Pharmacogenetics of childhood uncontrolled asthma

References

• Serebrisky D, Wiznia A. Pediatric asthma: a global epidemic. Ann Glob Health. 2019;85:6.
   Google Scholar
• Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380:2163–2196.
   PubMed Web of Science ®Google Scholar
• Moore WC, Bleecker ER, Curran-Everett D, et al. Characterization of the severe asthma phenotype by the national heart, lung, and blood institute’s severe asthma research program. J Allergy Clin Immunol. 2007;119:405–413.
   PubMed Web of Science ®Google Scholar
• Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med. 2015;373:1241–1249.
   PubMed Web of Science ®Google Scholar
• Holgate ST, Wenzel S, Postma DS, et al. Asthma. Nat Rev Dis Primers. 2015;1:15025.
   PubMed Web of Science ®Google Scholar
• Conrad LA, Cabana MD, Rastogi D. Defining pediatric asthma: phenotypes to endotypes and beyond. Pediatr Res. 2021;90:45–51.
   PubMed Web of Science ®Google Scholar
• Asher MI, Rutter CE, Bissell K, et al. Worldwide trends in the burden of asthma symptoms in school-aged children: global asthma network phase I cross-sectional study. Lancet. 2021;398:1569–1580.
   PubMed Web of Science ®Google Scholar
• Caminati M, Morais-Almeida M, Bleecker E, et al. Biologics and global burden of asthma: a worldwide portrait and a call for action. World Allergy Organ J. 2021;14:100502.
   PubMed Web of Science ®Google Scholar
• Busse WW, Bleecker ER, FitzGerald JM, et al. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. Lancet Respir Med. 2019;7:46–59.
   PubMed Web of Science ®Google Scholar
• Matucci A, Vultaggio A, Danesi R. The use of intravenous versus subcutaneous monoclonal antibodies in the treatment of severe asthma: a review. Respir Res. 2018;19:154.
   PubMed Web of Science ®Google Scholar
• Ferrante G, Fasola S, Malizia V, et al. Pharmacogenomics: a step forward precision medicine in childhood asthma. Genes (Basel). 2022;13(4):599.
   PubMed Web of Science ®Google Scholar
• Slob EM, Maitland-Van der Zee AH, Koppelman GH, et al. Precision medicine in childhood asthma. Curr Opin Allergy Clin Immunol. 2019;19:141–147.
   PubMed Web of Science ®Google Scholar
• Fajt ML, Wenzel SE. Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care. J Allergy Clin Immunol. 2015;135:299–310. quiz 1.
   PubMed Web of Science ®Google Scholar
• Jones BL. The impact of pharmacogenetics in the treatment of allergic disease and asthma. Mo Med. 2011;108:361–365.
   PubMedGoogle Scholar
• McGeachie MJ, Stahl EA, Himes BE, et al. Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenet Genomics. 2013;23:324–328.
   PubMed Web of Science ®Google Scholar
• Miller SM, Ortega VE. Pharmacogenetics and the development of personalized approaches for combination therapy in asthma. Curr Allergy Asthma Rep. 2013;13:443–452.
   PubMed Web of Science ®Google Scholar
• Mougey EB, Chen C, Tantisira KG, et al. Pharmacogenetics of asthma controller treatment. Pharmacogenomics J. 2013;13:242–250.
   PubMed Web of Science ®Google Scholar
• Ortega VE, Wechsler ME. Asthma pharmacogenetics: responding to the call for a personalized approach. Curr Opin Allergy Clin Immunol. 2013;13:399–409.
   PubMed Web of Science ®Google Scholar
• Pascual RM, Bleecker ER. Pharmacogenetics of asthma. Curr Opin Pharmacol. 2010;10:226–235.
   PubMed Web of Science ®Google Scholar
• Stockmann C, Fassl B, Gaedigk R, et al. Fluticasone propionate pharmacogenetics: cYP3A4*22 polymorphism and pediatric asthma control. J Pediatr. 2013;162:1222–1227.
   PubMed Web of Science ®Google Scholar
• Davis JS, Weiss ST, Tantisira KG. Asthma pharmacogenomics: 2015 update. Curr Allergy Asthma Rep. 2015;15:42.
   PubMed Web of Science ®Google Scholar
• Wang AL, Tantisira KG. Personalized management of asthma exacerbations: lessons from genetic studies. Expert Rev Precis Med Drug Dev. 2016;1:487–495.
   PubMed Web of Science ®Google Scholar
• Dahlin A, Litonjua A, Irvin CG, et al. Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J. 2016;16:151–157.
   PubMed Web of Science ®Google Scholar
• Tantisira KG, Lake S, Silverman ES, et al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004;13:1353–1359.
   PubMed Web of Science ®Google Scholar
• Marshall CL, Hasani K, Mookherjee N. Immunobiology of steroid-unresponsive severe asthma. Front Allergy. 2021;2:718267.
   PubMedGoogle Scholar
• McGeachie MJ, Sordillo JE, Dahlin A, et al. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. Respir Res. 2020;21:31.
   PubMed Web of Science ®Google Scholar
• Vijverberg SJ, Koster ES, Tavendale R, et al. ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Clin Exp Allergy. 2015;45:1051–1059.
   PubMed Web of Science ®Google Scholar
• Keskin O, Uluca U, Birben E, et al. Genetic associations of the response to inhaled corticosteroids in children during an asthma exacerbation. Pediatr Allergy Immunol. 2016;27:507–513.
   PubMed Web of Science ®Google Scholar
• Salhi M, Lahmar O, Salah MO, et al. GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population. J Asthma. 2021;58:197–206.
   PubMed Web of Science ®Google Scholar
• Duong-Thi-Ly H, Nguyen-Thi-Thu H, Nguyen-Hoang L, et al. Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review. J Int Med Res. 2017;45:1818–1830.
   PubMed Web of Science ®Google Scholar
• Hernandez-Pacheco N, Farzan N, Francis B, et al. Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clin Exp Allergy. 2019;49:789–798.
   PubMed Web of Science ®Google Scholar
• Hernandez-Pacheco N, Vijverberg SJ, Herrera-Luis E, et al. Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use. Eur Respir J. 2021;57:57.
   Web of Science ®Google Scholar
• Tantisira KG, Lasky-Su J, Harada M, et al. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011;365:1173–1183.
   PubMed Web of Science ®Google Scholar
• Israel E, Lasky-Su J, Markezich A, et al. Genome-wide association study of short-acting beta2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med. 2015;191:530–537.
   PubMed Web of Science ®Google Scholar
• Tse SM, Krajinovic M, Chauhan BF, et al. Genetic determinants of acute asthma therapy response in children with moderate-to-severe asthma exacerbations. Pediatr Pulmonol. 2019;54:378–385.
   PubMed Web of Science ®Google Scholar
• Scaparrotta A, Franzago M, Marcovecchio ML, et al. Role of THRB, ARG1, and ADRB2 genetic variants on bronchodilators response in asthmatic children. J Aerosol Med Pulm Drug Deliv. 2019;32:164–173.
   PubMed Web of Science ®Google Scholar
• Slob EMA, Vijverberg SJH, Palmer CNA, et al. Pharmacogenetics of inhaled long-acting beta2-agonists in asthma: a systematic review. Pediatr Allergy Immunol. 2018;29:705–714.
   PubMed Web of Science ®Google Scholar
• Kersten ET, Koppelman GH, Thio BJ. Concerns with beta2-agonists in pediatric asthma - a clinical perspective. Paediatr Respir Rev. 2017;21:80–85.
   PubMed Web of Science ®Google Scholar
• Blake K, Lima J. Pharmacogenomics of long-acting beta2-agonists. Expert Opin Drug Metab Toxicol. 2015;11:1733–1751.
   PubMed Web of Science ®Google Scholar
• Ruffles T, Jones CJ, Palmer C, et al. Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents. Eur Respir J. 2021;58:58.
   Web of Science ®Google Scholar
• Ortega VE, Daya M, Szefler SJ, et al. Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma. Lancet Child Adolesc Health. 2021;5:862–872.
   PubMedGoogle Scholar
• Slob EMA, Richards LB, Vijverberg SJH, et al. Genome-wide association studies of exacerbations in children using long-acting beta2-agonists. Pediatr Allergy Immunol. 2021;32:1197–1207.
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Phillips BR, Martinez FD, et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol. 2005;115:233–242.
   PubMed Web of Science ®Google Scholar
• Sampson AP, Siddiqui S, Buchanan D, et al. Variant LTC synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax. 2000;55(Suppl 2):S28–31.
   PubMedGoogle Scholar
• Telleria JJ, Blanco-Quiros A, Varillas D, et al. ALOX5 promoter genotype and response to montelukast in moderate persistent asthma. Respir med. 2008;102:857–861.
   PubMed Web of Science ®Google Scholar
• Klotsman M, York TP, Pillai SG, et al. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. Pharmacogenet Genomics. 2007;17:189–196.
   PubMed Web of Science ®Google Scholar
• Kang MJ, Kwon JW, Kim BJ, et al. Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. J Hum Genet. 2011;56:284–289.
   PubMed Web of Science ®Google Scholar
• Farzan N, Vijverberg SJ, Kabesch M, et al. The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: where do we stand? Pediatr Pulmonol. 2018;53:836–845.
   PubMed Web of Science ®Google Scholar
• Condreay L, Chiano M, Ortega H, et al. No genetic association detected with mepolizumab efficacy in severe asthma. Respir med. 2017;132:178–180.
   PubMed Web of Science ®Google Scholar
• Need AC, Goldstein DB. Next generation disparities in human genomics: concerns and remedies. Trends Genet. 2009;25:489–494.
   PubMed Web of Science ®Google Scholar
• Mak ACY, White MJ, Eckalbar WL, et al. Whole-genome sequencing of pharmacogenetic drug response in racially diverse children with asthma. Am J Respir Crit Care Med. 2018;197:1552–1564.
   PubMed Web of Science ®Google Scholar
• Sharma N, Dixit P, Awasthi S, et al. Genetic variations of the FCER2 gene and asthma susceptibility in north Indian children: a case-control study. Biomarkers. 2013;18:660–667.
   PubMed Web of Science ®Google Scholar
• Tantisira KG, Silverman ES, Mariani TJ, et al. FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. J Allergy Clin Immunol. 2007;120:1285–1291.
   PubMed Web of Science ®Google Scholar
• Herrera-Luis E, Ortega VE, Ampleford EJ, et al. Multi-ancestry genome-wide association study of asthma exacerbations. Pediatr Allergy Immunol. 2022;33:e13802.
   PubMed Web of Science ®Google Scholar
• Fainardi V, Passadore L, Labate M, et al. An overview of the obese-asthma phenotype in children. Int J Environ Res Public Health. 2022;19(2):636.
   PubMed Web of Science ®Google Scholar
• Lang JE. Obesity and childhood asthma. Curr Opin Pulm Med. 2019;25:34–43.
   PubMed Web of Science ®Google Scholar
• Shan LS, Zhou QL, Shang YX. Bidirectional association between asthma and obesity during childhood and adolescence: a systematic review and meta-analysis. Front Pediatr. 2020;8:576858.
   PubMed Web of Science ®Google Scholar
• Gold DR, Damokosh AI, Dockery DW, et al. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol. 2003;36:514–521.
   PubMed Web of Science ®Google Scholar
• Bantula M, Roca-Ferrer J, Arismendi E, et al. Asthma and obesity: two diseases on the rise and bridged by inflammation. J Clin Med. 2021;10(2):169.
   PubMed Web of Science ®Google Scholar
• Han X, Zhu Z, Xiao Q, et al. Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma. Commun Biol. 2022;5:1098.
   PubMed Web of Science ®Google Scholar
• Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr. 2013;13:121.
   PubMed Web of Science ®Google Scholar
• Boulet LP, Des Cormiers A. The link between obesity and asthma: a Canadian perspective. Can Respir J. 2007;14:217–220.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Guo Y, Shi H, et al. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol. 2020;145:537–549.
   PubMed Web of Science ®Google Scholar
• Stenius-Aarniala B, Poussa T, Kvarnstrom J, et al. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000;320:827–832.
   PubMed Web of Science ®Google Scholar
• Strunk RC, Colvin R, Bacharier LB, et al. Airway obstruction worsens in young adults with asthma who become obese. J Allergy Clin Immunol Pract. 2015;3:765–71 e2.
   PubMed Web of Science ®Google Scholar
• Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest. 2000;118:1315–1321.
   PubMed Web of Science ®Google Scholar
• De A, Rastogi D. Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management. Expert Rev Endocrinol Metab. 2019;14:335–349.
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Fischer ME, Wurfel MM, et al. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol. 2005;116:1235–1241.
   PubMed Web of Science ®Google Scholar
• Jiang D, Wang L, Bai C, et al. Association between abdominal obesity and asthma: a meta-analysis. Allergy, Asthma Clin Immunol. 2019;15:16.
   PubMed Web of Science ®Google Scholar
• Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax. 2001;56(Suppl 2):ii64–73.
   PubMedGoogle Scholar
• Rastogi D, Suzuki M, Greally JM. Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep. 2013;3:2164.
   PubMed Web of Science ®Google Scholar
• Muc M, Todo-Bom A, Mota-Pinto A, et al. Leptin and resistin in overweight patients with and without asthma. Allergol IMMUNOPATH (Madr). 2014;42:415–421.
   PubMed Web of Science ®Google Scholar
• Zhang MY, Dini AA, Yang XK, et al. Association between serum/plasma adiponectin levels and immune-mediated diseases: a meta-analysis. Arch Dermatol Res. 2017;309:625–635.
   PubMed Web of Science ®Google Scholar
• Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115:911–919. quiz 20.
   PubMed Web of Science ®Google Scholar
• Shore SA, Schwartzman IN, Mellema MS, et al. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol. 2005;115:103–109.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM, Mutic AD, Mohammad AF, et al. Obesity is associated with sustained symptomatology and unique inflammatory features in children with asthma. J Allergy Clin Immunol Pract. 2022;10:815–26 e2.
   PubMed Web of Science ®Google Scholar
• Otelea MR, Arghir OC, Zugravu C, et al. Adiponectin and asthma: knowns, unknowns and controversies. Int J Mol Sci. 2021;22(16):8971.
   PubMed Web of Science ®Google Scholar
• Sideleva O, Suratt BT, Black KE, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186:598–605.
   PubMed Web of Science ®Google Scholar
• Leivo-Korpela S, Lehtimaki L, Vuolteenaho K, et al. Adiponectin is associated with dynamic hyperinflation and a favourable response to inhaled glucocorticoids in patients with COPD. Respir med. 2014;108:122–128.
   PubMed Web of Science ®Google Scholar
• Palma G, Sorice GP, Genchi VA, et al. Adipose tissue inflammation and pulmonary dysfunction in obesity. Int J Mol Sci. 2022;23(13):7349.
   PubMed Web of Science ®Google Scholar
• Dahlin A, Tantisira KG. Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics. 2012;13:1387–1404.
   PubMed Web of Science ®Google Scholar
• Wang AL, Gruzieva O, Qiu W, et al. DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics. Clin Exp Allergy. 2019;49:1225–1234.
   PubMed Web of Science ®Google Scholar
• Wang AL, Panganiban R, Qiu W, et al. Drug repurposing to treat glucocorticoid resistance in asthma. J Pers Med. 2021;11(3):11.
   Web of Science ®Google Scholar
• Li J, Panganiban R, Kho AT, et al. Circulating MicroRNAs and treatment response in childhood asthma. Am J Respir Crit Care Med. 2020;202:65–72.
   PubMed Web of Science ®Google Scholar
• Xiao C, Biagini Myers JM, Ji H, et al. Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response. J Allergy Clin Immunol. 2015;136:923–31 e3.
   PubMed Web of Science ®Google Scholar
• Kho AT, McGeachie MJ, Moore KG, et al. Circulating microRnas and prediction of asthma exacerbation in childhood asthma. Respir Res. 2018;19:128.
   PubMed Web of Science ®Google Scholar
• Qiu W, Rogers AJ, Damask A, et al. Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis. Hum Mol Genet. 2014;23:5017–5024.
   PubMed Web of Science ®Google Scholar
• Cornejo S, Tantisira K, Raby BA, et al. Nuclear bioavailability of the glucocorticoid receptor in a pediatric asthma cohort with variable corticosteroid responsiveness. Pediatr Res. 2015;78:505–512.
   PubMed Web of Science ®Google Scholar
• Himes BE, Jiang X, Wagner P, et al. RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. PLoS ONE. 2014;9:e99625.
   PubMed Web of Science ®Google Scholar
• Zeskind B. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011;365:2432. author reply 3-4.
   PubMedGoogle Scholar
• Choy DF, Jia G, Abbas AR, et al. Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma. J Allergy Clin Immunol. 2016;138:1230–3 e8.
   PubMed Web of Science ®Google Scholar
• Hernandez-Pacheco N, Gorenjak M, Jurgec S, et al. Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma. Allergy. 2021;76:1238–1243.
   PubMed Web of Science ®Google Scholar
• Schofield JPR, Burg D, Nicholas B, et al. Stratification of asthma phenotypes by airway proteomic signatures. J Allergy Clin Immunol. 2019;144:70–82.
   PubMed Web of Science ®Google Scholar
• Zamora-Mendoza BN, Espinosa-Tanguma R, Ramirez-Elias MG, et al. Surface-enhanced raman spectroscopy: a non invasive alternative procedure for early detection in childhood asthma biomarkers in saliva. Photodiagnosis Photodyn Ther. 2019;27:85–91.
   PubMed Web of Science ®Google Scholar
• Gagliardo R, Gras D, La Grutta S, et al. Airway lipoxin A4/formyl peptide receptor 2-lipoxin receptor levels in pediatric patients with severe asthma. J Allergy Clin Immunol. 2016;137:1796–1806.
   PubMed Web of Science ®Google Scholar
• Nacaroglu HT, Gayret OB, Erol M, et al. Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients. Allergol IMMUNOPATH (Madr). 2017;45:534–540.
   PubMed Web of Science ®Google Scholar
• Kelly RS, Sordillo JE, Lutz SM, et al. Pharmacometabolomics of bronchodilator response in asthma and the role of age-metabolite interactions. Metabolites. 2019;9(9):179.
   PubMed Web of Science ®Google Scholar
• Kelly RS, Chawes BL, Blighe K, et al. An integrative transcriptomic and metabolomic study of lung function in children with asthma. Chest. 2018;154:335–348.
   PubMed Web of Science ®Google Scholar
• de Vries R, Dagelet YWF, Spoor YWF, et al. Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label. Eur Respir J. 2018;51(1):51.
   Web of Science ®Google Scholar
• Goodrich JK, Singer-Berk M, Son R, et al. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021;12:3505.
   PubMed Web of Science ®Google Scholar
• Sordillo JE, Lutz SM, Jorgenson E, et al. A polygenic risk score for asthma in a large racially diverse population. Clin Exp Allergy. 2021;51:1410–1420.
   PubMed Web of Science ®Google Scholar
• Zhai S, Zhang H, Mehrotra DV, et al. Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods. Nat Commun. 2022;13:5278.
   PubMed Web of Science ®Google Scholar