Hepcidin and interleukin-6 responses to endurance exercise over the menstrual cycle

References

• Badenhorst, C. E., Dawson, B., Cox, G. R., Laarakkers, C. M., Swinkels, D. W., & Peeling, P. (2015). Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise. European Journal of Applied Physiology, 115(12), 2521–2530.
   PubMed Web of Science ®Google Scholar
• Bruinvels, G., Burden, R., Brown, N., Richards, T., & Pedlar, C. (2016 Feb). The prevalence and impact of heavy menstrual bleeding (Menorrhagia) in elite and non-elite athletes. Clarke SL, editor. PLoS One, 11(2), e0149881.
   PubMed Web of Science ®Google Scholar
• Dahlquist, D. T., Stellingwerff, T., Dieter, B. P., McKenzie, D. C., & Koehle, M. S. (2017 Oct). Effects of macro- and micronutrients on exercise-induced hepcidin response in highly trained endurance athletes. Applied Physiology, Nutrition and Metabolism, 42(10), 1036–1043.
   PubMed Web of Science ®Google Scholar
• Dasharathy, S. S., Mumford, S. L., Pollack, A. Z., Perkins, N. J., Mattison, D. R., Wactawski-Wende, J., et al. (2012). Menstrual bleeding patterns among regularly menstruating women. American Journal of Epidemiology, 175(6), 536–545.
   PubMed Web of Science ®Google Scholar
• Díaz, V., Peinado, A. B., Barba-Moreno, L., Altamura, S., Butragueño, J., González-Gross, M., et al. (2015). Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E. Physiological Reports, 3(8), e12475.
   PubMed Web of Science ®Google Scholar
• Girasole, G., Jilka, R. L., Passeri, G., Boswell, S., Boder, G., Williams, D. C., et al. (1992). 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens. Journal of Clinical Investigation, 89(3), 883–891.
   PubMed Web of Science ®Google Scholar
• Harvey, L. J., Armah, C. N., Dainty, J. R., Foxall, R. J., Lewis, D. J., Langford, N. J., et al. (2005). Impact of menstrual blood loss and diet on iron deficiency among women in the UK. British Journal of Nutrition, 94(4), 557–564.
   PubMed Web of Science ®Google Scholar
• Janse de Jonge, X., Thompson, B., & Han, A. (2019 Jun;1). Methodological recommendations for menstrual cycle research in sports and exercise. Medicine & Science in Sports & Exercise [Internet]. http://insights.ovid.com/crossref?an=00005768-900000000-96573
   PubMed Web of Science ®Google Scholar
• Jilka, R., Hangoc, G., Girasole, G., Passeri, G., Williams, D., Abrams, J., et al. (1992). Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science (80-), 3(257), 88–91.
   Google Scholar
• Kroot, J. C. C., Laarakkers, C. M., Geurts-Moespot, A. J., Grebenchtchikov, N., Pickkers, P., van Ede, A. E., et al. (2010). Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders. Clinical Chemistry, 56, 1570–1579.
   PubMed Web of Science ®Google Scholar
• Lebrun, C. M., McKenzie, D. C., Prior, J. C., & Taunton, J. E. (1995). Effects of menstrual cycle phase on athletic performance. Medicine & Science in Sports & Exercise, 27(3), 437–444.
   PubMed Web of Science ®Google Scholar
• Lehtihet, M., Bonde, Y., Beckman, L., Berinder, K., Hoybye, C., Rudling, M., et al. (2016). Circulating hepcidin-25 is reduced by endogenous estrogen in humans. PLoS One, 11(2), e0148802.
   PubMed Web of Science ®Google Scholar
• Li, X., Rhee, D. K., Malhotra, R., Mayeur, C., Hurst, L., Ager, E., et al. (2016). Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. Journal of Clinical Investigation, 126(1), 389–401.
   PubMed Web of Science ®Google Scholar
• McClung, J. P., Karl, J. P., Cable, S. J., Williams, K. W., Nindl, B. C., Young, A. J., et al. (2009). Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: Effects on iron status, physical performance, and mood. American Journal of Clinical Nutrition, 90(1), 124–131.
   PubMed Web of Science ®Google Scholar
• Middleton, L. E., & Wenger, H. A. (2006). Effects of menstrual phase on performance and recovery in intense intermittent activity. European Journal of Applied Physiology, 96(1), 53–58.
   PubMed Web of Science ®Google Scholar
• Milic, R., Martinovic, J., Dopsaj, M., & Dopsaj, V. (2011). Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands. European Journal of Applied Physiology, 111(3), 449–458.
   PubMed Web of Science ®Google Scholar
• Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., et al. (2004). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. Journal of Clinical Investigation, 113(9), 1271–1276.
   PubMed Web of Science ®Google Scholar
• Newlin, M. K., Williams, S., McNamara, T., Tjalsma, H., & Swinkels, D. W. (2012). The effects of acute exercise bouts on hepcidin in women. International Journal of Sport Nutrition and Exercise Metabolism, 22(2), 79–88.
   PubMed Web of Science ®Google Scholar
• Peake, J. M., Neubauer, O., Della Gatta, P. A., & Nosaka, K. (2017 Mar). Muscle damage and inflammation during recovery from exercise. Journal of Applied Physiology, 122(3), 559–570.
   PubMed Web of Science ®Google Scholar
• Pedersen, B. K., Steensberg, A., & Schjerling, P. (2001). Exercise and interleukin-6. Current Opinion in Hematology, 8, 137–141.
   PubMed Web of Science ®Google Scholar
• Peeling, P., Dawson, B., Goodman, C., Landers, G., & Trinder, D. (2008). Athletic induced iron deficiency: New insights into the role of inflammation, cytokines and hormones. European Journal of Applied Physiology, 103(4), 381–391.
   PubMed Web of Science ®Google Scholar
• Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W., et al. (2009a). Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. European Journal of Applied Physiology, 106, 51–59.
   PubMed Web of Science ®Google Scholar
• Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W., et al. (2009b). Effects of exercise on hepcidin response and iron metabolism during recovery. International Journal of Sport Nutrition and Exercise Metabolism, 19, 583–597.
   PubMed Web of Science ®Google Scholar
• Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W., et al. (2009c). Training surface and intensity: Inflammation, hemolysis, and hepcidin expression. Med Sci Sport Exerc, 41(5), 1138–1145.
   PubMed Web of Science ®Google Scholar
• Peeling, P., McKay, A. K. A., Pyne, D. B., Guelfi, K. J., McCormick, R. H., Laarakkers, C. M., et al. (2017 Jun). Factors influencing the post-exercise hepcidin-25 response in elite athletes. European Journal of Applied Physiology, 117(6), 1233–1239.
   PubMed Web of Science ®Google Scholar
• Peeling, P., Sim, M., Badenhorst, C. E., Dawson, B., Govus, A. D., Abbiss, C. R., et al. (2014). Iron status and the acute post-exercise hepcidin response in athletes. PLoS One, 9(3), e93002.
   PubMed Web of Science ®Google Scholar
• Pottratz, S., Bellido, T., Mocharla, H., Crabb, D., & Manolagas, S. (1994). 17-β estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. Journal of Clinical Investigation, 93(3), 944–950.
   PubMed Web of Science ®Google Scholar
• Robertson, L S, Iwanowicz, L R, & Marranca, J M. (2009). Identification of centrarchid hepcidins and evidence that 17beta-estradiol disrupts constitutive expression of hepcidin-1 and inducible expression of hepcidin-2 in largemouth bass (Micropterus salmoides). Fish Shellfish Immunol, 26(6), 898–907.
   PubMed Web of Science ®Google Scholar
• Robson-Ansley, P., Walshe, I., & Ward, D. (2011). The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise. Cytokine, 53(2), 196–200.
   PubMed Web of Science ®Google Scholar
• Roecker, L., Meier-Buttermilch, R., Brechtel, L., Nemeth, E., & Ganz, T. (2005). Iron-regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology, 95, 569–571.
   PubMed Web of Science ®Google Scholar
• Schmidt, W., Maassen, N., Trost, F., & Boning, D. (1988 Mar). Training induced effects on blood volume, erythrocyte turnover and haemoglobin oxygen binding properties. European Journal of Applied Physiology and Occupational Physiology, 57(4), 490–498.
   PubMed Web of Science ®Google Scholar
• Schumacher, Y. O., Schmid, A., Grathwohl, D., Bultermann, D., & Berg, A. (2002). Hematological indices and iron status in athletes of various sports and performances. Medicine & Science in Sports & Exercise, 34, 869–875.
   PubMed Web of Science ®Google Scholar
• Sim, M., Dawson, B., Landers, G., Swinkels, D. W., Tjalsma, H., Yeap, B. B., et al. (2015). Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females. Journal of Science and Medicine in Sport, 18(1), 8–12.
   PubMed Web of Science ®Google Scholar
• Sim, M., Dawson, B., Landers, G., Swinkels, D. W., Wiegerinck, E., Yeap, B. B., et al. (2017). Interleukin-6 and hepcidin levels during hormone-deplete and hormone-replete phases of an oral contraceptive cycle: A pilot study. Annals of Nutrition & Metabolism, 70(2), 100–105.
   PubMed Web of Science ®Google Scholar
• Skarpańska-Stejnborn, A., Basta, P., Trzeciak, J., Michalska, A., Kafkas, M. E., & Woitas-Ślubowska, D. (2017). Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers. Journal of The international Society of Sports Nutrition, 14(7). doi:10.1186/s12970-017-0165-z. eCollection 2017
   PubMedGoogle Scholar
• Skarpańska-Stejnborn, A., Basta, P., Trzeciak, J., & Szcześniak-Pilaczyńska, Ł. (2015 Feb). Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes. European Journal of Applied Physiology, 115(2), 345–351.
   PubMed Web of Science ®Google Scholar
• Suzuki, K. (2018 Jan). Cytokine response to exercise and Its Modulation. Antioxidants, 7(1), 17. doi: 10.3390/antiox7010017
   Web of Science ®Google Scholar
• Telford, R. D., Sly, G. J., Hahn, A. G., Cunningham, R. B., Bryant, C., & Smith, J. A. (2003). Footstrike is the major cause of hemolysis during running. Journal of Applied Physiology, 94, 38–42.
   PubMed Web of Science ®Google Scholar
• Weight, L. M., Byrne, M. J., & Jacobs, P. (1991 Aug). Haemolytic effects of exercise. Clinical Science, 81(2), 147–152.
   Web of Science ®Google Scholar
• Yang, Q, Jian, J, Katz, S, Abramson, S B, & Huang, X. (2012). 17-β Estradiol inhibits iron Hormone hepcidin through an estrogen responsive element half-site. Endocrinology, 153(7), 3170–3178.
   PubMed Web of Science ®Google Scholar