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Review

Vitamin D in dairy cows: metabolism, status and functions in the immune system

ORCID Icon & ORCID Icon
Pages 1-33 | Received 17 Sep 2021, Accepted 30 Nov 2021, Published online: 07 Mar 2022

References

  • Aatsinki S-M, Elkhwanky M-S, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, et al. 2019. Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes. Diabetes. 68:918–931.
  • Abboud M, Puglisi DA, Davies BN, Rybchyn M, Whitehead NP, Brock KE, Cole L, Gordon-Thomson C, Fraser DR, Mason RS. 2013. Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology. 154:3022–3030.
  • Abboud M, Rybchyn MS, Liu J, Gordon-Thomson C, Brennan-Speranza TC, Cole L, Greenfield H, Fraser DR, Mason RS. 2017. The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells. J Steroid Biochem Mol Biol. 173:173–179.
  • Abdel-Shafy H, Bortfeldt RH, Reissmann M, Brockmann GA. 2018. Validating genome-wide associated signals for clinical mastitis in German Holstein cattle. Anim Genet. 49:82–85.
  • Adams JS, Singer FR, Gacad MA, Sharma OP, Hayes MJ, Vouros P, Holick MF. 1985. Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab. 60:960–966.
  • Aiba I, Yamasaki T, Shinki T, Izumia S, Yamamoto K, Yamada S, Terato H, Ide H, Ohyama Y. 2006. Characterization of rat and human CYP2J enzymes as Vitamin D25-hydroxylases. Steroids. 71:849–856.
  • Al-Rayahi IAM, Sanyi RHH. 2015. The overlapping roles of antimicrobial peptides and complement in recruitment and activation of tumor-associated inflammatory cells. Fron Immunol. 6:2.
  • Ametaj BN, Beitz DC, Reinhardt TA, Nonnecke BJ. 1996. 1,25-Dihydroxyvitamin D3 inhibits secretion of interferon-γ by mitogen- and antigen-stimulated bovine mononuclear leukocytes. Veter Immunol Immunopathol. 52:77–90.
  • Anderson PH, Atkins GJ. 2008. The skeleton as an intracrine organ for vitamin D metabolism. Mol Aspects Med. 29:397–406.
  • Arnaud J, Constans J. 1993. Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet. 92:183–188.
  • Bacchetta J, Chun RF, Gales B, Zaritsky JJ, Leroy S, Wesseling-Perry K, Boregard N, Rastogi A, Salusky IB, Hewison M . 2014. Antibacterial responses by peritoneal macrophages are enhanced following vitamin D supplementation. PLoS One. 9:e116530.
  • Baldock PA, Thomas GP, Hodge JM, Baker SU, Dressel U, O’Loughlin PD, Nicholson GC, Briffa KH, Eisman JA, Gardiner EM. 2006. Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast. J Bone Miner Res. 21:1618–1626.
  • Baur AC, Brandsch C, Steinmetz B, Schutkowski A, Wensch-Dorendorf M, Stangl GI. 2020. Differential effects of vitamin D3 vs vitamin D2 on cellular uptake, tissue distribution and activation of vitamin D in mice and cells. J Steroid Biochem Mol Biol. 204:105768.
  • Bikle DD. 2008. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 17:348–352.
  • Bikle D. 2009. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 94:26–34.
  • Bikle DD. 2020. The free hormone hypothesis: when, why, and how to measure the free hormone levels to assess vitamin D, thyroid, sex hormone, and cortisol status. JBMR Plus. 5:e10418.
  • Bikle D, Bouillon R, Thadhani R, Schoenmakers I. 2017a. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? Steroid Biochem Mol Biol. 173:105–116.
  • Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. 1986. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 78:748–752.
  • Bikle DD, Malmstroem S, Schwartz J. 2017b. Current controversies: are free vitamin metabolite levels a more accurate assessment of vitamin D Status than total levels? Endocrinol Metab Clin North Am. 46:901–918.
  • Bikle DD, Schwartz J. 2019. Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions. Front Endocrinol (Lausanne). 10:317.
  • Bogdan C. 2001. Nitric oxide and the immune response. Nat Immunol. 2:907–916.
  • Boros S, Bindels RJ, Hoenderop JG. 2009. Active Ca(2+) reabsorption in the connecting tubule. Pflugers Arch. 458:99–109.
  • Bouillon R, Bikle D. 2019. Vitamin D metabolism revised: fall of dogmas. J Bone Miner Res. 34:1985–1992.
  • Bouillon R, Schuit F, Antonio L, Rastinejad F. 2020. Vitamin D binding protein: a historic overview. Front Endocrinol (Lausanne). 10:910.
  • Bouillon R, Xiang DZ, Convents R, Van Baelen H. 1992. Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein. J Steroid Biochem Mol Biol. 42:855–861.
  • Boyce BF, Xing L. 2008. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 473:139–146.
  • Boylan M, O’Brien MB, Beynon C, Meade KG. 2020. 1,25(OH)D vitamin D promotes NOS2 expression in response to bacterial and viral PAMPs in primary bovine salivary gland fibroblasts. Vet Res Commun. 44:83–88.
  • Bradford BJ, Yuan K, Farney JK, Mamedova LK, Carpenter AJ. 2015. Invited review: inflammation during the transition to lactation: new adventures with an old flame. J Dairy Sci. 98:6631–6650.
  • Carlsson M, Nilsson I, Brudin L, Von SP, Wanby P. 2017. Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D. Scand J Clin Lab Invest. 77:45–52.
  • Christakos S, Dhawan P, Porta A, Mady LJ, Seth T. 2011. Vitamin D and intestinal calcium absorption. Mol Cell Endocrinol. 347:25–29.
  • Chun RF, Hernandez I, Pereira R, Swinkles L, Huijs T, Zhou R, Liu NQ, Shieh A, Guemes M, Mallya SM, et al. 2016. Differential responses to vitamin D2 and vitamin D3 are associated with variations in free 25-hydroxyvitamin D. Endocrinology. 157:3420–3430.
  • Chun RF, Shieh A, Gottlieb C, Yacoubian V, Wang J, Hewison M, Adams JS. 2019. Vitamin D binding protein and the biological activity of vitamin D. Front Endocrinol (Lausanne). 10:718.
  • Contreras GA, O’Boyle NJ, Herdt TH, Sordillo LM. 2010. Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids. J Dairy Sci. 93:2508–2516.
  • Cristelo C, Machado A, Sarmento B, Gama FM. 2021. The roles of vitamin D and cathlecidin in type 1 diabetes susceptibility. Endocr Connect. 10:R1–R12.
  • Deiner C, Reiche M, Lassner D, Grienitz D, Twardziok S, Moesch A, Wenning P, Martens H. 2012. Allelic variations in coding regions of the vitamin D receptor gene in dairy cows and potential susceptibility to periparturient hypocalcaemia. J Dairy Res. 79:423–428.
  • Dimitrov V, Barbier C, Ismailova A, Wang Y, Dmowski K, Salehi-Tabar R, Memari B, Groulx-Boivin E, White JH. 2021. Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity. Endocrinology. 162:bqaa218.
  • Dimitrov V, White JH. 2016. Species-specific regulation of innate immunity by vitamin D signaling. J Steroid Biochem Mol Biol. 164:246–253.
  • Dittmer KE, Thompson KG. 2011. Vitamin D metabolism and rickets in domestic animals: a review. Vet Pathol. 48:389–407.
  • Duchow EG, Cooke NE, Seeman J, Plum LA, DeLuca HF. 2019. Vitamin D binding protein is required to utilize skin-generated vitamin D. Proc Natl Acad Sci U S A. 116:24527–24532.
  • Dueland S, Bouillon R, Van Baelen H, Pedersen JI, Helgerud P, Drevon CA. 1985. Binding protein for vitamin D and its metabolites in rat mesenteric lymph. Am J Physiol. 249:E1–5.
  • Dueland S, Pedersen JI, Helgerud P, Drevon CA. 1983. Absorption, distribution, and transport of vitamin D3 and 25-hydroxyvitamin D3 in the rat. Am J Physiol. 245:E463–467.
  • Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ. 2014. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One. 9:e111265.
  • Garbossa SG, Folli F. 2017. Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism. Rev Endocr Metab Disord. 18:243–258
  • Gessner DK, Koch C, Romberg FJ, Winkler A, Dusel G, Herzog E, Most E, Eder K. 2015. The effect of grape seed and grape marc meal extract on milk performance and the expression of genes of endoplasmic reticulum stress and inflammation in the liver of dairy cows in early lactation. J Dairy Sci. 98:8856–8868.
  • Gessner DK, Schlegel G, Keller J, Schwarz FJ, Ringseis R, Eder K. 2013. Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation. J Dairy Sci. 96:1038–1043.
  • Gnagnarella P, Raimondi S, Aristarco V, Johansson H, Bellerba F, Corso F, De Angelis SP, Belloni P, Caini S, Gandini S. 2021. Ethnicity as modifier of risk for vitamin D receptors polymorphisms: comprehensive meta-analysis of all cancer sites. Crit Rev Oncol Hematol. 158:103202.
  • Golder HM, McGrath J, Lean IJ. 2021. Effect of 25-hydroxyvitamin D3 during prepartum transition and lactation on production, reproduction, and health of lactating dairy cows. J Dairy Sci. 104:5345–5374.
  • Guillot X, Semerano L, Saidenberg-Kermanach N, Falgarone G, Boissier M-C. 2010. Vitamin D and inflammation. Joint Bone Spine. 77:552–557.
  • Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. 2011. Vitamin D3 is more potent than vitamin D2 in humans. Clin Endocrinol Metab. 96:E447–52.
  • Henderson CM, Fink SL, Bassyouni H, Argiropoulos B, Brown L, Laha TJ, Jackson KJ, Lewkonia R, Ferreira P, Hoofnagle AN, et al. 2019. Vitamin D-binding protein deficiency and homozygous deletion of the GC gene. N Engl J Med. 380:1150–1157.
  • Heulens N, Korf H, Mathyssen C, Everaerts S, De Smidt E, Dooms C, Yserbyt J, Gysemans C, Gayan-Ramirez G, Mathieu C, et al. 2016. 1,25-dihydroxyvitamin D modulates antibacterial and inflammatory response in human cigarette smoke-exposed macrophages. PLoS One. 11:e0160482.
  • Hidiroglou M, Proulx JG, Roubos D. 1979. 25-hydroxyvitamin D in plasma of cattle. J Dairy Sci. 62:1076–1080.
  • Hodnik JJ, Ježek J, Starič J. 2020. A review of vitamin D and its importance to the health of dairy cattle. J Dairy Res. 87:84–87.
  • Holcombe SJ, Wisnieski L, Gandy J, Norby B, Sordillo LM. 2018. Reduced serum vitamin D concentrations in healthy early-lactation dairy cattle. J Dairy Sci. 101:1488–1494.
  • Hollis BW. 1984. Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites. J Steroid Biochem. 21:81–86.
  • Horst RL, Goff JP, Reinhardt TA. 1994. Calcium and vitamin D metabolism in the dairy cow. J Dairy Sci. 77:1936–1951.
  • Horst RL, Reinhardt TA. 1983. Vitamin D metabolism in ruminants and its relevance to the periparturient cow. J Dairy Sci. 66:661–678.
  • Huhtakangas JA, Olivera CJ, Bishop JE, Zanello LP, Norman AW. 2004. The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro. Mol Endocrinol. 18:2660–2671.
  • Hymøller L, Jensen SK. 2010a. Stability in the rumen and effect on plasma status of single oral doses of vitamin D and vitamin E in high-yielding dairy cows. J Dairy Sci. 93:5748–5757.
  • Hymøller L, Jensen SK. 2010b. Vitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage. J Dairy Sci. 93:2025–2029.
  • Hymøller L, Jensen SK. 2012. 25-Hydroxycholecalciferol status in plasma is linearly correlated to daily summer pasture time in cattle at 56°N. Br J Nutr. 108:666–671.
  • Hymøller L, Jensen SK, Kaas P, Jakobsen J. 2017. Physiological limit of the daily endogenous cholecalciferol synthesis from UV light in cattle. J Anim Physiol Anim Nutr (Berl). 101:215–221.
  • Hymøller L, Jensen SK, Lindqvist H, Johansson B, Nielsen MO, Nadeau E. 2009. Supplementing dairy steers and organically managed dairy cows with synthetic vitamin D3 is unnecessary at pasture during exposure to summer sunlight. J Dairy Res. 76:372–378.
  • Ismailova A, White JH. 2021. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 29:1–13.
  • Jacquillet G, Unwin R. 2019. Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi). Pflügers Arch. 471:83–98.
  • Jäpelt RB, Jakobsen J. 2013. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Front Plant Sci. 4:136.
  • Jones KS, Assar S, Harnpanich D, Bouillon R, Lambrechts D, Prentice A, Schoenmakers I. 2014b. 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J Clin Endocrinol Metab. 99:3373–3381.
  • Jones G, Byrnes B, Palma F, Segev D, Mazur Y. 1980. Displacement potency of vitamin D2 analogs in competitive protein-binding assays for 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, and 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 50:773–775.
  • Jones G, Prosser DE, Kaufmann M. 2014a. Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res. 55:13–31.
  • Kiela PR, Ghishan FK. 2016. Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol. 30:145–159.
  • Koivisto O, Hanel A, Carlberg C. 2020. Key vitamin D target genes with functions in the immune system. Nutrients. 12:1140.
  • Kutuzova GD, Deluca HF. 2004. Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties. Arch Biochem Biophys. 432:152–166.
  • Lehmann U, Hirche F, Stangl GI, Hinz K, Westphal S, Dierkes J. 2013. Bioavailability of vitamin D2 and D3 in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab. 98:4339–4345.
  • Levy JA. 2009. The unexpected pleiotropic activities of RANTES. J Immunol. 182:3945–3946.
  • Li H-M, Liu Y, Zhang R-J, Ding J-Y, Shen C-L. 2021. Vitamin D receptor gene polymorphisms and osteoarthritis: a meta-analysis. Rheumatology (Oxford). 60:538–548.
  • Lippolis JD, Reinhardt TA, Sacco RA, Nonnecke BJ, Nelson CD. 2011. Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3. PLoS One. 6:e25479.
  • Littledike ET, Horst RL. 1982. Vitamin D3 toxicity in dairy cows. J Dairy Sci. 65:749–759.
  • Liu J, Greenfield H, Strobel N, Fraser DR. 2013. The influence of latitude on the concentration of vitamin D3 and 25-hydroxy-vitamin D3 in Australian red meat. Food Chem. 140:432–435.
  • Liu L, Shen T, Yang W, Yu H, Gao S, Huang B, Xu C. 2020. Ketotic cows display a different serum nonesterified fatty acid composition. J Dairy Res. 87:52–55.
  • Louw JA, Werbeck A, Louw ME, Kotze TJ, Cooper R, Labadarios D. 1992. Blood vitamin concentrations during the acute-phase response. Crit Care Med. 20:934–941.
  • Lowry BM, Guo C, Zhang Y, Fantacone ML, Logan IE, Campbell Y, Zhang W, Le M, Indra AK, Ganguli-Indra G, et al. 2020. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. J Steroid Biochem Mol Biol. 198:105552.
  • Makris K, Sempos C, Cavalier E. 2020. The measurement of vitamin D metabolites: part I-metabolism of vitamin D and the measurement of 25-hydroxyvitamin D. Hormones (Athens). 19:81–96.
  • Mangin M, Sinha R, Fincher K. 2014. Inflammation and vitamin D: the infection connection. Inflamm Res. 63:803–819.
  • Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. 2018. Vitamin D toxicity-a clinical perspective. Front Endocrinol (Lausanne). 9:550.
  • Margier M, Collet X, Le May C, Desmarchelier C, André F, Lebrun C, Defoort C, Bluteau A, Borel P, Lespine A, et al. 2019. ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux. FASEB J. 33:2084–2094.
  • Martens PJ, Gysemans C, Verstuyf A, Mathieu AC. 2020. Vitamin D’s effect on immune function. Nutrients. 12:1248.
  • Medzhitov R. 2007. Recognition of microorganisms and activation of the immune response. Nature. 449:819–826.
  • Mello JRB. 2003. Calcinosis-calcinogenic plants. Toxicon. 41:1–12.
  • Merriman KE, Kweh MF, Powell JL, Lippolis JD, Nelson CD. 2015. Multiple β-defensin genes are upregulated by the vitamin D pathway in cattle. J Steroid Biochem Mol Biol. 154:120–129.
  • Merriman KE, Poindexter MB, Kweh MF, Santos JEP, Nelson CD. 2017. Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle. J Steroid Biochem Mol Biol. 173:33–41.
  • Merriman KE, Powell JL, Santos JEP, Nelson CD. 2018. Intramammary 25-hydroxyvitamin D3 treatment modulates innate immune responses to endotoxin-induced mastitis. J Dairy Sci. 101:7593–7607.
  • Meyer MB, Pike JW. 2020. Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression. Steroid Biochem Mol Biol. 196:105500.
  • Naderi S, Bohlouli M, Yin T, König S. 2018. Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets. Anim Genet. 49:178–192.
  • National Research Council. 2001. Nutrient requirements of dairy cattle. 7th rev. ed. Washington D.C: National Academy Press.
  • Nelson CD, Lippolis JD, Reinhardt TA, Sacco RE, Powell JL, Drewnoski ME, O’Neil M, Beitz DC, Weiss WP. 2016. Vitamin D status of dairy cattle: outcomes of current practices in the dairy industry. J Dairy Sci. 99:10150–10160.
  • Nelson CD, Nonnecke BJ, Reinhardt TA, Waters WR, Beitz DC, Lippolis JD. 2011. Regulation of mycobacterium-specific mononuclear cell responses by 25-hydroxyvitamin D3. PLoS One. 6:e21674.
  • Nelson CD, Reinhardt TA, Beitz DC, Lippolis JD. 2010a. In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection. PLoS One. 5:e15469.
  • Nelson CD, Reinhardt TA, Lippolis JD, Sacco RE, Nonnecke BJ. 2012. Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements. Nutrients. 4:181–196.
  • Nelson CD, Reinhardt TA, Thacker TC, Beitz DC, Lippolis JD. 2010b. Modulation of the bovine innate immune response by production of 1alpha,25-dihydroxyvitamin D3 in bovine monocytes. J Dairy Sci. 93:1041–1049.
  • Nemere I, Garbi N, Hammerling G, Hintze KJ. 2012. Role of the 1,25D3-MARRS receptor in the 1,25(OH)2D3-stimulated uptake of calcium and phosphate in intestinal cells. Steroids. 77:897–902.
  • Nonnecke BJ, Waters WR, Foote MR, Horst RL, Fowler MA, Miller BL. 2003. In vitro effects of 1,25-dihydroxyvitamin D3 on interferon-gamma and tumor necrosis factor-alpha secretion by blood leukocytes from young and adult cattle vaccinated with mycobacterium bovis BCG. Int J Vitam Nutr Res. 73:235–244.
  • Norman AW. 2012. The history of the discovery of vitamin D and its daughter steroid hormone. Ann Nutr Metab. 61:199–206.
  • Nykjaer A, Fyfe JC, Kozyraki R, Leheste JR, Jacobsen C, Nielsen MS, Verroust PJ, Aminoff M, de La Chapelle A, Moestrup SK, et al. 2001. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D3. Proc Natl Acad Sci U S A. 98:13895–13900.
  • O’Brien MB, Beynon CL, McLoughlin RM, Meade KG. 2021. The immune response in bovine primary dermal fibroblasts is influenced by interleukin 8 promoter haplotype and vitamin D. Vet Immunol Immunopathol. 238:110291.
  • Oberg F, Botling J, Nilsson K. 1993. Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells. J Immunol. 150:3487–3495.
  • Peelen E, Knippenberg S, Muris AH, Thewissen M, Smolders J, Tervaert JW, Hupperts R, Damoiseaux J. 2011. Effects of vitamin D on the peripheral adaptive immune system: a review. Autoimmun Rev. 10:733–743.
  • Poindexter MB, Kweh MF, Zimpel R, Zuniga J, Lopera C, Zenobi MG, Jiang Y, Engstrom M, Celi P, Santos JEP, et al. 2020. Feeding supplemental 25-hydroxyvitamin D3 increases serum mineral concentrations and alters mammary immunity of lactating dairy cows. J Dairy Sci. 103:805–822.
  • Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. 2011. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 26:1609–1616.
  • Prabhu AV, Luu W, Sharpe LJ, Brown AJ. 2017. Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis. J Steroid Biochem Mol Biol. 165:363–368.
  • Pulendran B, Tang H, Manicassamy S. 2010. Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol. 11:647–655.
  • Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, et al. 2010. Knight JC.A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 20:1352–1360.
  • Reboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier JF, Jourdheuil-Rahmani D, Dufour C, Collet X, Borel P. 2011. Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol Nutr Food Res. 55:691–702.
  • Reichel H, Koeffler HP, Barbers R, Norman AW. 1987. Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J Clin Endocrinol Metab. 65:1201–1209.
  • Reid IR, Baldock PA, Cornish J. 2018. Effects of leptin on the skeleton. Endocr Rev. 39:938–959.
  • Reid D, Toole BJ, Knox S, Talwar D, Harten J, O’Reilly DS, Blackwell S, Kinsella J, McMillan DC, Wallace AM. 2011. The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. Am J Clin Nutr. 93:1006–1011.
  • Rodney RM, Martinez N, Block E, Hernandez LL, Celi P, Nelson CD, Santos EP, Lean IJ. 2018. Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Vitamin D, mineral, and bone metabolism. J Dairy Sci 101:2519–2543.
  • Roizen JD, Casella A, Lai M, Long C, Tara Z, Caplan I, O’Lear L, Levine MA. 2018a. Decreased serum 25-hydroxyvitamin D in aging male mice is associated with reduced hepatic Cyp2r1 abundance. Endocrinology. 159:3083–3089.
  • Roizen JD, Li D, O’Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda CP, Thummel KE, Thacher TD, et al. 2018b. CYP3A4 mutation causes vitamin D-dependent rickets type 3. J Clin Invest. 128:1913–1918.
  • Roizen JD, Long C, Casella A, O’Lear L, Caplan I, Lai M, Sasson I, Singh R, Makowski AJ, Simmons R, et al. 2019. Obesity decreases hepatic 25-hydroxylase activity causing low serum 25-hydroxyvitamin D. J Bone Miner Res. 34:1068–1073.
  • Rybchyn MS, Abboud M, Puglisi DA, Gordon-Thomson C, Brennan-Speranza TC, Mason RS, Fraser DR. 2020. Skeletal muscle and the maintenance of vitamin D status. Nutrients. 12:3270.
  • Safadi FF, Thornton P, Magiera H, Hollis BW, Gentile M, Haddad JG, Liebhaber SA, Cooke NE. 1999. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest. 103:239–251.
  • Saito A, Iino N, Takeda T, Gejyo F. 2007. Role of megalin, a proximal tubular endocytic receptor, in calcium and phosphate homeostasis. Ther Apher Dial. 11:S23–26.
  • Saponaro F, Saba A, Zucchi R. 2020. An update on vitamin D metabolism. Int J Mol Sci. 21:6573.
  • Sassi F, Tamone C, D’Amelio P. 2018. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 10:1656.
  • Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, et al. 2007. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 117:803–811.
  • Scherberich JE, Kellermeyer M, Ried C, Hartinger A. 2005. 1-alpha-calcidol modulates major human monocyte antigens and toll-like receptors TLR 2 and TLR4 in vitro. Eur J Med Res. 10:179–182.
  • Schlegel G, Ringseis R, Windisch W, Schwarz FJ, Eder K. 2012. Effects of a rumen-protected mixture of conjugated linoleic acids on hepatic expression of genes involved in lipid metabolism in dairy cows. J Dairy Sci. 95:3905–3918.
  • Schröder B, Breves G. 2006. Mechanisms and regulation of calcium absorption from the gastrointestinal tract in pigs and ruminants: comparative aspects with special emphasis on hypocalcemia in dairy cows. Anim Health Res Rev. 7:31–41.
  • Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS. 2018. Determination of free 25(OH)D concentrations and their relationships to total 25(OH)D in multiple clinical populations. J Clin Endocrinol Metab. 103:3278–3288.
  • Schwartz JB, Kane L, Bikle D. 2016. Response of vitamin D concentration to vitamin D3 administration in older adults without sun exposure: a randomized double-blind trial. J Am Geriatr Soc. 64:65–72.
  • Shieh A, Chun RF, Ma C, Witzel S, Meyer B, Rafison B, Swinkels L, Huijs T, Pepkowitz S, Holmquist B, et al. 2016. Effects of high-dose vitamin D2 versus D3 on total and free 25-hydroxyvitamin D and markers of calcium balance. J Clin Endocrinol Metab. 101:3070–3080.
  • Shieh A, Ma C, Chun RF, Wittwer-Schegg J, Swinkels L, Huijs T, Wang J, Donangelo I, Hewison M, Adams JS. 2018. Associations between change in total and free 25-hydroxyvitamin D with 24,25-dihydroxyvitamin D and parathyroid hormone. J Clin Endocrinol Metab. 103:3368–3375.
  • Silver J, Russell J, Sherwood LM. 1985. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci U S A. 82:4270–4273.
  • Sly LM, Lopez M, Nauseef WM, Reiner NE. 2001. 1alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J Biol Chem. 276:35482–35493.
  • Small AG, Harvey S, Kaur J, Putty T, Quach A, Munawara U, Perveen K, McPhee A, Hii CS, Ferrante A. 2021. Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens. Commun Biol. 25:401.
  • Solanki SS, Singh P, Kashyap P, Sansi MS, Ali SA. 2021. Promising role of defensins peptides as therapeutics to combat against viral infection. Microb Pathog. 155:104930.
  • Sommerfeldt JL, Horst RL, Littledike TE, Beitz DC. 1979. In vitro degradation of cholecalciferol in rumen fluid. J Dairy Sci. 64:157. (Abstract).
  • Sommerfeldt JL, Napoli JL, Littledike ET, Beitz DC, Horst RL. 1983. Metabolism of orally administered [3H]ergocalciferol and [3H]cholecalciferol by dairy calves. J Nutr. 113:2595–2600.
  • Sordillo LM. 2016. Nutritional strategies to optimize dairy cattle immunity. J Dairy Sci. 99:4967–4982.
  • Tabaei S, Motallebnezhad M, Tabaee SS. 2021. Vitamin D Receptor (VDR) gene polymorphisms and risk of Coronary Artery Disease (CAD): systematic review and meta-analysis. Biochem Genet. 59:813–836.
  • Téllez-Pérez AD, Alva-Murillo N, Ochoa-Zarzosa A, López-Meza JE. 2012. Cholecalciferol (vitamin D) differentially regulates antimicrobial peptide expression in bovine mammary epithelial cells: implications during Staphylococcus aureus internalization. Vet Microbiol. 160:91–98.
  • van de Peppel J, van Leeuwen JP. 2014. Vitamin D and gene networks in human osteoblasts. Front Physiol. 5:137.
  • Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C. 2002. A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 9:131–136.
  • Vieira-Neto A, Poindexter MB, Nehme Marinho M, Zimpel R, Husnain A, Silva ACM, Prim JG, Nelson CD, Santos JEP. 2021. Effect of source and amount of vitamin D on function and mRNA expression in immune cells in dairy cows. J Dairy Sci. 104:10796–10811.
  • Vieth R, Kessler MJ, Pritzker KP. 1990. Species differences in the binding kinetics of 25-hydroxyvitamin D3 to vitamin D binding protein. Can J Physiol Pharmacol. 68:1368–1371.
  • Waldron JL, Ashby HL, Cornes MP, Bechervaise J, Razavi C, Thomas OL, Chugh S, Deshpande S, Ford C, Gama R. 2013. Vitamin D: a negative acute phase reactant. J Clin Pathol. 66:620–622.
  • Wang Y, Chen J, Lee CSD, Nizkorodov A, Riemenschneider K, Martin D, Hyzy S, Schwartz Z, Boyan BD. 2010. Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol. 121:257–260.
  • Wang X, Shapses SA, Al-Hraishawi H. 2017. Feee and bioavailable 25-hydroxyvitamin D levels in patients with primary hyperparathyroidism. Endocr Pract. 23:66–71.
  • Wasserman RH. 1975. Active vitamin D-like substances in Solanum malacoxylon and other calcinogenic plants. Nutr Rev. 33:1–5.
  • Waters WR, Nonnecke BJ, Rahner TE, Palmer MV, Whipple DL, Horst RL. 2001. Modulation of mycobacterium bovis-specific responses of bovine peripheral blood mononuclear cells by 1,25-dihydroxyvitamin D3. Clin Diagn Lab Immunol. 8:1204–1212.
  • Wen G, Eder K, Ringseis R. 2020. 1,25-hydroxyvitamin D3 decreases endoplasmic reticulum stress-induced inflammatory response in mammary epithelial cells. PLoS One. 15:e0228945.
  • Wilkens MR, Cohrs I, Lifschitz AL, Fraser DR, Olszewski K, Schröder B, Breves G. 2013. Is the metabolism of 25-hydroxyvitamin D3 age-dependent in dairy cows? J Steroid Biochem Mol Biol. 136:44–46.
  • Wilkens MR, Firmenich CS, Schnepel N, Muscher-Banse AS. 2019. A reduced protein diet modulates enzymes of vitamin D and cholesterol metabolism in young ruminants. J Steroid Biochem Mol Biol. 186:196–202.
  • Wilkens MR, Kunert-Keil C, Brinkmeier H, Schröder B. 2009. Expression of calcium channel TRPV6 in ovine epithelial tissue. Vet J. 182:294–300.
  • Wilkens MR, Muscher-Banse AS. 2020. Review: regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants. Animal. 14:s29–s43.
  • Williams MH, Van Alstyne EL, Galbraith RM. 1988. Evidence of a novel association of unsaturated fatty acids with Gc (vitamin D-binding protein). Biochem Biophys Res Commun. 153:1019–1024.
  • Wu J, Shang DP, Yang S, Fu DP, Ling HY, Hou SS, Lu JM. 2016. Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomed Rep. 5:233–236.
  • Yu ZH, Chen M, Zhang QQ, Hu X. 2018. The association of vitamin d receptor gene polymorphism with lung cancer risk: an update meta-analysis. Comb Chem High Throughput Screen. 21:704–710.
  • Yue Y, Hymøller L, Jensen SK, Lauridsen C. 2018. Effect of vitamin D treatments on plasma metabolism and immune parameters of healthy dairy cows. Arch Anim Nutr. 72:205–220.
  • Yue Y, Hymøller L, Jensen SK, Lauridsen C, Purup S. 2017. Effects of vitamin D and its metabolites on cell viability and Staphylococcus aureus invasion into bovine mammary epithelial cells. Vet Microbiol. 203:245–251.
  • Zafalon RVA, Ruberti B, Rentas MF, Amaral AR, Vendramini THA, Chacar FC, Kogika MM, Brunetto MA. 2020. the role of vitamin D in small animal bone metabolism. Metabolites. 10:496.
  • Zasloff M. 2002. Antimicrobial peptides of multicellular organisms. Nature. 415:389–395.
  • Zella LA, Shevde NK, Hollis BW, Cooke NE, Pike JW. 2008. Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology. 149:3656–3667.
  • Zmijewski MA, Carlberg C. 2020. Vitamin D receptor(s): in the nucleus but also at membranes? Exp Dermatol. 29:876–884.