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Review

DMEK complications: current treatment and recommendations

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Pages 33-46 | Received 29 Nov 2017, Accepted 16 Jan 2018, Published online: 02 Feb 2018

References

  • Deng SX, Lee WB, Hammersmith KM, et al. Descemet membrane endothelial keratoplasty: safety and outcomes: a report by the american academy of ophthalmology. Ophthalmology. 2017;15. pii: S0161-6420(17)32521-6. [Epub ahead of print]. doi:10.1016/j.ophtha.2017.08.015.
  • Cursiefen C. Descemet membrane endothelial keratoplasty: the taming of the shrew. JAMA Ophthalmol. 2013;131:88–89.
  • Dirisamer M, Van Dijk K, Dapena I, et al. Prevention and management of graft detachment in Descemet membrane endothelial keratoplasty. Arch Ophthalmol. 2012;130:280–291.
  • Parekh M, Leon P, Ruzza A, et al. Graft detachment and re-bubbling rate in Descemet Membrane Endothelial Keratoplasty. Surv Ophthalmol. 2017;22:1–14.
  • Ampazas P, Droutsas K, Giallouros E, et al. Comparison of 5% sulfur hexafluoride versus 100% air tamponade in descemet membrane endothelial keratoplasty. Cornea. 2017;36:1189–1194.
  • Müller TM, Verdijk RM, Lavy I, et al. Histopathologic features of descemet membrane endothelial keratoplasty graft remnants, folds, and detachments. Ophthalmology. 2016;123:2489–2497.
  • Brockmann T, Brockmann C, Maier A-K, et al. Clinicopathology of graft detachment after Descemet’s membrane endothelial keratoplasty. Acta Ophthalmol. 2014;92:e556–61.
  • Dapena I, Moutsouris K, Droutsas K, et al. Standardized “no-touch” technique for Descemet membrane endothelial keratoplasty. Arch Ophthalmol. 2011;129:88–94.
  • Quilendrino R, Rodríguez-Calvo-de-Mora M, Baydoun L, et al. Prevention and management of descemet membrane endothelial keratoplasty complications. Cornea. 2017;36:1089–1095.
  • Tourtas T, Schlomberg J, Wessel JM, et al. Graft adhesion in Descemet membrane endothelial keratoplasty dependent on size of removal of host’s Descemet membrane. JAMA Ophthalmol. 2014;132:155–161.
  • Röck T, Bramkamp M, Bartz-Schmidt KU, et al. Causes that influence the detachment rate after Descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2015;253:2217–2222.
  • Saad A, Guilbert E, Grise-Dulac A, et al. Intraoperative OCT-assisted DMEK: 14 consecutive cases. Cornea. 2015;34:802–807.
  • Veldman PB, Dye PK, Holiman JD, et al. The S-stamp in descemet membrane endothelial keratoplasty safely eliminates upside-down graft implantation. Ophthalmology. 2016;123:161–164.
  • Bachmann BO, Laaser K, Cursiefen C, et al. A method to confirm correct orientation of descemet membrane during descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2010;149:922.
  • Bhogal M, Maurino V, Allan BD. Use of a single peripheral triangular mark to ensure correct graft orientation in Descemet membrane endothelial keratoplasty. J Cataract Refract Surg. 2015;41:2022–2024.
  • Maier A-KB, Gundlach E, Schroeter J, et al. Influence of the difficulty of graft unfolding and attachment on the outcome in descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2015;253:895–900.
  • Ćirković A, Beck C, Weller JM, et al. Anterior chamber air bubble to achieve graft attachment after DMEK: is bigger always better? Cornea. 2016;35:482–485.
  • Ćirković A, Schlötzer-Schrehardt U, Weller JM, et al. Clinical and ultrastructural characteristics of graft failure in DMEK: 1-year results after repeat DMEK. Cornea. 2015;34:11–17.
  • Monnereau C, Quilendrino R, Dapena I, et al. Multicenter study of Descemet membrane endothelial keratoplasty. JAMA Ophthalmol. 2014;132:1192–1197.
  • Terry MA, Straiko MD, Veldman PB, et al. Standardized DMEK technique: reducing complications using prestripped tissue, novel glass injector, and sulfur hexafluoride (SF6) gas. Cornea. 2015;34:845–852.
  • Oellerich S, Baydoun L, Peraza-Nieves J, et al. Multicenter study of 6-month clinical outcomes after Descemet Membrane endothelial keratoplasty. Cornea. 2017;36:1467–1476.
  • Rodríguez-Calvo-de-Mora M, Groeneveld-Van Beek EA, Frank LE, et al. Association between graft storage time and donor age with endothelial cell density and graft adherence after Descemet membrane endothelial keratoplasty. JAMA Ophthalmol. 2016;134:91–94.
  • Sales CS, Terry MA, Veldman PB, et al. Relationship between tissue unscrolling time and endothelial cell loss. Cornea. 2016;35:471–476.
  • Deng SX, Sanchez PJ, Chen L. Clinical outcomes of Descemet membrane endothelial keratoplasty using eye bank-prepared tissues. Am J Ophthalmol. 2015;159:590–596.
  • Regnier M, Auxenfans C, Maucort-Boulch D, et al. Eye bank prepared versus surgeon cut endothelial graft tissue for Descemet membrane endothelial keratoplasty: an observational study. Medicine (Baltimore). 2017;96:e6885.
  • Feng MT, Burkhart ZN, Price FW, et al. Effect of donor preparation-to-use times on Descemet membrane endothelial keratoplasty outcomes. Cornea. 2013;32:1080–1082.
  • Dapena I, Ham L, Droutsas K, et al. Learning curve in Descemet’s membrane endothelial keratoplasty: first series of 135 consecutive cases. Ophthalmology. 2011;118:2147–2154.
  • Baydoun L, Van Dijk K, Dapena I, et al. Repeat Descemet membrane endothelial keratoplasty after complicated primary Descemet membrane endothelial keratoplasty. Ophthalmology. 2015;122:8–16.
  • Price MO, Feng MT, McKee Y, et al. Repeat descemet membrane endothelial keratoplasty: secondary grafts with early intervention are comparable with fellow-eye primary grafts. Ophthalmology. 2015;122:1639–1644.
  • Dirisamer M, Yeh R-Y, Van Dijk K, et al. Recipient endothelium may relate to corneal clearance in Descemet membrane endothelial transfer. Am J Ophthalmol. 2012;154:290–291.
  • Birbal RS, Parker J, Dirisamer M, et al. Descemet membrane endothelial transfer: ultimate outcome. Cornea. 2017;29. [Epub ahead of print]. doi:10.1097/ICO.0000000000001395
  • Fernández López E, Baydoun L, Gerber-Hollbach N, et al. Rebubbling techniques for graft detachment after descemet membrane endothelial keratoplasty. Cornea. 2016;35:759–764.
  • Gerber-Hollbach N, Baydoun L, López EF, et al. Clinical outcome of rebubbling for graft detachment after descemet membrane endothelial keratoplasty. Cornea. 2017;36:771–776.
  • Yeh R-Y, Quilendrino R, Musa FU, et al. Predictive value of optical coherence tomography in graft attachment after Descemet’s membrane endothelial keratoplasty. Ophthalmology. 2013;120:240–245.
  • Van Dijk K, Parker J, Liarakos VS, et al. Incidence of irregular astigmatism eligible for contact lens fitting after Descemet membrane endothelial keratoplasty. J Cataract Refract Surg. 2013;39:1036–1046.
  • Feng MT, Srinivas SP, Miller JM, et al. Air reinjection and endothelial cell density in Descemet membrane endothelial keratoplasty: five-year follow-up. J Cataract Refract Surg. 2014;40:1116–1121.
  • Güell JL, Morral M, Gris O, et al. Comparison of sulfur hexafluoride 20% versus air tamponade in descemet membrane endothelial keratoplasty. Ophthalmology. 2015;122:1757–1764.
  • Botsford B, Vedana G, Cope L, et al. Comparison of 20% sulfur hexafluoride with air for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK). Arq Bras Oftalmol. 2016;79:299–302.
  • Schaub F, Enders P, Snijders K, et al. One-year outcome after Descemet membrane endothelial keratoplasty (DMEK) comparing sulfur hexafluoride (SF 6) 20% versus 100% air for anterior chamber tamponade. Br J Ophthalmol. 2017;101:902–908.
  • Acar BT, Muftuoglu O, Acar S. Comparison of sulfur hexafluoride and air for donor attachment in Descemet stripping endothelial keratoplasty in patients with pseudophakic bullous keratopathy. Cornea. 2014;33:219–222.
  • Busin M, Leon P, Scorcia V, et al. Contact lens-assisted pull-through technique for delivery of tri-folded (Endothelium in) DMEK grafts minimizes surgical time and cell loss. Ophthalmology. 2016;123:476–483.
  • Einan-Lifshitz A, Sorkin N, Boutin T, et al. Comparison of femtosecond laser-enabled descemetorhexis and manual descemetorhexis in descemet membrane endothelial keratoplasty. Cornea. 2017;36:767–770.
  • Naveiras M, Dirisamer M, Parker J, et al. Causes of glaucoma after Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2012;153:958–966.e1.
  • Price MO, Price FW Jr, Kruse FE, et al. Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after Descemet membrane endothelial keratoplasty. Cornea. 2014;33:880–886.
  • Maier A-KB, Wolf T, Gundlach E, et al. Intraocular pressure elevation and post-DMEK glaucoma following Descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2014;252:1947–1954.
  • Aravena C, Yu F, Deng SX. Outcomes of Descemet membrane endothelial keratoplasty in patients with previous glaucoma surgery. Cornea. 2017;36:284–289.
  • Parker J, Dirisamer M, Naveiras M, et al. Outcomes of Descemet membrane endothelial keratoplasty in phakic eyes. J Cataract Refract Surg. 2012;38:871–877.
  • Röck D, Bartz-Schmidt KU, Röck T, et al. Air bubble-induced high intraocular pressure after descemet membrane endothelial keratoplasty. Cornea. 2016;35:1035–1039.
  • Gonzalez A, Price FW, Srinivas SP, et al. Prevention and management of pupil block after descemet membrane endothelial keratoplasty. Cornea. 2016;35:1391–1395.
  • Phillips PM, Phillips LJ, Muthappan V, et al. Experienced DSAEK surgeon’s transition to DMEK: outcomes comparing the last 100 DSAEK surgeries with the first 100 DMEK surgeries exclusively using previously published techniques. Cornea. 2017;36:275–279.
  • Price MO, Scanameo A, Feng MT, et al. Descemet’s membrane endothelial keratoplasty: risk of immunologic rejection episodes after discontinuing topical corticosteroids. Ophthalmology. 2016;123:1232–1236.
  • Hoerster R, Stanzel TP, Bachmann BO, et al. Intensified topical steroids as prophylaxis for macular edema after posterior lamellar keratoplasty combined with cataract surgery. Am J Ophthalmol. 2016;163:174–179.e2.
  • Price MO, Feng MT, Scanameo A, et al. Loteprednol etabonate 0.5% gel vs. prednisolone acetate 1% solution after Descemet membrane endothelial keratoplasty: prospective randomized trial. Cornea. 2015;34:853–858.
  • Del Hierro Zarzuelo A, Boto De Los Bueis A. Alteraciones iridianas tras Queratoplastia endotelial automatizada con stripping de la Descemet. Arch Soc Esp Oftalmol. 2016;91:422–425.
  • Anwar DS, Chu CY, Prasher P, et al. Features of Urrets-Zavalia syndrome after Descemet stripping automated endothelial keratoplasty. Cornea. 2012;31:1330–1334.
  • Holtmann C, Spaniol K, Geerling G. Urrets-Zavalia syndrome after Descemet membrane endothelial keratoplasty. Eur J Ophthalmol. 2015;30:75–77.
  • Arnalich-Montiel F, Pérez-Sarriegui A, Lauzirika G, et al. Pupillary abnormalities in Descemet membrane endothelial keratoplasty after nearly full tamponade. Cornea. 2017;36:290–294.
  • Dapena I, Ham L, Netuková M, et al. Incidence of early allograft rejection after Descemet membrane endothelial keratoplasty. Cornea. 2011;30:1341–1345.
  • Heinzelmann S, Böhringer D, Eberwein P, et al. Outcomes of Descemet membrane endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty from a single centre study. Graefes Arch Clin Exp Ophthalmol. 2016;254:515–522.
  • Anshu A, Srinivas SP, Price FW. Risk of corneal transplant rejection significantly reduced with Descemet’s membrane endothelial keratoplasty. Ophthalmology. 2012;119:536–540.
  • Hori J, Joyce NC, Streilein JW. Immune privilege and immunogenicity reside among different layers of the mouse cornea. Invest Ophthalmol Vis Sci. 2000;41:3032–3042.
  • Baydoun L, Livny E, Ham L, et al. 360-Degree Scheimpflug imaging to predict allograft rejection after Descemet membrane endothelial keratoplasty. Cornea. 2016;35:1385–1390.
  • Hos D, Tuac O, Schaub F, et al. Incidence and clinical course of immune reactions after Descemet membrane endothelial keratoplasty: retrospective analysis of 1000 consecutive eyes. Ophthalmology. 2017;124:512–518.
  • Guerra FP, Anshu A, Price MO, et al. Descemet’s membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011;118:2368–2373.
  • Ham L, Dapena I, Liarakos VS, et al. Midterm results of descemet membrane endothelial keratoplasty: 4 to 7 years clinical outcome. Am J Ophthalmol. 2016;171:113–121.
  • Monnereau C, Bruinsma M, Ham L, et al. Endothelial cell changes as an indicator for upcoming allograft rejection following Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2014;158:485–495.
  • McCafferty S, Harris A, Kew C, et al. Pseudophakic cystoid macular edema prevention and risk factors; prospective study with adjunctive once daily topical nepafenac 0.3% versus placebo. BMC Ophthalmol. 2017;17:16.
  • Heinzelmann S, Maier P, Böhringer D, et al. Cystoid macular oedema following Descemet membrane endothelial keratoplasty. Br J Ophthalmol. 2015;99:98–102.
  • Packer M, Lowe J, Fine H. Incidence of acute postoperative cystoid macular edema in clinical practice. J Cataract Refract Surg. 2012;38:2108–2111.
  • Henderson BA, Kim JY, Ament CS, et al. Clinical pseudophakic cystoid macular edema. J Cataract Refract Surg. 2007;33:1550–1558.
  • Gulkilik G, Kocabora S, Taskapili M, et al. Cystoid macular edema after phacoemulsification: risk factors and effect on visual acuity. Can J Ophthalmol. 2006;41:699–703.
  • Chaurasia S, Price FW, Gunderson L, et al. Descemet’s membrane endothelial keratoplasty: clinical results of single versus triple procedures (combined with cataract surgery). Ophthalmology. 2014;121:454–458.
  • Debellemanière G, Guilbert E, Courtin R, et al. Impact of surgical learning curve in Descemet membrane endothelial keratoplasty on visual acuity gain. Cornea. 2017;36:1–6.
  • Schlögl A, Tourtas T, Kruse FE, et al. Long-term clinical outcome after Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2016;169:218–226.
  • Flanary WE, Vislisel JM, Wagoner MD, et al. Incidence of cystoid macular edema after Descemet membrane endothelial keratoplasty as a staged and solitary procedure. Cornea. 2016;35:1040–1044.
  • Baydoun L, Melles GRJ. Refining the terminology of graft failure in reports on endothelial keratoplasty outcomes. JAMA Ophthalmol. 2016;134:125–126.
  • Pavlovic I, Shajari M, Herrmann E, et al. Meta-analysis of postoperative outcome parameters comparing Descemet membrane endothelial keratoplasty versus Descemet stripping automated endothelial keratoplasty. Cornea. 2017;36:1445–1451.
  • Gorovoy MS. DMEK Complications. Cornea. 2014;33:101–104.
  • Arnalich-Montiel F, Pérez-Sarriegui A, Casado A. Impact of introducing 2 simple technique modifications on the Descemet membrane endothelial keratoplasty learning curve. Eur J Ophthalmol. 2016;27:16–20.
  • Veldman PB, Dye PK, Holiman JD, et al. Stamping an S on DMEK donor tissue to prevent upside-down grafts: laboratory validation and detailed preparation technique description. Cornea. 2015;34:1175–1178.
  • Heinzelmann S, Böhringer D, Eberwein P, et al. Graft dislocation and graft failure following Descemet membrane endothelial keratoplasty (DMEK) using precut tissue: a retrospective cohort study. Graefes Arch Clin Exp Ophthalmol. 2017;255:127-133
  • Baydoun L, Ham L, Borderie V, et al. Endothelial survival after Descemet membrane endothelial keratoplasty. JAMA Ophthalmol. 2015;133:1277–1279.
  • Martin TP, Reed JW, Legault C, et al. Cataract formation and cataract extraction after penetrating keratoplasty. Ophthalmology. 1994;101:113–119.
  • Price MO, Price FW. Cataract progression and treatment following posterior lamellar keratoplasty. J Cartaract Refract Surg. 2004;30:1310–1315.
  • Price MO, Price DA, Fairchild KM, et al. Rate and risk factors for cataract formation and extraction after Descemet stripping endothelial keratoplasty. Br J Ophthalmol. 2010;94:1468–1471.
  • Burkhart ZN, Feng MT, Price FW, et al. One-year outcomes in eyes remaining phakic after Descemet membrane endothelial keratoplasty. J Cataract Refract Surg. 2014;40:430–434.
  • Gundlach E, Maier A-KB, Tsangaridou M-A, et al. DMEK in phakic eyes: targeted therapy or highway to cataract surgery? Graefes Arch Clin Exp Ophthalmol. 2015;253:909–914.
  • Musa FU, Cabrerizo J, Quilendrino R, et al. Outcomes of phacoemulsification after Descemet membrane endothelial keratoplasty. J Cataract Refract Surg. 2013;39:836–840.
  • Price FW, Price MO. Combined Cataract/DSEK/DMEK: changing expectations. Asia Pac J Ophthalmol (Phila). 2017;6:388–392.
  • Fellman MA, Werner L, Liu ET, et al. Calcification of a hydrophilic acrylic intraocular lens after Descemet-stripping endothelial keratoplasty: case report and laboratory analyses. J Cataract Refract Surg. 2013;39:799–803.
  • MacLean KD, Apel A, Wilson J, et al. Calcification of hydrophilic acrylic intraocular lenses associated with intracameral air injection following DMEK. J Cataract Refract Surg. 2015;41:1310–1314.
  • Norouzpour A, Zarei-Ghanavati S. Hydrophilic acrylic intraocular lens opacification after descemet stripping automated endothelial keratoplasty. J Ophthalmic Vis Res. 2016;11:225.
  • Giers BC, Tandogan T, Auffarth GU, et al. Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment. BMC Ophthalmol. 2017;17:150.
  • Park JC, Habib NE, Moate RM. Intraocular lens opacification after corneal endothelial keratoplasty: electron microscopy and x-ray element spectroscopy analysis. J Cataract Refract Surg. 2015;41:140–145.
  • Mojzis P, Studeny P, Werner L, et al. Opacification of a hydrophilic acrylic intraocular lens with a hydrophobic surface after air injection in Descemet-stripping automated endothelial keratoplasty in a patient with Fuchs dystrophy. J Cataract Refract Surg. 2016;42:485–488.
  • Morgan-Warren PJ, Andreatta W, Patel AK. Opacification of hydrophilic intraocular lenses after Descemet stripping automated endothelial keratoplasty. Clin Ophthalmol. 2015;9:277–283.
  • Nieuwendaal CP, Van der Meulen IJE, Patryn EK, et al. Opacification of the intraocular lens after Descemet stripping endothelial keratoplasty. Cornea. 2015;34:1375–1377.
  • Ahad MA, Darcy K, Cook SD, et al. Intraocular lens opacification after Descemet stripping automated endothelial keratoplasty. Cornea. 2014;33:1307–1311.
  • Schrittenlocher S, Penier M, Schaub F, et al. Intraocular lens calcifications after (triple-) Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2017;179:129–136.
  • Neuhann IM, Neuhann TF, Rohrbach JM. Intraocular lens calcification after keratoplasty. Cornea. 2013;32:e6–10.
  • Tandogan T, Khoramnia R, Choi CY, et al. Optical and material analysis of opacified hydrophilic intraocular lenses after explantation: a laboratory study. BMC Ophthalmol. 2015;15:483.
  • Avetisov SE, Gamidov AA, Novikov IA, et al. [Chemical microanalysis of mineral deposits on explanted hydrophilic acrylic intraocular lenses]. Vestn Oftalmol. 2015;131:74–78.
  • Fernández-Buenaga R, Alio JL. Intraocular lens explantation after cataract surgery: indications, results, and explantation techniques. Asia Pac J Ophthalmol (Phila). 2017;6:372–380.
  • Gerber-Hollbach N, Parker J, Baydoun L, et al. Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. Br J Ophthalmol. 2016;100:1564–1568.
  • Müller TM, Lavy I, Baydoun L, et al. Case report of quarter-Descemet Membrane endothelial keratoplasty for fuchs endothelial dystrophy. Cornea. 2017;36:104–107.

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