174
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Nutrition and dry eye: a systematic review

ORCID Icon &
Pages 133-150 | Received 24 Jan 2019, Accepted 30 Apr 2019, Published online: 20 May 2019

References

  • Albietz JM. Prevalence of dry eye subtypes in clinical optometry practice. Optom Vis Sci. 2000;77(7):357–363.
  • Bhargava R, Kumar P. Oral omega-3 fatty acid treatment for dry eye in contact lens wearers. Cornea. 2015;34(4):413–420.
  • Xie W. Recent advances in laser in situ keratomileusis-associated dry eye. Clin Exp Optom. 2016;99(2):107–112.
  • Sagili S, Malhotra R. Dry eyes can be exacerbated by systemic antihypertensive medication. Scott Med J. 2012;57(2):121.
  • Dogru M, Tsubota K. Pharmacotherapy of dry eye. Expert Opin Pharmacother. 2011;12(3):325–334.
  • Milner MS, Beckman KA, Luchs JI, et al. Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment. Curr Opin Ophthalmol. 2017;27(Suppl 1):3–47.
  • Kastelan S, Tomić M, Salopek-Rabatić J, et al. Diagnostic procedures and management of dry eye. Biomed Res Int. 2013;2013:309723.
  • Marshall LL, Roach JM. Treatment of dry eye disease. Consult Pharm. 2016;31(2):96–106.
  • Lawrenson JG, Grzybowski A. Controversies in the use of nutritional supplements in ophthalmology. Curr Pharm Des. 2015;21(32):4667–4672.
  • Roncone M, Bartlett H, Eperjesi F. Essential fatty acids for dry eye: A review. Cont Lens Anterior Eye. 2010;33(2):49–54. quiz 100
  • Faustino JF, Ribeiro-Silva A, Dalto RF, et al. Vitamin A and the eye: an old tale for modern times. Arq Bras Oftalmol. 2016;79(1):56–61.
  • Akhtar S, Ahmed A, Randhawa MA, et al. Prevalence of vitamin A deficiency in south Asia: causes, outcomes, and possible remedies. J Health Popul Nutr. 2013;31(4):413–423.
  • Sommer A. Vitamin a deficiency and clinical disease: an historical overview. J Nutr. 2008;138(10):1835–1839.
  • Bhargava R, Kumar P, Arora Y. Short-term omega 3 fatty acids treatment for dry eye in young and middle-aged visual display terminal users. Eye Contact Lens. 2016;42(4):231–236.
  • Drouault-Holowacz S, Bieuvelet S, Burckel A, et al. Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial. Eur J Ophthalmol. 2009;19(3):337–342.
  • Gadaria-Rathod N, Dentone PG, Peskin E, et al. Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. J Ocul Pharmacol Ther. 2013;29(9):837–841.
  • Galbis-Estrada C, Pinazo-Durán MD, Cantú-Dibildox J, et al. Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids. Clin Interv Aging. 2013;8:711–719.
  • Galbis-Estrada C, Pinazo-Durán MD, Martínez-Castillo S, et al. A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids. Mol Vis. 2015;21:555–567.
  • Gatell-Tortajada J. Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study. Clin Interv Aging. 2016;11:571–578.
  • Jalbert I. Diet, nutraceuticals and the tear film. Exp Eye Res. 2013;117:138–146.
  • Kawakita T, Kawabata F, Tsuji T, et al. Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial. Biomed Res. 2013;34(5):215–220.
  • McCusker MM, Durrani K, Payette MJ, et al. An eye on nutrition: the role of vitamins, essential fatty acids, and antioxidants in age-related macular degeneration, dry eye syndrome, and cataract. Clin Dermatol. 2016;34(2):276–285.
  • Mohammadpour M, Mehrabi S, Hassanpoor N, et al. Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial. J Curr Ophthalmol. 2017;29(1):33–38.
  • Nebbioso M, Rusciano D, Pucci B, et al. Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial. Eur Rev Med Pharmacol Sci. 2013;17(8):1117–1122.
  • Wojtowicz JC, Butovich I, Uchiyama E, et al. Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea. 2011;30(3):308–314.
  • Panic N, Leoncini E, de Belvis G, et al. Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PLoS One. 2013;8(12):e83138.
  • Bernardo WM, Nobre MR, Jatene FB. [Evidence-based clinical practice. Part II–searching evidence databases]. Rev Assoc Med Bras. 1992 2004;50(1): 104–108.
  • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.
  • Scottish Intercollegiate Guidelines Network (SIGN). SIGN 50: a guideline developer’s handbook. Edinburgh: SIGN; 2012. Available from: http://www.sign.ac.uk
  • Larmo PS, Jarvinen RL, Setala NL, et al. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. 2010 Aug;140(8):1462–1468.
  • Hom MM, Asbell P, Barry B. Omegas and dry eye: more knowledge, more questions. Optom Vis Sci. 2015;92(9):948–956.
  • Rand AL, Asbell PA. Nutritional supplements for dry eye syndrome. Curr Opin Ophthalmol. 2011;22(4):279–282.
  • Cortina MS, Bazan HE. Docosahexaenoic acid, protectins and dry eye. Curr Opin Clin Nutr Metab Care. 2011;14(2):132–137.
  • Hitoe S, Tanaka J, Shimoda H. MaquiBright standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial. Panminerva Med. 2014;56(3 Suppl 1):1–6.
  • Barabino S, Rolando M, Nardi M, et al. The effect of an artificial tear combining hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome: a new treatment for dry eye. Eur J Ophthalmol. 2014;24(2):173–178.
  • Seitsalo H, Niemelä RK, Marinescu-Gava M, et al. Effectiveness of low-dose doxycycline (LDD) on clinical symptoms of Sjogren’s syndrome: a randomized, double-blind, placebo controlled cross-over study. J Negat Results Biomed. 2007;6:11.
  • Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, et al. Topical and systemic medications for the treatment of primary Sjogren’s syndrome. Nat Rev Rheumatol. 2012;8(7):399–411.
  • Nakayamada S, Fujimoto T, Nonomura A, et al. Usefulness of initial histological features for stratifying Sjogren’s syndrome responders to mizoribine therapy. Rheumatology (Oxford). 2009;48(10):1279–1282.
  • Nakayamada S, Saito K, Umehara H, et al. Efficacy and safety of mizoribine for the treatment of Sjogren’s syndrome: a multicenter open-label clinical trial. Mod Rheumatol. 2007;17(6):464–469.
  • Alpoz E, Güneri P, Onder G, et al. The efficacy of Xialine in patients with Sjogren’s syndrome: a single-blind, cross-over study. Clin Oral Investig. 2008;12(2):165–172.
  • Yamada H, Nakagawa Y, Wakamatsu E, et al. Efficacy prediction of cevimeline in patients with Sjogren’s syndrome. Clin Rheumatol. 2007;26(8):1320–1327.
  • Dry Eye A, Asbell PA, Maguire MG, et al. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med. 2018;378(18):1681–1690.
  • Garcia-Carrasco M, Jiménez-Herrera EA, Gálvez-Romero JL, et al. Vitamin D and Sjogren syndrome. Autoimmun Rev. 2017;16(6):587–593.
  • Yang CH, Albietz J, Harkin DG, et al. Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D. Cont Lens Anterior Eye. 2018;41(1):69–76.
  • Roh HC, Lee JK, Kim M, et al. Systemic comorbidities of dry eye syndrome: the Korean national health and nutrition examination survey V, 2010 to 2012. Cornea. 2016;35(2):187–192.
  • Epitropoulos AT, Donnenfeld ED, Shah ZA, et al. Effect of oral re-esterified omega-3 nutritional supplementation on dry eyes. Cornea. 2016;35(9):1185–1191.
  • Ngo W, Srinivasan S, Houtman D, et al. The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals. J Optom. 2017;10(1):26–33.
  • Butovich IA. On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids. Invest Ophthalmol Vis Sci. 2008;49(9):3779–3789.
  • Macsai MS. The role of omega-3 dietary supplementation in blepharitis and meibomian gland dysfunction (an AOS thesis). Trans Am Ophthalmol Soc. 2008;106:336–356.
  • Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 2012;3(1):1–7.
  • Pinna A, Blasetti F, Zinellu A, et al. Meibomian gland dysfunction and hypercholesterolemia. Ophthalmology. 2013;120(12):2385–2389.
  • King-Smith PE, Hinel EA, Nichols JJ. Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning. Invest Ophthalmol Vis Sci. 2010;51(5):2418–2423.
  • Suzuki S, Goto E, Dogru M, et al. Tear film lipid layer alterations in allergic conjunctivitis. Cornea. 2006;25(3):277–280.
  • King-Smith PE, Reuter KS, Braun RJ, et al. Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer images. Invest Ophthalmol Vis Sci. 2013;54(7):4900–4909.
  • Fenner BJ, Tong L. More to stable tears than thickness of the tear film lipid layer. Invest Ophthalmol Vis Sci. 2015;56(3):1601.
  • Finis D, Pischel N, Schrader S, et al. Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction. Cornea. 2013;32(12):1549–1553.
  • Giraldez MJ, Naroo SA, Resua CG. A preliminary investigation into the relationship between ocular surface temperature and lipid layer thickness. Cont Lens Anterior Eye. 2009;32(4):177–180. quiz 193, 195
  • Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21(6):495–505.
  • Rosenberg ES, Asbell PA. Essential fatty acids in the treatment of dry eye. Ocul Surf. 2010;8(1):18–28.
  • Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids. 2003;38(4):343–352.
  • Spite M, Claria J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014;19(1):21–36.
  • Pinazo-Duran MD, Galbis-Estrada C, Pons-Vázquez S, et al. Effects of a nutraceutical formulation based on the combination of antioxidants and omega-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders. Clin Interv Aging. 2013;8:139–148.
  • Pinna A, Piccinini P, Carta F. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. Cornea. 2007;26(3):260–264.
  • Simopoulos AP. The mediterranean diets: what is so special about the diet of Greece? The scientific evidence. J Nutr. 2001;131(11 Suppl):3065S–73S.
  • Aragona P, Bucolo C, Spinella R, et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren’s syndrome patients. Invest Ophthalmol Vis Sci. 2005;46(12):4474–4479.
  • Brignole-Baudouin F, Baudouin C, Aragona P, et al. A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients. Acta Ophthalmol. 2011;89(7):e591–7.
  • Miljanovic B, Trivedi KA, Dana MR, et al. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005;82(4):887–893.
  • Dyerberg J, Madsen P, Møller JM, et al. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. 2010;83(3):137–141.
  • Zhu W, Wu Y, Li G, et al. Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta-analysis of randomized controlled trials. Nutr Rev. 2014;72(10):662–671.
  • Schiffman RM, Christianson MD, Jacobsen G, et al. Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 2000;118(5):615–621.
  • Creuzot-Garcher C, Baudouin C, Labetoulle M, et al. [Efficacy assessment of Nutrilarm(R), a per os omega-3 and omega-6 polyunsaturated essential fatty acid dietary formulation versus placebo in patients with bilateral treated moderate dry eye syndrome]. J Fr Ophtalmol. 2011;34(7):448–455.
  • Jeon DH, Yeom H, Yang J, et al. Are serum vitamin D levels associated with dry eye disease? Results from the study group for environmental eye disease. J Prev Med Public Health. 2017;50(6):369–376.
  • Liu A, Ji J. Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies. Med Sci Monit. 2014;20:1583–1589.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.