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Original Articles

Oxytocin receptor gene variation predicts subjective responses to MDMA

, , , , &
Pages 592-599 | Received 25 Sep 2015, Accepted 11 Jan 2016, Published online: 17 Feb 2016

References

  • Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3(2), 128–134. doi:10.1093/scan/nsn004
  • Bedi, G., Phan, K. L., Angstadt, M., & de Wit, H. (2009). Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology, 207(1), 73–83. doi:10.1007/s00213-009-1635-z
  • Bravo, G. L. (2001). What does MDMA feel like? In J. Holland (Ed.), Ecstasy: The complete guide: A comprehensive look at the risks and benefits of MDMA. Rochester, VT: Park Street Press.
  • Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M. (2015). Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach. Translational Psychiatry, 5(10), e664. doi:10.1038/tp.2015.163
  • Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceedings of the National Academy of Sciences, 108(50), 19937–19942. doi:10.1073/pnas.1113079108
  • Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry, 65(9), 728–731. doi:10.1016/j.biopsych.2008.10.011
  • Doblin, R. (2002). A clinical plan for MDMA (Ecstasy) in the treatment of posttraumatic stress disorder (PTSD): Partnering with the FDA. Journal of Psychoactive Drugs, 34(2), 185–194. doi:10.1080/02791072.2002.10399952
  • Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., Verkes, R. J. (2009). Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Social Neuroscience, 4(4), 359–366. doi:10.1080/17470910802649470
  • First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. (1996). Structured clinical interview for DSM-IV axis I disorders. New York, NY: Biometrics Research Department.
  • Fischman, M. W., & Foltin, R. W. (1991). Utility of subjective effects measurements in assessing abuse liability of drugs in humans. British Journal of Addiction, 86(12), 1563–1570. doi:10.1111/j.1360-0443.1991.tb01749.x
  • Greer, G., & Tolbert, R. (1986). Subjective reports of the effects of MDMA in a clinical setting. Journal of Psychoactive Drugs, 18(4), 319–327. doi:10.1080/02791072.1986.10472364
  • Grewen, K. M., Girdler, S. S., Amico, J., & Light, K. C. (2005). Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosomatic Medicine, 67(4), 531–538. doi:10.1097/01.psy.0000170341.88395.47
  • Grinspoon, L., & Bakalar, J. B. (1986). Can drugs be used to enhance the psychotherapeutic process. American Journal of Psychotherapy, 40(3), 393–404.
  • Han, D. D., & Gu, H. H. (2006). Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacology, 6, 6. doi:10.1186/1471-2210-6-6
  • Hart, A. B., de Wit, H., & Palmer, A. A. (2013). Candidate gene studies of a promising intermediate phenotype: Failure to replicate. Neuropsychopharmacology, 38(5), 802–816. doi:10.1038/npp.2012.245
  • Hysek, C. M., Domes, G., & Liechti, M. E. (2012). MDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions. Psychopharmacology, 222(2), 293–302. doi:10.1007/s00213-012-2645-9
  • Hysek, C. M., Schmid, Y., Simmler, L. D., Domes, G., Heinrichs, M., Eisenegger, C., Liechti, M. E. (2013). MDMA enhances emotional empathy and prosocial behavior. Social Cognitive and Affective Neuroscience, nst161. doi:10.1093/scan/nst161
  • Jostins, L., Pickrell, J. K., MacArthur, D. G., & Barrett, J. C. (2012). Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality. Proceedings of the National Academy of Sciences, 109(18), E1048–E1048. doi:10.1073/pnas.1202539109
  • Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., … Taylor, S. E. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences, 107(36), 15717–15721. doi:10.1073/pnas.1010830107
  • Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014a). Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology, 46, 23–31. doi:10.1016/j.psyneuen.2014.04.006
  • Kirkpatrick, M. G., Lee, R., Wardle, M. C., Jacob, S., & de Wit, H. (2014b). Effects of MDMA and Intranasal Oxytocin on Social and Emotional Processing. Neuropsychopharmacology, 39(7), 1654–1663. doi:10.1016/j.psyneuen.2014.04.006
  • Kogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., & Rodrigues Saturn, S. (2011). Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition’. Proceedings of the National Academy of Sciences, 108(48), 19189–19192. doi:10.1073/pnas.1112658108
  • Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. doi:10.1038/nature03701
  • Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., … Lipsky, R. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6. doi:10.3389/fnhum.2012.00004
  • Kuypers, K. P., Torre Fornell, R. D. L., Farré Albadalejo, M., Lahoz, Y., Dziobek, I., Van Den Bos, W., & Ramaekers, J. G. (2014). No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS ONE, 9(6), e100719. doi:10.1371/journal.pone.0100719
  • Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., … Kroemer, H. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(5), 860–866. doi:10.1016/j.pnpbp.2009.04.004
  • Marsh, A. A., Henry, H. Y., Pine, D. S., Gorodetsky, E. K., Goldman, D., & Blair, R. (2012). The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology, 224(4), 469–476. doi:10.1007/s00213-012-2775-0
  • McGregor, I., Callaghan, P., & Hunt, G. (2009). From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? British Journal of Pharmacology, 154(2), 358–368. doi:10.1038/bjp.2008.132
  • McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2015). Distress of ostracism: Oxytocin receptor gene polymorphism confers sensitivity to social exclusion. Social Cognitive and Affective Neuroscience, nsu166. doi:10.1093/scan/nsu166
  • Mithoefer, M., Wagner, M., Mithoefer, A., Jerome, L., Martin, S., & Yazar-Klosinski, B. (2013). Durability of improvement in PTSD symptoms and absence of harmful effects or drug dependency after MDMA-assisted psychotherapy: A prospective long-term follow-up study. Journal of Psychopharmacology (Oxford, England), 27(1), 28–39. doi:10.1177/0269881112456611
  • Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011). The safety and efficacy of±3, 4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439–452. doi:10.1177/0269881110378371
  • Norman, G. J., Cacioppo, J. T., Morris, J. S., Karelina, K., Malarkey, W. B., DeVries, A. C., & Berntson, G. G. (2011). Selective influences of oxytocin on the evaluative processing of social stimuli. Journal of Psychopharmacology, 25(10), 1313–1319. doi:10.1177/0269881110367452
  • Riedlinger, J., & Montagne, M. (2001). Using MDMA in the treatment of depression. In J. Holland (Ed.), Ecstasy: The complete guide. Rochester, VT: Park Street Press.
  • Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences, 106(50), 21437–21441. doi:10.1073/pnas.0909579106
  • Sumnall, H. R., Cole, J. C., & Jerome, L. (2006). The varieties of ecstatic experience: An exploration of the subjective experiences of ecstasy. Journal of Psychopharmacology, 20(5), 670–682. doi:10.1177/0269881106060764
  • Ter Bogt, T. F., & Engels, R. C. M. E. (2005). “Partying” hard: Party style, motives for and effects of MDMA use at rave parties. Substance Use & Misuse, 40(9–10), 1479–1502. doi:10.1081/JA-200066822
  • Thompson, M., Callaghan, P., Hunt, G., Cornish, J., & McGregor, I. (2007). A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3, 4 methylenedioxymethamphetamine (“ecstasy”). Neuroscience, 146(2), 509–514. doi:10.1016/j.neuroscience.2007.02.032
  • Thompson, M., Hunt, G., & McGregor, I. (2009). Neural correlates of MDMA (“Ecstasy”)-induced social interaction in rats. Social Neuroscience, 4(1), 60–72. doi:10.1080/17470910802045042
  • Tops, M., van IJzendoorn, M. H., Riem, M. M., Boksem, M. A., & Bakermans-Kranenburg, M. J. (2011). Oxytocin receptor gene associated with the efficiency of social auditory processing. Frontiers in Psychiatry, (2). doi:10.3389/fpsyt.2011.00060
  • Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., … Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences, 107(31), 13936–13941. doi:10.1073/pnas.1003296107
  • Verrico, C. D., Miller, G. M., & Madras, B. K. (2006). MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: Implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology, 189(4), 489–503. doi:10.1007/s00213-005-0174-5
  • Wardle, M. C., & de Wit, H. (2014). MDMA alters emotional processing and facilitates positive social interaction. Psychopharmacology, 231(21), 1–11. doi:10.1007/s00213-014-3570-x
  • Wardle, M. C., Kirkpatrick, M. G., & de Wit, H. (2014). ‘Ecstasy’ as a social drug: MDMA preferentially affects responses to emotional stimuli with social content. Social Cognitive and Affective Neuroscience, nsu035. doi:10.1093/scan/nsu035
  • White, T. L., Justice, A. J. H., & de Wit, H. (2002). Differential subjective effects of d-amphetamine by gender, hormone levels and menstrual cycle phase. Pharmacology, Biochemistry and Behavior, 73(4), 729–741. doi:10.1016/S0091-3057(02)00818-3

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