Early-life exposure to air pollution and childhood allergic diseases: an update on the link and its implications

References

• Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med. 2006;355:2226–2235.
   PubMed Web of Science ®Google Scholar
• Asher MI, Montefort S, Björkstén B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: isaac phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–743.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li B, Huang C, et al. Ten cities cross-sectional questionnaire survey of children asthma and other allergies in china. Chin Sci Bull. 2013;58:4182–4189.
   Google Scholar
• Zhang Y, Zhang L. Increasing prevalence of allergic rhinitis in china. Allergy Asthma Immunol Res. 2019;11:156–169.
   PubMed Web of Science ®Google Scholar
• London SJ. Gene–air pollution interactions in asthma. Proc Am Thorac Soc. 2007;4:217–220.
   PubMedGoogle Scholar
• GBD. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: A systematic analysis for the global burden of disease study 2015. Lancet. 2016;388:1659–1724.
   PubMed Web of Science ®Google Scholar
• Lelieveld J, Evans JS, Fnais M, et al. The contribution of outdoor air pollution sources to premature mortality on a global scale. Nature. 2015;525:367.
   PubMed Web of Science ®Google Scholar
• Zhang J, Mauzerall DL, Zhu T, et al. Environmental health in china: progress towards clean air and safe water. Lancet. 2010;375:1110–1119.
   PubMed Web of Science ®Google Scholar
• Guarnieri M, Balmes JR. Outdoor air pollution and asthma. Lancet. 2014;383:1581–1592.
   PubMed Web of Science ®Google Scholar
• Naclerio R, Ansotegui IJ, Bousquet J, et al. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: impact of air pollution on patients with AR: current knowledge and future strategies. World Allergy Organ J. 2020;13:100106.
   PubMed Web of Science ®Google Scholar
• Burbank AJ, Sood AK, Kesic MJ, et al. Environmental determinants of allergy and asthma in early life. J Allergy Clin Immunol. 2017;140:1–12.
   PubMed Web of Science ®Google Scholar
• Exley D, Norman A, Hyland M. Adverse childhood experience and asthma onset: A systematic review. Eur Respir Rev. 2015;24:299–305.
   PubMed Web of Science ®Google Scholar
• H-hL H, Y-hM C, Coull BA, et al. Prenatal particulate air pollution and asthma onset in urban children. Identifying sensitive windows and sex differences. Am J Respir Crit Care Med. 2015;192:1052–1059.
   PubMed Web of Science ®Google Scholar
• Bowatte G, Lodge C, Lowe AJ, et al. The influence of childhood traffic‐related air pollution exposure on asthma, allergy and sensitization: A systematic review and a meta‐analysis of birth cohort studies. Allergy. 2015;70:245–256.
   PubMed Web of Science ®Google Scholar
• Brunst KJ, Ryan PH, Brokamp C, et al. Timing and duration of traffic-related air pollution exposure and the risk for childhood wheeze and asthma. Am J Respir Crit Care Med. 2015;192:421–427.
   PubMed Web of Science ®Google Scholar
• Hatfield S, Rogers N, Lloyd‐Lavery A, et al. What’s new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes. Clin Exp Dermatol 2016;41:843–846.
   Google Scholar
• Brauer M, Freedman G, Frostad J, et al. Ambient air pollution exposure estimation for the global burden of disease 2013. Environ Sci Technol. 2015;50:79–88.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Norbäck D, et al. Early life exposure to ambient air pollution and childhood asthma in china. Environ Res. 2015a;143:83–92.
   PubMed Web of Science ®Google Scholar
• Ahn K. The role of air pollutants in atopic dermatitis. J Allergy Clin Immunol. 2014;134:993–999.
   PubMed Web of Science ®Google Scholar
• Dick S, Friend A, Dynes K, et al. A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years. BMJ Open. 2014b;4:e006554b.
   Web of Science ®Google Scholar
• Deng Q, Lu C, Ou C, et al. Effects of early life exposure to outdoor air pollution and indoor renovation on childhood asthma in china. Build Environ. 2015b;93:84–91.
   Web of Science ®Google Scholar
• Franklin PJ. Indoor air quality and respiratory health of children. Paediatr Respir Rev. 2007;8:281–286.
   PubMed Web of Science ®Google Scholar
• Cavaleiro Rufo J, Madureira J, Oliveira Fernandes E, et al. Volatile organic compounds in asthma diagnosis: A systematic review and meta‐analysis. Allergy. 2016;71:175–188.
   PubMed Web of Science ®Google Scholar
• Choo CP, Jalaludin J. An overview of indoor air quality and its impact on respiratory health among malaysian school-aged children. Rev Environ Health. 2015;30:9–18.
   PubMed Web of Science ®Google Scholar
• Huang S, Garshick E, Weschler LB, et al. Home environmental and lifestyle factors associated with asthma, rhinitis and wheeze in children in Beijing, China. Environ Pollut. 2020;256:113426.
   PubMed Web of Science ®Google Scholar
• Fisk WJ, Lei-Gomez Q, Mendell MJ. Meta‐analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air. 2007;17:284–296.
   PubMed Web of Science ®Google Scholar
• Tischer C, Chen C, Heinrich J. Association between domestic mould and mould components, and asthma and allergy in children: A systematic review. Eur Respir J. 2011;38:812–814.
   PubMed Web of Science ®Google Scholar
• Castro-Rodriguez JA, Forno E, Rodriguez-Martinez CE, et al. Risk and protective factors for childhood asthma: what is the evidence? J Allergy Clin Immunol Pract. 2016;4:1111–1122.
   PubMed Web of Science ®Google Scholar
• Hehua Z, Qing C, Shanyan G, et al. The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review. Environ Res. 2017;159:519–530.
   PubMed Web of Science ®Google Scholar
• Pacheco SE. Catastrophic effects of climate change on children’s health start before birth. J Clin Invest. 2020. DOI:10.1172/JCI135005
   PubMed Web of Science ®Google Scholar
• Clark NA, Demers PA, Karr CJ, et al. Effect of early life exposure to air pollution on development of childhood asthma. Environ Health Perspect. 2010;118:284.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Li Y, et al. Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema. Environ Res. 2016a;150:119–127.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Ou C, et al. Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases/symptoms in preschool children. Chemosphere. 2016b;152:459–467.
   PubMed Web of Science ®Google Scholar
• Haahtela T, Holgate S, Pawankar R, et al. The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ. 2013;6:3.
   PubMedGoogle Scholar
• Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. 2017;18:1076.
   PubMed Web of Science ®Google Scholar
• Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364:701–709.
   PubMed Web of Science ®Google Scholar
• Haspeslagh E, Heyndrickx I, Hammad H, et al. The hygiene hypothesis: immunological mechanisms of airway tolerance. Curr Opin Immunol. 2018;54:102–108.
   PubMed Web of Science ®Google Scholar
• Okada H, Kuhn C, Feillet H, et al. The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. Clin Exp Immunol. 2010;160:1–9.
   PubMed Web of Science ®Google Scholar
• Bornehag C-G, Sundell J, Weschler CJ, et al. The association between asthma and allergic symptoms in children and phthalates in house dust: A nested case–control study. Environ Health Perspect. 2004;112:1393–1397.
   PubMed Web of Science ®Google Scholar
• Mendell MJ, Mirer AG, Cheung K, et al. Respiratory and allergic health effects of dampness, mold, and dampness-related agents: A review of the epidemiologic evidence. Environ Health Perspect. 2011;119:748–756.
   PubMed Web of Science ®Google Scholar
• Kan H, Chen R, Tong S. Ambient air pollution, climate change, and population health in china. Environ Int. 2012;42:10–19.
   PubMed Web of Science ®Google Scholar
• Watts J. Doctors blame air pollution for china’s asthma increases. Lancet. 2006;9537:719–720.
   Web of Science ®Google Scholar
• Rodriguez A, Brickley E, Rodrigues L, et al. Urbanisation and asthma in low-income and middle-income countries: A systematic review of the urban–rural differences in asthma prevalence. Thorax. 2019;74:1020–1030.
   PubMed Web of Science ®Google Scholar
• Schlink U, Thiem A, Kohajda T, et al. Quantile regression of indoor air concentrations of volatile organic compounds (VOC). Sci Total Environ. 2010;408:3840–3851.
   PubMed Web of Science ®Google Scholar
• Nazaroff W, Goldstein A. Indoor chemistry: research opportunities and challenges. Indoor Air. 2015;25:357–361.
   PubMed Web of Science ®Google Scholar
• Illi S, von Mutius E, Lau S, et al. Perennial allergen sensitisation early in life and chronic asthma in children: A birth cohort study. Lancet. 2006;368:763–770.
   PubMed Web of Science ®Google Scholar
• Peel JL, Klein M, Flanders WD, et al. Ambient air pollution and apnea and bradycardia in high-risk infants on home monitors. Environ Health Perspect. 2011;119:1321.
   PubMed Web of Science ®Google Scholar
• Dietert RR, Etzel RA, Chen D, et al. Workshop to identify critical windows of exposure for children’s health: immune and respiratory systems work group summary. Environ Health Perspect. 2000;108:483–490.
   PubMed Web of Science ®Google Scholar
• Schwartz J. Air pollution and children’s health. Pediatrics. 2004;113:1037–1043.
   PubMed Web of Science ®Google Scholar
• Dunnill M. Postnatal growth of the lung. Thorax. 1962;17:329.
   Google Scholar
• van den Hooven EH, Pierik FH, de Kluizenaar Y, et al. Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: A prospective cohort study. Environ Health Perspect. 2012;120:150.
   PubMed Web of Science ®Google Scholar
• Duijts L. Fetal and infant origins of asthma. Eur J Epidemiol. 2012;27:5–14.
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Cooper C, et al. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in england and wales. Lancet. 1986;327:1077–1081.
   Google Scholar
• Sbihi H, Allen RW, Becker A, et al. Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-center canadian birth cohort study. Environ Health Perspect. 2015;123:902.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Yu Y, et al. Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children. Respir Med. 2016c;121:67–73.
   PubMed Web of Science ®Google Scholar
• Eriksson JG. Developmental origins of health and disease–from a small body size at birth to epigenetics. Ann Med. 2016;48:456–467.
   PubMed Web of Science ®Google Scholar
• Antó JM. Recent advances in the epidemiologic investigation of risk factors for asthma: A review of the 2011 literature. Curr Allergy Asthma Rep. 2012;12:192–200.
   PubMed Web of Science ®Google Scholar
• Hatzler L, Hofmaier S, Papadopoulos NG. Allergic airway diseases in childhood–marching from epidemiology to novel concepts of prevention. Pediatr Allergy Immunol. 2012;23:616–622.
   PubMed Web of Science ®Google Scholar
• Thurston GD, Balmes JR, Garcia E, et al. Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report. J Allergy Clin Immunol. 2020;17:387–398.
   Google Scholar
• Barnett SBL, Nurmagambetov TA. Costs of asthma in the united states: 2002-2007. J Allergy Clin Immunol. 2011;127:145–152.
   PubMed Web of Science ®Google Scholar
• Wilson SR, Rand CS, Cabana MD, et al. Asthma outcomes: quality of life. J Allergy Clin Immunol. 2012;129:S88–123.
   PubMed Web of Science ®Google Scholar
• Gern JE. The urban environment and childhood asthma study. J Allergy Clin Immunol. 2010;125:545–549.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Jiang W, et al. Association of outdoor air pollution and indoor renovation with early childhood ear infection in china. Chemosphere. 2017a;169:288–296.
   PubMed Web of Science ®Google Scholar
• Dick S, Doust E, Cowie H, et al. Associations between environmental exposures and asthma control and exacerbations in young children: A systematic review. BMJ Open. 2014a;4:e003827.
   PubMed Web of Science ®Google Scholar
• Lu C, Hu X, Miao Y, et al. Early life exposure to environmental pollution increases childhood asthma, allergy and infection. Chin Sci Bull. 2018;63:954–967.
   Google Scholar
• Hendricks A, Eichenfield L, Shi V. The impact of airborne pollution on atopic dermatitis—a literature review. Br J Dermatol. 2019;doi. DOI:10.1111/bjd.18781
   PubMed Web of Science ®Google Scholar
• Lu C, Deng L, Ou C, et al. Preconceptional and perinatal exposure to traffic-related air pollution and eczema in preschool children. J Dermatol Sci. 2017;85:85–95.
   PubMed Web of Science ®Google Scholar
• É L, M-A B, Duque DR, et al. Effect modification of perinatal exposure to air pollution and childhood asthma incidence. Eur Respir J. 2018;51:1701884.
   Web of Science ®Google Scholar
• Lee J-Y, Lamichhane DK, Lee M, et al. Preventive effect of residential green space on infantile atopic dermatitis associated with prenatal air pollution exposure. Int J Environ Res Public Health. 2018;15:102.
   Web of Science ®Google Scholar
• Yang SI, Lee SY, Kim HB, et al. Prenatal particulate matter affects new asthma via airway hyperresponsiveness in schoolchildren. Allergy. 2019;74:675–684.
   PubMed Web of Science ®Google Scholar
• Huang C, Wen H, Chen P, et al. Prenatal air pollutant exposure and occurrence of atopic dermatitis. Br J Dermatol. 2015;173:981–988.
   PubMed Web of Science ®Google Scholar
• Aguilera I, Pedersen M, Garciaesteban R, et al. Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study. Environ Health Perspect. 2013;121:387–392.
   PubMed Web of Science ®Google Scholar
• Nishimura KK, Galanter JM, Roth LA, et al. Early-life air pollution and asthma risk in minority children. The gala ii and sage ii studies. Am J Respir Crit Care Med. 2013;188:309–318.
   PubMed Web of Science ®Google Scholar
• Huang Q, Ren Y, Liu Y, et al. Associations of gestational and early life exposure to air pollution with childhood allergic rhinitis. Atmos Environ. 2019;200:190–196.
   Web of Science ®Google Scholar
• Liu W, Cai J, Huang C, et al. Associations of gestational and early life exposures to ambient air pollution with childhood atopic eczema in shanghai, china. Sci Total Environ. 2016a;572:34–42.
   PubMed Web of Science ®Google Scholar
• Liu W, Huang C, Hu Y, et al. Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in shanghai, china: A retrospective cohort study. Environ Int. 2016b;92:284–293.
   PubMed Web of Science ®Google Scholar
• To T, Zhu J, Stieb D, et al. Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema. Eur Respir J. 2020;55:1900913.
   PubMed Web of Science ®Google Scholar
• Bové H, Bongaerts E, Slenders E, et al. Ambient black carbon particles reach the fetal side of human placenta. Nat Commun. 2019;10:1–7.
   PubMed Web of Science ®Google Scholar
• Jung CR, Chen WT, Tang YH, et al. Fine particulate matter exposure during pregnancy and infancy and incident asthma. J Allergy Clin Immunol. 2019;143:2254–2262.
   PubMed Web of Science ®Google Scholar
• Pennington AF, Strickland MJ, Klein M, et al. Exposure to mobile source air pollution in early life and childhood asthma incidence: the Kaiser Air Pollution and Pediatric Asthma Study. Epidemiology. 2018;29:22–30.
   PubMed Web of Science ®Google Scholar
• Gruzieva O, Xu C-J, Breton CV, et al. Epigenome-wide meta-analysis of methylation in children related to prenatal no2 air pollution exposure. Environ Health Perspect. 2017;125:104–110.
   PubMed Web of Science ®Google Scholar
• Patel MM, Chillrud SN, Deepti K, et al. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in new york city adolescents. Environ Res. 2013;121:71–78.
   PubMed Web of Science ®Google Scholar
• Frampton MW, Boscia J, Jr NJ R, et al. Nitrogen dioxide exposure: effects on airway and blood cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L155–65.
   PubMed Web of Science ®Google Scholar
• Solomon C, Christian D, Chen L, et al. Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. Eur Respir J. 2000;15:922–928.
   PubMed Web of Science ®Google Scholar
• Poynter ME, Persinger RL, Irvin CG, et al. Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse. Am J Physiol Lung Cell Mol Physiol. 2006;290:L144–52.
   PubMed Web of Science ®Google Scholar
• Gowers AM, Cullinan P, Ayres JG, et al. Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review. Respirology. 2012;17:887–898.
   PubMed Web of Science ®Google Scholar
• Gern JE, Brooks GD, Meyer P, et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol. 2006;117:72–78.
   PubMed Web of Science ®Google Scholar
• Heaton T, Rowe J, Turner S, et al. An immunoepidemiological approach to asthma: identification of in-vitro t cell response patterns associated with different wheezing phenotypes in children. Lancet. 2005;365:142–149.
   PubMed Web of Science ®Google Scholar
• Luyten LJ, Saenen ND, Janssen BG, et al. Air pollution and the fetal origin of disease: a systematic review of the molecular signatures of air pollution exposure in human placenta. Environ Res. 2018;166:310–323.
   PubMed Web of Science ®Google Scholar
• Bose S, Chiu Y-HM, Hsu -H-HL, et al. Prenatal nitrate exposure and childhood asthma. Influence of maternal prenatal stress and fetal sex. Am J Respir Crit Care Med. 2017;196:1396–1403.
   PubMed Web of Science ®Google Scholar
• Brunekreef B, Stewart AW, Anderson HR, et al. Self-reported truck traffic on the street of residence and symptoms of asthma and allergic disease: A global relationship in isaac phase 3. Environ Health Perspect. 2009;117:1791–1798.
   PubMed Web of Science ®Google Scholar
• Carlsten C, Dybuncio A, Becker A, et al. Traffic-related air pollution and incident asthma in a high-risk birth cohort. Occup Environ Med. 2011;68:291–295.
   PubMed Web of Science ®Google Scholar
• Gehring U, Wijga AH, Hoek G, et al. Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: A population-based birth cohort study. Lancet Respir Med. 2015;3:933–942.
   PubMed Web of Science ®Google Scholar
• Rancière F, Bougas N, Viola M, et al. Early exposure to traffic-related air pollution, respiratory symptoms at 4 years of age, and potential effect modification by parental allergy, stressful family events, and sex: A prospective follow-up study of the paris birth cohort. Environ Health Perspect. 2017;125:737–745.
   PubMed Web of Science ®Google Scholar
• Deng Q, Deng L, Lu C, et al. Parental stress and air pollution increase childhood asthma in china. Environ Res. 2018;165:23–31.
   PubMed Web of Science ®Google Scholar
• Norbäck D, Lu C, Zhang Y, et al. Sources of indoor particulate matter (PM) and outdoor air pollution in china in relation to asthma, wheeze, rhinitis and eczema among pre-school children: synergistic effects between antibiotics use and PM10 and second hand smoke. Environ Int. 2019;125:252–260.
   PubMed Web of Science ®Google Scholar
• Smargiassi A, Kosatsky T, Hicks J, et al. Risk of asthmatic episodes in children exposed to sulfur dioxide stack emissions from a refinery point source in montreal, canada. Environ Health Perspect. 2009;117:653.
   PubMed Web of Science ®Google Scholar
• Dong GH, Chen T, Liu MM, et al. Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study. PLoS One. 2011;6:e22470.
   PubMed Web of Science ®Google Scholar
• Pénard-Morand C, Raherison C, Charpin D, et al. Long-term exposure to close-proximity air pollution and asthma and allergies in urban children. Eur Respir J. 2010;36:33–40.
   PubMed Web of Science ®Google Scholar
• Pikhart H, Bobak M, Gorynski P, et al. Outdoor sulphur dioxide and respiratory symptoms in Czech and Polish school children: a small-area study (SAVIAH). Int Arch Occup Environ Health. 2001;74:574–578.
   PubMed Web of Science ®Google Scholar
• Bharadwaj P, Zivin JG, Mullins JT, et al. Early-life exposure to the great smog of 1952 and the development of asthma. Am J Respir Crit Care Med. 2016;194:1475–1482.
   PubMed Web of Science ®Google Scholar
• Buckley JP, Richardson DB. Seasonal modification of the association between temperature and adult emergency department visits for asthma: a case-crossover study. Environ Health. 2012;11:55–60.
   PubMed Web of Science ®Google Scholar
• D’amato G, Pawankar R, Vitale C, et al. Climate change and air pollution: effects on respiratory allergy. Allergy Asthma Immunol Res. 2016;8:391–395.
   PubMed Web of Science ®Google Scholar
• Gielen MH, van der Zee SC, van Wijnen JH, et al. Acute effects of summer air pollution on respiratory health of asthmatic children. Am J Respir Crit Care Med. 1997;155:2105–2108.
   PubMed Web of Science ®Google Scholar
• Hajat S, Haines A, Goubet S, et al. Association of air pollution with daily gp consultations for asthma and other lower respiratory conditions in london. Thorax. 1999;54:597–605.
   PubMed Web of Science ®Google Scholar
• Samoli E, Nastos P, Paliatsos A, et al. Acute effects of air pollution on pediatric asthma exacerbation: evidence of association and effect modification. Environ Res. 2011;111:418–424.
   PubMed Web of Science ®Google Scholar
• Gleason JA, Bielory L, Fagliano JA. Associations between ozone, PM2.5, and four pollen types on emergency department pediatric asthma events during the warm season in new jersey: A case-crossover study. Environ Res. 2014;132:421–429.
   PubMed Web of Science ®Google Scholar
• Aga E, Samoli E, Touloumi G, et al. Short-term effects of ambient particles on mortality in the elderly: results from 28 cities in the aphea2 project. Eur Respir J. 2003;21:28s–33s.
   Web of Science ®Google Scholar
• Abe T, Tokuda Y, Ohde S, et al. The relationship of short-term air pollution and weather to ed visits for asthma in Japan. Am J Emerg Med. 2009;27:153–159.
   PubMed Web of Science ®Google Scholar
• De Sario M, Katsouyanni K, Michelozzi P. Climate change, extreme weather events, air pollution and respiratory health in europe. Eur Respir J. 2013;42:826–843.
   PubMed Web of Science ®Google Scholar
• Mohr LB, Luo S, Mathias E, et al. Influence of season and temperature on the relationship of elemental carbon air pollution to pediatric asthma emergency room visits. J Asthma. 2008;45:936–943.
   PubMed Web of Science ®Google Scholar
• Murrison LB, Brandt EB, Myers JB, et al. Environmental exposures and mechanisms in allergy and asthma development. J Clin Invest. 2019;129:1504–1515.
   PubMed Web of Science ®Google Scholar
• Wang B, Chen H, Chan YL, et al. Why Do Intrauterine Exposure to Air Pollution and Cigarette Smoke Increase the Risk of Asthma? Front Cell Dev Biol. 2020;8:38.
   PubMed Web of Science ®Google Scholar
• Nawrot TS, Saenen ND, Schenk J, et al. Placental circadian pathway methylation and in utero exposure to fine particle air pollution. Environ Int. 2018;114:231–241.
   PubMed Web of Science ®Google Scholar
• Rider CF, Carlsten C. Air pollution and DNA methylation: effects of exposure in humans. Clin Epigenetics. 2019;11:131.
   PubMed Web of Science ®Google Scholar
• Ahluwalia SK, Matsui EC. The indoor environment and its effects on childhood asthma. Curr Opin Allergy Clin Immunol. 2011;11:137–143.
   PubMed Web of Science ®Google Scholar
• Gautier C, Charpin D. Environmental triggers and avoidance in the management of asthma. J Asthma Allergy. 2017;10:47.
   PubMed Web of Science ®Google Scholar
• Wang X, Liu W, Hu Y, et al. Home environment, lifestyles behaviors, and rhinitis in childhood. Int J Hyg Environ Health. 2016;219:220–231.
   PubMed Web of Science ®Google Scholar
• Cai J, Liu W, Hu Y, et al. Associations between home dampness-related exposures and childhood eczema among 13,335 preschool children in shanghai, china: A cross-sectional study. Environ Res. 2016;146:18–26.
   PubMed Web of Science ®Google Scholar
• Wang H, Li B, Yu W, et al. Early-life exposure to home dampness associated with health effects among children in chongqing, china. Build Environ. 2015;94:327–334.
   Web of Science ®Google Scholar
• Sun Y, Hou J, Kong X, et al. “Dampness” and “dryness”: what is important for children’s allergies? A cross-sectional study of 7366 children in northeast chinese homes. Build Environ. 2018;139:38–45.
   Web of Science ®Google Scholar
• Franck U, Weller A, Röder SW, et al. Prenatal VOC exposure and redecoration are related to wheezing in early infancy. Environ Int. 2014;73:393–401.
   PubMed Web of Science ®Google Scholar
• Herbarth O, Fritz GJ, Rehwagen M, et al. Association between indoor renovation activities and eczema in early childhood. Int J Hyg Environ Health. 2006;209:241–247.
   PubMed Web of Science ®Google Scholar
• Mendell MJ. Indoor residential chemical emissions as risk factors for respiratory and allergic effects in children: A review. Indoor Air. 2007;17:259–277.
   PubMed Web of Science ®Google Scholar
• Wen HJ, Chen PC, Chiang TL, et al. Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. Br J Dermatol. 2009;161:1166–1172.
   PubMed Web of Science ®Google Scholar
• Sun C, Zhang J, Huang C, et al. High prevalence of eczema among preschool children related to home renovation in china: A multi‐city‐based cross‐sectional study. Indoor Air. 2019;29:748–760.
   PubMed Web of Science ®Google Scholar
• Xu F, Yan S, Zheng Q, et al. Residential risk factors for atopic dermatitis in 3-to 6-year old children: A cross-sectional study in shanghai, china. Int J Environ Res Public Health. 2016;13:537.
   Web of Science ®Google Scholar
• Gilmour MI, Jaakkola MS, London SJ, et al. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect. 2006;114:627–633.
   PubMed Web of Science ®Google Scholar
• Kasznia-Kocot J, Kowalska M, Górny RL, et al. Environmental risk factors for respiratory symptoms and childhood asthma. Ann Agric Environ Med. 2010;17:221–229.
   PubMed Web of Science ®Google Scholar
• Lee Y, Shaw C, Su H, et al. Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in taiwan. Eur Respir J. 2003;21:964–970.
   PubMed Web of Science ®Google Scholar
• Liu F, Zhao Y, Liu Y-Q, et al. Asthma and asthma related symptoms in 23,326 Chinese children in relation to indoor and outdoor environmental factors: the seven northeastern cities (SNEC) study. Sci Total Environ. 2014;497:10–17.
   PubMed Web of Science ®Google Scholar
• Deng Q, Lu C, Li Y, et al. Association between prenatal exposure to industrial air pollution and onset of early childhood ear infection in china. Atmos Environ. 2017b;157:18–26.
   Web of Science ®Google Scholar
• Jiang W, Lu C, Miao Y, et al. Outdoor particulate air pollution and indoor renovation associated with childhood pneumonia in china. Atmos Environ. 2018;174:76–81.
   Web of Science ®Google Scholar
• Lu C, Cao L, Norbäck D, et al. Combined effects of traffic air pollution and home environmental factors on preterm birth in China. Ecotoxicol Environ Saf. 2019;184:109639.
   PubMed Web of Science ®Google Scholar
• Lu C, Zhang W, Zheng X, et al. Combined effects of ambient air pollution and home environmental factors on low birth weight. Chemosphere. 2020;240:124836.
   PubMed Web of Science ®Google Scholar
• Sim SW, Moey KSP, Tan NC. The use of facemasks to prevent respiratory infection: a literature review in the context of the Health Belief Model. Singapore Med J. 2014;55:160.
   PubMed Web of Science ®Google Scholar
• Trasande L, Thurston GD. The role of air pollution in asthma and other pediatric morbidities. J Allergy Clin Immunol. 2005;115:689–699.
   PubMed Web of Science ®Google Scholar
• Warburton D, Warburton N, Wigfall C, et al. Impact of Seasonal Winter Air Pollution on Health across the Lifespan in Mongolia and Some Putative Solutions. Ann Am Thorac Soc. 2018;15(S2):S86–90.
   PubMed Web of Science ®Google Scholar
• Wigfall C, Mandukhai G, Jargalsaikhan B, et al. Implementing attitudes measurement to influence winter air pollution mask wearing by pregnant women in Ulaanbaatar: a pilot study. Cent Asian J Med Sci. 2017;3:269–281.
   Google Scholar
• Holt PG, Jones CA. The development of the immune system during pregnancy and early life. Allergy. 2000;55:688–697.
   PubMed Web of Science ®Google Scholar
• Gascon M, Casas M, Morales E, et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. J Allergy Clin Immunol. 2015;135:370–378.
   PubMed Web of Science ®Google Scholar
• Kozyrskyj AL, Bahreinian S, Azad MB. Early life exposures: impact on asthma and allergic disease. Curr Opin Allergy Clin Immunol. 2011;11:400–406.
   PubMed Web of Science ®Google Scholar
• Warner JO. The early life origins of asthma and related allergic disorders. Arch Dis Child. 2004;89:97–102.
   PubMed Web of Science ®Google Scholar
• Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax. 1998;53:927–932.
   PubMed Web of Science ®Google Scholar
• Wright RJ, Brunst KJ. Programming of respiratory health in childhood: influence of outdoor air pollution. Curr Opin Pediatr. 2013;25:232–239.
   PubMed Web of Science ®Google Scholar
• Prescott SL. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol. 2013;131:23–30.
   PubMed Web of Science ®Google Scholar
• Busses WW, Lemanske RF. Asthma. N Engl J Med. 2001;344:350–352.
   PubMed Web of Science ®Google Scholar
• Nadeau K, McDonald-Hyman C, Noth EM, et al. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol. 2010;126:845–852.
   PubMed Web of Science ®Google Scholar
• Salvi SS, Suresh Babu K, Holgate ST. Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype? Am J Respir Crit Care Med. 2001;164:1343–1346.
   PubMed Web of Science ®Google Scholar
• Takano H, Yoshikawa T, Ichinose T, et al. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med. 1997;156:36–42.
   PubMed Web of Science ®Google Scholar
• Zmirou D, Gauvin S, Pin I, et al. Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study. J Epidemiol Community Health. 2004;58:18–23.
   PubMed Web of Science ®Google Scholar
• Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8:205–217.
   PubMed Web of Science ®Google Scholar
• Li N, Hao M, Phalen RF, et al. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol. 2003;109:250–265.
   PubMed Web of Science ®Google Scholar
• Martino D, Prescott S. Epigenetics and prenatal influences on asthma and allergic airways disease. Chest. 2011;139:640–647.
   PubMed Web of Science ®Google Scholar
• Miller RL, Ho S. Environmental Epigenetics and Asthma Current Concepts and Call for Studies. Am J Respir Crit Care Med. 2008;177:567–573.
   PubMed Web of Science ®Google Scholar
• Qi C, Xu C, Koppelman G. The role of epigenetics in the development of childhood asthma. Expert Rev Clin Immunol. 2019;15:1287–1302.
   Google Scholar
• Bayram H, Bauer A, Abdalati W, et al. Environment, global climate change, and cardiopulmonary health. Am J Respir Crit Care Med. 2017;195:718–724.
   PubMed Web of Science ®Google Scholar
• D’Amato G, Baena-Cagnani C, Cecchi L, et al. Climate change, air pollution and extreme events leading to increasing prevalence of allergic respiratory diseases. Multidiscip Resp Med. 2013;8:12–20.
   PubMed Web of Science ®Google Scholar
• Cakmak S, Dales R, Frances C. Does air pollution increase the effect of aeroallergens on hospitalization for asthma? J Allergy Clin Immunol. 2012;129:228–231.
   PubMed Web of Science ®Google Scholar
• D’Amato G, Vitale C, De Martino A, et al. Effects on asthma and respiratory allergy of Climate change and air pollution. Multidiscip Resp Med. 2015;10:39–46.
   PubMed Web of Science ®Google Scholar
• Corson L, Zhu H, Quan C, et al. Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice. Allergy Asthma Clin Immunol. 2010;6:7–17.
   PubMedGoogle Scholar
• Hamada K, Suzaki Y, Leme A, et al. Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A. 2007;70:688–695.
   PubMed Web of Science ®Google Scholar
• Manners S, Alam R, Schwartz DA, et al. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014;134:63–72.
   PubMed Web of Science ®Google Scholar
• Venter ZS, Aunan K, Chowdhury S, et al. COVID-19 lockdowns cause global air pollution declines with implications for public health risk. medRxiv preprint. 2020. DOI: 10.1101/2020.04.10.20060673
   Google Scholar
• Contini D, Costabile F. Does Air Pollution Influence COVID-19 Outbreaks? Atmosphere. 2020;11:377.
   Web of Science ®Google Scholar
• Wu X, Nethery RC, Sabath BM, et al. Exposure to air pollution and COVID-19 mortality in the United States. medRxiv. 2020. DOI:10.1101/2020.04.05.20054502
   Google Scholar