1,927
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Challenges and ethical considerations for using cloned primates for human brain discovery

&
Pages 1071-1074 | Received 15 Jul 2018, Accepted 22 Oct 2018, Published online: 25 Oct 2018

References

  • Wilmut I, Bai Y, Taylor J. Somatic cell nuclear transfer: origins, the present position and future opportunities. Phil Trans R Soc B. 2015;370:20140366.
  • Loi P, Iuso D, Czernik M, et al. A new dynamic era for somatic cell nuclear transfer? Trends Biotechnol. 2016;34:791–797.
  • Mitalipov SM, Zhou Q, Byrne JA, et al. Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Hum Reprod. 2007;22:2232–2242.
  • Liu Z, Cai Y, Wang Y, et al. Cloning of macaque monkeys by somatic cell nuclear transfer. Cell. 2018;172:881–887.
  • Cibelli JB, Gurdon JB. Custom-made oocytes to clone non-human primates. Cell. 2018;172:647–649.
  • Puzzo D, Gulisano W, Palmeri A, et al. Rodent models for Alzheimer’s disease drug discovery. Expert Opin Drug Discov. 2015;10:703–711.
  • Li W, Sayana P, Jankovic J. Animal models of Parkinson’s disease: a gateway to therapeutics. Neuro Therapeut. 2014;11:92–110.
  • Yang S-H, Cheng P-H, Banta H, et al. Towards a transgenic model of Huntington’s disease in a non-human primate. Nature. 2008;453:921–924.
  • Jennings CG, Landman R, Zhou Y, et al. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2016;19:1123–1130.
  • Grobarczyk B 1, Franco B, Hanon K, et al. Generation of isogenic human iPS cell line precisely corrected by genome editing using the CRISPR/Cas9 system. Stem Cell Rev. 2015;11:774–787.
  • Brennand K, Marchetto MC, Benvenisty N, et al. Creating patient-specific, neural cells for the in vitro study if brain disorders. Stem Cell Rep. 2015;5:933–945.
  • Tomaskovic-Crook E, Crook JM. Clinically amendable, defined, and rapid induction of brain organoids from induced pluripotent stem cells. Methods Mol Biol. 2017. DOI:10.07/7651_2017_95
  • Wang Z, Wang SN, Xu TY, et al. Organoid technology for brain and therapeutic research. CNS Neurosci Ther. 2017;23:771–778.
  • Trounson A, Shepherd KA, DeWitt ND. Human disease modeling with induced pluripotent stem cells. Curr Opin Genes Dev. 2012;22:509–516.
  • Trounson AO. Future and application of cloning. Methods Mol Biol. 2006;348:319–332.
  • Yuan Q, Zhou Z, Lindell SG, et al. The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human. BMC Genet. 2012;13:52.
  • Rogers J, Raveendran M, Fawcett GL, et al. CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Mol Psychiatry. 2013;18:700–707.
  • Haus T, Ferguson B, Rogers J, et al. Genome typing of nonhuman primate models: implications for biomedical research. Trends Genet. 2014;30:482–487.
  • Dugger SA, Platt A, Goldstein DB. Drug discovery in the era of precision medicine. Nat Rev Drug Discov. 2018;17:183–196.
  • Verbanck M, Chen CY, Neale B, et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nature Genet. 2018. DOI:10.1038/s41588-018-0099-7.
  • Zhang J, Li H, Trounson A, et al. Combining hiPSCs and human genetics: major applications in drug development. Cell Stem Cell. 2017;21(2):161–165.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.