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Review

Protocols for drug allergy desensitization in children

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Pages 91-100 | Received 10 Sep 2019, Accepted 25 Nov 2019, Published online: 08 Dec 2019

References

  • Johansson S, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832–836.
  • Demoly P, Adkinson NF, Brockow K, et al. International consensus on drug allergy. Allergy. 2014;69(4):420–437.
  • Muraro A, Lemanske RF, Castells M, et al. Precision medicine in allergic disease – food allergy, drug allergy, and anaphylaxis – PRACTALL document of the European Academy of Allergy and clinical immunology and the American Academy of Allergy, asthma and immunology. Allergy. 2017;72(7):1006–1021.
  • Castells MC, Tennant NM, Sloane DE, et al. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008;122(3):574–580.
  • Isabwe GAC, de Las Vecillas Sanchez L, Castells M. Management of adverse reactions to biologic agents. Allergy Asthma Proc. 2017;38(6):409–418.
  • Castells M. Drug hypersensitivity and anaphylaxis in cancer and chronic inflammatory diseases: the role of desensitizations. Front Immunol. 2017;8:1472.
  • Cernadas JR, Brockow K, Romano A, et al. General considerations on rapid desensitization for drug hypersensitivity – a consensus statement. Allergy. 2010;65(11):1357–1366.
  • Solensky R. Drug hypersensitivity. Med Clin North Am. 2006;90(1):233–260.
  • Hong D, Dioun A. Indications, protocols and outcomes of drug desensitization for chemotherapy and monoclonal anti-bodies in adults and children. J Allergy Clin Immunol Pract. 2014;2(1):13–19.
  • Gell P, Coombs R, Lachmann P. Classification of allergic reactions for clinical hypersensitivity disease. In: Gell PGH, Coombs RPA, editors. Clinical aspects of immunology. Oxford (United Kingdom): Blackwell Scientific Publications; 1968. p. 575–579.
  • Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med. 2003;139(8):683–693.
  • Pichler WJ, Hausmann O. Classification of drug hypersensitivity into allergic, p‐i, and pseudo‐allergic forms. Int Arch Allergy Immunol. 2016;171(3–4):166–179.
  • Pichler WJ. Immune pathomechanism and classification of drug hypersensitivity. Allergy. 2019;74(8):1457–1471.
  • de Las Vecillas Sánchez L, Alenazy LA, Garcia-Neuer M, et al. Drug hypersensitivity and desensitizations: mechanisms and new approaches. Int J Mol Sci. 2017;18(6):pii: E1316.
  • Scherer K, Brockow K, Aberer W, et al. Desensitization in delayed drug hypersensitivity reactions - an EAACI position paper of the drug allergy interest group. Allergy. 2013;68(7):844–852.
  • Phillips EJ, Chung WH, Mockenhaupt M, et al. Drug hypersensitivity: pharmacogenetics and clinical syndromes. J Allergy Clin Immunol. 2011;127(3 Suppl):S60–66.
  • Sancho-Serra Mdel C, Simarro M, Castells M. Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting FcεRI internalization. Eur J Immunol. 2011;41(4):1004–1013.
  • Woo HY, Kim YS, Kang NI, et al. Mechanism for acute oral desensitization to antibiotics. Allergy. 2006;61(8):954–958.
  • Liu A, Fanning L, Chong H, et al. Desensitization regimens for drug allergy: state of the art in the 21st century. Clin Exp Allergy. 2011;41(12):1679–1689.
  • Bonamichi-Santos R, Castells M. Desensitization for drug hypersensitivity to chemotherapy and monoclonal antibodies. Curr Pharm Des. 2016;22(45):6870–6880.
  • Caimmi S, Caffarelli C, Saretta F, et al. Drug desensitization in allergic children. Acta Biomed. 2019;90(Suppl 3):20–29.
  • Teraki Y, Shiohara T. Successful desensitization to fixed drug eruption: the presence of CD25+ CD4+ T cells in the epidermis of fixed drug eruption lesions may be involved in the induction of desensitization. Dermatology. 2004;209(1):29–32.
  • Mizukawa Y, Yamazaki Y, Shiohara T. In vivo dynamics of intraepidermal CD8+ T cells and CD4+ T cells during the evolution of fixed drug eruption. Br J Dermatol. 2008;158(6):1230–1238.
  • Mizukawa Y, Shiohara T. Fixed drug eruption: a prototypic disorder mediated by effector memory T cells. Curr Allergy Asthma Rep. 2009;9(1):71–77.
  • Gomes ER, Brockow K, Kuyucu S, et al. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy. 2016;71(2):149–161.
  • Rebelo Gomes E, Fonseca J, Araujo L, et al. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy. 2008;38(1):191–198.
  • Erkoçoğlu M, Kaya A, Civelek E, et al. Prevalence of confirmed immediate type drug hypersensitivity reactions among school children. Pediatr Allergy Immunol. 2013;24(2):160–167.
  • Esposito S, Castellazzi L, Tagliabue C, et al. Allergy to antibiotics in children: an overestimated problem. Int J Antimicrob Agents. 2016;48(4):361–366.
  • Vezir E, Erkocoglu M, Civelek E, et al. The evaluation of drug provocation tests in pediatric allergy clinic: A single center experience. Allergy Asthma Proc. 2014;35(2):156–162.
  • Cars O, Mölstad S, Melander A. Variation in antibiotic use in the European Union. Lancet. 2001;357(9271):1851–1853.
  • Solensky R. Allergy to β-lactam antibiotics. J Allergy Clin Immunol. 2012;130(6):1442.
  • Diaferio L, Chiriac AM, Leoni MC, et al. Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number. Pediatr Allergy Immunol. 2019;30(4):462–468.
  • Guvenir H, Dibek Misirlioglu E, Capanoglu M, et al. Proven non-β-lactam antibiotic allergy in children. Int Arch Allergy Immunol. 2016;169(1):45–50.
  • Mori F, Liccioli G, Barni S, et al. Management of suspected antibiotic reactions in children. Pediatr Infect Dis J. 2019;38(7):e149–e152.
  • Kuyucu S, Mori F, Atanaskovic-Markovic M, et al. Hypersensitivity reactions to non-betalactam antibiotics in children: an extensive review. Pediatr Allergy Immunol. 2014;5(6):534–543.
  • Santos RB, Galvão VR. Monoclonal antibodies hypersensitivity: prevalence and management. Immunol Allergy Clin North Am. 2017 Nov;37(4):695–711.
  • Lafay-Cousin L, Sung L, Carret A-S, et al. Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma. Cancer. 2008;112(4):892–899.
  • Dodgshun AJ, Hansford JR, Cole T, et al. Carboplatin hypersensitivity reactions in pediatric low grade glioma are protocol specific and desensitization shows poor efficacy. Pediatr Blood Cancer. 2016;63(1):17–20.
  • Genc DB, Canpolat C, Berrak SG. Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma. Support Care Cancer. 2012;20(2):385–393.
  • Sahiner UM, Yavuz ST, Gokce M, et al. Anaphylactic reaction in polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient. Pediatr Int. 2013;55(4):531–533.
  • Akbayram S, Dogan M, Akgun C, et al. A desensitization protocol in children with L-asparaginase hypersensitivity. J Pediatr Hematol Oncol. 2010;32(5):e187–191.
  • Picard M, Galvão VR. Current knowledge and management of hypersensitivity reactions to monoclonal antibodies. J Allergy Clin Immunol Pract. 2017;5(3):600–609.
  • Kidon M, Blanca-Lopez N, Gomes E, et al. EAACI/ENDA position paper: diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents. Pediatr Allergy Immunol. 2018;29(5):469–480.
  • Cavkaytar O, Du Toit G, Caimmi D. Characteristics of NSAID-induced hypersensitivity reactions in childhood. Pediatr Allergy Immunol. 2019;30(1):25–35.
  • Cousin M, Chiriac A, Molinari N, et al. Phenotypical characterization of children with hypersensitivity reactions to NSAIDs. Pediatr Allergy Immunol. 2016;27(7):743–748.
  • Guvenir H, Dibek Misirlioglu E, Vezir E, et al. Nonsteroidal anti-inflammatory drug hypersensitivity among children. Allergy Asthma Proc. 2015;36(5):386–393.
  • Alves C, Romeira AM, Abreu C, et al. Non-steroidal anti-inflammatory drug hypersensitivity in children. Allergol Immunopathol (Madr). 2017;45(1):40–47.
  • Mertes PM, Alla F, Tréchot P, et al. Anaphylaxis during anesthesia in France: an 8-year national survey. J Allergy Clin Immunol. 2011;128(2):366–373.
  • McNeil MM, Weintraub ES, Duffy J, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016;137(3):868–878.
  • Callahan MJ, Poznauskis L, Zurakowski D, et al. Nonionic iodinated intravenous contrast material–related reactions: incidence in large urban children’s hospital—retrospective analysis of data in 12 494 patients. Radiology. 2009;250(3):674–681.
  • Dillman JR, Ellis JH, Cohan RH, et al. Frequency and severity of acute allergic-like reactions to gadolinium-containing IV contrast media in children and adults. Am J Roentgenol. 2007;189(6):1533–1538.
  • de Groot H, Mulder WM. Clinical practice: drug desensitization in children. Eur J Pediatr. 2010;169(11):1305–1309.
  • Joint Task Force on Practice Parameters. American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105(4):259–273.
  • Collado-Chagoya R, Hernandez-Romero J, Eliosa-Alvarado GA, et al. Tolerance induction to antituberculosis drugs in a patient with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap. Allergy Rhinol (Providence). 2018;9:2152656718783618.
  • Witcher RH, Ramirez MM. Successful phenobarbital desensitization after DRESS reaction in the management of refractory status epilecticus. J Pharm Pract. 2018;32(2):228–230.
  • Dioun AF. Management of multiple drug allergies in children. Curr Allergy Asthma Rep. 2012;12(1):79–84.
  • Atanaskovic-Markovic M, Gomes E, Cernadas JR, et al. Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper. Pediatr Allergy Immunol. 2019;30(3):269–276.
  • Mirakian R, Leech SC, Krishna MT, et al. Management of allergy to penicillins and other beta-lactams. Clin Exp Allergy. 2015;45(2):300–327.
  • Rubio M, Bousquet JP, Gomes E, et al. Results of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy. 2012;42(1):123–130.
  • Sullivan T, Yecies L, Shatz G, et al. Desensitization of patients allergic to penicillin using orally administered β-lactam antibiotics. J Allergy Clin Immunol. 1982;69(3):275–282.
  • Naclerio R, Mizrahi E, Adkinson JN. Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin. J Allergy Clin Immunol. 1983;71(3):294–301.
  • Borish L, Tamir R, Rosenwasser LJ. Intravenous desensitization to beta-lactam antibiotics. J Allergy Clin Immunol. 1987;80(3 Pt 1):314–319.
  • Wendel GD, Stark BJ, Jamison RB, et al. Penicillin allergy and desensitization in serious infections during pregnancy. N Engl J Med. 1985;312(19):1229–1232.
  • Solensky R. Drug desensitization. Immunol Allergy Clin North Am. 2004;24(3):425–443.
  • Sullivan TJ. Allergy, Principles and Practice. In: Middleton E Jr, Reed CE, Ellis EF, et al., editors. Drug allergy. St. Louis: Mosby Co; 1993. p. 1726–1746.
  • Stark BJ, Earl HS, Gross GN, et al. Acute and chronic desensitization of penicillin-allergic patients using oral penicillin. J Allergy Clin Immunol. 1987;79(3):523–532.
  • Turvey SE, Cronin B, Arnold AD, et al. Antibiotic desensitization for the allergic patient: 5 Years of experience and practice. Ann Allergy Asthma Immunol. 2004;92(4): 436–32.
  • Ghosal S, Taylor CJ. Intravenous desensitization to ceftazidime in cystic fibrosis patients. J Antimicrob Chemother. 1997;39(4):556–557.
  • Legere HJ, Palis RI, Bouza TR, et al. A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity. J Cyst Fibros. 2009;8(6):418–424.
  • Wong JT, Ripple RE, MacLean JA, et al. Vancomycin hypersensitivity: synergism with narcotics and ″desensitization” by a rapid continuous intravenous protocol. J Allergy Clin Immunol. 1994;94(2 Pt 1):189–194.
  • Earl HS, Sullivan TJ. Acute desensitization of a patient with cystic fibrosis allergic to both beta-lactam and aminoglycoside antibiotics. J Allergy Clin Immunol. 1987;79(3):477–483.
  • Roy M, Ahmad S, Roy AK. Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis. J Community Hosp Intern Med Perspect. 2018;8(6):345–348.
  • Demoly P, Messaad D, Sahla H, et al. Six-hour trimethoprim-sulfamethoxazole–graded challenge in HIV-infected patients. J Allergy Clin Immunol. 1998;102(6 Pt 1):1033–1036.
  • Yoshizawa S, Yasuoka A, Kikuchi Y, et al. A 5-day course of oral desensitization to trimethoprim/sulfamethoxazole (T/S) in patients with human immunodeficiency virus type-1 infection who were previously intolerant to T/S. Ann Allergy Asthma Immunol. 2000;85(3):241–244.
  • Theodore CM, Holmes D, Rodgers M, et al. Co-trimoxazole desensitization in HIV-seropositive patients. Int J STD AIDS. 1998;9(3):158–161.
  • Beall G, Sanwo M, Hussain H. Drug reactions and desensitization in AIDS. Immunol Allergy Clin North Am. 1997;17(2):319–338.
  • Cernadas JR. Desensitization to antibiotics in children. Pediatr Allergy Immunol. 2013;24(1):3–9.
  • Gómez-Traseira C, Boyano-Martínez T, Escosa-García L, et al. Trimethoprim-sulfamethoxazole (cotrimoxazole) desensitization in an HIV-infected 5-yr-old girl. Pediatr Allergy Immunol. 2015;26(3):287–289.
  • D’Amelio CM, Del Pozo JL, Vega O, et al. Successful desensitization in a child with delayed cotrimoxazole hypersensitivity: A case report. Pediatr Allergy Immunol. 2016;27(3):320–321.
  • Hildebrand KJ, Atkinson A, Kitai I. Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization. Pediatr Infect Dis J. 2014;33(7):787.
  • Logsdon S, Ramirez-Avila L, Castells M, et al. Successful rifampin desensitization in a pediatric patient with latent tuberculosis. Pediatr Allergy Immunol. 2014;25(4):404–405.
  • Guvenir H, Dibek Misirlioglu E, Toyran M, et al. Linezolid desensitization in a pediatric patient. Ann Allergy Asthma Immunol. 2016;117(2):198.
  • Gupta M, Gomes JM, Irizarry J, et al. The use of standardized drug desensitization protocols at a pediatric institution. J Allergy Clin Immunol Pract. 2017;5(3):834–836.
  • Rodríguez Del Río P, Andión M, Ruano D, et al. Initial experience with carboplatin desensitization: A case series in a paediatric hospital. Pediatr Allergy Immunol. 2018;29(1):111–115.
  • Marin Ponzo JF, Carmona Alvarez MT, Toledo Lopez A, et al. Asparaginase desensitization in two patients with previous hypersensitivity. Farm Hosp. 2006;30(2):132–134.
  • Aydogan M, Yologlu N, Gacar G, et al. Successful rapid rituximab desensitization in an adolescent patient with nephrotic syndrome: increase in number of Treg cells after desensitization. J Allergy Clin Immunol. 2013;132(2):478–480.
  • Dilley MA, Lee JP, Platt CD, et al. Rituximab desensitization in pediatric patients: results of a case series. Pediatr Allergy Immunol Pulmonol. 2016;29(2):91–94.
  • Messaad D, Sablayrolles P, Pujol JL, et al. Successful docetaxel tolerance induction. Allergy. 2003;58(12):1320–1321.
  • Caimmi SM, Caimmi D, Riscassi S, et al. A new pediatric protocol for rapid desensitization to monoclonal antibodies. Int Arch Allergy Immunol. 2014;165(3):214–218.
  • Blanca-Lopez N, Perez-Alzate D, Canto G, et al. Practical approach to the treatment of NSAIS hypersensitivity. Expert Rev Clin Immunol. 2017;13(11):1017–1027.
  • McNeil MM, DeStefano F. Vaccine-associated hypersensitivity. J Allergy Clin Immunol. 2018;141(2):463–472.
  • Franceschini F, Bottau P, Caimmi S, et al. Evaluating children with suspected allergic reactions to vaccines for infectious diseases. Allergy Asthma Proc. 2018;39(3):177–183.
  • Carey AB, Meltzer EO. Diagnosis and “desensitization” in tetanus vaccine hypersensitivity. Ann Allergy. 1992;69(4):336–338.
  • Lavi S, Zimmerman B, Koren G, et al. Administration of measles, mumps, and rubella virus vaccine (live) to egg-allergic children. JAMA. 1990;263(2):269–271.
  • Toker O, Tal Y, Horev L, et al. Valproic acid hypersensitivity and desensitization. Dev Med Child Neurol. 2015;57(11):1076–1078.
  • Ng P C, Huang CH, Rajakulendran M, et al. Successful desensitization to gonadotropin-releasing hormone analogue triptorelin acetate using a sustained-release depot preparation. Pediatr Allergy Immunol. 2018;29(6):660–663.
  • Rosa JS, Vuong VB, Haskin O, et al. A novel outpatient desensitization protocol for recombinant human erythropoietin allergy in a pediatric patient. Allergy Asthma Clin Immunol. 2018;14:8.
  • Davies GI, Davies D, Charles S, et al. Successful desensitization to deferasirox in a paediatric patient with β-Thalassaemia major. Pediatr Allergy Immunol. 2017;28(2):199–201.
  • Guvenir H, Misirlioglu ED, Aydin F, et al. Successful methylprednisolone desensitization in a pediatric patient. Pediatr Allergy Immunol. 2017;28(3):305–306.

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