102
Views
0
CrossRef citations to date
0
Altmetric
Review

Long term outcomes following anti-VEGF therapy for diabetic macular edema

, &
Pages 307-319 | Received 11 Jul 2022, Accepted 29 Sep 2022, Published online: 14 Oct 2022

References

  • Varma R, Bressler NM, Doan QV, et al. Prevalence of and risk factors for diabetic macular edema in the United States. JAMA Ophthalmol. 2014;132(11):1334–1340.
  • Bhagat N, Grigorian RA, Tutela A, et al. Diabetic macular edema: pathogenesis and treatment. Surv Ophthalmol. 2009;54(1):1–32.
  • Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema pathophysiology, screening, and novel therapies. Diabetes Care. 2003;26(9):2653–2664.
  • ETDRS Study Research Group, Photocoagulation for diabetic macular edema: early treatment diabetic retinopathy study report number 1. Arch Ophthalmol. 1985;103(12):1796–1806.
  • Rajendram R, Fraser-Bell S, Kaines A, et al. A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-Month data: report 3. Arch Ophtalmol. 2012;130(8):972–979.
  • Brown DM, Nguyen QD, Marcus DM, et al. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology. 2013;120(10):2013–2022.
  • Schmidt-Erfurth U, Lang GE, Holz FG, et al. Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study. Ophthalmology. 2014;121(5):1045–1053.
  • Ishibashi T, Li X, Koh A, et al. The REVEAL study: ranibizumab monotherapy or combined with laser versus laser monotherapy in Asian patients with diabetic macular edema. Ophthalmology. 2015;122(7):1402–1415.
  • Wells JA, Glassman AR, Ayala AR, et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema: two-year results from a comparative effectiveness randomized clinical trial. Ophthalmology. 2016;123(6):1351–1359.
  • Bressler SB, Glassman AR, Almukhtar T, et al. Five-year outcomes of ranibizumab with prompt or deferred laser versus laser or triamcinolone plus deferred ranibizumab for diabetic macular edema. Am J Ophthalmol. 2016;164:57–68.
  • Do DV, Nguyen QD, Khwaja AA, et al. Ranibizumab for edema of the macula in diabetes study: 3-year outcomes and the need for prolonged frequent treatment. JAMA Ophthalmol. 2013;131(2):139–145.
  • Do DV, Nguyen QD, Boyer D, et al. One-year outcomes of the da VINCI study of VEGF trap-eye in eyes with diabetic macular edema. Ophthalmology. 2012;119(8):1658–1665.
  • Heier JS, Korobelnik JF, Brown DM, et al. Intravitreal aflibercept for diabetic macular edema: 148-week results from the vista and VIVID studies. Ophthalmology. 2016;123(11):2376–2385.
  • Waheed NK, Duker JS. OCT in the management of diabetic macular edema. Curr Ophthalmol Rep. 2013;1(3):128–133.
  • Browning DJ, Stewart MW, Lee C. Diabetic macular edema: evidence-based management. Indian J Ophthalmol. 2018;66(12):1736–1750.
  • Baskin DE. Optical coherence tomography in diabetic macular edema. Curr Opin Ophthalmol. 2010;21(3):172–177.
  • Kumar V, Surve A, Kumawat D, et al. Ultra-wide field retinal imaging: a wider clinical perspective. Indian J Ophthalmol. 2021;69(4):824–835.
  • Ghasemi Falavarjani K, Tsui I, Sadda SR. Ultra-wide-field imaging in diabetic retinopathy. Vision Res. 2017;139:187–190.
  • Wecker T, Ehlken C, Bühler A, et al. Five-year visual acuity outcomes and injection patterns in patients with pro-re-nata treatments for AMD, DME, RVO and myopic CNV. Br J Ophthalmol. 2017;101(3):353–359.
  • Zirpel JJ, Pfister IB, Gerhardt C, et al. Long-term outcomes of intravitreal therapy for symptomatic diabetic macular oedema in a real-world setting in Switzerland. Graefe’s Arch Clin Exp Ophthalmol. 2021;259(12):3569–3578.
  • Arevalo JF, Lasave AF, Wu L, et al. Intravitreal bevacizumab for diabetic macular oedema: 5-year results of the Pan-American collaborative retina study group. Br J Ophthalmol. 2016;100(12):1605–1610.
  • Sun JK, wen WP, Taylor S, et al. Durability of diabetic retinopathy improvement with as-needed ranibizumab: open-label extension of RIDE and RISE studies. Ophthalmology. 2019;126(5):712–720.
  • Borrelli E, Grosso D, Barresi C, et al. Long-term visual outcomes and morphologic biomarkers of vision loss in eyes with diabetic macular edema treated with anti-VEGF therapy. Am J Ophthalmol. 2022;235:80–89.
  • Kessler LJ, Auffarth GU, Bagautdinov D, et al. Ellipsoid zone integrity and visual acuity changes during diabetic macular edema therapy: a longitudinal study. J Diabetes Res. 2021;2021:1–10.
  • Maggio E, Sartore M, Attanasio M, et al. Anti–vascular endothelial growth factor treatment for diabetic macular edema in a real-world clinical setting. Am J Ophthalmol. 2018;195:209–222.
  • Maguire MG, Liu D, Glassman AR, et al. Visual field changes over 5 years in patients treated with panretinal photocoagulation or ranibizumab for proliferative diabetic retinopathy. JAMA Ophthalmol. 2022;138(3):285–293.
  • Hutton DW, Stein JD, Glassman AR, et al. Five-year cost-effectiveness of intravitreous ranibizumab therapy vs panretinal photocoagulation for treating proliferative diabetic retinopathy: a secondary analysis of a randomized clinical trial. JAMA Ophthalmol. 2019;137(12):1424–1432.
  • Boyer DS, Nguyen QD, Brown DM, et al. Outcomes with as-needed ranibizumab after initial monthly therapy: long-term outcomes of the phase III RIDE and RISE trials. Ophthalmology. 2015;122(12):2504–2513.
  • Gross JG, Glassman AR, Liu D, et al. Five-year outcomes of panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA Ophthalmol. 2018;136(10):1138–1148.
  • Bressler SB, Odia I, Glassman AR, et al. Changes in diabetic retinopathy severity when treating diabetic macular edema with ranibizumab DRCR.NET protocol I 5-year report. Retina. 2018;38(10):1896–1904.
  • Wykoff CC, Elman MJ, Regillo CD, et al. Predictors of diabetic macular edema treatment frequency with ranibizumab during the open-label extension of the RIDE and RISE trials. Ophthalmology. 2016;123(8):1716–1721.
  • Wykoff CC, Ou WC, Khurana RN, et al. Long-term outcomes with as-needed aflibercept in diabetic macular oedema: 2-year outcomes of the ENDURANCE extension study. Br J Ophthalmol. 2018;102(5):631–636.
  • Glassman AR, Wells JA, Josic K, et al. Five-year outcomes after initial aflibercept, bevacizumab, or ranibizumab treatment for diabetic macular edema (Protocol T extension study). Ophthalmology. 2020;127(9):1201–1210.
  • Elman MJ, Ayala A, Bressler NM, et al. Intravitreal ranibizumab for diabetic macular edema with prompt vs. deferred laser treatment: 5-year randomized trial results. Ophthalmology. 2015;122(2):375–381.
  • Ciulla TA, Hussain RM, Taraborelli D, et al. Longer-term anti-vegf therapy outcomes in neovascular age-related macular degeneration, diabetic macular edema, and vein occlusion-related macular edema clinical outcomes in 130 247 eyes. Ophthalmol Retina. 2022;6(9):796–806.
  • Biechl AC, Bhandari S, Nguyen V, et al. Changes in real-world treatment patterns for diabetic macular oedema from 2009 to 2019 and 5-year outcomes: data from the fight retinal blindness! Registry. Clin Exp Ophthalmol. 2020;48(6):802–812.
  • Weingessel B, Miháltz K, Gleiss A, et al. Treatment of diabetic macular edema with intravitreal antivascular endothelial growth factor and prompt versus deferred focal laser during long-term follow-up and identification of prognostic retinal markers. J. Ophthal. 2018; 2018: 1–11.
  • Maguire MG, Liu D, Bressler SB, et al. Lapses in care among patients assigned to ranibizumab for proliferative diabetic retinopathy a post hoc analysis of a randomized clinical trial supplemental content and journal club slides. JAMA Ophthalmol. 2021;139. 1266–1273.
  • Khoshnood B, Mesbah M, Jeanbat V, et al. Transforming scales of measurement of visual acuity at the group level. Ophthalmic Physiol Optics. 2010;30(6):816–823.
  • Rosenthal Robert. Meta-analytic procedures for social research. In: Brickman L, Rog D, editors. Applied social research methods series. Vol. 6. Newbury (CA): SAGE Publications, Inc; 1993.
  • Elman MJ, Aiello LP, Beck RW, et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117(6):1064–1077.
  • Gross JG, Glassman AR, Jampol LM, et al. Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA. 2015;314(20):2137–2146. Erratum in: JAMA. 315(9), 944 (2016). Erratum in: JAMA. 321(10), 1008 (2019).
  • Romero-Aroca P, de La Riva-Fernandez S, Valls-Mateu A, et al. Cost of diabetic retinopathy and macular oedema in a population, an eight year follow up. BMC Ophthalmol. 2016;16(1). doi:10.1186/s12886-016-0318-x.
  • Gabrielle PH, Nguyen V, Bhandari S, et al. Initial observation or treatment for diabetic macular oedema with good visual acuity: two-year outcomes comparison in routine clinical practice: data from the Fight Retinal Blindness! Registry. Acta Ophthalmol. 2022;100(3):285–294.
  • Virgili G, Parravano M, Evans JR, et al.Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis. Cochrane Database Syst Rev. 2017;6(6). Published online 2017 Jun 22. [Accessed 2022 Aug 31]
  • Brown DM, Emanuelli A, Bandello F, et al. KESTREL and KITE: 52-week results from two phase III pivotal trials of brolucizumab for diabetic macular edema. Am J Ophthalmol. 2022;238:157–172.
  • Wykoff CC, Abreu F, Adamis AP, et al. Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials. Lancet. 2022;399(10326): 741–755.
  • Roche Doing now what patients need next [Internet]. cited 2022 Aug 31. Available from: https://www.roche.com/media/releases/med-cor-2021-10-22b.
  • Urbančič M, Topčić IG. Dexamethasone implant in the management of diabetic macular edema from clinician’s perspective. Clin Ophthalmol. 2019;13:821–828.
  • Madjedi K, Pereira A, Ballios BG, et al. Switching between anti-VEGF agents in the management of refractory diabetic macular edema: a systematic review. Surv Ophthalmol. 2022;67(5):1364–1372.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.