Allergic reactions to penicillins and cephalosporins: diagnosis, assessment of cross-reactivity and management

References

• Blanca M. Allergic reactions to penicillins. A changing world? Allergy. 1995;50:777–782.
   PubMed Web of Science ®Google Scholar
• Celik G, Pichler WJ, Adkinson NF Jr. Drug allergy. In: Adkinson NF Jr, Brochner Bruce S, Busse WW, et al., editors. Middleton´s allergy principles and practice. 7th ed. Philadelphia: Mosby Elsevier; 2009. p. 1205–1226.
   Google Scholar
• Antunez C, Martin E, Cornejo-Garcia JA, et al. Immediate hypersensitivity reactions to penicillins and other betalactams. Curr Pharm Des. 2006;12:327–333.
   PubMed Web of Science ®Google Scholar
• Gómez E, Torres MJ, Mayorga C, et al. Immunologic evaluation of drug allergy. Allergy Asthma Immunol Res. 2012;4:251–263.
   PubMed Web of Science ®Google Scholar
• Marwood J, Aguirrebarrena G, Kerr S, et al. De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing. Emerg Med Australas. 2017;29:509–515.
   PubMed Web of Science ®Google Scholar
• Knezevic B, Sprigg D, Seet J, et al. The revolving door: antibiotic allergy labelling in a tertiary care centre. Intern Med J. 2016;46:1276–1283.
   PubMed Web of Science ®Google Scholar
• Li M, Krishna MT, Razaq S, et al. A real-time prospective evaluation of clinical pharmaco-economic impact of diagnostic label of ‘penicillin allergy’ in a UK teaching hospital. J Clin Pathol. 2014;67:1088–1092.
   PubMed Web of Science ®Google Scholar
• Blumenthal KG, Li Y, Banerji A, et al. The cost of penicillin allergy evaluation. J Allergy Clin Immunol Pract. 2018;6:1019–1027.
   PubMed Web of Science ®Google Scholar
• Wu JH, Langford BJ, Schwartz KL, et al. Potential negative effects of antimicrobial allergy labelling on patient care: a systematic review. Can J Hosp Pharm. 2018;71:29–35.
   PubMed Web of Science ®Google Scholar
• Weiss ME, Adkinson NF. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy. 1988;18:515–540.
   PubMedGoogle Scholar
• Blanca M, Vega JM, Garcia JJ, et al. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Exp Allergy. 1989;19:556–558.
   PubMed Web of Science ®Google Scholar
• Neghy KW, Caffrey AR, Morrill HJ, et al. Are non-allergic drug reactions commonly documented as medication “allergies”? A national cohort of Veterans’ admissions from 2000 to 2014. Pharmacoepidemiol Drug Saf. 2017;26:472–476.
   PubMed Web of Science ®Google Scholar
• Khasawneh FA, Slaton MA, Katzen SL, et al. The prevalence and reliability of self-reported penicillin allergy in a community hospital. Int J Gen Med. 2013;6:905–909.
   PubMedGoogle Scholar
• McConeghy KW, Caffrey AR, Morrill HJ, et al. Are non-allergic drug reactions commonly documented as medication “allergies”? A national cohort of Veterans’ admissions from 2000 to 2014. Pharmacoepidemiol Drug Saf. 2017;26:472–476.
   PubMed Web of Science ®Google Scholar
• Al-Ahmad M, Rodriguez Bouza T, Arifhodzic N. Penicillin allergy evaluation: experience from a drug allergy clinic in an Arabian Gulf Country, Kuwait. Asia Pac Allergy. 2014;4:106–112.
   PubMedGoogle Scholar
• Blanca M, Vega JM, Garcia J, et al. Allergy to penicillin with good tolerance to other penicillins; study of the incidence in subjects allergic to beta-lactams. Clin Exp Allergy. 1990;20:475–481.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Romano A, Mayorga C, et al. Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing. Allergy. 2001;56:850–856.
   PubMed Web of Science ®Google Scholar
• MacDougall C. Penicillins, cephalosporins, and other B-lactam antibiotics. In: Brunton LL, Hilal-Dandan R, Knollmann BC, editors. The pharmacological basic of therapeutics. New York: Mc Graw Hill Education; 2018. p. 1023–1038.
   Google Scholar
• Blanca M, Garcia J, Vega JM, et al. Anaphylaxis to penicillins after non- therapeutic exposure: an immunological investigation. Clin Exp Allergy. 1996;26:335–340.
   PubMed Web of Science ®Google Scholar
• Blanca M, Romano A, Torres MJ, et al. Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams. Clin Exp Allergy. 2007;37:166–173.
   PubMed Web of Science ®Google Scholar
• Blanca M, Vega JM, Garcia J, et al. New aspects of allergic reactions to betalactams: cross-reactions and unique specificities. Clin Exp Allergy. 1994;24:407–415.
   PubMed Web of Science ®Google Scholar
• Romano A, Mayorga C, Torres MJ, et al. Immediate allergic reactions to cephalosporins: cross-reactivity and selective responses. J Allergy Clin Immunol. 2000;106:1177–1183.
   PubMed Web of Science ®Google Scholar
• Yoo HS, Kim SH, Kwon HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014;55:1473–1483.
   PubMed Web of Science ®Google Scholar
• Moreno F, Blanca M, Mayorga C, et al. Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int Arch Allergy Immunol. 1995;108:74–81.
   PubMed Web of Science ®Google Scholar
• Park HS, Kim KU, Lee YM, et al. Occupational asthma and IgE sensitization to 7-aminocephalosporanic acid. J Allergy Clin Immunol. 2004;113:785–787.
   PubMed Web of Science ®Google Scholar
• Yun J, Cai F. Lee FJ and Pichler W. T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance. Asia Pac Allergy. 2016;6:77–89.
   PubMed Web of Science ®Google Scholar
• Blanca-Lopez N, Perez-Alzate D, Canto G, et al. Practical approach to the treatment of NSAID hypersensitivity. Expert Rev Clin Immunol. 2017;13:1017–1027.
   PubMed Web of Science ®Google Scholar
• Terrados S, Blanca M, Garcia J, et al. Nonimmediate reactions to betalactams: prevalence and role of the different penicillins. Allergy. 1995;50:563–567.
   PubMed Web of Science ®Google Scholar
• Ariza A, Collado D, Vida Y, et al. Study of protein haptenation by amoxicillin through the use of a biotinylated antibiotic. PLoS One. 2014;9:e90891.
   PubMed Web of Science ®Google Scholar
• Sánchez-Gómez FJ, González-Morena JM, Vida Y, et al. Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cells. Allergy. 2017;72:385–396.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Morena JM, Montanez MI, Aldini G, et al. Formation and context factors in drug hypersensitivity: insight from proteomic studies. Curr Pharm Des. 2016;22:6748–6758.
   PubMed Web of Science ®Google Scholar
• Azoury ME, Filì L, Bechara R, et al. Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy. Allergy. 2018;73:1662–1672.
   PubMed Web of Science ®Google Scholar
• Blanca M, Vega JM, Perez E, et al. Determination of specific IgE antibodies to benzylpenicillin and amoxicillin in sera from patients allergic to beta-lactams. Int Arch Allergy Appl Immunol. 1991;94:376.
   PubMedGoogle Scholar
• Blanca M, Mayorga C, Sanchez F, et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxicillin measured by RAST in a group of penicillin allergic patients. Allergy. 1991;46:632–638.
   PubMed Web of Science ®Google Scholar
• Mayorga C, Obispo T, Jimeno L, et al. Epitope mapping of beta-lactam antibiotics with the use of monoclonal antibodies. Toxicology. 1995;97:225–234.
   PubMed Web of Science ®Google Scholar
• Fernandez M, Warbrick EV, Blanca M, et al. Activation and hapten inhibition of mast cells sensitized with monoclonal IgE anti-penicillin antibodies: evidence for two-site recognition of the penicillin derived determinant. Eur J Immunol. 1995;25:2486–2491.
   PubMed Web of Science ®Google Scholar
• Blanca M, Carmona MJ, Moreno F, et al. Selective immediate allergic response to penicillin V. Allergy. 1996;51:961–963.
   PubMed Web of Science ®Google Scholar
• Sánchez-Morillas L, Rojas-Pérez-Ezquerra P, González-Mendiola R, et al. Selective sensitization to Penicillin V with tolerance to other betalactams. Recent Pat Inflamm Allergy Drug Discov. 2014;8:74–76.
   PubMedGoogle Scholar
• Perez-Inestrosa E, Suau R, Montañez MI, et al. Cephalosporin chemical reactivity and its immunological implications. Curr Opin Allergy Clin Immunol. 2005;5:323–330.
   PubMed Web of Science ®Google Scholar
• Amalfi MO, Sullivan A, Jenkins RE, et al. Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. Allergy. 2017;72:896–907.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Mayorga C, Pamies R, et al. Immunologic response to different determinants of benzylpenicillin, amoxicillin, and ampicillin. Comparison between urticaria and anaphylactic shock. Allergy. 1999;54:936–943.
   PubMed Web of Science ®Google Scholar
• Lopez S, Gomez E, Torres MJ, et al. Betalactam antibiotics affect human dendritic cells maturation through MAPK/NF-kB systems. Role in allergic reactions to drugs. Toxicol Appl Pharmacol. 2015;288:289–299.
   PubMed Web of Science ®Google Scholar
• Pinheiro V, Pestana C, Pinho A, et al. Occupational allergic contact dermatitis caused by antibiotics in healthcare workers - relationship with non-immediate drug eruptions. Contact Dermatitis. 2018;78:281–286.
   PubMed Web of Science ®Google Scholar
• Fernandez TD, Canto G, Blanca M. Molecular mechanisms of maculopapular exanthema. Curr Opin Infect Dis. 2009;22:272–278.
   PubMed Web of Science ®Google Scholar
• Labrosse R, Graham F, Bégin P, et al. A pediatric case of selective fixed drug eruption to amoxicillin. Pediatr Allergy Immunol. 2017;28:848–850.
   PubMed Web of Science ®Google Scholar
• Saissi EH, Beau-Salinas G, Jonville-Bera AP, et al. Drugs associated with acute generalized exanthematic pustulosis. Ann Dermatol Venereol. 2003;130:612–618.
   PubMed Web of Science ®Google Scholar
• Gomez E, Blanca-Lopez N, Salas M, et al. Induction of accelerated reactions to amoxicillin by T-cell effector mechanisms. Ann Allergy Asthma Immunol. 2013;110:267–273.
   PubMed Web of Science ®Google Scholar
• Karadag AS, Ozlu E, Akdeniz N, et al. Oral mucosal involvement and petechial lesions: a SDRIFE case with unusual findings. Cutan Ocul Toxicol. 2016;35:157–159.
   PubMed Web of Science ®Google Scholar
• de Lemos AS, Ghabril M, Rockey DC, et al.; Drug-Induced Liver Injury Network (DILIN). Amoxicillin-clavulanate-induced liver injury. Dig Dis Sci. 2016;61:2406–2416.
   PubMed Web of Science ®Google Scholar
• Lopes L, Filipe P, Alves A, et al. Nicolau syndrome after benzathine penicillin treated with hyperbaric oxygen therapy. Int J Dermatol. 2015;54:103–106.
   Web of Science ®Google Scholar
• Garcia-Martin E, Ayuso P, Martinez C, et al. Histamine pharmacogenomics. Pharmacogenomics. 2009;10:867–883.
   PubMed Web of Science ®Google Scholar
• Blanca M, Torres MJ, García JJ, et al. Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics. J Allergy Clin Immunol. 1999;103:918–924.
   PubMed Web of Science ®Google Scholar
• Romano A, Gaeta F, Valluzzi RL, et al. Natural evolution of skin-test sensitivity in patients with IgE-mediated hypersensitivity to cephalosporins. Allergy. 2014;69:806–809.
   PubMed Web of Science ®Google Scholar
• van Kester MS, Langeveld TJC, Bouwsma H, et al. A breathtaking DRESS due to amoxicillin-clavulanate presenting as polymorphic eruption of the pregnancy. J Eur Acad Dermatol Venereol. 2018;32:e436–e437.
   PubMed Web of Science ®Google Scholar
• Blumenthal KG, Kuhlen JL Jr, Weil AA, et al. Adverse drug reactions associated with ceftaroline use: a two-center retrospective cohort. J Allergy Clin Immunol Pract. 2016;4:740–746.
   PubMed Web of Science ®Google Scholar
• Atanasković-Marković M, Medjo B, Gavrović-Jankulović M, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Pediatr Allergy Immunol. 2013;24:645–649.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Blanca M. The complex clinical picture of betalactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems and clavams. Med Clin North Am. 2010;94:805–820.
   PubMed Web of Science ®Google Scholar
• Romano A, Blanca M, Torres MJ, et al. Diagnosis of nonimmediate reactions to beta-lactam antibiotics. Allergy. 2004;59:1153–1160.
   PubMed Web of Science ®Google Scholar
• Macy E, Blumenthal KG. Are cephalosporins safe for use in penicillin allergy without prior allergy evaluation? J Allergy Clin Immunol Pract. 2018;6:82–89.
   PubMed Web of Science ®Google Scholar
• Yoon K, Lee M, Patel R, et al. Successful implementation of a simple algorithm to manage penicillin allergy in an acute care community hospital. Ann Pharmacother. 2018;52:603–604.
   PubMed Web of Science ®Google Scholar
• Gugkaeva Z, Crago JS, Yasnogorodsky M. Next step in antibiotic stewardship: pharmacist-provided penicillin allergy testing. J Clin Pharm Ther. 2017;42:509–512.
   PubMed Web of Science ®Google Scholar
• Blanca M, Mayorga C, Torres MJ, et al. Side-chain-specific reactions to betalactams: 14 years later. Clin Exp Allergy. 2002;32:192–197.
   PubMed Web of Science ®Google Scholar
• Harandian F, Pham D, Ben-Shoshan M. Positive penicillin allergy testing results: a systematic review and meta-analysis of papers published from 2010 through 2015. Postgrad Med. 2016;128:557–562.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Blanca M, Fernandez J, et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy. 2003;58:961–972.
   PubMed Web of Science ®Google Scholar
• Barni S, Mori F, Sarti L, et al. Utility of skin testing in children with a history of non-immediate reactions to amoxicillin. Clin Exp Allergy. 2015;45:1472–1474.
   PubMed Web of Science ®Google Scholar
• Romano A, Torres MJ, Fernandez J, et al. Allergic reactions to ampicillin. Studies on the specificity and selectivity in subjects with immediate reactions. Clin Exp Allergy. 1997;27:1425–1431.
   PubMed Web of Science ®Google Scholar
• Geng B, Eastman JJ, Mori K, et al. Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation. Ann Allergy Asthma Immunol. 2017;119:258–261.
   PubMed Web of Science ®Google Scholar
• Sáenz de San Pedro B, Mayorga C, Torres MJ, et al. Boosted IgE response after anaphylaxis reaction to cefuroxime with cross-reactivity with cefotaxime. Ann Allergy Asthma Immunol. 2002;89:101–103.
   PubMed Web of Science ®Google Scholar
• Antúnez C, Fernández T, Blanca-Lopez N, et al. IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response. Allergy. 2006;61:940–946.
   PubMed Web of Science ®Google Scholar
• Hjortlund J, Mortz CG, Stage TB. Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance. Clin Transl Allergy. 2014;4:34.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Mayorga C, Cornejo-García JA, et al. IgE antibodies to penicillin in skin test negative patients. Allergy. 2002;57:965.
   PubMed Web of Science ®Google Scholar
• Blanca M, Mayorga C, Torres MJ, et al. Clinical evaluation of Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy. 2001;56:862–870.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Padial A, Mayorga C, et al. The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams. Clin Exp Allergy. 2004;34:1768–1775.
   PubMed Web of Science ®Google Scholar
• Torres MJ, Sánchez-Sabaté E, Alvarez J, et al. Skin test evaluation in nonimmediate allergic reactions to penicillins. Allergy. 2004;59:219–224.
   PubMed Web of Science ®Google Scholar
• Phillips EJ, Bigliardi P, Bircher AJ, et al. Controversies in drug allergy: testing for delayed reactions. J Allergy Clin Immunol. 2019;143:66–73.
   PubMed Web of Science ®Google Scholar
• Padial A, Antunez C, Blanca-Lopez N, et al. Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy. 2008;38:822–828.
   PubMed Web of Science ®Google Scholar
• Blanca-López N, Zapatero L, Alonso E, et al. Skin testing and drug provocation in the diagnosis of nonimmediate reactions to aminopenicillins in children. Allergy. 2009;64:229–233.
   PubMed Web of Science ®Google Scholar
• De Week AL, Sanz ML, Gamboa PM, et al. ENDA (European Network for Drug Allergy). Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil activation test and sulfidoleukotriene production: a multicenter study. J Investig Allergol Clin Immunol. 2009;19:91–109.
   PubMed Web of Science ®Google Scholar
• Blanca M, Mayorga C, Perez E, et al. Determination of IgE antibodies to the benzyl penicilloyl determinant. A comparison between poly-L-lysine and human serum albumin as carriers. J Immunol Methods. 1992;153:99–105.
   PubMed Web of Science ®Google Scholar
• Fontaine C, Mayorga C, Bousquet PJ, et al. Relevance of the determination of serum- specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. Allergy. 2007;62:47–52.
   PubMed Web of Science ®Google Scholar
• Zhao Z. Baldo BA and Rimmer J. Beta-lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin. Clin Exp Allergy. 2002;32:1644–1650.
   PubMedGoogle Scholar
• Decuyper II, Ebo DG, Uyttebroek AP, et al. Quantification of specific IgE antibodies in immediate drug hypersensitivity: more shortcomings than potentials? Clin Chim Acta. 2016;460:184–189.
   PubMed Web of Science ®Google Scholar
• Ariza A, Barrionuevo E, Mayorga C, et al. IgE to penicillins with different specificities can be identified by a multiepitope macromolecule: bihaptenic penicillin structures and IgE specificities. J Immunol Methods. 2014;406:43–50.
   PubMed Web of Science ®Google Scholar
• Soler M, Mesa-Antunez P, Estevez ME, et al. Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis. Biosens Bioelectron. 2015;66:115–123.
   PubMed Web of Science ®Google Scholar
• Porebski G, Gschwend-Zawodniak A, Pichler WJ. In vitro diagnosis of T cell-mediated drug allergy. Clin Exp Allergy. 2011;41:461–470.
   PubMed Web of Science ®Google Scholar
• Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy. 1997;27:175–181.
   PubMed Web of Science ®Google Scholar
• Luque I, Leyva L, Torres JM, et al. In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions. Allergy. 2001;56:611–618.
   PubMed Web of Science ®Google Scholar
• Trautmann A, Seitz CS, Stoevesandt J, et al. Aminopenicillin-associated exanthem: lymphocyte transformation testing revisited. Clin Exp Allergy. 2014;44:1531–1538.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Pena R, Antunez R, Martin E, et al. Allergic reactions to betalactams. Expert Opin Drug Saf. 2006;5:31–48.
   PubMed Web of Science ®Google Scholar
• Aberer W, Bircher A, Romano A, et al. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy. 2003;58:854–863.
   PubMed Web of Science ®Google Scholar
• Esposito S, Castellazzi L, Tagliabue C, et al. Allergy to antibiotics in children: an overestimated problem. Int J Antimicrob Agents. 2016;48:361–366.
   PubMed Web of Science ®Google Scholar
• Bourke J, Pavlos R, James I, et al. Improving the effectiveness of penicillin allergy de-labeling. J Allergy Clin Immunol Pract. 2015;3:365–374.
   PubMed Web of Science ®Google Scholar
• Gomes ER, Brockow K, Kuyucu S, et al. ENDA/EAACI drug allergy interest group. Drug hypersensitivity in children: report from the pediatric task force of the EAACI drug allergy interest group. Allergy. 2016;71:149–161.
   PubMed Web of Science ®Google Scholar
• Mill C, Primeau MN, Medoff E, et al. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and nonimmediate reactions to amoxicillin in children. JAMA Pediatr. 2016;170(6):e160033.
   PubMed Web of Science ®Google Scholar
• Moral L, Caubet JC. Oral challenge without skin tests in children with non-severe beta-lactam hypersensitivity: time to change the paradigm? Pediatr Allergy Immunol. 2017;28:724–727.
   PubMed Web of Science ®Google Scholar
• Vega JM1, Blanca M, García JJ, et al. Tolerance to aztreonam in patients allergic to beta-lactam antibiotics. Allergy. 1991;46:196–202.
   PubMed Web of Science ®Google Scholar
• Blanca M, Fernandez J, Miranda A, et al. Cross-reactivity between penicillins and cephalosporins: clinical and immunologic studies. J Allergy Clin Immunol. 1989;83:381–385.
   PubMed Web of Science ®Google Scholar
• Miranda A, Blanca M, Vega JM, et al. Cross-reactivity between a penicillin and a cephalosporin with the same side chain. J Allergy Clin Immunol. 996(98):671–677.
   Google Scholar
• Antunez C, Blanca-Lopez N, Torres MJ, et al. Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins. J Allergy Clin Immunol. 2006;117:404–410.
   PubMed Web of Science ®Google Scholar
• Romano A, Valluzzi RL, Caruso C, et al. Cross-reactivity and tolerability of cephalosporins in patients with IgE-mediated hypersensitivity to penicillins. J Allergy Clin Immunol Pract. 2018;6:1662–1672.
   PubMed Web of Science ®Google Scholar
• Zagursky RJ, Pichichero ME. Cross-reactivity in β-lactam allergy. J Allergy Clin Immunol Pract. 2018;6:72–81.
   PubMed Web of Science ®Google Scholar
• Martinez Tadeo JA, Perez Rodriguez E, Almeida Sanchez Z, et al. No cross-reactivity with cephalosporins in patients with penicillin allergy. J Investig Allergol Clin Immunol. 2015;25:216–217.
   PubMed Web of Science ®Google Scholar
• Buonomo A, Pascolini L, Rizzi A, et al. Cross-reactivity and tolerability of ertapenem in patients with IgE-mediated hypersensitivity to β-lactams. J Investig Allergol Clin Immunol. 2016;26:100–105.
   PubMed Web of Science ®Google Scholar
• Romano A, Valluzzi RL, Caruso C, et al. Cross-reactivity and tolerability of cephalosporins in patients with IgE-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2016;138:179–186.
   PubMed Web of Science ®Google Scholar
• Callero A, Berroa F, Infante S, et al. Tolerance to cephalosporins in nonimmediate hypersensitivity to penicillins in pediatric patients. J Investig Allergol Clin Immunol. 2014;24:134–136.
   PubMed Web of Science ®Google Scholar
• Blumenthal KG, Youngster I, Shenoy ES, et al. Tolerability of cefazolin after immune-mediated hypersensitivity reactions to nafcillin in the outpatient setting. Antimicrob Agents Chemother. 2014;58:3137–3143.
   PubMed Web of Science ®Google Scholar
• Buonomo A, Nucera E, Pecora V, et al. Cross-reactivity and tolerability of cephalosporins in patients with cell-mediated allergy to penicillins. J Investig Allergol Clin Immunol. 2014;24(5):331–337. PubMed PMID: 25345303.
   PubMed Web of Science ®Google Scholar
• Romano A, Gaeta F, Valluzzi RL, et al. Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins. Allergy. 2013;68:1618–1621.
   PubMed Web of Science ®Google Scholar
• Schneider JA, Cohen PR. Stevens-Johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures. Adv Ther. 2017;34:1235–1244.
   PubMed Web of Science ®Google Scholar
• Dorafshar AH, Dickie SR, Cohn AB, et al. Antishear therapy for toxic epidermal necrolysis: an alternative treatment approach. Plast Reconstr Surg. 2008;122(1):154.
   PubMed Web of Science ®Google Scholar
• Mockenhaupt M. Stevens-Johnson syndrome and toxic epidermal necrolysis: clinical patterns, diagnosticconsiderations, etiology, and therapeutic management. Semin Cutan Med Surg. 2014;33:10–16.
   PubMed Web of Science ®Google Scholar
• Schneck J, Fagot JP, Sekula P, et al. Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective study on patients included in the prospective EuroSCAR study. J Am Acad Dermatol. 2008;58:33.
   PubMed Web of Science ®Google Scholar
• Lee HY, Lim YL, Thirumoorthy T, et al. The role of intravenous immunoglobulin in toxic epidermal necrolysis: a retrospective analysis of 64 patients managed in a specialized centre. Br J Dermatol. 2013;169(6):1304–1309.
   PubMed Web of Science ®Google Scholar
• Wojtkiewicz A, Wysocki M, Fortuna J, et al. Beneficial and rapid effect of infliximab on the course of toxic epidermal necrolysis. Acta Derm Venereol. 2008;88(4):420–421.
   PubMed Web of Science ®Google Scholar
• Lee HY, Fook-Chong S, Koh HY, et al. Cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis: retrospective analysis of a cohort treated in a specialized referral center. J Am Acad Dermatol. 2017;76(1):106–113.
   PubMed Web of Science ®Google Scholar
• Gomez MB, Torres MJ, Mayorga C, et al. Immediate allergic reactions to betalactams: facts and controversies. Curr Opin Allergy Clin Immunol. 2004;4:261–266.
   PubMed Web of Science ®Google Scholar
• Sullivan TJ. Antigen-specific desensitization of patients allergic to penicillin. J Allergy Clin Immunol. 1982;69:500–508.
   PubMed Web of Science ®Google Scholar
• Stark BJ, Earl HS, Gross GN, et al. Acute and chronic desensitization of penicillin-allergic patients using oral penicillin. J Allergy Clin Immunol. 1987;79:523–532.
   PubMed Web of Science ®Google Scholar
• Graybill JR, Sande MA, Reinarz JA, et al. Controlled penicillin anaphylaxis leading to desensitization. South Med J. 1974;67:62–64.
   PubMed Web of Science ®Google Scholar
• Win PH, Brown H, Zankar A, et al. Rapid intravenous cephalosporin desensitization. J Allergy Clin Immunol. 2005;116:225–228.
   PubMed Web of Science ®Google Scholar
• Dallé J, Ramos MC, Jimenez MF, et al. Oral desensitisation to penicillin for the treatment of pregnant woman with syphilis: a successful program. Rev Bras Ginecol Obstet. 2018 Jan;40(1):43–46.
   PubMedGoogle Scholar
• Whitaker P, Naisbit D, Peckham D. Nonimmediate β-lactam reactions in patients with cystic fibrosis. Curr Opin Clin Immunol. 2012;12:369–375.
   PubMed Web of Science ®Google Scholar
• Whitaker P, Shaw N, Gooi J, et al. Rapid desensitization for non-immediate reactions in patients with cystic fibrosis. J Cystic Fibrosis. 2011 Jul;10(4):282–285.
   PubMed Web of Science ®Google Scholar
• Estep PM, Ferreira JA, Dupree LH, et al. Impact of an antimicrobial stewardship initiative to evaluate b-lactam allergy in patients ordered aztreonam. Am J Health Syst Pharm. 2016;73(5 suppl 1):S8–S13.
   PubMed Web of Science ®Google Scholar
• Leis JA, Palmay L, Ho G, et al. Point-of-care beta-lactam allergy skin testing by antimicrobial stewardship programs: a pragmatic multicenter prospective evaluation. Clin Infect Dis. 2017;65:1059–1065.
   PubMed Web of Science ®Google Scholar
• Charneski L, Deshpande G, Smith SW. Impact of an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. Pharmacotherapy. 2011;31:742–747.
   PubMed Web of Science ®Google Scholar
• Unger NR, Gauthier TP, Cheung LW. Penicillin skin testing: potential implications for antimicrobial stewardship. Pharmacotherapy. 2013;33:856–867.
   PubMed Web of Science ®Google Scholar