References
- Dorr H, Meineke V. Acute radiation syndrome caused by accidental radiation exposure – therapeutic principles. BMC Med. 2011;9:126.
- Fliedner TM, Dorr DH, Meineke V. Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. Br J Radiol Suppl. 2005;27:1–8.
- Stone HB, Moulder JE, Coleman CN, et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3–4, 2003. Radiat Res. 2004;162:711–728.
- Singh VK, Seed TM. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. Int J Radiat Biol. 2017;93:851–869.
- Williams JP, Brown SL, Georges GE, et al. Animal models for medical countermeasures to radiation exposure. Radiat Res. 2010;173:557–578.
- Williams JP, Jackson IL, Shah JR, et al. Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop. Radiat Res 2012;177:e0025–39
- Centers for Disease Control and Prevention. Strategic National Stockpile (SNS). 2014. Available at: http://www.cdc.gov/phpr/stockpile/stockpile.htm [Last accessed Feb 15, 2014]
- Esbitt D. The Strategic National Stockpile: roles and responsibilities of health care professionals for receiving the stockpile assets. Disaster Manag Response. 2003;1:68–70.
- Moroni M, Coolbaugh TV, Lombardini E, et al. Hematopoietic radiation syndrome in the Gottingen minipig. Radiat Res. 2011;176:89–101.
- Dalgaard L. Comparison of minipig, dog, monkey and human drug metabolism and disposition. J Pharmacol Toxicol Methods. 2015;74:80–92.
- Riccobono D, Agay D, Scherthan H, et al. Application of adipocyte-derived stem cells in treatment of cutaneous radiation syndrome. Health Phys. 2012;103:120–126.
- Gratwohl A, John L, Baldomero H, et al. FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits. Blood. 1998;92:765–769.
- Kaur A, Vemalapally N, Severson G, et al. Development of pediatric model of hemtopoietic acute radiation syndrome (H-ARS) and countermeasure testing using the G0ttingen minipig. Rad J. 2017;2:75–81.
- U.S. Food and Drug Administration. Guidance for industry: product developoment under the Animal Rule. 2015. Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM399217.pdf [Last accessed 2016 Jul 5]
- Valente M, Denis J, Grenier N, et al. Revisiting biomarkers of total-body and partial-body exposure in a baboon model of irradiation. PLoS One. 2015;10:e0132194.
- Kraus VB. Biomarkers as drug development tools: discovery, validation, qualification and use. Nat Rev Rheumatol. 2018. in press. DOI:10.1038/s41584-018-0005-9
- U.S. Food and drug Administration. FDA approves Leukine for acute radiation syndrome. 2018. Available at: https://www.fda.gov/downloads/EmergencyPreparedness/Counterterrorism/MedicalCountermeasures/AboutMCMi/UCM603226.pdf [Last accessed 2018 Apr 01]
- Farese AM, Cohen MV, Katz BP, et al. Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res. 2013;179:89–100.
- U.S. Food and Drug Administration. FDA approves Neupogen for treatment of patients with radiation-induced myelosuppression following a radiological/nuclear incident. 2015. Available at: http://www.fda.gov/EmergencyPreparedness/Counterterrorism/MedicalCountermeasures/AboutMCMi/ucm443245.htm [Last accessed 2016 Jul 6]
- Clayton NP, Charpentier EJJ, LaCasse ER, et al. Sargramostim significantly improved the mortality rate at Day 60 in a non-human primate model of hematopoietic acute radiation syndrome with minimal supportive care when administered 48 h after total body irradiation. 42nd Conference of the European Radiation Reasearch Society. Amsterdam, Netherlands 2016:190
- Hankey KG, Farese AM, Blaauw EC, et al. Pegfilgrastim improves survival of lethally irradiated nonhuman primates. Radiat Res. 2015;183:643–655.
- National Institute of Allergic and Infectious Diseases. Pegfilgrastim approved for treating acute radiation syndrome. 2015. Available at: https://www.niaid.nih.gov/topics/radnuc/Pages/pegfilgrastim.aspx [Last accessed Aug 18, 2016]
- U.S. Food and Drug Administration. Investigational New Drug (IND) Application. 2017. Available at: https://www.fda.gov/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/investigationalnewdrugindapplication/default.htm [Last accessed 2017 Dec 23]
- Singh VK, Newman VL, Romaine PL, et al. Use of biomarkers for assessing radiation injury and efficacy of countermeasures. Expert Rev Mol Diagn. 2016;16:65–81.