174
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Dietary glutathione supplementation attenuates oxidative stress and improves intestinal barrier in diquat-treated weaned piglets

ORCID Icon, , , ORCID Icon, , , & ORCID Icon show all
Pages 141-154 | Received 20 Jun 2022, Accepted 17 Mar 2023, Published online: 03 May 2023

References

  • Aquilano K, Baldelli S, Ciriolo MR. 2014. Glutathione: new roles in redox signaling for an old antioxidant. Front Pharmacol. 5:196.
  • Ardite E, Sans M, Panés J, Romero FJ, Piqué JM, Fernández-Checa JC. 2000. Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Lab Invest. 80:735–744.
  • Babaeenezhad E, Dezfoulian O, Hadipour Moradi F, Rahimi Monfared S, Fattahi MD, Nasri M, Amini A, Ahmadvand H. 2022. Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug Chem Toxicol. 1–10.
  • Cao S, Wu H, Wang C, Zhang Q, Jiao L, Lin F, Hu C. 2018. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 96:1795–1805.
  • Chen J, Wu F, Long Y, Yu W. 2015. Glutathione supplementation attenuates oxidative stress and improves vascular hyporesponsiveness in experimental obstructive jaundice. Oxid Med Cell Longev. 2015:1–10.
  • Chen J, Yu B, Chen D, Huang Z, Mao X, Zheng P, Yu J, Luo J, He J. 2018. Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs. J Nutr Biochem. 59:84–92.
  • Chen Q, Zhou J, Chen Z, Luo Q, Xu J, Song G. 2019. Tumor-specific expansion of oxidative stress by glutathione depletion and use of a Fenton nanoagent for enhanced chemodynamic therapy. ACS Appl Mater Interfaces. 11:30551–30565.
  • Davies G, Simmonds N, Stevens T, Grandison A, Blake D, Rampton D. 1992. Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut. 33:1467–1472.
  • Dhivya H. 2012. Glutathione: a master antioxidant and an immune system modulator. J Biol Inf Sci. 1:28–30.
  • Favilli F, Marraccini P, Iantomasi T, Vincenzini MT. 1997. Effect of orally administered glutathione on glutathione levels in some organs of rats: role of specific transporters. Br J Nutr. 78:293–300.
  • Forman HJ, Zhang H, Rinna A. 2009. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 30:1–12.
  • Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. 2018. Glutathione: antioxidant properties dedicated to nanotechnologies. Antioxidants. 7:62.
  • Groschwitz KR, Hogan SP. 2009. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 124:3–20.
  • Hagen TM, Wierzbicka GT, Sillau A, Bowman BB, Jones DP. 1990. Bioavailability of dietary glutathione: effect on plasma concentration. Am J Physiol Gastrointest Liver Physiol. 259:524–529.
  • Hao Y, Xing M, Gu X. 2021. Research progress on oxidative stress and its nutritional regulation strategies in pigs. Animals. 11:1384.
  • JanssenDuijghuijsen L, Grefte S, van Dartel D, Wichers H, van Norren K, Keijer J. 2016. Mitochondrial ATP production and intestinal epithelial permeability—an in vitro model. Biochim Biophys Acta Bioenerg. 1857:e119.
  • Kariya C, Leitner H, Min E, van Heeckeren C, van Heeckeren A, Day BJ. 2007. A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am J Physiol Lung Cell Mol Physiol. 292:1590–1597.
  • Koch RE, Hill GE. 2016. An assessment of techniques to manipulate oxidative stress in animals. Funct Ecol. 31:9–21.
  • Kwiecień S, Brzozowski T, Konturek S. 2002. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol. 53:39–50.
  • Kwon DH, Cha HJ, Lee H, Hong SH, Park C, Park SH, Kim GY, Kim S, Kim HS, Hwang HJ, et al. 2019. Protective effect of glutathione against oxidative stress-induced cytotoxicity in RAW 264.7 macrophages through activating the nuclear factor erythroid 2-related factor-2/heme oxygenase-1 pathway. Antioxidants. 8:82.
  • Li K, Jiang L, Wang J, Xia L, Zhao R, Cai C, Wang P, Zhan X, Wang Y. 2019. Maternal dietary supplementation with different sources of selenium on antioxidant status and mortality of chicken embryo in a model of diquat-induced acute oxidative stress. Anim Feed Sci Technol. 261:114369.
  • Liu L, Wu C, Chen D, Yu B, Huang Z, Luo Y, Zheng P, Mao X, Yu J, Luo J, et al. 2020. Selenium-enriched yeast alleviates oxidative stress-induced intestinal mucosa disruption in weaned pigs. Oxid Med Cell Longev. 2020:1–11.
  • Liu J, Zhang Y, Li Y, Yan H, Zhang H. 2019. L-tryptophan enhances intestinal integrity in diquat-challenged piglets associated with improvement of redox status and mitochondrial function. Animals. 9:266.
  • Mårtensson J, Jain A, Meister A. 1990. Glutathione is required for intestinal function. Proc Natl Acad Sci USA. 87:1715–1719.
  • Ming JH, Ye JY, Zhang YX, Xu P, Xie J. 2015. Effects of dietary reduced glutathione on growth performance, non-specific immunity, antioxidant capacity and expression levels of IGF-I and HSP70 mRNA of grass carp (Ctenopharyngodon idella). Aquaculture. 438:39–46.
  • Munro D, Treberg JR. 2017. A radical shift in perspective: mitochondria as regulators of reactive oxygen species. J Exp Biol. 220:1170–1180.
  • National Research Council (NRC). 2012. Nutrient requirements of swine. 11th ed. Washington (DC): National Academy Press.
  • Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler TW. 2006. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys. 454:7–15.
  • Palamara AT, Perno C-F, Ciriolo MR, Dini L, Balestra E, D’Agostini C, Di Francesco P, Favalli C, Rotilio G, Garaci E. 1995. Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. Antiviral Res. 27:237–253.
  • Phaniendra A, Jestadi DB, Periyasamy L. 2015. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 30:11–26.
  • Ren L, Qi K, Zhang L, Bai Z, Ren C, Xu X, Zhang Z, Li X. 2019. Glutathione might attenuate cadmium-induced liver oxidative stress and hepatic stellate cell activation. Biol Trace Elem Res. 191:443–452.
  • Ren Q, Sun S, Zhang XD. 2021. Redox-active nanoparticles for inflammatory bowel disease. Nano Res. 14:2535–2557.
  • Tan M, Tang C, Zhang Y, Cheng Y, Cai L, Chen X, Gao Y, Deng Y, Pan M. 2015. SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids. Free Radic Res. 49:935–945.
  • Vakifahmetoglu-Norberg H, Ouchida AT, Norberg E. 2017. The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun. 482:426–431.
  • Vincenzini MT, Favilli F, Iantomasi T. 1992. Intestinal uptake and transmembrane transport systems of intact GSH; characteristics and possible biological role. Biochim Biophys Acta Biomembr. 1113:13–23.
  • Wu KC, Zhang Y, Klaassen CD. 2012. Nrf2 protects against diquat-induced liver and lung injury. Free Radic Res. 46:1220–1229.
  • Xia Z, Wu S. 2018. Effects of glutathione on the survival, growth performance and non-specific immunity of white shrimps (Litopenaeus vannamei). Fish Shellfish Immunol. 73:141–144.
  • Yabuki Y, Fukunaga K. 2013. Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress. Neuroscience. 250:394–407.
  • Yin J, Liu M, Ren W, Duan J, Yang G, Zhao Y, Fang R, Chen L, Li T, Yin Y. 2015. Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets. PLoS One. 10:e0122893.
  • Yuan D, Hussain T, Tan B, Liu Y, Ji P, Yin Y. 2017. The evaluation of antioxidant and anti-inflammatory effects of eucommia ulmoides flavones using diquat-challenged piglet models. Oxid Med Cell Longev. 2017:1–9.
  • Zhang H, Liu Y, Fang X, Gu L, Luo C, Chen L, Wang Q. 2021. Vitamin D3 protects mice from diquat-induced oxidative stress through the NF-κB/Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev. 2021:1–15.
  • Zheng P, Yu B, Lv M, Chen D. 2010. Effects of oxidative stress induced by diquat on arginine metabolism of postweaning pigs. Asian-Australas J Anim Sci. 23:98–105.
  • Zhou Y, Jiang Z, Lu H, Xu Z, Tong R, Shi J, Jia G. 2019. Recent advances of natural polyphenols activators for Keap1‐Nrf2 signaling pathway. Chem Biodivers. 16:e1900400.
  • Zhu Y, Luo Y, Sun G, Wang P, Hu X, Chen F. 2020. Inhibition of acrylamide by glutathione in asparagine/glucose model systems and cookies. Food Chem. 329:127171.
  • Zou T, Yang J, Guo X, He Q, Wang Z, You J. 2021. Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations. J Anim Sci Biotechnol. 12:1–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.