The relationship between expectancy, anxiety, and the nocebo effect: a systematic review and meta-analysis with recommendations for future research

References

• Agripino, M. E. d. J., Lima, L. V., Freitas, I. F., Souto, N. B. R., Carvalho, T. C. S., & DeSantana, J. M. (2016). Influence of therapeutic approach in the TENS-induced hypoalgesia. The Clinical Journal of Pain, 32(7), 594–601. https://doi.org/10.1097/AJP.0000000000000243
   PubMed Web of Science ®Google Scholar
• Albu, S., & Meagher, M. W. (2016). Expectation of nocebo hyperalgesia affects EEG alpha-activity. International Journal of Psychophysiology, 109, 147–152. https://doi.org/10.1016/j.ijpsycho.2016.08.009
   PubMed Web of Science ®Google Scholar
• Aslaksen, P. M., Åsli, O., Øvervoll, M., & Bjørkedal, E. (2016). Nocebo hyperalgesia and the startle response. Neuroscience, 339, 599–607. https://doi.org/10.1016/j.neuroscience.2016.10.040
   PubMed Web of Science ®Google Scholar
• Aslaksen, P. M., & Lyby, P. S. (2015). Fear of pain potentiates nocebo hyperalgesia. Journal of Pain Research, 8, 703–710. https://doi.org/10.2147/jpr.S91923
   PubMed Web of Science ®Google Scholar
• Aslaksen, P. M., Zwarg, M. L., Eilertsen, H. I., Gorecka, M. M., & Bjokedal, E. (2015). Opposite effects of the same drug: Reversal of topical analgesia by nocebo information. Pain, 156(1), 39–46. https://doi.org/10.1016/j.pain.0000000000000004
   PubMed Web of Science ®Google Scholar
• Bąbel, P., Bajcar, E. A., Adamczyk, W., Kicman, P., Lisińska, N., Świder, K., & Colloca, L. (2017). Classical conditioning without verbal suggestions elicits placebo analgesia and nocebo hyperalgesia. PLoS One, 12(7), e0181856. https://doi.org/10.1371/journal.pone.0181856
   PubMed Web of Science ®Google Scholar
• Bagaric, B., Jokic-Begic, N., & Jokic, C. (2021). The nocebo effect: A review of contemporary experimental research. International Journal of Behavioral Medicine, 29(3), 255–265. https://doi.org/10.1007/s12529-021-10016-y
   PubMed Web of Science ®Google Scholar
• Bajcar, E. A., Adamczyk, W. M., Wiercioch-Kuzianik, K., & Bąbel, P. (2020a). Nocebo hyperalgesia can be induced by classical conditioning without involvement of expectancy. PLoS One, 15(5), e0232108. https://doi.org/10.1371/journal.pone.0232108
   PubMed Web of Science ®Google Scholar
• Bajcar, E. A., Wiercioch-Kuzianik, K., Adamczyk, W. M., & Bąbel, P. (2020b). To experience or to be informed? Classical conditioning induces nocebo hyperalgesia even when placebo analgesia is verbally suggested-results of a preliminary study. Pain Medicine, 21(3), 548–560. https://doi.org/10.1093/pm/pnz123
   PubMed Web of Science ®Google Scholar
• Bajcar, E. A., Wiercioch-Kuzianik, K., Farley, D., Buglewicz, E., Paulewicz, B., & Bąbel, P. (2021). Order does matter: The combined effects of classical conditioning and verbal suggestions on placebo hypoalgesia and nocebo hyperalgesia. Pain, 162(8), 2237–2245. https://doi.org/10.1097/j.pain.0000000000002211
   PubMed Web of Science ®Google Scholar
• Bar-Haim, Y. (2010). Research review: Attention bias modification (ABM): A novel treatment for anxiety disorders. Journal of Child Psychology and Psychiatry, 51(8), 859–870. https://doi.org/10.1111/j.1469-7610.2010.02251
   PubMed Web of Science ®Google Scholar
• Barnes, K., Faasse, K., Geers, A. L., Helfer, S. G., Sharpe, L., Colloca, L., & Colagiuri, B. (2019). Can positive framing reduce nocebo side effects? Current evidence and recommendation for future research. Frontiers in Pharmacology, 10, 167–167. https://doi.org/10.3389/fphar.2019.00167
   PubMed Web of Science ®Google Scholar
• Barsky, A. J., Saintfort, R., Rogers, M. P., & Borus, J. F. (2002). Nonspecific medication side effects and the nocebo phenomenon. JAMA: Journal of the American Medical Association, 287(5), 622–627. https://doi.org/10.1001/jama.287.5.622
   PubMed Web of Science ®Google Scholar
• Bartels, D. J., van Laarhoven, A. I., Haverkamp, E. A., Wilder-Smith, O. H., Donders, A. R., van Middendorp, H., van de Kerkhof, P. C. M., Evers, A. W. (2014). Role of conditioning and verbal suggestion in placebo and nocebo effects on itch. PLoS One, 9(3), e91727. https://doi.org/10.1371/journal.pone.0091727
   PubMed Web of Science ®Google Scholar
• Bartels, L., van, A. I. M., Stroo, M., Hijne, K., Peerdeman, K., Donders, A. R., Kerkhof, P. C. M. v. d., & Evers, A. W. (2017). Minimizing nocebo effects by conditioning with verbal suggestion: A randomized clinical trial in healthy humans. PloS One, 12(9), e0182959. https://doi.org/10.1371/journal.pone.0182959
   PubMed Web of Science ®Google Scholar
• Benedetti, F. (2014). Placebo effects: From the neurobiological paradigm to translational implications. Neuron, 84(3), 623–637. https://doi.org/10.1016/j.neuron.2014.10.023
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Amanzio, M., Casadio, C., Oliaro, A., & Maggi, G. (1997). Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain, 71(2), 135–140. https://doi.org/10.1016/S0304-3959(97)03346-0
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Amanzio, M., Vighetti, S., & Asteggiano, G. (2006). The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. The Journal of Neuroscience, 26(46), 12014–12022. https://doi.org/10.1523/JNEUROSCI.2947-06.2006
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Lanotte, M., Lopiano, L., & Colloca, L. (2007). When words are painful: Unraveling the mechanisms of the nocebo effect. Neuroscience, 147(2), 260–271. https://doi.org/10.1016/j.neuroscience.2007.02.020
   PubMed Web of Science ®Google Scholar
• Bjørkedal, E., & Flaten, M. (2012). Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females. Journal of Pain Research, 5, 289–300. https://doi.org/10.2147/JPR.S33559
   PubMedGoogle Scholar
• Blasini, M., Corsi, N., Klinger, R., & Colloca, L. (2017). Nocebo and pain: An overview of the psychoneurobiological mechanisms. Pain Reports, 2(2), e585. https://doi.org/10.1097/PR9.0000000000000585
   PubMedGoogle Scholar
• Blythe, J. S., Peerdeman, K. J., Veldhuijzen, D. S., Van Schothorst, M. M. E., Thomaidou, M. A., Van Laarhoven, A. I. M., & Evers, A. W. M. (2021). Nocebo effects on cowhage-evoked itch: a randomized controlled trial of classical conditioning and observational learning. Acta Dermato-Venereological, 101, adv00370. https://doi.org/10.2340/00015555-3723
   PubMed Web of Science ®Google Scholar
• Borenstein, M., Hedges, L., Higgins, J., & Rothstein, H. (2014). Comprehensive meta-analysis (Version 3.3.070) [Computer software]. Biostat. https://www.metaanalysis.com.
   Google Scholar
• Bräscher, A. K., Kleinbohl, D., Holzl, R., & Becker, S. (2017a). differential classical conditioning of the nocebo effect: Increasing heat-pain perception without verbal suggestions. Frontiers in Psychology, 8, 2163. https://doi.org/10.3389/fpsyg.2017.02163
   PubMed Web of Science ®Google Scholar
• Bräscher, A. K., Raymaekers, K., Van Den Bergh, O., & Witthöft, M. (2017b). Are media reports able to cause somatic symptoms attributed to WiFi radiation? An experimental test of the negative expectation hypothesis. Environmental Research, 156, 265–271. https://doi.org/10.1016/j.envres.2017.03.040
   PubMed Web of Science ®Google Scholar
• Bräscher, A. K., Schulz, S. M., Van Den Bergh, O., & Witthöft, M. (2020). Prospective study of nocebo effects related to symptoms of idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF). Environmental Research, 190, 110019. https://doi.org/10.1016/j.envres.2020.110019
   PubMed Web of Science ®Google Scholar
• Camerone, E. M., Piedimonte, A., Testa, M., Wiech, K., Vase, L., Zamfira, D. A., Benedetti, F.., & Carlino, M. (2021). The effect of temporal information on placebo analgesia and nocebo hyperalgesia. Psychosomatic Medicine, 83(1), 43–50. https://doi.org/10.1097/psy.0000000000000882
   PubMed Web of Science ®Google Scholar
• Cohen, J. (1988). Statistical power analysis for the behavioural sciences. Routledge Academic.
   Google Scholar
• Colagiuri, B., Park, J., Barnes, K., Sharpe, L., Boakes, R. A., Colloca, L., & Livesey, E. J. (2021). Pre-exposure, but not overshadowing, inhibits nocebo hyperalgesia. The Journal of Pain, 22(7), 864–877. https://doi.org/10.1016/j.jpain.2021.02.008
   PubMed Web of Science ®Google Scholar
• Colagiuri, B., & Quinn, V. F. (2018). Autonomic arousal as a mechanism of the persistence of nocebo hyperalgesia. The Journal of Pain, 19(5), 476–486. https://doi.org/10.1016/j.jpain.2017.12.006
   PubMed Web of Science ®Google Scholar
• Colagiuri, B., Quinn, V. F., & Colloca, L. (2015). Nocebo hyperalgesia, partial reinforcement, and extinction. The Journal of Pain, 16(10), 995–1004. https://doi.org/10.1016/j.jpain.2015.06.012
   PubMed Web of Science ®Google Scholar
• Colagiuri, B., & Zachariae, R. (2010). Patient expectancy and post-chemotherapy nausea: A meta-analysis. Annals of Behavioral Medicine, 40(1), 3–14. https://doi.org/10.1007/s12160-010-9186-4
   PubMed Web of Science ®Google Scholar
• Coleshill, M. J., Sharpe, L., & Colagiuri, B. (2021). No evidence that attentional bias towards pain-related words is associated with verbally induced nocebo hyperalgesia: A dot-probe study. Pain Reports, 6(1), e921. https://doi.org/10.1097/pr9.0000000000000921
   PubMedGoogle Scholar
• Colloca, L. (2012). The influence of the nocebo effect in clinical trials. Open Access Journal of Clinical Trials, 4, 61–68. https://doi.org/10.2147/OAJCT.S33730
   Google Scholar
• Colloca, L., & Benedetti, F. (2007). Nocebo hyperalgesia: How anxiety is turned into pain. Current Opinion in Anaesthesiology, 20(5), 435–439. https://doi.org/10.1097/ACO.0b013e3282b972fb
   PubMed Web of Science ®Google Scholar
• Colloca, L., Corsi, N., & Fiorio, M. (2018). The interplay of exercise, placebo and nocebo effects on experimental pain. Scientific Reports, 8(1), 14758. https://doi.org/10.1038/s41598-018-32974-2
   PubMedGoogle Scholar
• Colloca, L., Petrovic, P., Wager, T. D., Ingvar, M., & Benedetti, F. (2010). How the number of learning trials affects placebo and nocebo responses. Pain, 151(2), 430–439. https://doi.org/10.1016/j.pain.2010.08.007
   PubMed Web of Science ®Google Scholar
• Corsi, N., & Colloca, L. (2017). Placebo and nocebo effects: The advantage of measuring expectations and psychological factors. Frontiers in Psychology, 8, 1–11. https://doi.org/10.3389/fpsyg.2017.00308
   PubMed Web of Science ®Google Scholar
• Corsi, N., Emadi Andani, M., Sometti, D., Tinazzi, M., & Fiorio, M. (2019). When words hurt: Verbal suggestion prevails over conditioning in inducing the motor nocebo effect. European Journal of Neuroscience, 50(8), 3311–3326. https://doi.org/10.1111/ejn.14489
   PubMed Web of Science ®Google Scholar
• Corsi, N., Emadi Andani, M., Tinazzi, M., & Fiorio, M. (2016). Changes in perception of treatment efficacy are associated to the magnitude of the nocebo effect and to personality traits. Scientific Reports, 6(1), 30671–30671. https://doi.org/10.1038/srep30671
   PubMedGoogle Scholar
• Crichton, F., & Petrie, K. J. (2015). Health complaints and wind turbines: The efficacy of explaining the nocebo response to reduce symptom reporting. Environmental Research, 140, 449–455. https://doi.org/10.1016/j.envres.2015.04.016
   PubMed Web of Science ®Google Scholar
• Deeks, J. J., Higgins, J. P. T., & Altman, D. G. (Eds.). (2022). Chapter 10: Analysing data and undertaking meta-analyses. In: J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, & V. A. Welch (Eds.). Cochrane handbook for systematic reviews of interventions version 6.3. www.training.cochrane.org/handbook
   Google Scholar
• Diener, E., & Emmons, R. A. (1984). The independence of positive and negative affect. Journal of Personality and Social Psychology, 47(5), 1105–1117. https://doi.org/10.1037/0022-3514.47.5.1105
   PubMed Web of Science ®Google Scholar
• Duval, S., & Tweedie, R. (2000). Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56(2), 455–463. https://doi.org/10.1111/j.0006-341X.2000.00455.x
   PubMed Web of Science ®Google Scholar
• Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629–634. https://doi.org/10.1136/bmj.315.7109.629
   PubMed Web of Science ®Google Scholar
• Elsenbruch, S., Roderigo, T., Enck, P., & Benson, S. (2019). Can a brief relaxation exercise modulate placebo or nocebo effects in a visceral pain model? Frontiers in Psychiatry, 10, 144. https://doi.org/10.3389/fpsyt.2019.00144
   PubMed Web of Science ®Google Scholar
• Elsenbruch, S., Schmid, J., Basler, M., Cesko, E., Schedlowski, M., & Benson, S. (2012). How positive and negative expectations shape the experience of visceral pain: An experimental pilot study in healthy women. Journal of Neurogastroenterology and Motility, 24(10), 9. https://doi.org/10.1111/j.1365-2982.2012.01950.x
   Google Scholar
• Emadi Andani, M., Tinazzi, M., Corsi, N., & Fiorio, M. (2015). Modulation of inhibitory corticospinal circuits induced by a nocebo procedure in motor performance. PLoS One, 10(4), 18. https://doi.org/10.1371/journal.pone.0125223
   Web of Science ®Google Scholar
• Evers, A. W., Colloca, L., Blease, C., Annoni, M., Atlas, L. Y., Benedetti, F., Bingel, U., Büchel, C., Carvalho, C., Colagiuri, B., Crum, A. J., Enck, P., Gaab, J., Geers, A. L., Howick, J., Jensen, K. B., Kirsch, I., Meissner, K., Napadow, V., … Kelley, J. M. (2018). Implications of placebo and nocebo effects for clinical practice: Expert consensus. Psychotherapy and Psychosomatics, 87(4), 204–210. https://doi.org/10.1159/000490354
   PubMed Web of Science ®Google Scholar
• Faasse, K. (2019). Nocebo effects in health psychology. Australian Psychologist, 54(6), 453–465. https://doi.org/10.1111/ap.12392
   Web of Science ®Google Scholar
• Faasse, K., Huynh, A., Pearson, S., Geers, A. L., Helfer, S. G., & Colagiuri, B. (2019). The influence of side effect information framing on nocebo effects. Annals of Behavioral Medicine, 53(7), 621–629. https://doi.org/10.1093/abm/kay071
   PubMed Web of Science ®Google Scholar
• Freeman, S., Yu, R., Egorova, N., Chen, X., Kirsch, I., Claggett, B., Kaptchuk, T. J., Gollub, R. L., & Kong, J. (2015). Distinct neural representations of placebo and nocebo effects. Neuroimage, 112, 197–207. https://doi.org/10.1016/j.neuroimage.2015.03.015
   PubMed Web of Science ®Google Scholar
• Frisaldi, E., Piedimonte, A., & Benedetti, F. (2015). Placebo and nocebo effects: A complex interplay between psychological factors and neurochemical networks. The American Journal of Clinical Hypnosis, 57(3), 267–284. https://doi.org/10.1080/00029157.2014.976785
   PubMed Web of Science ®Google Scholar
• Geers, A. L., Faasse, K., Guevarra, D. A., Clemens, K. S., Helfer, S. G., & Colagiuri, B. (2021). Affect and emotions in placebo and nocebo effects: What do we know so far? Social and Personality Psychology Compass, 15(1), e12575. https://doi.org/10.1111/spc3.12575
   Web of Science ®Google Scholar
• Gendolla, G. H. E., Abele, A. E., Andrei, A., Spurk, D., & Richter, M. (2005). Negative mood, self-focused attention, and the experience of physical symptoms: The joint impact hypothesis. Emotion, 5(2), 131–144. https://doi.org/10.1037/1528-3542.5.2.131
   PubMed Web of Science ®Google Scholar
• Hahn, R. A. (1997). The nocebo phenomenon: Concept, evidence and implications for public health. Preventive Medicine, 26(5), 607–611. https://doi.org/10.1006/pmed.1996.0124
   PubMed Web of Science ®Google Scholar
• Higgins, J. P. T., Savović, J., Page, M. J., Elbers, R. G., & Sterne, J. A. C. (2022). Chapter 8: Assessing risk of bias in a randomized trial. In: J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, & V. A. Welch (Eds.). Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). Cochrane, 2022. www.training.cochrane.org/handbook.
   Google Scholar
• Hurst, P., Schipof-Godart, L., Szabo, A., Raglin, J., Hettinga, F., Roelands, B., Lane, A., Foad, A., Coleman, D., & Beedie, C. (2020). The placebo and nocebo effect on sports performance: A systematic review. European Journal of Sport Science, 20(3), 279–292. https://doi.org/10.1080/17461391.2019.1655098
   PubMed Web of Science ®Google Scholar
• Icenhour, A., Labrenz, F., Ritter, C., Theysohn, N., Forsting, M., Bingel, U., & Elsenbruch, S. (2017). Learning by experience? Visceral pain-related neural and behavioral responses in a classical conditioning paradigm. Journal of Neurogastroenterology and Motility, 29(6), e13026–n/a. https://doi.org/10.1111/nmo.13026
   Google Scholar
• Johansen, O., Brox, J., & Flaten, M. (2003). Placebo and nocebo responses, cortisol, and circulating beta-endorphin. Psychosomatic Medicine, 65(5), 786–790. https://doi.org/10.1097/01.PSY.0000082626.56217.CF
   PubMed Web of Science ®Google Scholar
• Keitel, A., Wojtecki, L., Hirschmann, J., Hartmann, C. J., Ferrea, S., Sudmeyer, M., & Schnitzler, A. (2013). Motor and cognitive placebo-/nocebo-responses in Parkinson's disease patients with deep brain stimulation. [References]. Behavioural Brain Research, 250, 199–205. https://doi.org/10.1016/j.bbr.2013.04.051
   PubMed Web of Science ®Google Scholar
• Kirsch, I. (1997). Response expectancy theory and application: A decennial review. Applied and Preventive Psychology, 6(2), 69–79. https://doi.org/10.1016/S0962-1849(05)80012-5
   Google Scholar
• Kong, J., Gollub, R. L., Polich, G., Kirsch, I., LaViolette, P., Vangel, M., Rosen B., Kaptchuk, T. J. (2008). A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. Journal of Neuroscience, 28(49), 13354–13362. https://doi.org/10.1523/jneurosci.2944-08.2008
   PubMed Web of Science ®Google Scholar
• Kruger, T. H., Grob, C., de Boer, C., Peschel, T., Hartmann, U., Tenbergen, G., & Schedlowski, M. (2016). Placebo and nocebo effects in sexual medicine: An experimental approach. Journal of Sex & Marital Therapy, 42(8), 721–739. https://doi.org/10.1080/0092623x.2015.1113590
   PubMed Web of Science ®Google Scholar
• Kvavilashvili, L., & Ellis, J. A. (1999). The effects of positive and negative placebos on human memory performances. Memory, 7(4), 421–437. https://doi.org/10.1080/741944922
   Web of Science ®Google Scholar
• Lenaert, B., Bennett, M., Boddez, Y., & Van Heugten, C. (2021). The influence of nocebo information on fatigue and urge to stop: An experimental investigation. Journal of Behavior Therapy and Experimental Psychiatry, 72, 101656. https://doi.org/10.1016/j.jbtep.2021.101656
   PubMed Web of Science ®Google Scholar
• Leventhal, H., Brissette, I., & Leventhal, E. A. (2003). The common-sense model of self-regulation of health and illness. In L. D. Cameron, & H. Leventhal (Eds.), The self-regulation of health and illness behaviour (pp. 42–65). Routledge.
   Google Scholar
• Mao, A., Barnes, K., Sharpe, L., Geers, A. L., Helfer, S. G., Faasse, K., & Colagiuri, B. (2021). Using positive attribute framing to attenuate nocebo side effects: A cybersickness study. Annals of Behavioral Medicine, 55(8), 769–778. https://doi.org/10.1093/abm/kaaa115
   PubMed Web of Science ®Google Scholar
• Meeuwis, S. H., Van Middendorp, H., Lavrijsen, A. P. M., Veldhuijzen, D. S., & Evers, A. W. M. (2021). Open- and closed-label placebo and nocebo suggestions about a sham transdermal patch. Psychosomatic Medicine, 83(1), 33–42. https://doi.org/10.1097/psy.0000000000000862
   PubMed Web of Science ®Google Scholar
• Meeuwis, S. H., Van Middendorp, H., Van Laarhoven, A. I. M., Veldhuijzen, D. S., Lavrijsen, A. P. M., & Evers, A. W. (2019). Effects of openand closed-label nocebo and placebo suggestions on itch and itch expectations. Frontiers in Psychiatry, 10, 436. https://doi.org/10.3389/fpsyt.2019.00436
   PubMed Web of Science ®Google Scholar
• Mitsikostas, D. D., Chalarakis, N. G., Mantonakis, L. I., Delicha, E.-M., & Sfikakis, P. P. (2012). Nocebo in fibromyalgia: Meta-analysis of placebo-controlled clinical trials and implications for practice. European Journal of Neurology, 19(5), 672–680. https://doi.org/10.1111/j.1468-1331.2011.03528.x
   PubMed Web of Science ®Google Scholar
• Mitsikostas, D. D., Mantonakis, L., & Chalarakis, N. (2014). Nocebo in clinical trials for depression: A meta-analysis. Psychiatry Research, 215(1), 82–86. https://doi.org/10.1016/j.psychres.2013.10.019
   PubMed Web of Science ®Google Scholar
• Napadow, V., Li, A., Loggia, M. L., Kim, J., Mawla, I., Desbordes, G., Schalock P. C., Lerner E. A., Tran T. N., Ring J., Rosen B. R., Kaptchuk T. J., & Pfab, F. (2015). The imagined itch: Brain circuitry supporting nocebo-induced itch in atopic dermatitis patients. Allergy, 70(11), 1485–1492. https://doi.org/10.1111/all.12727
   PubMed Web of Science ®Google Scholar
• Okusogu, C., & Colloca, L. (2019). Placebo hypoalgesia: Above and beyond expectancy and conditioning. Current Opinion in Behavioral Sciences, 26, 75–81. https://doi.org/10.1016/j.cobeha.2018.10.008
   PubMed Web of Science ®Google Scholar
• Pan, Y., Kinitz, T., Stapic, M., & Nestoriuc, Y. (2019). Minimizing drug adverse events by informing about the nocebo effect-an experimental study. Frontiers in Psychiatry, 10, 504–504. https://doi.org/10.3389/fpsyt.2019.00504
   PubMed Web of Science ®Google Scholar
• Papadopoulos, D., & Mitsikostas, D. D. (2012). A meta-analytic approach to estimating nocebo effects in neuropathic pain trials. Journal of Neurology, 259(3), 436–447. https://doi.org/10.1007/s00415-011-6197-4
   PubMed Web of Science ®Google Scholar
• Petersen, G. L., Finnerup, N. B., Colloca, L., Amanzio, M., Price, D. D., Jensen, T. S., & Vase, L. (2014). The magnitude of nocebo effects in pain: A meta-analysis. Pain, 155(8), 1426–1434. https://doi.org/10.1016/j.pain.2014.04.016
   PubMed Web of Science ®Google Scholar
• Quinn, V. F., Livesey, E. J., & Colagiuri, B. (2017). Latent inhibition reduces nocebo nausea, even without deception. Annals of Behavioral Medicine, 51(3), 432–441. https://doi.org/10.1007/s12160-016-9867-8
   PubMed Web of Science ®Google Scholar
• Quinn, V. F., MacDougall, H. G., & Colagiuri, B. (2015). Galvanic vestibular stimulation: A new model of placebo-induced nausea. Journal of Psychosomatic Research, 78(5), 484–488. https://doi.org/10.1016/j.jpsychores.2014.12.011
   PubMed Web of Science ®Google Scholar
• Roderigo, T., Benson, S., Schöls, M., Hetkamp, M., Schedlowski, M., Enck, P., & Elsenbruch, S. (2017). Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of visceroception. Pain, 158(8), 1489–1498. https://doi.org/10.1097/j.pain.0000000000000940
   PubMed Web of Science ®Google Scholar
• Schmid, J., Bingel, U., Ritter, C., Benson, S., Schedlowski, M., Gramsch, C., Forsting, M., & Elsenbruch, S. (2015). Neural underpinnings of nocebo hyperalgesia in visceral pain: A fMRI study in healthy volunteers. Neuroimage, 120, 114–122. https://doi.org/10.1016/j.neuroimage.2015.06.060
   PubMed Web of Science ®Google Scholar
• Schmid, J., Theysohn, N., Ga, F., Benson, S., Gramsch, C., Forsting, M., Gizewski, E. R., & Elsenbruch, S. (2013). Neural mechanisms mediating positive and negative treatment expectations in visceral pain: A functional magnetic resonance imaging study on placebo and nocebo effects in healthy volunteers. Pain, 154(11), 2372–2380. https://doi.org/10.1016/j.pain.2013.07.013
   PubMed Web of Science ®Google Scholar
• Shafiq, F., Mitsikostas, D. D., & Zis, P. (2017). Nocebo in motor neuron disease: Systematic review and meta-analysis of placebo-controlled clinical trials. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18(7-8), 576–582. https://doi.org/10.1080/21678421.2017.1335325
   PubMed Web of Science ®Google Scholar
• Shi, Y., Huang, S., Zhan, H., Wang, Y., Zeng, Y., Cai, G., Yang, J., & Wu, W. (2020). Personality differences of brain networks in placebo analgesia and nocebo hyperalgesia: A psychophysiological interaction (PPI) approach in fMRI. Neural Plasticity, 2020, 8820443. https://doi.org/10.1155/2020/8820443
   PubMed Web of Science ®Google Scholar
• Shi, Y., Wang, Y., Zeng, Y., Zhan, H., Huang, S., Cai, G., Yang, J., & Wu, W. (2021). Personality differences in brain network mechanisms for placebo analgesia and nocebo hyperalgesia in experimental pain: A functional magnetic resonance imaging study. Annals of Translational Medicine, 9(5), 371–371. https://doi.org/10.21037/atm-20-5123
   PubMed Web of Science ®Google Scholar
• Sinke, C., Schmidt, K., Forkmann, K., & Bingel, U. (2017). Expectation influences the interruptive function of pain: Behavioural and neural findings. European Journal of Pain, 21(2), 343–356. https://doi.org/10.1002/ejp.928
   PubMed Web of Science ®Google Scholar
• Skvortsova, A., Veldhuijzen, D. S., Van Middendorp, H., Colloca, L., & Evers, A. W. (2020). Effects of oxytocin on placebo and nocebo effects in a pain conditioning paradigm: A randomized controlled trial. The Journal of Pain, 21(3-4), 430–439. https://doi.org/10.1016/j.jpain.2019.08.010
   PubMed Web of Science ®Google Scholar
• Stegen, K., Diest, I., Van De Woestijne, K., & De Bergh, O. (2001). Do persons with negative affect have an attentional bias to bodily sensations? Cognition and Emotion, 15(6), 813–829. https://doi.org/10.1080/02699930143000211
   Web of Science ®Google Scholar
• Thomaidou, M. A., Veldhuijzen, D. S., Meulders, A., & Evers, A. W. M. (2021). An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia. Pain, 162(1), 287–299. https://doi.org/10.1097/j.pain.0000000000002017
   PubMed Web of Science ®Google Scholar
• Thomaidou, M. A., Veldhuijzen, D. S., Peerdeman, K. J., Wiebing, N. Z. S., Blythe, J. S., & Evers, A. W. M. (2020). Learning mechanisms in nocebo hyperalgesia: The role of conditioning and extinction processes. Pain, 161(7), 1597–1608. https://doi.org/10.1097/j.pain.0000000000001861
   PubMed Web of Science ®Google Scholar
• Tu, Y. H., Wilson, G., Camprodon, J., Dougherty, D. D., Vangel, M., Benedetti, F., Kaptchuk, T. J., Gollub, R. L., & Kong, J. (2021). Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability. PNAS, 118(19), e2101273118. https://doi.org/10.1073/pnas.2101273118
   PubMed Web of Science ®Google Scholar
• van den Bergh, O., Winters, W., Devriese, S., & Diest, I. V. (2002). Learning subjective health complaints. Scandinavian Journal of Psychology, 43(2), 147–152. https://doi.org/10.1111/1467-9450.00280
   PubMed Web of Science ®Google Scholar
• Van Laarhoven, A. I. M., Vogelaar, M. L., Wilder-Smith, O. H., Van Riel, P., Van De Kerkhof, P. C. M., Kraaimaat, F. W., & Evers, A. W. M. (2011). Induction of nocebo and placebo effects on itch and pain by verbal suggestions. Pain, 152(7), 1486–1494. https://doi.org/10.1016/j.pain.2011.01.043
   PubMed Web of Science ®Google Scholar
• Varelmann, D., Pancaro, C., Cappiello, E., & Camann, W. (2011). Nocebo-induced hyperalgesia during local anesthetic injection. Obstetric Anesthesia Digest, 31(2), 124–125. https://doi.org/10.1097/01.aoa.0000397164.02159.09
   Google Scholar
• Vögtle, E., Barke, A., & Kröner-Herwig, B. (2013). Nocebo hyperalgesia induced by social observational learning. Pain, 154(8), 1427–1433. https://doi.org/10.1016/j.pain.2013.04.041
   PubMed Web of Science ®Google Scholar
• Vögtle, E., Kröner-Herwig, B., & Barke, A. (2019). Nocebo hyperalgesia can be induced by the observation of a model showing natural pain expressions. Clinical Journal of Pain, 35(9), 737–743. https://doi.org/10.1097/ajp.0000000000000734
   PubMed Web of Science ®Google Scholar
• Vögtle, E., Kroner-Herwig, B., & Barke, N. (2016). Nocebo hyperalgesia: Contributions of social observation and body-related cognitive styles. Journal of Pain Research, 9, 241–249. https://doi.org/10.2147/jpr.S96228
   PubMed Web of Science ®Google Scholar
• Webster, R. K., Weinman, J., & Rubin, G. J. (2016). A systematic review of factors that contribute to nocebo effects. Health Psychology, 35(12), 1334–1355. https://doi.org/10.1037/hea0000416
   PubMed Web of Science ®Google Scholar
• Wei, H., Zhou, L., Zhang, H., Chen, J., Lu, X., & Hu, L. (2018). The influence of expectation on nondeceptive placebo and nocebo effects. Pain Research and Management, 2018, 1–8. https://doi.org/10.1155/2018/8459429
   Web of Science ®Google Scholar
• Weng, L., Peerdeman, K. J., Della Porta, D., Van Laarhoven, A. I. M., & Evers, A. W. M. (2021). Can placebo and nocebo effects generalize within pain modalities and across somatosensory sensations?. Pain. https://doi.org/10.1097/j.pain.0000000000002390
   Web of Science ®Google Scholar
• Winkler, A., & Hermann, C. (2019). Placebo- and nocebo-effects in cognitive neuroenhancement: when expectation shapes perception. Frontiers in Psychiatry, 10, 12. https://doi.org/10.3389/fpsyt.2019.00498
   PubMed Web of Science ®Google Scholar
• Zhang, H., Zhou, L., Wei, H., Lu, X., & Hu, L. (2017). The sustained influence of prior experience induced by social observation on placebo and nocebo responses. Journal of Pain Research, 10, 2769–2780. https://doi.org/10.2147/jpr.S147970
   PubMed Web of Science ®Google Scholar