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Editorial

Is anti-ageing drug discovery becoming a reality?

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Pages 135-138 | Received 28 Aug 2019, Accepted 06 Dec 2019, Published online: 10 Dec 2019

References

  • Gardner TS. The effect of yeast nucleic acid on the survival time of 600 day old albino mice. J Gerontol. 1946 Oct;1(Pt 1 4):445–452.
  • Gardner TS, Forbes FB. The effect of sodium thiocyanate and yeast nucleic acid on the survival time of 700 day old albino mice. J Gerontol. 1946 Oct;1(Pt 1 4):453–456.
  • Gardner TS. The use of drosophila melanogaster as a screening agent for longevity factors; the effects of biotin, pyridoxine, sodium yeast nucleate, and pantothenic acid on the life span of the fruit fly. J Gerontol. 1948 Jan;3(1):9–13.
  • Gardner TS. The use of drosophila melanogaster as screening agent for longevity factors; pantothenic acid as a longevity factor in royal jelly. J Gerontol. 1948 Jan;3(1):1–8.
  • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956 Jul;11(3):298–300.
  • Piskovatska V, Strilbytska O, Koliada A, et al. Health benefits of anti-aging drugs. Subcell Biochem. 2019;91:339–392.
  • Vaiserman A, Lushchak O. Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives. J Transl Med. 2017;15(1):160.
  • Moskalev A, Chernyagina E, de Magalhaes JP, et al. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY). 2015 Sep;7(9):616–628.
  • Barardo D, Thornton D, Thoppil H, et al. The DrugAge database of aging-related drugs. Aging Cell. 2017 Jun;16(3):594–597.
  • Moskalev AA. Is aging a disease? A geneticist’s point of view. Adv Gerontol. 2018;8(2):125–126.
  • Kaeberlein M. How healthy is the healthspan concept? Geroscience. 2018;40(4):361–364.
  • Sholl J, Rattan SIS. Biomarkers of health and healthy ageing from the Outside-In. In: Moskalev A, editor. Biomarkers of Human Aging. Cham: Springer International Publishing; 2019. p. 37–46.
  • Moskalev A, Chernyagina E, Tsvetkov V, et al. Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell. 2016;15(3):407–415.
  • Pomatto LCD, Davies KJA. The role of declining adaptive homeostasis in ageing. J Physiol. 2017;595(24):7275–7309.
  • Moskalev A, Chernyagina E, Kudryavtseva A, et al. Geroprotectors: a unified concept and screening approaches. Aging Dis. 2017;8(3):354–363.
  • López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013;153(6):1194–1217.
  • Rikans LE, Hornbrook KR. Lipid peroxidation, antioxidant protection and aging. Biochimica et Biophysica Acta (BBA). Mol Basis Dis. 1997;1362(2):116–127.
  • Hatami A, Zhu C, Relano-Gines A, et al. Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington’s disease. Febs J. 2018 Aug;285(16):3002–3012.
  • Zesiewicz T, Heerinckx F, De Jager R, et al. Randomized, clinical trial of RT001: early signals of efficacy in Friedreich’s ataxia. Mov Disord. 2018 Jul;33(6):1000–1005.
  • Blumenthal HT. Amyloidosis: a universal disease of aging? J Gerontol A Biol Sci Med Sci. 2004 Apr;59(4):361–369.
  • Chen XQ, Mobley WC. Exploring the pathogenesis of Alzheimer disease in basal forebrain cholinergic neurons: converging insights from alternative hypotheses. Front Neurosci. 2019;13:446.
  • Honig LS, Vellas B, Woodward M, et al. Trial of solanezumab for mild dementia due to Alzheimer’s disease. N Engl J Med. 2018 Jan 25;378(4):321–330.
  • Barzilai N, Crandall JP, Kritchevsky SB, et al. Metformin as a Tool to Target Aging. Cell Metab. 2016 Jun 14;23(6):1060–1065.
  • Justice JN, Ferrucci L, Newman AB, et al. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME biomarkers workgroup. Geroscience. 2018 Dec;40(5–6):419–436.
  • Piskovatska V, Stefanyshyn N, Storey KB, et al. Metformin as a geroprotector: experimental and clinical evidence. Biogerontology. 2019;20(1):33–48.
  • Konopka AR, Miller BF. Taming expectations of metformin as a treatment to extend healthspan. Geroscience. 2019 Apr;41(2):101–108.
  • Ryu D, Mouchiroud L, Andreux PA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879–888.
  • Andreux PA, Blanco-Bose W, Ryu D, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019 ;1(6):595–603.
  • Gil J. Cellular senescence causes ageing. Nat Rev Mol Cell Biol. 2019;20(7):388.
  • Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554–563.
  • Niedernhofer LJ, Robbins PD. Senotherapeutics for healthy ageing [Correspondence]. Nat Rev Drug Discov. 2018;17:377. 04/13/online.
  • A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee. ClinicalTrials.gov registered clinical study. [cited 2019 Dec 1]. Available from: https://clinicaltrials.gov/ct2/show/NCT03513016
  • Boutouja F, Stiehm CM, Platta HW. mTOR: a cellular regulator interface in health and disease. Cells. 2019;8(1):18.
  • Mannick JB, Morris M, Hockey HP, et al. TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci Transl Med. 2018 Jul 11;10:449.
  • resTORbio announces that the phase 3 PROTECTOR 1 trial of RTB101 in clinically symptomatic respiratory illness did not meet the primary endpoint [cited 2019 Dec 1]. Available from: https://www.globenewswire.com/news-release/2019/11/15/1947932/0/en/resTORbio-Announces-That-the-Phase-3-PROTECTOR-1-Trial-of-RTB101-in-Clinically-Symptomatic-Respiratory-Illness-Did-Not-Meet-the-Primary-Endpoint.html

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