), 1154–1208. doi: 10.11124/JBISRIR-2016-003018
  • Apóstolo, J., Cooke, R., Bobrowicz-Campos, E., Santana, S., Marcucci, M., Cano, A., … Holland, C. (2018). Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: A systematic review. JBI Database of Systematic Reviews and Implementation Reports, 16(1), 140–232. doi: 10.11124/JBISRIR-2017-003382
  • Bamidis, P. D. (2012). Long lasting memories: Mind and body fitness for life. Retrieved from http://www.longlastingmemories.eu/sites/default/files/LLM_D1.4_final_report_public_v2.2doc.pdf
  • Behm, L., Eklund, K., Wilhelmson, K., Zidén, L., Gustafsson, S., Falk, K., & Dahlin-Ivanoff, S. (2016). Health promotion can postpone frailty: Results from the RCT elderly persons in the risk zone. Public Health Nursing, 33(4), 303–315. doi: 10.1111/phn.12240
  • Bonnefoy, M., Boutitie, F., Mercier, C., Gueyffier, F., Carre, C., Guetemme, G., … Cornu, C. (2012). Efficacy of a home-based intervention programme on the physical activity level and functional ability of older people using domestic services: A randomised study. The Journal of Nutrition, Health & Aging, 16(4), 370–377. doi: 10.1007/s12603-011-0352-6
  • Cadore, E. L., Casas-Herrero, A., Zambom-Ferraresi, F., Idoate, F., Millor, N., Gómez, M., … Izquierdo, M. (2014). Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians. Age, 36(2), 773–785. doi: 10.1007/s11357-013-9586-z
  • Cameron, I. D., Fairhall, N., Langron, C., Lockwood, K., Monaghan, N., Aggar, C., & Kurrle, S. E. (2013). A multifactorial interdisciplinary intervention reduces frailty in older people: Randomized trial. BMC Medicine, 11(1), 1–10. doi: 10.1186/1741-7015-11-1
  • Carrapatoso, S. M. G. (2015). Relationships of walking at individual, interpersonal and environmental levels among seniors (Doctoral dissertation). University of Porto, Portugal. Retrieved from https://repositorio-aberto.up.pt/bitstream/10216/83109/2/122321.pdf
  • Carvalho, J., Marques, E., Soares, J. M., & Mota, J. (2010). Isokinetic strength benefits after 24 weeks of multicomponent exercise training and a combined exercise training in older adults. Ageing Clinical and Experimental Research, 22(1), 63–69. doi: 10.1007/BF03324817
  • Chan, D.-C. D., Tsou, H.-H., Yang, R.-S., Tsauo, J.-Y., Chen, C.-Y., Hsiung, C. A., & Kuo, K. N. (2012). A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatrics, 12(58), 1–12.
  • Clegg, A., Barber, S., Young, J., Iliffe, S., & Forster, A. (2014). The Home-based Older People’s Exercise (HOPE) trial: A pilot randomised controlled trial of a home-based exercise intervention for older people with frailty. Age and Ageing, 43(5), 687–695. doi: 10.1093/ageing/afu033
  • Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people. The Lancet, 381(9868), 752–762. doi: 10.1016/S0140-6736(12)62167-9
  • Cohen, H. J., Feussner, J. R., Weinberger, M., Carnes, M., Hamdy, R. C., Hsieh, F., … Lavori, P. (2002). A controlled trial of inpatient and outpatient geriatric evaluation and management. New England Journal of Medicine, 346(12), 905–912. doi: 10.1056/NEJMsa010285
  • Collard, R. M., Boter, H., Schoevers, R. A., & Voshaar, R. C. O. (2012). Prevalence of frailty in community-dwelling older persons: A systematic review. Journal of the American Geriatrics Society, 60(8), 1487–1492. doi: 10.1111/j.1532-5415.2012.04054.x
  • D’Avanzo, B., Shaw, R., Riva, S., Apóstolo, J., Bobrowicz-Campos, E., Kurpas, D., & Holland, C. (2017). Stakeholders’ views and experiences of care and interventions for addressing frailty and pre-frailty: A meta-synthesis of qualitative evidence. PLoS ONE, 12(7), e0180127. doi: 10.1371/journal.pone.0180127
  • De Vriendt, P., Peersman, W., Florus, A., Verbeke, M., & Van De Velde, D. (2016). Improving health related quality of life and independence in community dwelling frail older adults through a client-centred and activity-oriented program. A pragmatic randomized controlled trial. The Journal of Nutrition, Health & Aging, 20(1), 35–40. doi: 10.1007/s12603-016-0673-6
  • Eklund, K., Wilhelmson, K., Gustafsson, H., Landahl, S., & Dahlin-Ivanoff, S. (2013). One-year outcome of frailty indicators and activities of daily living following the randomised controlled trial; “Continuum of care for frail older people”. BMC Geriatrics, 13(76).
  • European Innovation Partnership on Active and Healthy Ageing. (2013). A Compilation of Good Practices - Prevention and Early Diagnosis of Frailty and Functional Decline, both Physical and Cognitive, in Older People. European Commission. Retrieved from https://ec.europa.eu/research/innovation-union/pdf/active-healthy-ageing/gp_a3.pdf Retrieved from https://ec.europa.eu/research/innovation-union/pdf/active-healthy-ageing/gp_a3.pdf
  • Fairhall, N., Sherrington, C., Kurrle, S. E., Lord, S. R., Lockwood, K., Howard, K., … Cameron, I. D. (2015). Economic evaluation of a multifactorial, interdisciplinary intervention versus usual care to reduce frailty in frail older people. Journal of the American Medical Directors Association, 16(1), 41–48. doi: 10.1016/j.jamda.2014.07.006
  • Favela, J., Castro, L. A., Franco-Marina, F., Sánchez-García, S., Juárez-Cedillo, T., Bermudez, C. E., & García-Peña, C. (2013). Nurse home visits with or without alert buttons versus usual care in the frail elderly: A randomized controlled trial. Clinical Interventions in Aging, 8, 85–95.
  • Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., & Walston, J. D. (2004). Interventions on frailty working group. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report. Journal of the American Geriatrics Society, 52(4), 625–634. doi: 10.1111/j.1532-5415.2004.52174.x
  • Fiatarone, M. A., O’Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., … Evans, W. J. (1994). Exercise training and nutritional supplementation for physical frailty in very elderly people. New England Journal of Medicine, 330, 1769–1775. doi: 10.1056/NEJM199406233302501
  • Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. doi: 10.1016/0022-3956(75)90026-6
  • Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004). Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. Journals of Gerontology Series A - Biological Sciences and Medical Sciences, 59(3), M255–M263. doi: 10.1093/gerona/59.3.M255
  • Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., … McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. Journals of Gerontology Series A – Biological Sciences and Medical Sciences, 56(3), M146–M157. doi: 10.1093/gerona/56.3.M146
  • Gill, T. M., Baker, D. I., Gottschalk, M., Peduzzi, P. N., Allore, H., & Byers, A. (2002). A program to prevent functional decline in physically frail, elderly persons who live at home. New England Journal of Medicine, 347(14), 1068–1074. doi: 10.1056/NEJMoa020423
  • Giné-Garriga, M., Guerra, M., Pagès, E., Manini, T. M., Jiménez, R., & Unnithan, V. B. (2010). The effect of functional circuit training on physical frailty in frail older adults: A randomized controlled trial. Journal of Aging and Physical Activity, 18(4), 401–424. doi: 10.1123/japa.18.4.401
  • Gustafsson, S., Wilhelmson, K., Eklund, K., Gosman-Hedström, G., Zidén, L., Kronlöf, G. H., … Synneve, D. I. (2012). Health-promoting interventions for persons aged 80 and older are successful in the short term – results from the randomized and three-armed elderly persons in the risk zone study. Journal of the American Geriatrics Society, 60(3), 447–454. doi: 10.1111/j.1532-5415.2011.03861.x
  • Gwyther, H., Cooke, R., Shaw, R., Marcucci, M., Cano, A., & Holland, C. (2017). Perceptions and experiences of frailty interventions: Quantitative and qualitative results from a survey of partners within the European Innovation Partnership on Active and Healthy Ageing (EIP-AHA). Ageing and Society, 1–25. doi: 10.1017/S0144686X17000265
  • Hars, M., Herrmann, F. R., Fielding, R. A., Reid, K. F., Rizzoli, R., & Trombetti, A. (2014). Long-term exercise in older adults: 4-year outcomes of music-based multitask training. Calcified Tissue International, 95(5), 393–404. doi: 10.1007/s00223-014-9907-y
  • Hay, J., LaBree, L., Luo, R., Clark, F., Carlson, M., Mandel, D.,  …  Azen, S. P. (2002). Cost-effectiveness of preventive occupational therapy for independent-living older adults. Journal of the American Geriatrics Society, 50(8), 1381–1388. doi: 10.1046/j.1532-5415.2002.50359.x
  • Hazzard, W. R., Bierman, R. L., Blass, J. P., Ettinger, W. H., & Halter, J. B. (Eds.). (1999). Frailty: In principles of geriatric medicine and gerontology. New York, NY: McGraw Hill.
  • Jakobsson, U. (2008). The ADL-staircase: Further validation. International Journal of Rehabilitation Research, 31(1), 85–88. doi: 10.1097/MRR.0b013e3282f45166
  • Jakobsson, U., & Karlsson, S. (2011). Predicting mortality with the ADL-staircase in frail elderly. Physical & Occupational Therapy In Geriatrics, 29(2), 136–147. doi: 10.3109/02703181.2010.538491
  • Kim, C.-O., & Lee, K.-R. (2013). Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: A community-based randomized controlled study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(3), 309–316. doi: 10.1093/gerona/gls167
  • Kim, H., Suzuki, T., Kim, M., Kojima, N., Ota, N., Shimotoyodome, A., & Yoshida, H. (2015). Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: A randomized double blind, placebo-controlled, follow-up trial. PLoS ONE, 10(2), e0116256. doi: 10.1371/journal.pone.0116256
  • Langlois, F., Vu, T. T. M., Kergoat, M.-J., Chassé, K., Dupuis, G., & Bherer, L. (2012). The multiple dimensions of frailty: Physical capacity, cognition, and quality of life. International Psychogeriatrics, 24(09), 1429–1436. doi: 10.1017/S1041610212000634
  • Li, C.-M., Chen, C.-Y., Li, C.-Y., Wang, W.-D., & Wu, S.-C. (2010). The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: A randomized, controlled trial. Archives of Gerontology and Geriatrics, 50, S39–S42. doi: 10.1016/S0167-4943(10)70011-X
  • Milne, A. C., Avenell, A., & Potter, J. (2006). Meta-analysis: Protein and energy supplementation in older people. Annals of Internal Medicine, 144(1), 37–48. doi: 10.7326/0003-4819-144-1-200601030-00008
  • Monteserin, R., Brotons, C., Moral, I., Altimir, S., San José, A., Santaeugenia, S., Sellares J. & Padrós, J. (2010). Effectiveness of a geriatric intervention in primary care: A randomized clinical trial. Family Practice, 27(3), 239–245. doi: 10.1093/fampra/cmp101
  • Muller, M., van den Beld, A. W., van der Schouw, Y. T., Grobbee, D. E., & Lamberts, S. W. (2006). Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men. The Journal of Clinical Endocrinology & Metabolism, 91(10), 3988–3991. doi: 10.1210/jc.2005-2433
  • Netuveli, G., & Blane, D. (2008). Quality of life in older ages. British Medical Bulletin, 85(1), 113–126. doi: 10.1093/bmb/ldn003
  • Ng, T.-P., Feng, L., Nyunt, M., Feng, L., Niti, M., Tan, B., … Yap, K. (2015). Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: A randomized controlled trial. The American Journal of Medicine, 128(11), 1225–1236. e1221. doi: 10.1016/j.amjmed.2015.06.017
  • O’ Caoimh, R., Weathers, E., Hally, R., O’ Sullivan, R., FitzGerald, C., Cornally, N., & William Molloy, D. (2015). The Community Assessment of Risk and Treatment Strategies (CARTS): An integrated care pathway to manage frailty and functional decline in community dwelling older adults. In M. Helfert, A. Holzinger, M. Ziefle, A. Fred, J. O’Donoghue, & C. Röcker (Eds.), Information and communication technologies for ageing well and e-health: First international conference, ICT4AgeingWell 2015, Lisbon, Portugal, May 20–22, 2015. Revised selected papers (pp. 3–18). Cham: Springer International Publishing.
  • Palummeri, E. (2012a). Adapted physical activity. Retrieved from http://www.regione.liguria.it/argomenti/vivere-e-lavorare-in-liguria/salute-e-politiche-sociali.html
  • Palummeri, E. (2012b). Adapted physical activity: Findings. Retrieved from https://ec.europa.eu/research/innovation-union/pdf/active-healthy-ageing/rs_liguria.pdf
  • Palummeri, E. (2012c). Memory training: Findings. Retrieved from https://ec.europa.eu/research/innovation-union/pdf/active-healthy-ageing/rs_liguria.pdf
  • Pawson, R. (2002). Evidence-based policy: The promise of ‘realist synthesis’. Evaluation, 8(3), 340–358. doi: 10.1177/135638902401462448
  • Pawson, R. (2006). Evidence-based policy: A realist perspective. London: Sage.
  • Pawson, R., Greenhalgh, T., Harvey, G., & Walshe, K. (2005). Realist review – a new method of systematic review designed for complex policy interventions. Journal of Health Services Research and Policy, 10(suppl 1), 21–34. doi: 10.1258/1355819054308530
  • Payette, H., Boutier, V., Coulombe, C., & Gray-Donald, K. (2002). Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: A prospective randomized community trial. Journal of the American Dietetic Association, 102(8), 1088–1095. doi: 10.1016/S0002-8223(02)90245-2
  • Rechel, B., Grundy, E., Robine, J. M., Cylus, J., Mackenbach, J. P., Knai, C., & McKee, M. (2013). Ageing in the European Union. The Lancet, 381(9874), 1312–1322. doi: 10.1016/S0140-6736(12)62087-X
  • Ritchie, J., Spencer, L., & O’Connor, W. (2003). Carrying out qualitative analysis. In Qualitative research practice: A guide for social science students and researchers (Vol. 1), 219–263. London: Sage.
  • Rockwood, K., & Mitnitski, A. (2007). Frailty in relation to the accumulation of deficits. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 62(7), 722–727. doi: 10.1093/gerona/62.7.722
  • Rodríguez-Mañas, L., Féart, C., Mann, G., Viña, J., Chatterji, S., Chodzko-Zajko, W., & Scuteri, A. (2013). Searching for an operational definition of frailty: A Delphi method based consensus statement. The frailty operative definition-consensus conference project. Journals of Gerontology Series A – Biological Sciences and Medical Sciences, 68(1), 62–67. doi: 10.1093/gerona/gls119
  • Schultz-Larsen, K., & Avlund, K. (2007). Tiredness in daily activities: A subjective measure for the identification of frailty among non-disabled community-living older adults. Archives of Gerontology and Geriatrics, 44(1), 83–93. doi: 10.1016/j.archger.2006.03.005
  • Shaw, R., Gwyther, H., Holland, C., Bujinowska-Fedak, M., Kurpas, D., Cano, A., … D'Avanzo, B. (2017). Understanding frailty: Meanings and beliefs about screening and prevention across key stakeholder groups in Europe. Ageing and Society, 38(6), 1223–1252. doi: 10.1017/S0144686X17000745
  • Sousa, M., & Costa, R. (2013). PAPI. Retrieved from http://apoiopsicologicoid.wixsite.com/papi
  • Theou, O., Stathokostas, L., Roland, K., Jakobi, J., Patterson, C., Vandervoort, A., & Jones, G. (2011). The effectiveness of exercise interventions for the management of frailty: A systematic review. Journal of Aging Research, April, 4, 569194.
  • Todres, L., Galvin, K., & Dahlberg, K. (2006). Lifeworld-led healthcare: Revisiting a humanising philosophy that integrates emerging trends. Medicine, Health Care and Philosophy, 10(1), 53–63. doi: 10.1007/s11019-006-9012-8
  • Topinková, E. (2008). Aging, disability and frailty. Annals of Nutrition and Metabolism, 52(Suppl.1), 6–11.
  • Van Craen, K., Braes, T., Wellens, N., Denhaerynck, K., Flamaing, J., Moons, P.,  …  Milisen, K. (2010). The effectiveness of inpatient geriatric evaluation and management units: A systematic review and meta-analysis. Journal of the American Geriatrics Society, 58(1), 83–92. doi: 10.1111/j.1532-5415.2009.02621.x
  • Van Damme, N., Buijck, B., Goossens, E., & Beeckman, D. (2015). Reducing malnutrition: a focus on a gastrological approach, and instrument development for food satisfaction and food quality indicators. Paper presented at the CARE4: International Scientific Nursing and Midwifery congress, Antwerp, Belgium.
  • van Hout, H. P., Jansen, A. P., van Marwijk, H. W., Pronk, M., Frijters, D. F., & Nijpels, G. (2010). Prevention of adverse health trajectories in a vulnerable elderly population through nurse home visits: A randomized controlled trial [ISRCTN05358495]. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65(7), 734–742. doi: 10.1093/gerona/glq037
  • Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., … Fried, L. P. (2006). Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American geriatrics society/national institute on aging research conference on frailty in older adults. Journal of the American Geriatrics Society, 54(6), 991–1001. doi: 10.1111/j.1532-5415.2006.00745.x
  • Wanderley, F., Mota, J., & Carvalho, J. (2010). Effects of a moderate-intensity walking program on blood pressure, body composition and functional fitness in older women: Results of a pilot study. Archives of Exercise in Health and Disease, 1(2), 50–57. doi: 10.5628/aehd.v1i2.87
  • Wolf, S. L., Barnhart, H. X., Kutner, N. G., McNeely, E., Coogler, C., & Xu, T. (1996). Reducing frailty and falls in older persons: An investigation of Tai Chi and computerized balance training. Journal of the American Geriatrics Society, 44(5), 489–497. doi: 10.1111/j.1532-5415.1996.tb01432.x
  • Wong, G., Greenhalgh, T., Westhorp, G., & Pawson, R. (2012). Realist methods in medical education research: What are they and what can they contribute? Medical Education, 46(1), 89–96. doi: 10.1111/j.1365-2923.2011.04045.x
  • Wong, G., Westhorp, G., Pawson, R., & Greenhalgh, T. (2013). Realist synthesis: RAMESES training materials. London: The RAMESES Project.
  • Young, H. (2003). Challenges and solutions for care of frail older adults. Online Journal Issues in Nursing, 8(2), 46–69.