Advanced search
Publication Cover
Acta Orthopaedica Volume 87, 2016 - Issue 5
Journal homepage
2,948
Views
36
CrossRef citations to date
0
Altmetric
Original Articles

Inter-trabecular bone formation: a specific mechanism for healing of cancellous bone

A narrative review

Olof H SandbergOrthopedics, Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.Correspondence[email protected]
&
Per AspenbergOrthopedics, Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Pages 459-465 | Received 18 Feb 2016, Accepted 30 May 2016, Published online: 30 Jun 2016

  • Alexander K A, Chang M K, Maylin E R, Kohler T, Muller R, Wu A C, et al. Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res 2011; 26 (7): 1517–32.
  • Alt V, Thormann U, Ray S, Zahner D, Durselen L, Lips K, et al. A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures. Acta Biomater 2013; 9 (6): 7035–42.
  • Aspenberg P, Sandberg O. Distal radial fractures heal by direct woven bone formation. Acta Orthop 2013; 84 (3): 297–300.
  • Aspenberg P, Genant H K, Johansson T, Nino A J, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 2010; 25 (2): 404–14.
  • Bernhardsson M, Sandberg O, Aspenberg P. Experimental models for cancellous bone healing in the rat. Acta Orthop 2015: 86(6): 745–50.
  • Bogoch E, Gschwend N, Rahn B, Moran E, Perren S. Healing of cancellous bone osteotomy in rabbits–Part I: Regulation of bone volume and the regional acceleratory phenomenon in normal bone. J Orthop Res 1993a; 11 (2): 285–91.
  • Bogoch E, Gschwend N, Rahn B, Moran E, Perren S. Healing of cancellous bone osteotomy in rabbits–Part II: Local reversal of arthritis-induced osteopenia after osteotomy. J Orthop Res 1993b; 11 (2): 292–8.
  • Charnley J, Baker S L. Compression arthrodesis of the knee; a clinical and histological study. J Bone Joint Surg Br 1952; 34-B (2): 187–99.
  • Chen W T, Han da C, Zhang P X, Han N, Kou Y H, Yin X F, et al. A special healing pattern in stable metaphyseal fractures. Acta Orthop 2015; 86 (2): 238–42.
  • Claes L, Veeser A, Gockelmann M, Simon U, Ignatius A. A novel model to study metaphyseal bone healing under defined biomechanical conditions. Arch Orthop Trauma Surg 2009; 129 (7): 923–8.
  • Claes L, Reusch M, Gockelmann M, Ohnmacht M, Wehner T, Amling M, et al. Metaphyseal fracture healing follows similar biomechanical rules as diaphyseal healing. J Orthop Res 2011; 29 (3): 425–32.
  • Colnot C. Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J Bone Miner Res 2009; 24 (2): 274–82.
  • Cooper S. A Dictionary of practical surgery. Harper & Bros. 1845.
  • Diamond T H, Clark W A, Kumar S V. Histomorphometric analysis of fracture healing cascade in acute osteoporotic vertebral body fractures. Bone 2007; 40 (3): 775–80.
  • Draenert K, Draenert Y. The architecture of metaphyseal bone healing. Scan Electron Microsc 1979; (2): 521–8.
  • Dupuytren G. (Ed. Clark F L G) On the injuries and diseases of bones. The Sydenham society, London, 1847.
  • Einhorn T A, Simon G, Devlin V J, Warman J, Sidhu S P, Vigorita V J. The osteogenic response to distant skeletal injury. J Bone Joint Surg Am 1990; 72 (9): 1374–8.
  • Gaudilliere B, Fragiadakis G K, Bruggner R V, Nicolau M, Finck R, Tingle M, et al. Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 2014; 6 (255): 255ra131.
  • Gazit D, Karmish M, Holzman L, Bab I. Regenerating marrow induces systemic increase in osteo- and chondrogenesis. Endocrinology 1990; 126 (5): 2607–13.
  • Gerstenfeld L C, Cho T J, Kon T, Aizawa T, Cruceta J, Graves B D, et al. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs 2001; 169 (3): 285–94.
  • Glass G E, Chan J K, Freidin A, Feldmann M, Horwood N J, Nanchahal J. TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells. Proc Natl Acad Sci U S A 2011; 108 (4): 1585–90.
  • Guihard P, Boutet M A, Brounais-Le Royer B, Gamblin A L, Amiaud J, Renaud A, et al. Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol 2015; 185 (3): 765–75.
  • Gulliver G. On the reparation of fractured bones. 1835.
  • Han D, Han N, Chen Y, Zhang P, Jiang B. Healing of cancellous fracture in a novel mouse model. Am J Transl Res 2015; 7 (11): 2279–90.
  • Han N, Zhang P X, Wang W B, Han D C, Chen J H, Zhan H B, et al. A new experimental model to study healing process of metaphyseal fracture. Chin Med J (Engl) 2012; 125 (4): 676–9.
  • Han D, Han N, Xue F, Zhang P. A novel specialized staging system for cancellous fracture healing, distinct from traditional healing pattern of diaphysis corticalfracture? Int J Clin Exp Med 2015; 8 (1): 1301–4.
  • Histing T, Klein M, Stieger A, Stenger D, Steck R, Matthys R, et al. A new model to analyze metaphyseal bone healing in mice. J Surg Res 2012; 178 (2): 715–21.
  • Jarry L, Uhthoff H K. Differences in healing of metaphyseal and diaphyseal fractures. Can J Surg 1971; 14 (2): 127–35.
  • Jungbluth P, Hakimi A R, Grassmann J P, Schneppendahl J, Betsch M, Kropil P, et al. The early phase influence of bone marrow concentrate on metaphyseal bone healing. Injury 2013; 44 (10): 1285–94.
  • Kaspar D, Neidlinger-Wilke C, Holbein O, Claes L, Ignatius A. Mitogens are increased in the systemic circulation during bone callus healing. J Orthop Res 2003; 21 (2): 320–5.
  • Kolios L, Hoerster A K, Sehmisch S, Malcherek M C, Rack T, Tezval M, et al. Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis? Calcif Tissue Int 2010; 86 (1): 23–32.
  • Kon T, Cho T J, Aizawa T, Yamazaki M, Nooh N, Graves D, et al. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 2001; 16 (6): 1004–14.
  • Lutz M, Steck R, Sitte I, Rieger M, Schuetz M, Klestil T. The metaphyseal bone defect in distal radius fractures and its implication on trabecular remodeling-a histomorphometric study (case series). J Orthop Surg Res 2015; 10: 61.
  • McClelland D, Thomas P B, Bancroft G, Moorcraft C I. Fracture healing assessment comparing stiffness measurements using radiographs. Clin Orthop Relat Res 2007; 457: 214–9.
  • McDonald M M, Morse A, Mikulec K, Peacock L, Yu N, Baldock P A, et al. Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats. J Orthop Res 2012; 30 (10): 1541–8.
  • Meunier A, Aspenberg P. Parecoxib impairs early metaphyseal bone healing in rats. Arch Orthop Trauma Surg 2006; 126 (7): 433–6.
  • Monfoulet L, Rabier B, Chassande O, Fricain J C. Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration. Calcif Tissue Int 2010; 86 (1): 72–81.
  • Morgan E F, Mason Z D, Bishop G, Davis A D, Wigner N A, Gerstenfeld L C, et al. Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone 2008; 43 (6): 1031–8.
  • Obrant K J. Trabecular bone changes in the greater trochanter after fracture of the femoral neck. Acta Orthop Scand 1984; 55 (1): 78–82.
  • Procter P, Bennani P, Brown C J, Arnoldi J, Pioletti D P, Larsson S. Variability of the pullout strength of cancellous bone screws with cement augmentation. Clin Biomech 2015; 30 (5): 500–6.
  • Rabie A B, Dan Z, Samman N. Ultrastructural identification of cells involved in the healing of intramembranous and endochondral bones. Int J Oral Maxillofac Surg 1996; 25 (5): 383–8.
  • Raggatt L J, Wullschleger M E, Alexander K A, Wu A C, Millard S M, Kaur S, et al. Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification. Am J Pathol 2014; 184 (12): 3192–204.
  • Sandberg O. Metaphyseal fracture healing. In: Division of Clinical Sciences Metaphyseal fracture healing. Linköping University: Sweden; 2016; Doctoral dissertation; 22.
  • Sandberg O, Aspenberg P. Different effects of indomethacin on healing of shaft and metaphyseal fractures. Acta Orthop 2015a; 86 (2): 243–7.
  • Sandberg O H, Aspenberg P. Glucocorticoids inhibit shaft fracture healing but not metaphyseal bone regeneration under stable mechanical conditions. Bone Joint Res 2015b; 4 (10): 170–5.
  • Schatzker J, Waddell J, Stoll J E. The effects of motion on the healing of cancellous bone. Clin Orthop Relat Res 1989; (245): 282–7.
  • Schindeler A, Liu R, Little D G. The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation 2009; 77 (1): 12–8.
  • Schlundt C, El Khassawna T, Serra A, Dienelt A, Wendler S, Schell H, et al. Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone 2015. [Epub ahead of print]
  • Sevitt S. The healing of fractures of the lower end of the radius. A histological and angiographic study. J Bone Joint Surg Br 1971; 53 (3): 519–31.
  • Siclari V A, Zhu J, Akiyama K, Liu F, Zhang X, Chandra A, et al. Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. Bone 2013; 53 (2): 575–86.
  • Skoglund B, Holmertz J, Aspenberg P. Systemic and local ibandronate enhance screw fixation. J Orthop Res 2004; 22 (5): 1108–13.
  • Stuermer E K, Sehmisch S, Rack T, Wenda E, Seidlova-Wuttke D, Tezval M, et al. Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat. Langenbecks Arch Surg 2010; 395 (2): 163–72.
  • Tsiridis E, Morgan E F, Bancroft J M, Song M, Kain M, Gerstenfeld L, et al. Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing. J Orthop Res 2007; 25 (9): 1193–203.
  • Tu J, Henneicke H, Zhang Y, Stoner S, Cheng T L, Schindeler A, et al. Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone 2014; 69: 12–22.
  • Uhthoff H K, Rahn B A. Healing patterns of metaphyseal fractures. Clin Orthop Relat Res 1981; (160): 295–303.
  • Uusitalo H, Rantakokko J, Ahonen M, Jamsa T, Tuukkanen J, KaHari V, et al. A metaphyseal defect model of the femur for studies of murine bone healing. Bone 2001; 28 (4): 423–9.
  • Weber A J, Li G, Kalak R, Street J, Buttgereit F, Dunstan C R, et al. Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids 2010; 75 (3): 282–6.
  • Vicenti G, Pesce V, Tartaglia N, Abate A, Mori C M, Moretti B. Micromotion in the fracture healing of closed distal metaphyseal tibial fractures: A multicentre prospective study. Injury 2014; 45Suppl6: S27–S35.
  • Wu A C, Raggatt L J, Alexander K A, Pettit A R. Unraveling macrophage contributions to bone repair. Bonekey Rep 2013; 2: 373.
  • Xiao W, Mindrinos M N, Seok J, Cuschieri J, Cuenca A G, Gao H, et al. A genomic storm in critically injured humans. J Exp Med 2011; 208 (13): 2581–90.
  • Zhang X, Schwarz E M, Young D A, Puzas J E, Rosier R N, O’Keefe R J. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 2002; 109 (11): 1405–15.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.