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Global Public Health
An International Journal for Research, Policy and Practice
Volume 14, 2019 - Issue 1
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Commentaries

Traditional, complementary, and alternative medical cures for HIV: rationale and implications for HIV cure research

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References

  • Akileswaran, C., Macalino, G., Bhakta, N., Mayer, K., Kumarasamy, N., & Solomon, S. (2004). Sources of information about traditional therapies to treat HIV seropositive patients in Chennai, India. Paper presented at the International Conference on AIDS, Bangkok.
  • Amon, J. J. (2008). Dangerous medicines: Unproven AIDS cures and counterfeit antiretroviral drugs. Globalization and Health, 4(1), 1.
  • Amusa, S. (2013). Towards promoting an African Medical System: A critique of government responses to claims of a cure for HIV/AIDS in Nigeria, 1986–2007. Health, Culture and Society, 4(1), 37. doi: 10.5195/HCS.2013.111
  • Analytical treatment interruption in HIV positive patients (ISALA). (2016). ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/show/NCT02590354
  • Audet, C. M., Hamilton, E., Hughart, L., & Salato, J. (2015). Engagement of traditional healers and birth attendants as a controversial proposal to extend the HIV health workforce. Current HIV/AIDS Reports, 12(2), 238–245. doi: 10.1007/s11904-015-0258-8
  • Authorities rush to control illegal medicines boom. (2006, September 27). Plus News. Retrieved from http://afrol.com/articles/21565
  • Babb, D. A., Pemba, L., Seatlanyane, P., Charalambous, S., Churchyard, G. J., & Grant, A. D. (2007). Use of traditional medicine by HIV-infected individuals in South Africa in the era of antiretroviral therapy. Psychology, Health & Medicine, 12(3), 314–320. doi: 10.1080/13548500600621511
  • Bohannon, J. (2014). A challenge to pseudoscience. Science, 345(6192), 16. doi: 10.1126/science.345.6192.16
  • Cassidy, R., & Leach, M. (2009). Science, politics, and the presidential AIDS ‘cure’. African Affairs, 108(433), 559–580. doi: 10.1093/afraf/adp057
  • CC-11050 in human immunodeficiency virus-1-infected adults with suppressed plasma viremia on antiretroviral therapy (APHRODITE). (2016). ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/show/NCT02652546
  • Chomat, A. M. B., Wilson, I. B., Wanke, C. A., Selvakumar, A., John, K., & Isaac, R. (2009). Knowledge, beliefs, and health care practices relating to treatment of HIV in Vellore, India. AIDS Patient Care and STDs, 23(6), 477–484. doi: 10.1089/apc.2008.0222
  • Corneli, A. L., Bentley, M. E., Sorenson, J. R., Henderson, G. E., Van Der Horst, C., Moses, A., & Heilig, C. M. (2006). Using formative research to develop a context-specific approach to informed consent for clinical trials. Journal of Empirical Research on Human Research Ethics, 1(4), 45–60. doi: 10.1525/jer.2006.1.4.45
  • Cox, K. (2000). Setting the context for research: Exploring the philosophy and environment of a cancer clinical trials unit. Journal of Advanced Nursing, 32(5), 1058–1065. doi: 10.1046/j.1365-2648.2000.01574.x
  • Dalal, K., & Dawad, S. (2009). Non-utilization of public healthcare facilities: Examining the reasons through a national study of women in India. Rural and Remote Health, 9(3), 1178.
  • Dawson, L., & Kass, N. E. (2005). Views of US researchers about informed consent in international collaborative research. Social Science & Medicine, 61(6), 1211–1222. doi: 10.1016/j.socscimed.2005.02.004
  • Dein, S., & Bhui, K. (2005). Issues concerning informed consent for medical research among non-westernized ethnic minority patients in the UK. Journal of the Royal Society of Medicine, 98(8), 354–356. doi: 10.1177/014107680509800806
  • Dubé, K., Henderson, G. E., & Margolis, D. M. (2014). Framing expectations in early HIV cure research. Trends in Microbiology, 22(10), 547–549. doi: 10.1016/j.tim.2014.08.003
  • Earnshaw, V. A., & Kalichman, S. C. (2013). Stigma experienced by people living with HIV/AIDS stigma, discrimination and living with HIV/AIDS (pp. 23–38): Dordrecht: Springer.
  • Efavirenz and lamivudine/zidovudine for treatment-naive HIV infected people in Wenxi County, Shanxi Province, China. (2016). ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/show/NCT00100594
  • Foote-Ardah, C. E. (2003). The meaning of complementary and alternative medicine practices among people with HIV in the United States: Strategies for managing everyday life. Sociology of Health & Illness, 25(5), 481–500. doi: 10.1111/1467-9566.00355
  • Gappoo, S., Montgomery, E. T., Gerdts, C., Naidoo, S., Chidanyika, A., Nkala, B., & Team, M. (2009). Novel strategies implemented to ensure high participant retention rates in a community based HIV prevention effectiveness trial in South Africa and Zimbabwe. Contemporary Clinical Trials, 30(5), 411–418. doi: 10.1016/j.cct.2009.05.002
  • Gyasi, R. M., Poku, A. A., Boateng, S., Amoah, P. A., Mumin, A. A., Obodai, J., & Agyemang-Duah, W. (2017). Integration for coexistence? Implementation of intercultural health care policy in Ghana from the perspective of service users and providers. Journal of Integrative Medicine, 15(1), 44–55. doi: 10.1016/S2095-4964(17)60312-1
  • Gyasi, R. M., Tagoe-Darko, E., & Mensah, C. M. (2013). Use of traditional medicine by HIV/AIDS patients in Kumasi Metropolis, Ghana: A cross-sectional survey. American International Journal of Contemporary Research, 3(4), 117–129.
  • Hahn, R. A., & Kleinman, A. (1983). Biomedical practice and anthropological theory: Frameworks and directions. Annual Review of Anthropology, 12, 305–333. doi: 10.1146/annurev.an.12.100183.001513
  • Haire, B. G. (2011). Because we can: Clashes of perspective over researcher obligation in the failed PrEP trials. Developing World Bioethics, 11(2), 63–74. doi: 10.1111/j.1471-8847.2010.00292.x
  • Hardon, A., Desclaux, A., Egrot, M., Simon, E., Micollier, E., & Kyakuwa, M. (2008). Alternative medicines for AIDS in resource-poor settings: Insights from exploratory anthropological studies in Asia and Africa. Journal of Ethnobiology and Ethnomedicine, 4(1), 16. doi: 10.1186/1746-4269-4-16
  • Hare, M. L. (1993). The emergence of an urban US Chinese medicine. Medical Anthropology Quarterly, 7(1), 30–49. doi: 10.1525/maq.1993.7.1.02a00030
  • Horng, S., & Grady, C. (2003). Misunderstanding in clinical research: Distinguishing therapeutic misconception, therapeutic misestimation, & therapeutic optimism. IRB: Ethics & Human Research, 25(1), 11–16. doi: 10.2307/3564408
  • Hoyler, E., Martinez, R., Mehta, K., Nisonoff, H., & Boyd, D. (2016). Beyond medical pluralism: Characterising health-care delivery of biomedicine and traditional medicine in rural Guatemala. Global Public Health, 1–15.
  • Kagawa-Singer, M. (2000). Improving the validity and generalizability of studies with underserved US populations expanding the research paradigm. Annals of Epidemiology, 10(8), S92–S103. doi: 10.1016/S1047-2797(00)00192-7
  • Kayombo, E. J., Uiso, F. C., Mbwambo, Z. H., Mahunnah, R. L., Moshi, M. J., & Mgonda, Y. H. (2007). Experience of initiating collaboration of traditional healers in managing HIV and AIDS in Tanzania. Journal of Ethnobiology and Ethnomedicine, 3(1), 6. doi: 10.1186/1746-4269-3-6
  • Langlois-Klassen, D., Kipp, W., Jhangri, G. S., & Rubaale, T. (2007). Use of traditional herbal medicine by AIDS patients in Kabarole District, western Uganda. The American Journal of Tropical Medicine and Hygiene, 77(4), 757–763. doi: 10.4269/ajtmh.2007.77.757
  • Lewin, S., Glenton, C., & Oxman, A. D. (2009). Use of qualitative methods alongside randomised controlled trials of complex healthcare interventions: Methodological study. BMJ, 339, b3496. doi: 10.1136/bmj.b3496
  • Lidz, C. W., & Appelbaum, P. S. (2002). The therapeutic misconception: Problems and solutions. Medical Care, 40(9), V-55–V-63.
  • Littlewood, R. A., & Vanable, P. A. (2011). A global perspective on complementary and alternative medicine use among people living with HIV/AIDS in the era of antiretroviral treatment. Current HIV/AIDS Reports, 8(4), 257–268. doi: 10.1007/s11904-011-0090-8
  • Lo, B., & Grady, C. (2013). Ethical considerations in HIV cure research: Points to consider. Current Opinion in HIV and AIDS, 8(3), 243. doi: 10.1097/COH.0b013e32835ea1c5
  • Mack, N., Kirkendale, S., Omullo, P., Odhiambo, J., Ratlhagana, M., & Masaki, M. (2013). Implementing good participatory practice guidelines in the FEM-PrEP Preexposure Prophylaxis Trial for HIV Prevention among African Women: A focus on local stakeholder involvement. Open Access Journal of Clinical Trials, 5, 127–135. doi: 10.2147/OAJCT.S45717
  • Magazi, B., Stadler, J., Delany-Moretlwe, S., Montgomery, E., Mathebula, F., Hartmann, M., & van der Straten, A. (2014). Influences on visit retention in clinical trials: Insights from qualitative research during the VOICE trial in Johannesburg, South Africa. BMC Women’s Health, 14(1), 1. doi: 10.1186/1472-6874-14-88
  • Mahajan, A. P., Sayles, J. N., Patel, V. A., Remien, R. H., Ortiz, D., Szekeres, G., & Coates, T. J. (2008). Stigma in the HIV/AIDS epidemic: A review of the literature and recommendations for the way forward. AIDS (London, England), 22(Suppl. 2), S57–S65. doi: 10.1097/01.aids.0000327438.13291.62
  • Malik, A. Y. (2011). Physician-researchers’ experiences of the consent process in the sociocultural context of a developing country. AJOB Primary Research, 2(3), 38–46. doi: 10.1080/21507716.2011.616183
  • Marshall, P. A. (2006). Informed consent in international health research. Journal of Empirical Research on Human Research Ethics, 1(1), 25–41. doi: 10.1525/jer.2006.1.1.25
  • Mignone, J., Bartlett, J., O’Neil, J., & Orchard, T. (2007). Best practices in intercultural health: Five case studies in Latin America. Journal of Ethnobiology and Ethnomedicine, 3(1), 31. doi: 10.1186/1746-4269-3-31
  • Miller, S., Le, P. V., Craig, S., Adams, V., Tudor, C., Sonam, … Varner, M. W. (2007). How to make consent informed: Possible lessons from Tibet. IRB: Ethics & Human Research, 29, 7–14.
  • Mills, E., Montori, V., Perri, D., Phillips, E., & Koren, G. (2005). Natural health product–HIV drug interactions: A systematic review. International Journal of STD & AIDS, 16(3), 181–186. doi: 10.1258/0956462053420103
  • Mills, E., Singh, S., Wilson, K., Peters, E., Onia, R., & Kanfer, I. (2006). The challenges of involving traditional healers in HIV/AIDS care. International Journal of STD & AIDS, 17(6), 360–363. doi: 10.1258/095646206777323382
  • Moatti, J. P., N'Doye, I., Hammer, S. M., Hale, P., & Kazatchkine, M. (2003). Antiretroviral treatment for HIV infection in developing countries: An attainable new paradigm. Nature Medicine, 9(12), 1449–1452. http://www.nature.com/nm/journal/v9/n12/suppinfo/nm1203-1449_S1.html doi: 10.1038/nm1203-1449
  • Molyneux, C., Peshu, N., & Marsh, K. (2004). Understanding of informed consent in a low-income setting: Three case studies from the Kenyan coast. Social Science & Medicine, 59(12), 2547–2559. doi: 10.1016/j.socscimed.2004.03.037
  • Nations, M. K., & de Souza, M. A. (1996). Umbanda healers as effective AIDS educators: Case-control study in Brazilian urban slums (favelas). Tropical Doctor, 27, 60–66. doi: 10.1177/00494755970270S118
  • NCCIH. (2008, 2016 June). Complementary, alternative or integrative healing: What’s in a name? Retrieved from https://nccih.nih.gov/health/integrative-health
  • Ndebele, P. M., Wassenaar, D., Munalula, E., & Masiye, F. (2012). Improving understanding of clinical trial procedures among low literacy populations: An intervention within a microbicide trial in Malawi. BMC Medical Ethics, 13(1), 329. doi: 10.1186/1472-6939-13-29
  • Obadare, E., & Okeke, I. N. (2011). Biomedical loopholes, distrusted state, and the politics of HIV/AIDS ‘cure’ in Nigeria. African Affairs, 110(439), 191–211. doi: 10.1093/afraf/adr001
  • O’Brien, S., & Broom, A. (2014). HIV in (and out of) the clinic: Biomedicine, traditional medicine and spiritual healing in Harare. SAHARA-J, 11(1), 94–104. doi: 10.1080/17290376.2014.938102
  • Peay, H. L., & Henderson, G. E. (2015). What motivates participation in HIV cure trials? A call for real-time assessment to improve informed consent. Journal of Virus Eradication, 1(2), 51.
  • Ramjee, G., Coumi, N., Dladla-Qwabe, N., Ganesh, S., Gappoo, S., Govinden, R., & Morar, N. (2010). Experiences in conducting multiple community-based HIV prevention trials among women in KwaZulu-Natal, South Africa. AIDS Research and Therapy, 7(1), 10. doi: 10.1186/1742-6405-7-10
  • Rich, Z. C., Liu, C., Ma, Q., Hu, F., Cai, W., Tang, X., & Tucker, J. D. (2015). Physician perceptions of HIV cure in China: A mixed methods review and implications for HIV cure research. Asian Pacific Journal of Tropical Disease, 5(9), 687–690. doi: 10.1016/S2222-1808(15)60913-6
  • Rodrigues, R. J., Antony, J., Krishnamurthy, S., Shet, A., & De Costa, A. (2013). ‘What do I know? Should I participate?’ Considerations on participation in HIV related research among HIV infected adults in Bangalore, South India. PloS One, 8(2), e53054. doi: 10.1371/journal.pone.0053054
  • Roura, M., Nsigaye, R., Nhandi, B., Wamoyi, J., Busza, J., Urassa, M., & Zaba, B. (2010). ‘Driving the devil away’: Qualitative insights into miraculous cures for AIDS in a rural Tanzanian ward. BMC Public Health, 10(1), 75. doi: 10.1186/1471-2458-10-427
  • Safety, tolerability, and efficacy of asunaprevir and daclatasvir in subjects coinfected with HIV-HCV. (2016). ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/show/NCT02124044
  • Sparber, A., Ford, D., & Kvochak, P. A. (2004). National Institutes of Health's Clinical Center sets new policy on use of herbal and other alternative supplements by patients enrolled in clinical trials. Cancer Investigation, 22(1), 132–137. doi: 10.1081/CNV-120027588
  • State House Website. (2015). The breakthrough – Part 1 [Web]. https://www.youtube.com/watch?v=eADHnTdrMGo: YouTube
  • Staunton, C. (2015). Informed consent for HIV cure research in South Africa: Issues to consider. BMC Medical Ethics, 16(1), 6. doi: 10.1186/1472-6939-16-3
  • Syed, I. A., Sulaiman, S. A. S., Hassali, M. A., Thiruchelvam, K., Syed, S. H., & Lee, C. K. (2016). Beliefs and practices of complementary and alternative medicine (CAM) among HIV/AIDS patients: A qualitative exploration. European Journal of Integrative Medicine, 8(1), 41–47. doi: 10.1016/j.eujim.2015.09.135
  • Syvertsen, J. L., Bazzi, A. M. R., Scheibe, A., Adebajo, S., Strathdee, S. A., & Wechsberg, W. M. (2014). The promise and peril of pre-exposure prophylaxis (prep): Using social science to inform prep interventions among female sex workers. African Journal of Reproductive Health, 18(3), 74–83.
  • Tekola, F., Bull, S. J., Farsides, B., Newport, M. J., Adeyemo, A., Rotimi, C. N., & Davey, G. (2009). Tailoring consent to context: Designing an appropriate consent process for a biomedical study in a low income setting. PLoS Neglected Tropical Diseases, 3(7), e482. doi: 10.1371/journal.pntd.0000482
  • Thielman, N. M., Ostermann, J., Whetten, K., Whetten, R., Itemba, D., Maro, V., & Team, T. C. R. (2014). Reduced adherence to antiretroviral therapy among HIV-infected Tanzanians seeking cure from the Loliondo healer. Journal of Acquired Immune Deficiency Syndromes, 65(3), e104. doi: 10.1097/01.qai.0000437619.23031.83
  • Toledo, L., McLellan-Lemal, E., Henderson, F. L., & Kebaabetswe, P. M. (2015). Knowledge, attitudes, and experiences of HIV pre-exposure prophylaxis (PrEP) trial participants in Botswana. World Journal of AIDS, 5(2), 10. doi: 10.4236/wja.2015.51002
  • Tucker, J. D., Volberding, P. A., Margolis, D. M., Rennie, S., & Barré-Sinoussi, F. (2014). Words matter: Discussing research towards an HIV cure in research and clinical contexts. Journal of Acquired Immune Deficiency Syndromes, 67(3), e110. doi: 10.1097/QAI.0000000000000305
  • Van Damme, L., Corneli, A., Ahmed, K., Agot, K., Lombaard, J., Kapiga, S., & Onyango, J. (2012). Preexposure prophylaxis for HIV infection among African women. New England Journal of Medicine, 367(5), 411–422. doi: 10.1056/NEJMoa1202614
  • van den Bout-van den Beukel, C. J., Koopmans, P. P., van der Ven, A. J., De Smet, P. A., & Burger, D. M. (2006). Possible drug–metabolism interactions of medicinal herbs with antiretroviral agents. Drug Metabolism Reviews, 38(3), 477–514. doi: 10.1080/03602530600754065
  • Verhoef, M. J., Mulkins, A., Carlson, L. E., Hilsden, R. J., & Kania, A. (2007). Assessing the role of evidence in patients’ evaluation of complementary therapies: A quality study. Integrative Cancer Therapies, 6(4), 345–353. doi: 10.1177/1534735407309482
  • WHO-UNAIDS. (2005). The 3 by 5 initiative: Treat three million people with HIV/AIDS by 2005. Retrieved from http://www.who.int/3by5/en/
  • World Health Organization. (2016). Traditional medicine: Definitions. Retrieved from http://www.who.int/medicines/areas/traditional/definitions/en/
  • Zou, J., Yamanaka, Y., John, M., Watt, M., Ostermann, J., & Thielman, N. (2009). Religion and HIV in Tanzania: Influence of religious beliefs on HIV stigma, disclosure, and treatment attitudes. BMC Public Health, 9(1), 153. doi: 10.1186/1471-2458-9-75

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