Dangerous liaisons? The role of inflammation and comorbidities in HIV and SARS-CoV-2 infection

References

• Karmen-Tuohy S, Carlucci PM, Zervou FN, et al. Outcomes among HIV-positive patients hospitalized with COVID-19. 2020;85:6–10.
   Google Scholar
• Geretti AM, Stockdale AJ, Kelly SH, et al. Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO clinical characterization protocol (UK): a prospective observational study. Clin Infect Dis. 2020;ciaa1605. 10.1093/cid/ciaa1605
   PubMed Web of Science ®Google Scholar
• Horby PW, Mafham M, Bell JL, et al. Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2020;396: 1345-1352.
   PubMedGoogle Scholar
• Zhang C, Wu Z, Li JW, et al. Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality. Int J Antimicrob Agents. 2020;55(5):105954.
   PubMed Web of Science ®Google Scholar
• Maddaloni E, Buzzetti R. Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics. Diabetes Metab Res Rev. 2020; e33213321.
   Web of Science ®Google Scholar
• Liu B, Li M, Zhou Z, et al. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun. Academic Press 2020;111: 102452.
   PubMed Web of Science ®Google Scholar
• Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020;383(23):2255–2273.
   PubMed Web of Science ®Google Scholar
• Channappanavar R, Fehr AR, Vijay R, et al. Dysregulated type i interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe. 2016;19(2):181–193.
   PubMed Web of Science ®Google Scholar
• Wiche Salinas TR, Zheng B, Routy J, et al. Targeting the interleukin‐17 pathway to prevent acute respiratory distress syndrome associated with SARS‐CoV‐2 infection. Respirology. 2020;25(8):797-799.
   PubMed Web of Science ®Google Scholar
• Curtis BM, Scharnowske S, Watson AJ. Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. Proc Natl Acad Sci. 1992;89(17):8356-8360.
   Web of Science ®Google Scholar
• Martín-Moreno A, Muñoz-Fernández MA. Dentritic Cells, the double agent in the war against HIV-1. Front Immunol. 2019;10:2485.
   PubMed Web of Science ®Google Scholar
• Campana P, Parisi V, Leosco D, et al. Dendritic cells and SARS-CoV-2 Infection: still an unclarified connection. Cells 2020; 9(9): 2046.
   Google Scholar
• Brufsky A, Lotze MT. DC/L‐SIGNs of hope in the COVID‐19 pandemic. J Med Virol. 2020;92: 1396-1398.
   PubMed Web of Science ®Google Scholar
• Ssentongo P, Ssentongo AE, Heilbrunn ES, et al. Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: a systematic review and meta-analysis. PLoS One. 2020; 15(8): e0238215.
   PubMed Web of Science ®Google Scholar
• Di Castelnuovo A, Bonaccio M, Costanzo S, et al. Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the multicentre Italian CORIST Study. Nutr Metab Cardiovasc Dis. 2020;30(11):1899–1913.
   PubMed Web of Science ®Google Scholar
• Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106(16):2067–2072.
   PubMed Web of Science ®Google Scholar
• Marfella R, Paolisso P, Sardu C, et al. Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients. Diabetes Metab. 2020; 46(5): 403–405.
   PubMed Web of Science ®Google Scholar
• Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355(9206):773–778.
   PubMed Web of Science ®Google Scholar
• Jain SK, Nagi DK, Slavin BM, et al. Insulin therapy in type 2 diabetic subjects suppresses plasminogen activator inhibitor (PAI‐1) activity and proinsulin‐like molecules independently of glycaemic control. Diabet Med. 1993;10(1):27–32.
   PubMed Web of Science ®Google Scholar
• Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in china. N Engl J Med. 2020;382(18):1708–1720. .
   PubMed Web of Science ®Google Scholar
• Sardu C, Gambardella J, Morelli MB, et al. Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. J Clin Med. 2020; 9(5): 1417.
   Web of Science ®Google Scholar
• Sardu C, Gambardella J, Morelli MB, et al. IsCOVID-19 an endothelial disease? Clinical and basic evidence.J Clin Med. 2020 ;9 (5):1417.
   Google Scholar
• Sardu C, Maggi P, Messina V, et al. Could anti-hypertensive drug therapy affect the clinical prognosis of hypertensive patients with covid-19 infection? Data from centers of southern italy. J Am Heart Assoc. 2020;9(17):e016948. .
   PubMed Web of Science ®Google Scholar
• Lindesmith L, Moe C, Marionneau S, et al. Human susceptibility and resistance to Norwalk virus infection. Nat Med. 2003;9(5):548–553. .
   PubMed Web of Science ®Google Scholar
• Cheng Y, Cheng G, Chui CH, et al. ABO blood group and susceptibility to severe acute respiratory syndrome [5]. J Am Med Assoc. 2005;293 (12):1450–1451.
   Google Scholar
• Zhao J, Yang Y, Huang H, et al. Relationship between the ABO blood group and the COVID-19 susceptibility. Clin Infec Dis. 2020;ciaa1150
   Google Scholar
• Ohira T, Cushman M, Tsai MY, et al. ABO blood group, other risk factors and incidence of venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE). J Thromb Haemost. 2007;5(7):1455–1461.
   PubMed Web of Science ®Google Scholar
• Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology. 2009;25(2):48–59.
   PubMedGoogle Scholar
• Sardu C, Marfella R, Maggi P, et al. Implications of AB0 blood group in hypertensive patients with covid-19. BMC Cardiovasc Disord. 2020;20(1):373.
   PubMed Web of Science ®Google Scholar
• Guillon P, Clément M, Sébille V, et al. Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008;18 (12): 1085-1093.
   Web of Science ®Google Scholar
• Bowman E, Funderburg NT. Lipidome abnormalities and cardiovascular disease risk in HIV infection. Curr HIV/AIDS Rep. 2019;16(3):214–223. .
   PubMed Web of Science ®Google Scholar
• De Francesco D, Wit FW, Bürkle A, et al. Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS. 2019;33(2):259–268.
   PubMed Web of Science ®Google Scholar
• Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–1131.
   PubMed Web of Science ®Google Scholar
• Pandrea I, Cornell E, Wilson C, et al. Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates. Blood. 2012;120(7):1357–1366.
   PubMed Web of Science ®Google Scholar
• Margolick JB, Bream JH, Martínez-Maza O, et al. Frailty and circulating markers of inflammation in HIV+ and HIV2 men in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr. 2017;74(4):407–417.
   PubMed Web of Science ®Google Scholar
• Erlandson KM, Allshouse AA, Jankowski CM, et al. Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy. J Infect Dis. 2013; 208(2): 249–259.
   PubMed Web of Science ®Google Scholar
• Desquilbet L, Jacobson LP, Fried LP, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol - Ser A Biol Sci Med Sci. 2007;62(11):1279–1286.
   PubMed Web of Science ®Google Scholar
• Helleberg M, Afzal S, Kronborg G, et al. Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study. Clin Infect Dis. 2013;56(5):727–734.
   PubMed Web of Science ®Google Scholar
• Ikeda MLR, Barcellos NT, Alencastro PR, et al. Alcohol drinking pattern: a comparison between HIV-infected patients and individuals from the general population. PLoS One. 2016;11(6):e0158535.
   PubMed Web of Science ®Google Scholar
• Garin N, Velasco C, De Pourcq JT, et al. Recreational drug use among individuals living with HIV in Europe: review of the prevalence, comparison with the general population and HIV guidelines recommendations. Front Microbiol. 2015 ;6:690.
   Google Scholar
• Castro JG, Alcaide ML. High rates of stis in HIV-infected patients attending an STI clinic. South Med J. 2016;109(1):1–4.
   PubMed Web of Science ®Google Scholar
• Scully EP. Sex differences in HIV infection: mystique versus machismo. Pathog Immun. 2018 ;3:82–113. http://www.ncbi.nlm.nih.gov/pubmed/30140783.
   Google Scholar
• Hackler E, Lew J, Gore MO, et al. Racial differences in cardiovascular biomarkers in the general population. J Am Heart Assoc. 2019;8(18):e012729.
   PubMed Web of Science ®Google Scholar
• Kityo C, Makamdop KN, Rothenberger M, et al. Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest. 2018;128(7):2763–2773.
   PubMed Web of Science ®Google Scholar
• Hocini H, Bonnabau H, Lacabaratz C, et al. HIV controllers have low inflammation associated with a strong HIV-specific immune response in blood. J Virol. 2019;93(10):93. .
   Web of Science ®Google Scholar
• Ter Horst R, Jaeger M, Smeekens SP, et al. Host and environmental factors influencing individual human cytokine responses. Cell. 2016;167 (4): 1111-1124.
   Web of Science ®Google Scholar
• Hunt PW, Lee SA, Siedner MJ, et al. Morbidity, and mortality in treated HIV infection. J Infect Dis. 2016;214(suppl 2):S44–S50.
   PubMed Web of Science ®Google Scholar
• Kulkarni M, Bowman E, Gabriel J, et al. Altered monocyte and endothelial cell adhesion molecule expression is linked to vascular inflammation in human immunodeficiency virus infection. Open Forum Infect Dis. 2016 ;3:ofw224.
   Google Scholar
• Bowman ER, Kulkarni M, Gabriel J, et al. Altered lipidome composition is related to markers of monocyte and immune activation in antiretroviral therapy treated human immunodeficiency virus (HIV) infection and in uninfected persons. Front Immunol. 2019;10:785.
   PubMed Web of Science ®Google Scholar
• D’Antoni ML, Mitchell BI, McCurdy S, et al. Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression. J Leukoc Biol. 2018;104(6):1241–1252.
   PubMed Web of Science ®Google Scholar
• Desquilbet L, Margolick JB, Fried LP, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009;50(3):299–306.
   PubMed Web of Science ®Google Scholar
• Pallikkuth S, Pahwa R, Kausalya B, et al. Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells. PLoS One. 2018;13(10):e0206256.
   PubMed Web of Science ®Google Scholar
• Funderburg NT, Zidar DA, Shive C, et al. Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome. Blood. 2012;120(23):4599–4608.
   PubMed Web of Science ®Google Scholar
• Duffau P, Ozanne A, Bonnet F, et al. Multimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults. AIDS. 2018;32(12):1651–1660.
   PubMed Web of Science ®Google Scholar
• Erlandson KM, Ng DK, Jacobson LP, et al. Inflammation, immune activation, immunosenescence, and hormonal biomarkers in the frailty-related phenotype of men with or at risk for HIV infection. J Infect Dis. 2017;215(2):228–237.
   PubMed Web of Science ®Google Scholar
• Mudd JC, Murphy P, Manion M, et al. Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. Blood. 2013;121(15):2914–2922.
   PubMed Web of Science ®Google Scholar
• Zeng M, Southern PJ, Reilly CS, et al. Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog. 2012;8(1):e1002437.
   PubMed Web of Science ®Google Scholar
• Shive CL, Mudd JC, Funderburg NT, et al. Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease. J Infect Dis. 2014;210(4):619–629.
   PubMed Web of Science ®Google Scholar
• Murdaca G, Pioggia G, Negrini S. Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Mol Allergy. 2020;18 (1):23.
   Google Scholar
• Yanai H. Metabolic Syndrome and COVID-19. Cardiol Res. 2020;11(6): 360-365.
   Web of Science ®Google Scholar
• Vecchi V, Maggi P, Rizzo M, et al. The metabolic Syndrome and HIV Infection. Curr Pharm Des. 2014;20 (31):4975-5003.
   Web of Science ®Google Scholar
• Peng X, Ouyang J, Isnard S, et al. Sharing CD4+ T cell loss: when COVID-19 and HIV collide on immune system. Front Immunol. 2020;11:596631.
   PubMed Web of Science ®Google Scholar
• Planas D, Routy J-P AP. New Th17-specific therapeutic strategies for HIV remission. Curr Opin HIV AIDS. 2019;14(2):14.
   Web of Science ®Google Scholar
• Parackova Z, Bloomfield M, Klocperk A, et al. Neutrophils mediate th17 promotion in COVID‐19 patients. J Leukoc Biol. 2021;109: 73-76.
   PubMed Web of Science ®Google Scholar
• Di Biagio A, Ricci E, Calza L, et al. Factors associated with hospital admission for COVID-19 in HIV patients. AIDS. 2020;34(13):1983–1985.
   PubMed Web of Science ®Google Scholar
• Inciarte A, Gonzalez-Cordon A, Rojas J, et al. Clinical characteristics, risk factors, and incidence of symptomatic coronavirus disease 2019 in a large cohort of adults living with HIV: a single-center, prospective observational study. AIDS. 2020;34(12):1775–1780.
   PubMed Web of Science ®Google Scholar
• Hadi YB, Naqvi SFZ, Kupec JT, et al. Characteristics and outcomes of COVID-19 in patients with HIV: a multicentre research network study. AIDS. 2020;34(13):F3–F8.
   PubMed Web of Science ®Google Scholar
• Winston A, De Francesco D, Post F, et al. Comorbidity indices in people with HIV and considerations for coronavirus disease 2019 outcomes. AIDS. 2020;34(12):1795–1800.
   PubMed Web of Science ®Google Scholar
• Tegally H, Wilkinson E, Giovanetti M, et al. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. medRxiv [internet]. 2020;2020 December 21.20248640. Available from: http://medrxiv.org/content/early/2020/12/22/2020.12.21.20248640.abstract.
   Google Scholar