You don't need to administer a placebo to elicit a placebo effect: Social factors trigger neurobiological pathways to enhance sports performance

References

• Amann, M., Proctor, L. T., Sebranek, J. J., Pegelow, D. F., & Dempsey, J. A. (2009). Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans. The Journal of Physiology, 587(1), 271–283. doi: 10.1113/jphysiol.2008
   PubMed Web of Science ®Google Scholar
• Amanzio, M., Benedetti, F., Porro, C. A., Palermo, S., & Cauda, F. (2013). Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain. Human Brain Mapping, 34(3), 738–752. doi: 10.1002/hbm.21471
   PubMed Web of Science ®Google Scholar
• Ashar, Y. K., Chang, L. J., & Wager, T. D. (2017). Brain mechanisms of the placebo effect: An affective appraisal account. Annual Review of Clinical Psychology, 13(1), 73–98. doi: 10.1146/annurev-clinpsy-021815-093015
   PubMedGoogle Scholar
• Atkinson, G., & Batterham, A. M. (2015). True and false interindividual differences in the physiological response to an intervention. Experimental Physiology, 100(6), 577–588. doi: 10.1113/EP085070
   PubMed Web of Science ®Google Scholar
• Beecher, H. K. (1955). The powerful placebo. Journal of the American Medical Association, 159(17), 1602–1606. doi: 10.1001/jama.1955.02960340022006
   PubMed Web of Science ®Google Scholar
• Beedie, C., Benedetti, F., Camerone, E., Barbiani, D., Lindheimer, J., & Roelands, B. (In Press). Moving beyond description: Towards a better understanding of physiological and neurobiological mechanisms of placebo effects in fatigue. European Journal of Sport Science.
   Google Scholar
• Beedie, C., Benedetti, F., Hurst, P., Coleman, D. A., Foad, A., Cohen, E., … Harvey, S. (2018). Consensus statement on placebo effects in sports and exercise: The need for conceptual clarity, methodological rigour, and the elucidation of neurobiological mechanisms. European Journal of Sport Science, 18(10), 1383–1389.
   PubMed Web of Science ®Google Scholar
• Beedie, C. J., & Foad, A. J. (2009). The placebo effect in sports performance. Sports Medicine, 39(4), 313–329.
   PubMed Web of Science ®Google Scholar
• Beedie, C., Foad, A. J., & Coleman, D. A. (2008). Identification of placebo responsive participants in 40 km laboratory cycling performance. Journal of Sports Science & Medicine, 7(1), 166–175.
   PubMed Web of Science ®Google Scholar
• Beedie, C., Foad, A., & Hurst, P. (2015). Capitalizing on the placebo component of treatments. Current Sports Medicine Reports, 14(4), 284–287. doi: 10.1249/JSR.0000000000000172
   PubMed Web of Science ®Google Scholar
• Beedie, C. J., Lane, A. M., & Wilson, M. G. (2012). A possible role for emotion and emotion regulation in physiological responses to false performance feedback in 10 mile laboratory cycling. Applied Psychophysiology and Biofeedback, 37(4), 269–277. doi: 10.1007/s10484-012-9200-7
   PubMed Web of Science ®Google Scholar
• Beedie, C., Whyte, G., Lane, A. M., Cohen, E., Raglin, J., Hurst, P., … Foad, A. (2017). ‘Caution, this treatment is a placebo. It might work, but it might not’: Why emerging mechanistic evidence for placebo effects does not legitimise complementary and alternative medicines in sport. British Journal of Sports Medicine, 52, 817–818.
   PubMed Web of Science ®Google Scholar
• Benedetti, F. (2013). Placebo and the new physiology of the doctor-patient relationship. Physiological Reviews, 93(3), 1207–1246. doi: 10.1152/physrev.00043.2012
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Amanzio, M., Rosato, R., & Blanchard, C. (2011). Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature Medicine, 17(10), 1228–1230. doi: 10.1038/nm.2435
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Barbiani, D., & Camerone, E. (2018). Critical life functions: Can placebo replace oxygen? International Review of Neurobiology, 138, 201–218. doi: 10.1016/bs.irn.2018.01.009
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Frisaldi, E., Carlino, E., Giudetti, L., Pampallona, A., Zibetti, M., … Lopiano, L. (2016). Teaching neurons to respond to placebos. The Journal of Physiology, 594(19), 5647–5660. doi: 10.1113/JP271322
   PubMed Web of Science ®Google Scholar
• Benedetti, F., Pollo, A., & Colloca, L. (2007). Opioid-mediated placebo responses boost pain endurance and physical performance: Is it doping in sport competitions? Journal of Neuroscience, 27, 11934–11939. doi: 10.1523/jneurosci.3330-07.2007
   PubMed Web of Science ®Google Scholar
• Branthwaite, A., & Cooper, P. (1981). Analgesic effects of branding in treatment of headaches. BMJ, 282(6276), 1576–1578.
   PubMed Web of Science ®Google Scholar
• Bryant, J. (2004). The Quest to Break the Four Minute Mile. London: Hutchinson.
   Google Scholar
• Carron, A. V., Colman, M. M., Wheeler, J., & Stevens, D. (2002). Cohesion and performance in sport: A meta-analysis. Journal of Sport and Exercise Psychology, 24, 168–188.
   Web of Science ®Google Scholar
• Christensen, U., Schmidt, L., Budtz-Jørgensen, E., & Avlund, K. (2006). Group cohesion and social support in exercise classes: Results from a Danish intervention study. Health Education & Behavior, 33(5), 677–689.
   PubMed Web of Science ®Google Scholar
• Coan, J. A., Schaefer, H. S., & Davidson, R. J. (2006). Lending a hand: Social regulation of the neural response to threat. Psychological Science, 17(12), 1032–1039. doi: 10.1111/j.1467-9280.2006.01832.x
   PubMed Web of Science ®Google Scholar
• Cohen, E., Ejsmond-Frey, R., Knight, N., & Dunbar, R. (2010). Rowers’ high: Behavioural synchrony is correlated with elevated pain thresholds. Biology Letters, 6(1), 106–108. doi: 10.1098/rsbl.2009.0670
   PubMed Web of Science ®Google Scholar
• Davis, A., & Cohen, E. (2018). The effects of social support on strenuous physical exercise. Adaptive Human Behavior and Physiology, 4(2), 171–187.
   PubMed Web of Science ®Google Scholar
• Davis, A., Taylor, J., & Cohen, E. (2015). Social bonds and exercise: Evidence for a reciprocal relationship. Plos One, 10(8), e0136705. doi: 10.1371/journal.pone.0136705
   PubMed Web of Science ®Google Scholar
• Den Hartigh, R. J., Gernigon, C., Van Yperen, N. W., Marin, L., & Van Geert, P. L. (2014). How psychological and behavioral team states change during positive and negative momentum. Plos One, 9(5), e97887.
   PubMed Web of Science ®Google Scholar
• Dunbar, R. I. M., Baron, R., Frangou, A., Pearce, E., van Leeuwen, E. J. C., Stow, J., … van Vugt, M. (2011). Social laughter is correlated with an elevated pain threshold. Proceedings of the Royal Society B: Biological Sciences, 279(1731), 1161–1167.
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I. (2012). The pain of social disconnection: Examining the shared neural underpinnings of physical and social pain. Nature Reviews Neuroscience, 13(6), 421–434.
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302(5643), 290. doi: 10.1126/science.1089134
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I., Master, S. L., Inagaki, T. K., Taylor, S. E., Shirinyan, D., Lieberman, M. D., & Naliboff, B. D. (2011). Attachment figures activate a safety signal-related neural region and reduce pain experience. Proceedings of the National Academy of Sciences, 108(28), 11721–11726. doi: 10.1073/pnas.1108239108
   PubMed Web of Science ®Google Scholar
• Filho, E., Dobersek, U., Gershgoren, L., Becker, B., & Tenenbaum, G. (2014). The cohesion–performance relationship in sport: A 10-year retrospective meta-analysis. Sport Sciences for Health, 10(3), 165–177. doi: 10.1007/s11332-014-0188-7
   Google Scholar
• Foad, A. J., Beedie, C. J., & Coleman, D. A. (2008). Pharmacological and psychological effects of caffeine ingestion in 40-km cycling performance. Medicine & Science in Sports & Exercise, 40(1), 158–165. doi: 10.1249/mss.0b013e3181593e02
   PubMed Web of Science ®Google Scholar
• Freeman, P., & Rees, T. (2008). The effects of perceived and received support on objective performance outcome. European Journal of Sport Science, 8(6), 359–368. doi: 10.1080/17461390802261439
   Web of Science ®Google Scholar
• Gotaas, T. (2012). Running: A global history. London: Reaktion Books.
   Google Scholar
• Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015). Genetics and the placebo effect: The placebome. Trends in Molecular Medicine, 21(5), 285–294. doi: 10.1016/j.molmed.2015.02.009
   PubMed Web of Science ®Google Scholar
• Harvey, S. C., & Beedie, C. J. (2017). Studying placebo effects in model organisms will help us understand them in humans. Biology Letters, 13(11), 20170585.
   PubMed Web of Science ®Google Scholar
• Harvey, S. C., & Beedie, C. J. (2017). Studying placebo effects in model organisms will help us understand them in humans. Biology Letters, 13(11), 20170585.
   PubMed Web of Science ®Google Scholar
• Henrich, J. (2015). The secret of our success: How culture is driving human evolution, domesticating our species, and making us smarter. Princeton, NJ: Princeton University Press.
   Google Scholar
• Hettinga, F. J., Konings, M. J., & Pepping, G.-J. (2017). The science of racing against opponents: Affordance competition and the regulation of exercise intensity in head-to-head competition. Frontiers in Physiology, 8, 118.
   PubMed Web of Science ®Google Scholar
• Humphrey, N., & Skoyles, J. (2012). The evolutionary psychology of healing: A human success story. Current Biology, 22(17), R695–R698. doi: 10.1016/j.cub.2012.06.018
   PubMed Web of Science ®Google Scholar
• Inagaki, T. K., Ray, L. A., Irwin, M. R., Way, B. M., & Eisenberger, N. I. (2016). Opioids and social bonding: Naltrexone reduces feelings of social connection. Social Cognitive and Affective Neuroscience, 11(5), 728–735. doi: 10.1093/scan/nsw006
   PubMed Web of Science ®Google Scholar
• Kaptchuk, T. J. (2002). The placebo effect in alternative medicine: Can the performance of a healing ritual have clinical significance? Annals of Internal Medicine, 136(11), 817–825.
   PubMed Web of Science ®Google Scholar
• Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., & Kirsch, I. (2008). Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ, 336(7651), 999–1003.
   PubMed Web of Science ®Google Scholar
• Kelley, J. M., Kraft-Todd, G., Schapira, L., Kossowsky, J., Riess, H., & Timmer, A. (2014). The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE, 9(4), e94207.
   PubMed Web of Science ®Google Scholar
• Kong, J., Wang, Z., Leiser, J., Minicucci, D., Edwards, R., Kirsch, I., … Gollub, R. L. (2018). Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study. NeuroImage: Clinical, 18, 325–334. doi: 10.1016/j.nicl.2018.01.021
   PubMed Web of Science ®Google Scholar
• Konings, M. J., & Hettinga, F. J. (2018). Pacing decision making in sport and the effects of interpersonal competition: A critical review. Sports Medicine, 48(8), 1829–1843.
   PubMed Web of Science ®Google Scholar
• Kraus, M. W., Huang, C., & Keltner, D. (2010). Tactile communication, cooperation, and performance: An ethological study of the NBA. Emotion, 10(5), 745–749. doi: 10.1037/a0019382
   PubMed Web of Science ®Google Scholar
• Lambert, E., Gibson, A. S. C., & Noakes, T. (2005). Complex systems model of fatigue: Integrative homoeostatic control of peripheral physiological systems during exercise in humans. British Journal of Sports Medicine, 39(1), 52–62.
   PubMed Web of Science ®Google Scholar
• Levine, J. D., Gordon, N. C., & Fields, H. L. (1978). The mechanism of placebo analgesia. Lancet, 312(8091), 654–657. doi: 10.1016/S0140-6736(78)92762-9
   Google Scholar
• Lieberman, M. D. (2007). Social cognitive neuroscience: A review of core processes. Annual Review of Psychology, 58(1), 259–289. doi: 10.1146/annurev.psych.58.110405.085654
   PubMed Web of Science ®Google Scholar
• Lindheimer, J., Szabó, A., Raglin, J., & Beedie, C. (In Press). Advancing the understanding of placebo effects in psychological outcomes of exercise: Lessons learned and future research directions. European Journal of Sport Science.
   Google Scholar
• Lordkipanidze, D., Vekua, A., Ferring, R., Rightmire, G. P., Agusti, J., Kiladze, G., … Zollikofer, C. P. E. (2005). The earliest toothless hominin skull. Nature, 434(7034), 717–718. doi: 10.1038/434717b
   PubMed Web of Science ®Google Scholar
• Machin, A. J., & Dunbar, R. I. (2011). The brain opioid theory of social attachment: A review of the evidence. Behaviour, 148(9-10), 985–1025.
   Web of Science ®Google Scholar
• Master, S. L., Eisenberger, N. I., Taylor, S. E., Naliboff, B. D., Shirinyan, D., & Lieberman, M. D. (2009). A picture's worth: Partner photographs reduce experimentally induced pain. Psychological Science, 20(11), 1316–1318. doi: 10.1111/j.1467-9280.2009.02444.x
   PubMed Web of Science ®Google Scholar
• Moerman, D. (2002). Meaning, medicine and the ‘placebo effect’. Cambridge: Cambridge University Press.
   Google Scholar
• Noakes, T. D. (2012). Fatigue is a brain-derived emotion that regulates the exercise behavior to ensure the protection of whole body homeostasis. Frontiers in Physiology, 3(82), 1–13. doi: 10.3389/fphys.2012.00082
   PubMedGoogle Scholar
• Noakes, T. D., Gibson, A. S. C., & Lambert, E. V. (2005). From catastrophe to complexity: A novel model of integrative central neural regulation of effort and fatigue during exercise in humans: Summary and conclusions. British Journal of Sports Medicine, 39(2), 120–124.
   PubMed Web of Science ®Google Scholar
• Novembre, G., Zanon, M., & Silani, G. (2015). Empathy for social exclusion involves the sensory-discriminative component of pain: A within-subject fMRI study. Social Cognitive and Affective Neuroscience, 10(2), 153–164. doi: 10.1093/scan/nsu038
   PubMed Web of Science ®Google Scholar
• Pickering, C., & Kiely, J. (2018). Are the current guidelines on caffeine use in sport optimal for everyone? Inter-individual variation in caffeine ergogenicity, and a move towards personalised sports nutrition. Sports Medicine, 48(1), 7–16. doi: 10.1007/s40279-017-0776-1
   PubMed Web of Science ®Google Scholar
• Pollak, K. A., Swenson, J. D., Vanhaitsma, T. A., Hughen, R. W., Jo, D., Light, K. C., … Light, A. R. (2014). Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects. Experimental Physiology, 99(2), 368–380. doi: 10.1113/expphysiol.2013.075812
   PubMed Web of Science ®Google Scholar
• Pollo, A., Carlino, E., & Benedetti, F. (2008). The top-down influence of ergogenic placebos on muscle work and fatigue. European Journal of Neuroscience, 28(2), 379–388. doi: 10.1111/j.1460-9568.2008.06344.x
   PubMed Web of Science ®Google Scholar
• Pollo, A., Carlino, E., & Benedetti, F. (2011). Placebo mechanisms across different conditions: From the clinical setting to physical performance. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1572), 1790–1798.
   PubMed Web of Science ®Google Scholar
• Reddish, P., Fischer, R., & Bulbulia, J. (2013). Let's dance together: Synchrony, shared intentionality and cooperation. Plos One, 8(8), e71182. doi: 10.1371/journal.pone.0071182
   PubMed Web of Science ®Google Scholar
• Schiphof-Godart, L., & Hettinga, F. J. (2017). Passion and pacing in endurance performance. Frontiers in Physiology, 8, 83.
   PubMed Web of Science ®Google Scholar
• Schiphof-Godart, L. S.-G., Roelands, B., & Hettinga, F. J. (2018). Drive in sports: How mental fatigue affects endurance performance. Frontiers in Psychology, 9, 1383.
   PubMed Web of Science ®Google Scholar
• Schnall, S., Harber, K. D., Stefanucci, J. K., & Proffitt, D. R. (2008). Social support and the perception of geographical slant. Journal of Experimental Social Psychology, 44(5), 1246–1255.
   PubMed Web of Science ®Google Scholar
• Smits, B. L., Pepping, G.-J., & Hettinga, F. J. (2014). Pacing and decision making in sport and exercise: The roles of perception and action in the regulation of exercise intensity. Sports Medicine, 44(6), 763–775.
   PubMed Web of Science ®Google Scholar
• Stein, D. J., Collins, M., Daniels, W., Noakes, T. D., & Zigmond, M. (2007). Mind and muscle: The cognitive-affective neuroscience of exercise. CNS Spectrums, 12(01), 19–22.
   PubMedGoogle Scholar
• Sullivan, P., & Rickers, K. (2013). The effect of behavioral synchrony in groups of teammates and strangers. International Journal of Sport and Exercise Psychology, 11(3), 286–291. doi: 10.1080/1612197X.2013.750139
   Google Scholar
• Sullivan, P., Rickers, K., & Gammage, K. L. (2014). The effect of different phases of synchrony on pain threshold. Group Dynamics: Theory, Research, and Practice, 18(2), 122–128. doi: 10.1037/gdn0000001
   Web of Science ®Google Scholar
• Szabó, A., Lindheimer, J., Raglin, J., & Beedie, C. (In Press). Why it is important to understand and study placebo and nocebo effects in sport? A psychological perspective. European Journal of Sport Science.
   Google Scholar
• Tambiah, S. J. (1990). Magic, science and religion and the scope of rationality (Vol. 1981). Cambridge, U.K.: Cambridge University Press.
   Google Scholar
• Tarr, B., Launay, J., Benson, C., & Dunbar, R. I. (2017). Naltrexone blocks endorphins released when dancing in synchrony. Adaptive Human Behavior and Physiology, 3(3), 241–254. doi: 10.1007/s40750-017-0067-y
   Web of Science ®Google Scholar
• Tarr, B., Launay, J., Cohen, E., & Dunbar, R. (2015). Let's dance! The role of synchrony and exertion in social bonding during group movement. Paper presented at the European Human Behaviour and Evolution Association Annual Conference, Helsinki, Finland.
   Google Scholar
• Tomasello, M. (2014). The ultra-social animal. European Journal of Social Psychology, 44(3), 187–194.
   PubMed Web of Science ®Google Scholar
• Tomasello, M., Melis, A. P., Tennie, C., Wyman, E., & Herrmann, E. (2012). Two key steps in the evolution of human cooperation: The interdependence hypothesis. Current Anthropology, 53(6), 673–692. doi: 10.1086/668207
   Web of Science ®Google Scholar
• Trezza, V., Baarendse, P. J., & Vanderschuren, L. J. (2010). The pleasures of play: Pharmacological insights into social reward mechanisms. Trends in Pharmacological Sciences, 31(10), 463–469.
   PubMed Web of Science ®Google Scholar
• Tuttle, A. H., Tohyama, S., Ramsay, T., Kimmelman, J., Schweinhardt, P., Bennett, G. J., & Mogil, J. S. (2015). Increasing placebo responses over time in U.S. clinical trials of neuropathic pain. PAIN, 156(12), 2616–2626.
   PubMed Web of Science ®Google Scholar
• Wager, T. D., Scott, D. J., & Zubieta, J.-K. (2007). Placebo effects on human μ-opioid activity during pain. Proceedings of the National Academy of Sciences, 104(26), 11056–11061. doi: 10.1073/pnas.0702413104
   PubMed Web of Science ®Google Scholar
• Wei, D., Allsop, S., Tye, K., & Piomelli, D. (2017). Endocannabinoid signaling in the control of social behavior. Trends in Neurosciences, 40(7), 385–396.
   PubMed Web of Science ®Google Scholar
• Wheatley, T., Kang, O., Parkinson, C., & Looser, C. E. (2012). From mind perception to mental connection: Synchrony as a mechanism for social understanding. Social and Personality Psychology Compass, 6(8), 589–606. doi: 10.1111/j.1751-9004.2012.00450.x
   Google Scholar