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Articles

Effect of conjugated linoleic acid on proliferation and cytokine expression of bovine peripheral blood mononuclear cells and splenocytes ex vivo

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Pages 73-85 | Received 05 Jan 2012, Accepted 10 Feb 2012, Published online: 30 Mar 2012

References

  • Albers , R , van der Wielen , RPJ , Brink , EJ , Hendriks , HFJ , Dorovska-Taran , VN and Mohede , ICM. 2003 . Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men . Eur J Clin Nutr , 57 : 595 – 603 .
  • Almeida , PE , Weber , PSD , Burton , JL , Tempelman , RJ , Steibel , JP and Zanella , AJ. 2007 . Gene expression profiling of peripheral mononuclear cells in lame dairy cows with foot lesions . Vet Immunol Immunopathol , 120 : 234 – 245 .
  • Bassaganya-Riera , J , Hontecillas , R and Beitz , DC. 2002 . Colonic anti-inflammatory mechanisms of conjugated linoleic acid . Clin Nutr , 21 : 451 – 459 .
  • Bassaganya-Riera , J , Pogranichniy , RM , Jobgen , SC , Halbur , PG , Yoon , KJ , O'Shea , M , Mohede , I and Hontecillas , R. 2003 . Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression . J Nutr , 133 : 3204 – 3214 .
  • Baumgard , LH , Corl , BA , Dwyer , DA , Saebo , A and Bauman , DE. 2000 . Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis . Am J Physiol-Reg I , 278 : R179 – R184 .
  • Calder , PC. 2008 . The relationship between the fatty acid composition of immune cells and their function . Prostaglandins Leukot Essent Fatty Acids , 79 : 101 – 108 .
  • Changhua , L , Jindong , Y , Defa , L , Lidan , Z , Shiyan , Q and Jianjun , X. 2005 . Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide . J Nutr , 135 : 239 – 244 .
  • Couper , KN , Blount , DG and Riley , EM. 2008 . IL-10: The master regulator of immunity to infection . J Immunol , 180 : 5771 – 5777 .
  • DeLany , JP , Blohm , F , Truett , AA , Scimeca , JA and West , DB. 1999 . Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake . Am J Physiol-Reg I , 276 ( 4 Pt 2 ) : R1172 – R1179 .
  • Goyarts , T , Dänicke , S , Grove , N , Tiemann , U and Rothkötter , HJ. 2006 . Methodical aspects of in vitro proliferation of porcine blood lymphocytes when exposed to deoxynivalenol (DON) . Landbauforschung Völkenrode , : 139 – 148 .
  • Griinari , JM , Corl , BA , Lacy , SH , Chouinard , PY , Nurmela , KV and Bauman , DE. 2000 . Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase . J Nutr , 130 : 2285 – 2291 .
  • Hussen , J , Dänicke , S and Schuberth , HJ. 2011 . The effect of a long term dietary supplementation with conjugated linoleic acid (CLA) on the composition of bovine peripheral blood mononuclear cells (PBMC) and the concentration of IgG isotypes in blood and milk . Proc Soc Nutr Physiol , 20 : 85
  • Kelley , DS , Taylor , PC , Rudolph , IL , Benito , P , Nelson , GJ , Mackey , BE and Erickson , KL. 2000 . Dietary conjugated linoleic acid did not alter immune status in young healthy women . Lipids , 35 : 1065 – 1071 .
  • Kelley , DS , Warren , JM , Simon , VA , Bartolini , G , Mackey , BE and Erickson , KL. 2002 . Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice . Lipids , 37 : 725 – 728 .
  • Kepler , CR , Hirons , KP , McNeill , JJ and Tove , SB. 1966 . Intermediates and products of the biohydrogenation of linoleic acid by Butyrinvibrio fibrisolvens . J Biol Chem , 241 : 1350 – 1354 .
  • Lacetera , N , Kuzminsky , G , Morera , R and Basirico , L. 2007 . Fatty acids affect proliferation of peripheral blood mononuclear cells in dairy cows . Ital J Anim Sci , 6 : 434 – 436 .
  • Lacetera , N , Scalia , D , Franci , O , Bernabucci , U , Ronchi , B and Nardone , A. 2004 . Short communication: effects of nonesterified fatty acids on lymphocyte function in dairy heifers . J Dairy Sci , 87 : 1012 – 1014 .
  • Lessard , M , Gagnon , N and Petit , HV. 2003 . Immune response of postpartum dairy cows fed flaxseed . J Dairy Sci , 86 : 2647 – 2657 .
  • Loiselle , M , Ster , C , Talbot , B , Zhao , X , Wagner , G , Boisclair , Y and Lacasse , P. 2009 . Impact of postpartum milking frequency on the immune system and the blood metabolite concentration of dairy cows . J Dairy Sci , 92 : 1900 – 1912 .
  • Mallard , BA , Dekkers , JC , Ireland , MJ , Leslie , KE , Sharif , S , Vankampen , CL , Wagter , L and Wilkie , BN. 1998 . Alteration in immune responsiveness during the peripartum period and its ramification on dairy cow and calf health . J Dairy Sci , 81 : 585 – 595 .
  • Mosmann , T. 1983 . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays . J Immunol Methods , 65 : 55 – 63 .
  • Neuvians , TP , Schams , D , Berisha , B and Pfaffl , MW. 2004 . Involvement of pro-inflammatory cytokines, mediators of inflammation, and basic fibroblast growth factor in prostaglandin F-2 alpha-induced luteolysis in bovine corpus luteum . Biol Reprod , 70 : 473 – 480 .
  • Nonnecke , BJ , Kimura , K , Goff , JP and Kehrli , ME. 2003 . Effects of the mammary gland on functional capacities of blood mononuclear leukocyte populations from periparturient cows . J Dairy Sci , 86 : 2359 – 2368 .
  • Nugent , AP , Roche , HM , Noone , EJ , Long , A , Kelleher , DK and Gibney , MJ. 2005 . The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers . Eur J Clin Nutr , 59 : 742 – 750 .
  • Nunes , EA , Bonatto , SJ , de Oliveira , HHP , Rivera , NLM , Maiorka , A , Krabbe , EL , Tanhoffer , RA and Fernandes , LC. 2008 . The effect of dietary supplementation with 9-cis: 12-trans and 10-trans: 12-cis conjugated linoleic acid (CLA) for nine months on serum cholesterol, lymphocyte proliferation and polymorphonuclear cells function in Beagle dogs . Res Vet Sci , 84 : 62 – 67 .
  • O'Brien , J , Wilson , I , Orton , T and Pognan , F. 2000 . Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity . Eur J Biochem , 267 : 5421 – 5426 .
  • O'Shea , M , Bassaganya-Riera , J and Mohede , ICM. 2004 . Immunomodulatory properties of conjugated linoleic acid . Am J Clin Nutr , 79 : 1199S – 1206S .
  • Perdomo , MC , Santos , JE and Badinga , L. 2011 . Trans-10, cis-12 conjugated linoleic acid and the PPAR-γ agonist rosiglitazone attenuate lipopolysaccharide-induced TNF-α production by bovine immune cells . Domest Anim Endocrinol , 41 : 118 – 125 .
  • Ramirez-Santana , C , Castellote , C , Castell , M , Rivero , M , Rodriguez-Palmero , M , Franch , A and Perez-Cano , FJ. 2009 . Long-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats . J Nutr , 139 : 76 – 81 .
  • Takahashi , K , Kawamata , K and Akiba , Y. 2007 . Effect of a mixture of conjugated linoleic acid (CLA) isomers on T cell subpopulation and responsiveness to mitogen in splenocytes of male broiler chicks . Asian-Aust J Anim Sci , 20 : 954 – 961 .
  • Tiemann , U , Brussow , KP , Jonas , L , Pohland , R , Schneider , F and Dänicke , S. 2006 . Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts . J Anim Sci , 84 : 236 – 245 .
  • Tricon , S , Burdge , GC , Kew , S , Banerjee , T , Russell , JJ , Grimble , RF , Williams , CM , Calder , PC and Yaqoob , P. 2004 . Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on immune cell function in healthy humans . Am J Clin Nutr , 80 : 1626 – 1633 .
  • von Soosten , D , Meyer , U , Weber , EM , Rehage , J , Flachowsky , G and Dänicke , S. 2011 . Effect of trans-10, cis-12 conjugated linoleic acid on performance, adipose depot weights, and liver weight in early-lactation dairy cows . J Dairy Sci , 94 : 2859 – 2870 .
  • Yang , W , Zerbe , H , Petzl , W , Brunner , RM , Günther , J , Draing , C , von Aulock , S , Schuberth , H-J and Seyfert , H-M. 2008 . Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly induce TNFα and interleukin-8 (CXCL8) expression in the udder . Mol Immunol , 45 ( 5 ) : 1385 – 1397 .

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