2,147
Views
2
CrossRef citations to date
0
Altmetric
Research Article

No association between blood count levels and whole-blood cobalt and chromium levels in 1,900 patients with metal-on-metal hip arthroplasty

, , , &

  • Akbar M, Brewer J M, Grant M H. Effect of chromium and cobalt ions on primary human lymphocytes in vitro. J Immunotoxicol 2011; 8(2): 140–9.
  • Boardman D, Middleton F, Kavanagh T. A benign psoas mass following metal-on-metal resurfacing of the hip. J Bone Joint Surg Br 2006; 88(3): 402–4.
  • Briggs T, Hanna S A, Kayani B, Tai S, Pollock R C, Cannon S R, Blunn G W, Carrington R. Metal-on-polyethylene versus metal-on-metal bearing surfaces in total hip arthroplasty: a prospective randomised study investigating metal ion levels and chromosomal aberrations in peripheral lymphocytes. Bone Joint J 2015; 97(9): 1183–91.
  • Brodner W, Bitzan P, Meisinger V, Kaider A, Gottsauner-Wolf F, Kotz R. Serum cobalt levels after metal-on-metal total hip arthroplasty. J Bone Joint Surg 2003; 85(11): 2168–73.
  • Cerulli J, Grabe D W, Gauthier I, Malone M, McGoldrick M D. Chromium picolinate toxicity. Ann Pharmacother 1998; 32(4): 428–31.
  • Chen Z, Wang Z, Wang Q, Cui W, Liu F, Fan W. Changes in early serum metal ion levels and impact on liver, kidney, and immune markers following metal-on-metal total hip arthroplasty. J Arthroplasty 2014; 29(3): 612–6.
  • Cheung A C, Banerjee S, Cherian J J, Wong F, Butany J, Gilbert C, Overgaard C, Syed K, Zywiel M G, Jacobs J J, Mont M A. Systemic cobalt toxicity from total hip arthroplasties: review of a rare condition, Part 1: history, mechanism, measurements, and pathophysiology. Bone Joint J 2016; 98-B(1): 6–13.
  • Cohen D. Out of joint: the story of the ASR. BMJ 2011; 342: d2905.
  • DePuy Orthopaedics. ASR Recall; 2010.
  • Dyer C. UK law firm starts action on “metal on metal” hip implants. BMJ 2010; 340: c2394.
  • Dyer C. UK patients lose legal claim that DePuy metal-on-metal hip implant was “defective”. BMJ 2018; 361: k2253.
  • Finley B L, Monnot A D, Gaffney S H, Paustenbach D J. Dose–response relationships for blood cobalt concentrations and health effects: a review of the literature and application of a biokinetic model. J Toxicol Environ Health B, Crit Rev 2012; 15(8): 493–523.
  • Finley B, Scott P K, Glynn M E, Paustenbach D, Donovan E, Thuett K A. Chromium speciation in the blood of metal-on-metal hip implant patients. Toxicol Environ Chemistry 2017; 99(1): 48–64.
  • Fox K A, Phillips T M, Yanta J H, Abesamis M G. Fatal cobalt toxicity after total hip arthroplasty revision for fractured ceramic components. Clin Toxicol 2016; 54(9): 874–7.
  • Gilbert C, Cheung A, Butany J, Zywiel M, Syed K, McDonald M, Wong F, Overgaard C. Hip pain and heart failure: the missing link. Can J Cardiol 2013; 29(5): 639.e1-2.
  • Gruber F W, Bock A, Trattnig S, Lintner F, Ritschl P. Cystic lesion of the groin due to metallosis: a rare long-term complication of metal-on-metal total hip arthroplasty. J Arthroplasty 2007; 22(6): 923–7.
  • Hailer N P, Blaheta R A, Dahlstrand H, Stark A. Elevation of circulating HLA DR CD8 T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty: a randomized trial. Acta Orthop 2011; 82(1): 6–12.
  • Hart A J, Skinner J A, Winship P, Faria N, Kulinskaya E, Webster D, Muirhead-Allwood S, Aldam C H, Anwar H, Powell J J. Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8 T-cell lymphopenia. J Bone Joint Surg Br 2009; 91(6): 835–42.
  • Horton S, Fleming K A, Kuti M, Looi L, Pai S A, Sayed S, Wilson M L. The top 25 laboratory tests by volume and revenue in five different countries. Am J Clin Pathol 2019; 151(5): 446–51.
  • Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L. Cobalt toxicity in humans: a review of the potential sources and systemic health effects. Toxicology 2017; 387: 43–56.
  • Markel D, Bergum C, Flynn J, Jackson N, Bou-Akl T, Ren W. Relationship of blood metal ion levels and leukocyte profiles in patients with articular surface replacement metal-on-metal hip replacement. Orthopedics 2018; 41(3): e424-31.
  • MHRA. Medical device alert. DePuy ASR™ hip replacement implants (MDA/2010/069). 2010; 2019.
  • Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin P H, Jandrot-Perrus M. Bioreactivity of stent material: activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. Platelets 2017; 2(6): 529–39.
  • Pandit H, Glyn-Jones S, McLardy-Smith P, Gundle R, Whitwell D, Gibbons C L, Ostlere S, Athanasou N, Gill H S, Murray D W. Pseudotumours associated with metal-on-metal hip resurfacings. J Bone Joint Surg Br 2008; 90(7): 847–51.
  • Paustenbach D J, Galbraith D A, Finley B L. Interpreting cobalt blood concentrations in hip implant patients. Clin Toxicol 2014; 52(2): 98–112.
  • Penny J Ø, Varmarken J, Ovesen O, Nielsen C, Overgaard S. Metal ion levels and lymphocyte counts: ASR hip resurfacing prosthesis vs. standard THA: 2-year results from a randomized study. Acta Orthop 2013; 84(2): 130–7.
  • Peters R M, Willemse P, Rijk P C, Hoogendoorn M, Zijlstra W P. Fatal cobalt toxicity after a non-metal-on-metal total hip arthroplasty. Case Rep Orthopedics 2017; 2017: 9123684.
  • Posada O M, Tate R J, Grant M H. Toxicity of cobalt–chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro. J Appl Toxicol 2015; 35(6): 614–22.
  • Quaiser S, Sharma A, Khan R. Survival after acute ingestion of chromic acid complicated by acute kidney injury: a case report. Egypt J Intern Med 2014; 26(4): 176.
  • Ray R R. Adverse hematological effects of hexavalent chromium: an overview. Interdiscip Toxicol 2016; 9(2): 55–65.
  • Reito A, Moilanen T, Puolakka T, Pajamäki J, Eskelinen A. Repeated metal ion measurements in patients with high risk metal-on-metal hip replacement. Int Orthop 2014; 38(7): 1353–61.
  • Reito A, Lainiala O, Nieminen J, Eskelinen A. Repeated metal ion measurement in patients with bilateral metal on metal (ASR™) hip replacements. Orthop Traumatol Surg Res 2016; 102(2): 167–73.
  • Silverman E J, Ashley B, Sheth N P. Metal-on-metal total hip arthroplasty: is there still a role in 2016? Curr Rev MusculoskeletaMed 2016; 9(1): 93–6.
  • Swiatkowska I, Mosselmans J F W, Geraki T, Wyles C C, Maleszewski J J, Henckel J, Sampson B, Potter D, Osman I, Trousdale R, Hart A J. Synchrotron analysis of human organ tissue exposed to implant material. J Trace Elements Med Biol 2018; 46: 128–37.
  • Tefferi A, Hanson C A, Inwards D J. How to interpret and pursue an abnormal complete blood cell count in adults. Mayo Clin Proc 2005; 80: 923–36.
  • Tvermoes B E, Unice K M, Paustenbach D J, Finley B L, Otani J M, Galbraith D A. Effects and blood concentrations of cobalt after ingestion of 1 mg/d by human volunteers for 90 d. Am J Clin Nutr 2014; 99 (3): 632–46.