Behavioral and autonomic reactivity to moral dilemmas in frontotemporal dementia versus Alzheimer’s disease

References

• Baez, S., Couto, B., Torralva, T., Sposato, L. A., Huepe, D., Montanes, P., … Ibanez, A. (2014). Comparing moral judgments of patients with frontotemporal dementia and frontal stroke. JAMA Neurology, 71(9), 1172–1176. doi:10.1001/jamaneurol.2014.347
   PubMed Web of Science ®Google Scholar
• Borg, J. S., Hynes, C., Van Horn, J., Grafton, S., & Sinnott-Armstrong, W. (2006). Consequences, action, and intention as factors in moral judgments: An fMRI investigation. Journal of Cognitive Neuroscience, 18(5), 803–817. doi:10.1162/jocn.2006.18.5.803
   PubMed Web of Science ®Google Scholar
• Carr, A. R., Paholpak, P., Daianu, M., Fong, S. S., Mather, M., Jimenez, E. E., … Mendez, M. F. (2015). An investigation of care-based vs. rule-based morality in frontotemporal dementia, Alzheimer’s disease, and healthy controls. Neuropsychologia, 78, 73–79. doi:10.1016/j.neuropsychologia.2015.09.033
   PubMed Web of Science ®Google Scholar
• Chiong, W., Wilson, S. M., D’Esposito, M., Kayser, A. S., Grossman, S. N., Poorzand, P., … Rankin, K. P. (2013). The salience network causally influences default mode network activity during moral reasoning. Brain: A Journal of Neurology, 136(Pt 6), 1929–1941. doi:10.1093/brain/awt066
   PubMed Web of Science ®Google Scholar
• Christensen, J. F., Flexas, A., Calabrese, M., Gut, N. K., & Gomila, A. (2014). Moral judgment reloaded: A moral dilemma validation study. Frontiers in Psychology, 5, 607. doi:10.3389/fpsyg.2014.00607
   PubMed Web of Science ®Google Scholar
• Ciaramelli, E., Muccioli, M., Làdavas, E., & di Pellegrino, G. (2007). Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Social Cognitive and Affective Neuroscience, 2(2), 84–92. doi:10.1093/scan/nsm001
   PubMed Web of Science ®Google Scholar
• Damasio, A. R. (1994). Descartes’ error: Emotion, reason, and the human brain. New York, NY: Putnam.
   Google Scholar
• Decety, J. (2011). The neuroevolution of empathy. Annals of the New York Academy of Sciences, 1231, 35–45. doi:10.1111/j.1749-6632.2011.06027.x
   PubMed Web of Science ®Google Scholar
• Decety, J., & Howard, L. H. (2013). The role of affect in the neurodevelopment of morality. Child Development Perspectives, 7(1), 49–54. doi:10.1111/cdep.12020
   Web of Science ®Google Scholar
• Decety, J., & Jackson, P. L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3(2), 71–100. doi:10.1177/1534582304267187
   PubMedGoogle Scholar
• Decety, J., Michalska, K. J., & Kinzler, K. D. (2012). The contribution of emotion and cognition to moral sensitivity: A neurodevelopmental study. Cerebral Cortex, 22(1), 209–220. doi:10.1093/cercor/bhr111
   PubMed Web of Science ®Google Scholar
• Diehl-Schmid, J., Perneczky, R., Koch, J., Nedopil, N., & Kurz, A. (2013). Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration. Cognitive And Behavioral Neurology, 26(2), 73–77. doi:10.1097/WNN.0b013e31829cff11
   PubMed Web of Science ®Google Scholar
• Drevets, W. C., & Raichle, M. E. (1998). Suppression of regional cerebral blood during emotional versus higher cognitive processes: Implications for interactions between emotion and cognition. Cognition and Emotion, 12, 353–385. doi:10.1080/026999398379646
   Web of Science ®Google Scholar
• Eslinger, P. J., Moore, P., Anderson, C., & Grossman, M. (2011). Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. Journal of Neuropsychiatry, 23(1), 74–82. doi:10.1176/appi.neuropsych.23.1.74
   PubMed Web of Science ®Google Scholar
• Figner, B., & Murphy, R. O. (2011). Using skin conductance in judgment and decision making research. In A. K. M. Schulte-Mecklenbeck & R. Ranyard (Eds.), A handbook of process tracing methods for decision research (pp. 163–184). New York, NY: Psychology Press.
   Google Scholar
• Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. doi:10.1016/0022-3956(75)90026-6
   PubMed Web of Science ®Google Scholar
• Foot, P. (1967). The problem of abortion and the doctrine of the double effect. Oxford Review, 5, 1–5.
   Google Scholar
• Gleichgerrcht, E., Torralva, T., Rattazzi, A., Marenco, V., Roca, M., & Manes, F. (2013). Selective impairment of cognitive empathy for moral judgment in adults with high functioning autism. Social Cognitive and Affective Neuroscience, 8(7), 780–788. doi:10.1093/scan/nss067
   PubMed Web of Science ®Google Scholar
• Gleichgerrcht, E., Torralva, T., Roca, M., Pose, M., & Manes, F. (2011). The role of social cognition in moral judgment in frontotemporal dementia. Social Neuroscience, 6(2), 113–122. doi:10.1080/17470919.2010.506751
   PubMed Web of Science ®Google Scholar
• Greene, J., & Haidt, J. (2002). How (and where) does moral judgment work?. Trends in Cognitive Sciences, 6(12), 517–523. doi:10.1016/S1364-6613(02)02011-9
   PubMed Web of Science ®Google Scholar
• Greene, J. D. (2013). Moral tribes. Emotion, reason, and the gap between us and them. New York, NY: Penguin Press.
   Google Scholar
• Greene, J. D., Nystrom, L. E., Engell, A. D., Darley, J. M., & Cohen, J. D. (2004). The neural bases of cognitive conflict and control in moral judgment. Neuron, 44(2), 389–400. doi:10.1016/j.neuron.2004.09.027
   PubMed Web of Science ®Google Scholar
• Greene, J. D., Sommerville, R. B., Nystrom, L. E., Darley, J. M., & Cohen, J. D. (2001). An fMRI investigation of emotional engagement in moral judgment. Science, 293(5537), 2105–2108. doi:10.1126/science.1062872
   PubMed Web of Science ®Google Scholar
• Haidt, J. (2001). The emotional dog and its rational tail: A social intuitionist approach to moral judgment. Psychological Review, 108(4), 814–834. doi:10.1037/0033-295X.108.4.814
   PubMed Web of Science ®Google Scholar
• Hauser, M. D., Cushman, F., Young, L., Jin, E., & Mikhail, J. (2007). A dissociation between moral judgments and justifications. Mind & Language, 22(1), 1–21. doi:10.1111/j.1468-0017.2006.00297.x
   Web of Science ®Google Scholar
• Kahane, G. (2015). Sidetracked by trolleys: Why sacrificial moral dilemmas tell us little (or nothing) about utilitarian judgment. Social Neuroscience, 10(5), 551–560. doi:10.1080/17470919.2015.1023400
   PubMed Web of Science ®Google Scholar
• Kahane, G., Everett, J. A., Earp, B. D., Farias, M., & Savulescu, J. (2015). ‘Utilitarian’ judgments in sacrificial moral dilemmas do not reflect impartial concern for the greater good. Cognition, 134, 193–209. doi:10.1016/j.cognition.2014.10.005
   PubMed Web of Science ®Google Scholar
• Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., & Damasio, A. (2007). Damage to the prefrontal cortex increases utilitarian moral judgements. Nature, 446(7138), 908–911. doi:10.1038/nature05631
   PubMed Web of Science ®Google Scholar
• Liao, S. M., Wiegmann, A., Alexander, J., & Vong, G. (2012). Putting the trolley in order: Experimental philosophy and the loop case. Philosophical Psychology, 25(5), 661–671.
   Google Scholar
• Liljegren, M., Naasan, G., Temlett, J., Perry, D. C., Rankin, K. P., Merrilees, J., … Miller, B. L. (2015). Criminal behavior in frontotemporal dementia and Alzheimer disease. JAMA Neurology, 72(3), 295–300. doi:10.1001/jamaneurol.2014.3781
   PubMed Web of Science ®Google Scholar
• Manfrinati, A., Lotto, L., Sarlo, M., Palomba, D., & Rumiati, R. (2013). Moral dilemmas and moral principles: When emotion and cognition unite. Cognition & Emotion, 27(7), 1276–1291. doi:10.1080/02699931.2013.785388
   PubMed Web of Science ®Google Scholar
• McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Jr., Kawas, C. H., … Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement, 7(3), 263–269. doi:10.1016/j.jalz.2011.03.005
   PubMed Web of Science ®Google Scholar
• Mendez, M. F. (2009). The neurobiology of moral behavior: Review and neuropsychiatric implications. CNS Spectrums, 14(11), 608–620.
   PubMed Web of Science ®Google Scholar
• Mendez, M. F., Anderson, E., & Shapira, J. S. (2005). An investigation of moral judgement in frontotemporal dementia. Cognitive and Behavioral Neurology, 18(4), 193–197. doi:10.1097/01.wnn.0000191292.17964.bb
   PubMed Web of Science ®Google Scholar
• Mendez, M. F., Chen, A. K., Shapira, J. S., & Miller, B. L. (2005). Acquired sociopathy and frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 20(2–3), 99–104. doi:10.1159/000086474
   PubMed Web of Science ®Google Scholar
• Mendez, M. F., & Shapira, J. S. (2009). Altered emotional morality in frontotemporal dementia. Cognitive Neuropsychiatry, 14(3), 165–179. doi:10.1080/13546800902924122
   PubMedGoogle Scholar
• Miller, B. L., Darby, A., Benson, D. F., Cummings, J. L., & Miller, M. H. (1997). Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia. The British Journal of Psychiatry, 170, 150–154. doi:10.1192/bjp.170.2.150
   PubMed Web of Science ®Google Scholar
• Moll, J., & de Oliveira-Souza, R. (2007). Moral judgments, emotions and the utilitarian brain. Trends in Cognitive Sciences, 11(8), 319–321. doi:10.1016/j.tics.2007.06.001
   PubMed Web of Science ®Google Scholar
• Moretto, G., Làdavas, E., Mattioli, F., & di Pellegrino, G. (2010). A psychophysiological investigation of moral judgment after ventromedial prefrontal damage. Journal of Cognitive Neuroscience, 22(8), 1888–1899. doi:10.1162/jocn.2009.21367
   PubMed Web of Science ®Google Scholar
• Navarrete, C. D., McDonald, M. M., Mott, M. L., & Asher, B. (2012). Virtual morality: Emotion and action in a simulated three-dimensional “trolley problem”. Emotion, 12(2), 364–370. doi:10.1037/a0025561
   PubMed Web of Science ®Google Scholar
• Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., … Benson, D. F. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51(6), 1546–1554. doi:10.1212/WNL.51.6.1546
   PubMed Web of Science ®Google Scholar
• Oliver, L. D., Mitchell, D. G., Dziobek, I., MacKinley, J., Coleman, K., Rankin, K. P., & Finger, E. C. (2015). Parsing cognitive and emotional empathy deficits for negative and positive stimuli in frontotemporal dementia. Neuropsychologia, 67, 14–26. doi:10.1016/j.neuropsychologia.2014.11.022
   PubMed Web of Science ®Google Scholar
• Piguet, O., Hornberger, M., Mioshi, E., & Hodges, J. R. (2011). Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management. The Lancet Neurology, 10(2), 162–172. doi:10.1016/S1474-4422(10)70299-4
   PubMed Web of Science ®Google Scholar
• Possin, K. L., Feigenbaum, D., Rankin, K. P., Smith, G. E., Boxer, A. L., Wood, K., … Kramer, J. H. (2013). Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias. Neurology, 80(24), 2180–2185. doi:10.1212/WNL.0b013e318296e940
   PubMed Web of Science ®Google Scholar
• Rankin, K. P., Kramer, J. H., & Miller, B. L. (2005). Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cognitive and Behavioral Neurology, 18(1), 28–36. doi:10.1097/01.wnn.0000152225.05377.ab
   PubMed Web of Science ®Google Scholar
• Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., … Miller, B. L. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain: A Journal of Neurology, 134(Pt 9), 2456–2477. doi:10.1093/brain/awr179
   PubMed Web of Science ®Google Scholar
• Rosas, A., & Koenigs, M. (2014). Beyond “utilitarianism”: Maximizing the clinical impact of moral judgment research. Social Neuroscience, 9(6), 661–667. doi:10.1080/17470919.2014.937506
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory, S. G., Aharon-Peretz, J., & Perry, D. (2009). Two systems for empathy: A double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain: A Journal of Neurology, 132(Pt 3), 617–627. doi:10.1093/brain/awn279
   PubMed Web of Science ®Google Scholar
• Tassy, S., Deruelle, C., Mancini, J., Leistedt, S., & Wicker, B. (2013). High levels of psychopathic traits alters moral choice but not moral judgment. Frontiers in Human Neuroscience, 7, 229. doi:10.3389/fnhum.2013.00229
   PubMed Web of Science ®Google Scholar
• Tassy, S., Oullier, O., Mancini, J., & Wicker, B. (2013). Discrepancies between judgment and choice of action in moral dilemmas. Frontiers in Psychology, 4, 250. doi:10.3389/fpsyg.2013.00250
   PubMed Web of Science ®Google Scholar
• Thomson, J. J. (1976). Killing, letting die, and the trolley problem. The Monist, 59(2), 204–217. doi:10.5840/monist197659224
   PubMed Web of Science ®Google Scholar
• Young, L., & Koenigs, M. (2007). Investigating emotion in moral cognition: A review of evidence from functional neuroimaging and neuropsychology. British Medical Bulletin, 84, 69–79. doi:10.1093/bmb/ldm031
   PubMed Web of Science ®Google Scholar
• Zhang, S., Hu, S., Chao, H. H., Ide, J. S., Luo, X., Farr, O. M., & Li, C. S. (2014). Ventromedial prefrontal cortex and the regulation of physiological arousal. Social Cognitive and Affective Neuroscience, 9(7), 900–908. doi:10.1093/scan/nst064
   PubMed Web of Science ®Google Scholar
• Zhang, S., Hu, S., Chao, H. H., Luo, X., Farr, O. M., & Li, C. S. (2012). Cerebral correlates of skin conductance responses in a cognitive task. Neuroimage, 62(3), 1489–1498. doi:10.1016/j.neuroimage.2012.05.036
   PubMed Web of Science ®Google Scholar