Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies

References

• Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8(7):481–490.
   PubMed Web of Science ®Google Scholar
• AAP Position Paper. Epidemiology of periodontal diseases. J Periodontol. 2005;76:1406–1419.
   PubMed Web of Science ®Google Scholar
• Petersen PE, Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000. 2012;60(1):15–39.
   PubMed Web of Science ®Google Scholar
• Otomo-Corgel J, Pucher JJ, Rethman MP, et al. State of the science: chronic periodontitis and systemic health. J Evid Based Dent Pract. 2012;12(S1):20–28.
   PubMedGoogle Scholar
• Oliveira FAF, Forte CPF, Silva PG, et al. Molecular analysis of oral bacteria in heart valve of patients with cardiovascular disease by real-time polymerase chain reaction. Medicine. 2015;94:e2067.
   PubMed Web of Science ®Google Scholar
• Westling K, Vondracek M. Actinobacillus (Aggregatibacter) actinomycetemcomitans (HACEK) identified by PCR/16S rRNA sequence analysis from the heart valve in a patient with blood culture negative endocarditis. Scand J Infect Dis. 2008;40(11–12):981–983.
   PubMed Web of Science ®Google Scholar
• Cui D, Houxuan L, Lei L, et al. Nonsurgical periodontal treatment reduced aortic inflammation in ApoE -/- mice with periodontitis. SpringerPlus. 2016;5:940.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Thurnheer T, Belibasakis GN. Involvement of the TREM-1/DAP12 pathway in the innate immune responses to Porphyromonas gingivalis. Mol Immunol. 2011;49:387–394.
   PubMed Web of Science ®Google Scholar
• Sima C, Glogauer M. Neutrophil dysfunction and host susceptibility to periodontal inflammation: current state of knowledge. Curr Oral Health Rep. 2014;1:95–103.
   Google Scholar
• How KY, Song KP, Chan KG. Porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line. Front Microbiol. 2016;7:53.
   PubMed Web of Science ®Google Scholar
• Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409–419.
   PubMed Web of Science ®Google Scholar
• Murdoch C, Aziz HA, Fang H-Y, et al. Khat (Catha edulis) alters the phenotype and antimicrobial activity of peripheral blood mononuclear cells. J Ethnopharmacol. 2011;138:780–787.
   PubMed Web of Science ®Google Scholar
• Hirschfeld J. Dynamic interactions of neutrophils and biofilms. J Oral Microbiol. 2014;6:26102.
   PubMed Web of Science ®Google Scholar
• Eloe-Fadrosh EA, Rasko DA. The human microbiome: from symbiosis to pathogenesis. Annu Rev Med. 2013;64:145–163.
   PubMed Web of Science ®Google Scholar
• Bao K, Belibasakis GN, Thurnheer T, et al. Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation. BMC Microbiol. 2014;14:258.
   PubMed Web of Science ®Google Scholar
• Belibasakis GN, Ozturk VO, Emingil G, et al. Soluble triggering receptors expressed on myeloid cells 1 (sTREM-1) in gingival crevicular fluid: association with clinical and microbiologic parameters. J Periodontol. 2014;85(1):204–210.
   PubMed Web of Science ®Google Scholar
• Paknejad M, Sattari M, Roozbahani Z, et al. Relationships between high-mobility group protein B1 and triggering receptor expressed on myeloid cells concentrations in gingival crevicular fluid and chronic periodontitis. Iran J Allergy Asthma Immunol. 2016;15(5):381–385.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Bao K, Wahlander A, et al. Secretome of gingival epithelium in response to subgingival biofilms. Mol Oral Microbiol. 2015;30:323–335.
   PubMed Web of Science ®Google Scholar
• Belibasakis GN, Bao K, Bostanci N. Transcriptional profiling of human gingival fibroblasts in response to multi-species in vitro subgingival biofilms. Mol Oral Microbiol. 2014;29:174–183.
   PubMed Web of Science ®Google Scholar
• Belibasakis GN, Kast J, Thurnheer T, et al. The expression of gingival epithelial junctions in response to subgingival biofilms. Virulence. 2015;6(7):704–709.
   PubMed Web of Science ®Google Scholar
• Bisson C, Massin F, Lefevre PA, et al. Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM) −1 in severe periodontitis. J Clin Periodontol. 2012;39:1141–1148.
   PubMed Web of Science ®Google Scholar
• Olsen I, Hajishengallis G. Major neutrophil functions subverted by Porphyromonas gingivalis. J Oral Microbiol. 2016;8:30936.
   PubMed Web of Science ®Google Scholar
• Rai V, Rao VH, Shao Z, et al. Dendritic cells expressing triggering receptor expressed on myeloid cells-1 correlate with plaque stability in symptomatic and asymptomatic patients with carotid stenosis. PLoS One. 2016;11(5):e0154802.
   PubMed Web of Science ®Google Scholar
• Rao VH, Rai V, Stoupa S, et al. Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis. Atherosclerosis. 2016;248:160–169.
   PubMed Web of Science ®Google Scholar
• Pelham CJ, Pandya AN, Agrawal DK. Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Expert Opin Ther Pat. 2014;24(12):1383–1395.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Oztürk VÖ, Emingil G, et al. Elevated oral and systemic levels of soluble triggering receptor expressed on myeloid cells −1 (sTREM-1) in periodontitis. J Dent Res. 2013;92(2):161–165.
   PubMed Web of Science ®Google Scholar
• Gibot S, Buonsanti C, Massin F, et al. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Infect Immun. 2006;74(5):2823–2830.
   PubMed Web of Science ®Google Scholar
• Dong L, Zhou Y, Zhu ZQ, et al. Soluble epoxide hydrolase inhibitor suppresses the expression of triggering receptor expressed on myeloid cells-1 by inhibiting NF-kB activation in murine macrophage. Inflammation. 2017;40(1):13–20.
   Web of Science ®Google Scholar
• Varanat M, Haase EM, Kay JG, et al. Activation of the TREM-1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria. Mol Oral Microbiol. 2017;32(4):275–287.
   PubMed Web of Science ®Google Scholar
• Hajishengallis G. Too old to fight? Aging and its toll on innate immunity. Mol Oral Microbiol. 2010;25:25–37.
   PubMed Web of Science ®Google Scholar
• McMahon L, Schwartz K, Yilmaz O, et al. Vitamin D-mediated induction of innate immunity in gingival epithelial cells. Infect Immun. 2011;79(6):2250–2256.
   PubMed Web of Science ®Google Scholar
• Sharif O, Bolshakov VN, Raines S, et al. Transcriptional profiling of the LPS induced NF-κB response in macrophages. BMC Immunol. 2007;8:1.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Belibasakis GN. Doxycycline inhibits TREM-1 induction by Porphyromonas gingivalis. FEMS Immunol Med Microbiol. 2012;66:37–44.
   PubMedGoogle Scholar
• Pandupuspitasari N, Khan F, Huang C, et al. Novel attributions of TREMs in immunity. Curr Issues Mol Biol. 2016;20:47–54.
   PubMed Web of Science ®Google Scholar
• El Mezayen R, El Gazzar M, Seeds MC, et al. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111:36–44.
   PubMed Web of Science ®Google Scholar
• Wu M, Peng A, Sun M, et al. TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating toll-like receptor signaling and Th1/Th2-type immune responses. Infect Immun. 2011;79:2709–2716.
   PubMed Web of Science ®Google Scholar
• Liang S, Domon H, Hosur KB, et al. Age related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech Ageing Dev. 2009;130:538–546.
   PubMed Web of Science ®Google Scholar
• Hall SC, Agrawal DK. Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end products in allergic airway inflammation. Expert Rev Respir Med. 2016;10(2):171–184.
   PubMed Web of Science ®Google Scholar
• Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001;410:1103–1107.
   PubMed Web of Science ®Google Scholar
• Pelham CJ, Agrawal DK. Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases. Expert Rev Clin Immunol. 2014;10(2):243–256.
   PubMed Web of Science ®Google Scholar
• Willi M, Belibasakis GN, Bostanci N. Expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. Clin Exp Immunol. 2014;178:190–200.
   PubMed Web of Science ®Google Scholar
• Chen SS, Wang K, Zhao J, et al. Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva. J Periodont Res. 2017;52(3):512–521.
   Web of Science ®Google Scholar
• Ozturk VO, Belibasakis GN, Emingil G, et al. Impact of aging on TREM-1 responses in the periodontium: a cross-sectional study in an elderly population. BMC Infect Dis. 2016;16:429.
   PubMed Web of Science ®Google Scholar
• Hajishengallis G. Immune evasion strategies of Porphyromonas gingivalis. J Oral Biosci. 2011;53(3):233–240.
   PubMedGoogle Scholar
• Hajishengallis G, Darveau RP, Curtis MA. The keystone-pathogen hypothesis. Nat Rev Microbiol. 2012;10(10):717–725.
   PubMed Web of Science ®Google Scholar
• Johnson JD, Chen R, Lenton PA, et al. Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis. J Periodontol. 2008;79:2305–2312.
   PubMed Web of Science ®Google Scholar
• Reddi D, Belibasakis GN. Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products. PLoS One. 2012;7:e43899.
   PubMed Web of Science ®Google Scholar
• Mysak J, Podzimek S, Sommerova P, et al. Porphyromonas gingivalis: major periodontopathic pathogen overview. J Immunol Res. 2014;2014:476068.
   PubMed Web of Science ®Google Scholar
• Bostanci N, Thurnheer T, Aduse-Opoku J, et al. Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains. PLoS One. 2013;8(10):e75784.
   PubMed Web of Science ®Google Scholar
• Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76(11):2066s–2074s.
   PubMed Web of Science ®Google Scholar
• Crotti TN, Dharmapatni AA, Alias E, et al. The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Res Ther. 2012;14(6):R245.
   PubMed Web of Science ®Google Scholar
• Crotti TN, Dharmapatni A, Alias E, et al. Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. J Immunol Res. 2015;2015:1–13.
   Web of Science ®Google Scholar
• Nguyen AH, Koenck C, Quirk SK, et al. Triggering receptor expressed on myeloid cells in cutaneous melanoma. Clin Translational Sci. 2015;8(5):441–444.
   PubMed Web of Science ®Google Scholar
• Thankam FG, Dilisio MF, Dietz NE, et al. TREM-1, HMGB1 and RAGE in the shoulder tendon: dual mechanisms for inflammation based on the coincidence of glenohumeral arthritis. PLoS One. 2016;11(10):e0165492.
   PubMed Web of Science ®Google Scholar
• Nguyen AH, Berim IG, Agrawal DK. Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells. Expert Rev Clin Immunol. 2015;11(7):849–857.
   PubMed Web of Science ®Google Scholar
• Subramanian S, Pallati P, Sharma P, et al. TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population. J Translational Med. 2017;15(1):85.
   PubMed Web of Science ®Google Scholar
• Subramanian S, Pallati P, Rai V, et al. Triggering receptor expressed on myeloid cells-1 is a novel biomarker for insulin resistance in the obese population. Obesity. 2017;25(3):527–538.
   PubMed Web of Science ®Google Scholar