156
Views
0
CrossRef citations to date
0
Altmetric
Review

Ophthalmic side effects of COVID-19 vaccines

, ORCID Icon, , , , , , , & ORCID Icon show all
Pages 129-143 | Received 28 Nov 2021, Accepted 12 Apr 2022, Published online: 20 Apr 2022

References

  • Seah I, Agrawal R. Can the coronavirus disease 2019 (COVID-19) affect the eyes? A review of coronaviruses and ocular implications in humans and animals. Ocul Immunol Inflamm. 2020;28(3):391–395.
  • Lim LW, Yip LW, Tay HW, et al. Sustainable practice of ophthalmology during COVID-19: challenges and solutions. Graefe’s Arch Clin Exp Ophthalmol. 2020;258(7):1427–1436.
  • Toro MD, Brézin AP, Burdon M, et al. Early impact of COVID-19 outbreak on eye care: insights from EUROCOVCAT group. London England: SAGE Publications Sage UK; 2021. p. 5–9.
  • Barton LM, Duval EJ, Stroberg E et al. COVID-19 autopsies, Oklahoma, USA. Am J Clin Pathol. 2020;153(6):725–733.
  • WHO. COVID-19 weekly epidemiological update. 2021. 2021 Apr 6.
  • Zhao J, Zhao S, Ou J, et al. COVID-19: coronavirus vaccine development updates. Front Immunol. 2020;11:3435.
  • Lin TP, C-n K, Zheng K, et al. COVID-19: update on its ocular involvements, and complications from its treatments and vaccinations. Asia-Pac J Ophthalmol. 2021;10(6):521–529.
  • Kadali RA, Janagama R, Peruru S, et al. Side effects of BNT162b2 mRNA COVID-19 vaccine: a randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers. Inter J Infect Dis. 2021;106:376–381.
  • El-Shitany NA, Harakeh S, Badr-Eldin SM, et al. Minor to moderate side effects of Pfizer-BioNTech COVID-19 vaccine among Saudi residents: a retrospective cross-sectional study. Int J Gen Med. 2021;14:1389.
  • Khames Aga QA A, Alkhaffaf WH, Hatem TH, et al. Safety of COVID‐19 vaccines. J Med Virol. 2021;93(12):6588–6594.
  • Austria QM, Lelli GJ, Segal KL, et al. Transient eyelid edema following COVID-19 vaccination. Ophthalmic Plast Reconstr Surg. 2021;37(5):501.
  • Mungmunpuntipantip R, Wiwanitkit VR. Transient Eyelid Edema Following COVID-19 Vaccination. Ophthalmic Plast Reconstr Surg. 2022;38(1):96.
  • Jin W, Tang Y, Wen C. An ocular adverse event in temporal association with COVID-19 vaccination in a patient with systemic lupus erythematosus: a case report. Hum Vaccin Immunother. 2021;17(11):1–3.
  • Kadali RAK, Janagama R, Peruru S, et al., Non‐life‐threatening adverse effects with COVID‐19 mRNA‐1273 vaccine: a randomized, cross‐sectional study on healthcare workers with detailed self‐reported symptoms. J Med Virol. 93(7): 4420–4429. 2021.
  • Santovito LS, Pinna G. Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report. Inflammation Res. 2021;70(9):931–933.
  • Jumroendararasame C, Panyakorn S, Othong R, et al. Transient visual field loss after COVID-19 vaccination: experienced by ophthalmologist, case report. Am J Ophthalmol Case Rep. 2021;24:101212.
  • Pichi F, Aljneibi S, Neri P, et al. Association of ocular adverse events with inactivated COVID-19 vaccination in patients in Abu Dhabi. JAMA Ophthalmol. 2021;139(10):1131–1135.
  • Wertheim M, Keel M, Cook S, et al. Corneal transplant rejection following influenza vaccination. Br J Ophthalmol. 2006;90(7):925.
  • Solomon A, Frucht-Pery J. Bilateral simultaneous corneal graft rejection after influenza vaccination. Am J Ophthalmol. 1996;6(121):708–709.
  • Vignapiano R, Vicchio L, Favuzza E, et al. Corneal graft rejection after yellow fever vaccine: a case report. Ocul Immunol Inflamm. 2021;1–4.https://doi.org/10.1080/09273948.2020.1870146.
  • Hamilton A, Massera R, Maloof A. Stromal rejection in a deep anterior lamellar keratoplasty following influenza vaccination. Clin Exp Ophthalmol. 2015;43(9):838–839.
  • Mungmunpuntipantip R, Wiwanitkit V. Correspondence on” acute corneal endothelial graft rejection following COVID-19 vaccination”. J Fr Ophtalmol. 2021;45. https://doi.org/10.1016/j.jfo.2021.10.003.
  • Wasser LM, Roditi E, Zadok D, et al. Keratoplasty rejection after the BNT162b2 messenger RNA vaccine. Cornea. 2021;40(8):1070.
  • Phylactou M, Li J-PO, Larkin DF. Characteristics of endothelial corneal transplant rejection following immunisation with SARS-CoV-2 messenger RNA vaccine. Br J Ophthalmol. 2021;105(7):893–896.
  • Ravichandran S, Natarajan R. Corneal graft rejection after COVID-19 vaccination. Indian J Ophthalmol. 2021;69(7):1953.
  • Crnej A, Khoueir Z, Cherfan G, et al. Acute corneal endothelial graft rejection following COVID-19 vaccination. J Fr Ophtalmol. 2021;44:e445–e447.
  • Rallis KI, Ting DS, Said DG, et al. Corneal graft rejection following COVID-19 vaccine. Eye. 2021;1–2.
  • Parmar DP, Garde PV, Shah SM, et al. Acute graft rejection in a high-risk corneal transplant following COVID-19 vaccination: a case report. Indian J Ophthalmol. 2021;69(12):3757–3758.
  • Nioi M, d’Aloja E, Fossarello M, et al. Dual corneal-graft rejection after mRNA vaccine (Bnt162b2) for covid-19 during the first six months of follow-up: case report, state of the art and ethical concerns. Vaccines (Basel). 2021;9(11):1274.
  • Rajagopal R, Priyanka TM. Stromal rejection in penetrating keratoplasty following COVID-19 vector vaccine (Covishield)–A case report and review of literature. Indian J Ophthalmol. 2022;70(1):319–321.
  • Khan TA, Sidhu N, Khan L, et al., Bilateral immune-mediated keratolysis after immunization with SARS-CoV-2 recombinant viral vector vaccine. Cornea. 2021;40(12):1629–1632.
  • Li S, Jia X, Yu F, et al. Herpetic keratitis preceded by COVID-19 vaccination. Vaccines (Basel). 2021;9(12):1394.
  • Herbort CP, Papasavvas I. Effect of SARS-CoV-2 mRNA vaccination on ocular herpes simplex and varicella-zoster virus reactivation: should preventive antiviral treatment be given in known herpes patients. J Ophthalmic Inflamm Infect. 2021;11(1):1–3.
  • Alkhalifah MI, Alsobki HE, Alwael HM, et al. Herpes simplex virus keratitis reactivation after SARS-CoV-2 BNT162b2 mRNA vaccination: a report of two cases. Ocul Immunol Inflamm. 2021;29(6):1–3.
  • Song MY, Koh KM, Hwang KY, et al. Relapsed disciform stromal herpetic keratitis following mRNA COVID-19 vaccination. Korean Journal of Ophthalmology. 2021.
  • Richardson-May J, Rothwell A, Rashid M. Reactivation of herpes simplex keratitis following vaccination for COVID-19. BMJ Case Reports CP. 2021;14(9):e245792.
  • Papasavvas I, de Courten C, Herbort CP. Varicella-zoster virus reactivation causing herpes zoster ophthalmicus (HZO) after SARS-CoV-2 vaccination–report of three cases. J Ophthalmic Inflamm Infect. 2021;11(1):1–4.
  • Thimmanagari K, Veeraballi S, Roach D, et al. Ipsilateral zoster ophthalmicus post COVID-19 vaccine in healthy young adults. Cureus. 2021;13(7):e16725.
  • Iwai S, Takayama K, Sora D, et al. A case of acute retinal necrosis associated with reactivation of varicella zoster virus after COVID-19 vaccination. Ocul Immunol Inflamm. 2021;1–3.https://doi.org/10.1080/09273948.2021.2001541.
  • Zheng F, Willis A, Kunjukunju N. Acute retinal necrosis from reactivation of varicella zoster virus following BNT162b2 mRNA COVID-19 vaccination. Ocul Immunol Inflamm. 2021 Dec;1:1–3.
  • Desai HD, Sharma K, Shah A, et al. Can SARS‐CoV‐2 vaccine increase the risk of reactivation of varicella zoster? A systematic review. J Cosmet Dermatol. 2021;20(11):3350–3361.
  • Benage M, Fraunfelder FW. Vaccine-associated uveitis. Mo Med. 2016;113(1):48.
  • Renisi G, Lombardi A, Stanzione M, et al. Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence? Inter J Infect Dis. 2021;110:95–97.
  • ElSheikh RH, Haseeb A, Eleiwa TK, et al. Acute uveitis following COVID-19 vaccination. Ocul Immunol Inflamm. 2021;29(6):1–3.
  • Lee S, Sankhala KK, Bose S, et al. Combined central retinal artery and vein occlusion with ischemic optic neuropathy after COVID-19 vaccination. Int Med Case Rep J. 2022;15:7.
  • Rabinovitch T, Ben-Arie-Weintrob Y, Hareuveni-Blum T, et al. UVEITIS AFTER THE BNT162b2 mRNA VACCINATION AGAINST SARS-CoV-2 INFECTION: a possible association. Retina (Philadelphia, Pa.). 2021 Dec 1 41(12):2462–2471.
  • Ferretti F, Cannatelli R, Benucci M, et al. How to manage covid-19 vaccination in immune-Mediated inflammatory diseases: an expert opinion by IMIDs study group. Front Immunol. 2021;12:656362.
  • Bolletta E, Iannetta D, Mastrofilippo V, et al. Uveitis and other ocular complications following COVID-19 vaccination. J Clin Med. 2021;10(24):5960.
  • Maleki A, Look-Why S, Manhapra A, et al. COVID-19 recombinant mRNA vaccines and serious ocular inflammatory side effects: real or coincidence? J Ophthalmic Vis Res. 2021;16(3):490.
  • Xu Y, Shen W. Presumed recurrent MEWDS following Covid-19 vaccination. Ocul Immunol Inflamm. 2021;29(6):1234–1237.
  • Atas F, Kaya M, Saatci AO. Acute multifocal placoid pigment epitheliopathy-like presentation following the first dose of BNT162B2 COVID-19 vaccination. Ocul Immunol Inflamm. 2021;1–4. DOI:https://doi.org/10.1080/09273948.2021.1995763
  • Ishay Y, Kenig A, Tsemach-Toren T, et al. Autoimmune phenomena following SARS-CoV-2 vaccination. Int Immunopharmacol. 2021;99:107970.
  • Papasavvas I, Herbort CP. Reactivation of Vogt-Koyanagi-Harada disease under control for more than 6 years, following anti-SARS-CoV-2 vaccination. J Ophthalmic Inflamm Infect. 2021;11(1):1–6.
  • Mudie LI, Zick JD, Dacey MS, et al. Panuveitis following vaccination for COVID-19. Ocul Immunol Inflamm. 2021;29(4):741–742.
  • Saraceno JJF, Souza GM, Dos Santos Finamor LP, et al. Vogt-Koyanagi-Harada syndrome following COVID-19 and chAdOx1 nCoV-19 (AZD1222) vaccine. Int J Retina Vitreous. 2021;7(1):1–7.
  • Reddy Y, Pandey A, Ojha A, et al. Harada-like syndrome post-Covishield vaccination: a rare adverse effect. Indian J Ophthalmol. 2022;70(1):321–323.
  • Koong LR, Chee WK, Toh ZH, et al. Vogt-Koyanagi-Harada disease associated with COVID-19 mRNA vaccine. Ocul Immunol Inflamm. 2021;29(6):1–4.
  • Goyal M, Murthy SI, Annum S. Bilateral multifocal choroiditis following COVID-19 vaccination. Ocul Immunol Inflamm. 2021;29(4):753–757.
  • Mungmunpuntipantip R, Wiwanitkit V. COVID-19 vaccination and bilateral multifocal choroiditis. Ocul Immunol Inflamm. 2021;29(6):1.
  • Fowler N, Martinez NRM, Pallares BV, et al. Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine. Am J Ophthalmol Case Rep. 2021;23:101136.
  • Shah P, Zaveri JS, Haddock LJ. Acute macular neuroretinopathy following the administration of an influenza vaccination. Ophthalmic Surg Lasers Imaging Retina. 2018;49(10):e165–e168.
  • Bhavsar KV, Lin S, Rahimy E, et al. Acute macular neuroretinopathy: a comprehensive review of the literature. Surv Ophthalmol. 2016;61(5):538–565.
  • Jampol LM, Tauscher R, Schwarz HP. COVID-19, COVID-19 vaccinations, and subsequent abnormalities in the retina: causation or coincidence? JAMA Ophthalmol. 2021;139(10):1135–1136.
  • Bøhler AD, Strøm ME, Sandvig KU, et al. Acute macular neuroretinopathy following COVID-19 vaccination. Eye. 2021;36(3):1–2.
  • Michel T, Stolowy N, Gascon P, et al. Acute macular neuroretinopathy after COVID-19 vaccine. 2021.
  • Book BAJ, Schmidt B, Foerster AMH. Bilateral acute macular neuroretinopathy after vaccination against SARS-CoV-2. JAMA Ophthalmol. 2021;139(7):e212471–e212471.
  • Gabka K, Groselli S, Ulbig M. Flickering scotoma after COVID vaccination: a further possible side effect of vaccination? Der Ophthalmologe. 2021;118(7):735–740.
  • Valenzuela DA, Groth S, Taubenslag KJ, et al. Acute macular neuroretinopathy following Pfizer-BioNTech COVID-19 vaccination. Am J Ophthalmol Case Rep. 2021;24:101200.
  • Gabrielle P-H, Baudin F, Ghezala IB, et al. Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine. Am J Ophthalmol Case Rep. 2022;25:101281.
  • Sanjay S, Gadde SGK, Kumar Yadav N, et al. Bilateral sequential acute macular neuroretinopathy in an asian Indian female with β thalassemia trait following (Corona Virus Disease) COVID-19 vaccination and probable recent COVID Infection-Multimodal imaging study. Ocul Immunol Inflamm. 2022;1–6.
  • Franchi A, Rauchegger T, Palme C, et al. Two cases of acute macular neuroretinopathy associated with the adenovirus-based COVID-19 vaccine vaxzevria (AstraZeneca). Ocul Immunol Inflamm. 2022;1–6. DOI:https://doi.org/10.1080/09273948.2022.2027463.
  • Mambretti M, Huemer J, Torregrossa G, et al. Acute macular neuroretinopathy following coronavirus disease 2019 vaccination. Ocul Immunol Inflamm. 2021;29(4):730–733.
  • Chen X, Rahimy E, Sergott RC, et al. Spectrum of retinal vascular diseases associated with paracentral acute middle maculopathy. Am J Ophthalmol. 2015;160(1):26–34. e1.
  • Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection. Eye. 2020;34(12):2352–2353.
  • Rubinstein TJ. Thyroid eye disease following COVID-19 vaccine in a patient with a history Graves’ disease: a case report. Ophthalmic Plast Reconstr Surg. 2021;37(6):e221–e223.
  • Endo B, Bahamon S, Martínez-Pulgarín DF. Central retinal vein occlusion after mRNA SARS-CoV-2 vaccination: a case report. Indian J Ophthalmol. 2021;69(10):2865.
  • Bialasiewicz A, Farah-Diab M, Mebarki H. Central retinal vein occlusion occurring immediately after 2nd dose of mRNA SARS-CoV-2 vaccine. Int Ophthalmol. 2021;41(12):3889–3892.
  • Shah PP, Gelnick S, Jonisch J, et al. Central retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 messenger RNA vaccine. Retin Cases Brief Rep. 2021. DOI:https://doi.org/10.1097/ICB.0000000000001214.
  • Goyal M, Murthy SI, Srinivas Y. Unilateral retinal vein occlusion in a young, healthy male following sputnik V vaccination. Indian J Ophthalmol. 2021;69(12):3793–3794.
  • Sonawane NJ, Yadav D, Kota AR, et al. Central retinal vein occlusion post-COVID-19 vaccination. Indian J Ophthalmol. 2022;70(1):308–309.
  • Tanaka H, Nagasato D, Nakakura S, et al. Exacerbation of branch retinal vein occlusion post SARS-CoV2 vaccination. Medicine (Baltimore). 2021;100(50):e28236.
  • Ikegami Y, Numaga J, Okano N, et al. Combined central retinal artery and vein occlusion shortly after mRNA-SARS-CoV-2 vaccination. QJM. 2021;114(12):884–885.
  • Subramony R, Lin LC, Knight DK, et al. Bilateral retinal detachments in a healthy 22-year-old woman after moderna SARS-CoV-2 vaccination. J Emerg Med. 2021;61(6):e146–e150.
  • Chen SD, Hodge C. Response to” bilateral retinal detachments in a healthy 22-Year-Old woman after moderna SARS-CoV-2 vaccination“ R. J Emerg Med. 2022;S0736-4679(21):7–00936.
  • Leber HM, Sant’Ana L, Konichi da Silva NR, et al. Acute thyroiditis and bilateral optic neuritis following SARS-CoV-2 vaccination with coronavac: a case report. Ocul Immunol Inflamm. 2021;29(6):1–7.
  • Yen M-Y, Liu J-H. Bilateral optic neuritis following bacille Calmette-Guérin (BCG) vaccination. J Clin Neuroophthalmol. 1991;11(4):246–249.
  • Topaloglu H, Berker M, Kansu T, et al. Optic neuritis and myelitis after booster tetanus toxoid vaccination. Lancet. 1992;339(8786):178–179.
  • Geier DA, Geier DA, Geier MR, et al. A case-control study of serious autoimmune adverse events following hepatitis B immunization. Autoimmunity. 2005;38(4):295–301.
  • Stübgen J-P. A literature review on optic neuritis following vaccination against virus infections. Autoimmun Rev. 2013;12(10):990–997.
  • Pappaterra MC, Rivera EJ, Oliver AL. Transient oculomotor palsy following the administration of the messenger RNA-1273 vaccine for SARS-CoV-2 diplopia following the COVID-19 vaccine. J Neuroophthalmol. 2021. DOI:https://doi.org/10.1097/WNO.0000000000001369
  • Reyes-Capo DP, Stevens SM, Cavuoto KM. Acute abducens nerve palsy following COVID-19 vaccination. J Am Assoc Pediatr Ophthalmol Strabismus. 2021;25(5):302–303.
  • Bourtoulamaiou A, Yadav S, Nayak H. Benign recurrent sixth (abducens) nerve palsy following measles-mumps-rubella vaccination. Case Rep Pediatr. 2015;2015:1–2. 2015.
  • Leiderman YI, Lessell S, Cestari DM. Recurrent isolated sixth nerve palsy after consecutive annual influenza vaccinations in a child. J Am Assoc Pediatr Ophthalmol Strabismus. 2009;13(3):317–318.
  • İremli BG, Şendur SN, Ünlütürk U. Three cases of subacute thyroiditis following SARS-CoV-2 vaccine: postvaccination Asia syndrome. J Clin Endocrinol Metab. 2021;106(9):2600–2605.
  • Vera-Lastra O, Ordinola Navarro A, Cruz Domiguez MP, et al. Two cases of Graves’ disease following SARS-CoV-2 vaccination: an autoimmune/inflammatory syndrome induced by adjuvants. Thyroid. 2021;31(9):1436–1439.
  • Bayas A, Menacher M, Christ M, et al. Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Lancet. 2021;397(10285):e11.
  • Panovska-Stavridis I, Pivkova-Veljanovska A, Trajkova S, et al. A rare case of superior ophthalmic vein thrombosis and thrombocytopenia following ChAdOx1 nCoV-19 vaccine against SARS-CoV-2. Mediterr J Hematol Infect Dis. 2021;13(1):e2021048.
  • Chuang TY, Burda K, Teklemariam E, et al. Tolosa-Hunt syndrome presenting after COVID-19 vaccination. Cureus. 2021;13(7). DOI:https://doi.org/10.7759/cureus.16791.
  • Oldenburg J, Klamroth R, Langer F, et al. Diagnosis and management of vaccine-related thrombosis following AstraZeneca COVID-19 vaccination: guidance statement from the GTH. Hämostaseologie. 2021.
  • Cook T, Roberts J. Impact of vaccination by priority group on UK deaths, hospital admissions and intensive care admissions from COVID‐19. Anaesthesia. 2021;76(5):608–616.
  • Cunningham JET, Moorthy RS, Fraunfelder FW, et al. Vaccine-associated uveitis. Ocul Immunol Inflamm. 2019;27(4):517–520.
  • Watad A, Bragazzi NL, McGonagle D, et al. Autoimmune/inflammatory syndrome induced by adjuvants (Asia) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: insights from an analysis of 500 cases. Clin Immunol. 2019;203:1–8.
  • Steinberg J, Thomas A, Iravani A. 18F-fluorodeoxyglucose PET/CT findings in a systemic inflammatory response syndrome after COVID-19 vaccine. Lancet. 2021;397(10279):e9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.