Acetaminophen does not affect cardiac and brain responses to social rejection but seems to attenuate behavioral adaptation in a social judgment task

References

• Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An Inventory for Measuring Depression. Archives of General Psychiatry, 4(6), 561–571.
   Web of Science ®Google Scholar
• Botvinick, M. M., Cohen, J. D., & Carter, C. S. (2004). Conflict monitoring and anterior cingulate cortex: An update. Trends in Cognitive Sciences, 8(12), 539–546. https://doi.org/10.1016/j.tics.2004.10.003
   PubMed Web of Science ®Google Scholar
• Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215–222. https://doi.org/10.1016/S1364-6613(00)01483-2
   PubMed Web of Science ®Google Scholar
• Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280(5364), 747–749. https://doi.org/10.1126/science.280.5364.747
   PubMed Web of Science ®Google Scholar
• Dekkers, L. M., Van Der Molen, M. J., Gunther Moor, B., Van Der Veen, F. M., & Van Der Molen, M. W. (2015). Cardiac and electro-cortical concomitants of social feedback processing in women. Social Cognitive and Affective Neuroscience, 10(11), 1506–1514. https://doi.org/10.1093/scan/nsv039
   PubMed Web of Science ®Google Scholar
• DeWall, C. N., MacDonald, G., Webster, G. D., Masten, C. L., Baumeister, R. F., Powell, C., … Eisenberger, N. I. (2010). Acetaminophen reduces social pain: Behavioral and neural evidence. Psychological Science, 21(7), 931–937. https://doi.org/10.1177/0956797610374741
   PubMed Web of Science ®Google Scholar
• Durso, G. R., Luttrell, A., & Way, B. M. (2015). Over-the-counter relief from pains and pleasures alike: Acetaminophen blunts evaluation sensitivity to both negative and positive stimuli. Psychological Science, 26(6), 750–758. https://doi.org/10.1177/0956797615570366
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I. (2012). The pain of social disconnection: Examining the shared neural underpinnings of physical and social pain. Nature Reviews Neuroscience, 13(6), 421–434. https://doi.org/10.1038/nrn3231
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I. (2015). Social pain and the brain: Controversies, questions, and where to go from here. Annual Review of Psychology, 66(1), 601–629. https://doi.org/10.1146/annurev-psych-010213-115146
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I., & Lieberman, M. D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8(7), 294–300. https://doi.org/10.1016/j.tics.2004.05.010
   PubMed Web of Science ®Google Scholar
• Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302(5643), 290–292. https://doi.org/10.1126/science.1089134
   PubMed Web of Science ®Google Scholar
• Eysenck, S. B., Eysenck, H. J., & Barrett, P. (1985). A revised version of the psychoticism scale. Personality and Individual Differences, 6(1), 21–29. https://doi.org/10.1016/0191-8869(85)90026-1
   Web of Science ®Google Scholar
• Firestone, L. L., Gyulai, F., Mintun, M., Adler, L. J., Urso, K., & Winter, P. M. (1996). Human brain activity response to fentanyl imaged by positron emission tomography. Anesthesia & Analgesia,82(6), 1247–1251.
   PubMed Web of Science ®Google Scholar
• Fung, K., & Alden, L. E. (2017). Once hurt, twice shy: Social pain contributes to social anxiety. Emotion, 17(2), 231. https://doi.org/10.1037/emo0000223
   PubMed Web of Science ®Google Scholar
• Gu, R., Ao, X., Mo, L., & Zhang, D. (2020). Neural correlates of negative expectancy and impaired social feedback processing in social anxiety. Social Cognitive and Affective Neuroscience, 15(3), 285–291. https://doi.org/10.1093/scan/nsaa038
   PubMed Web of Science ®Google Scholar
• Gunther Moor, B., Crone, E. A., & Van Der Molen, M. W. (2010). The heartbrake of social rejection: Heart rate deceleration in response to unexpected peer rejection. Psychological Science, 21(9), 1326–1333. https://doi.org/10.1177/0956797610379236
   PubMed Web of Science ®Google Scholar
• Harrewijn, A., Van Der Molen, M. J., Van Vliet, I. M., Tissier, R. L., & Westenberg, P. M. (2018). Behavioral and EEG responses to social evaluation: A two-generation family study on social anxiety. NeuroImage: Clinical, 17, 549–562. https://doi.org/10.1016/j.nicl.2017.11.010
   PubMed Web of Science ®Google Scholar
• Iannetti, G. D., Salomons, T. V., Moayedi, M., Mouraux, A., & Davis, K. D. (2013). Beyond metaphor: Contrasting mechanisms of social and physical pain. Trends in Cognitive Sciences, 17(8), 371–378. https://doi.org/10.1016/j.tics.2013.06.002
   PubMed Web of Science ®Google Scholar
• Kross, E., Berman, M. G., Mischel, W., Smith, E. E., & Wager, T. D. (2011). Social rejection shares somatosensory representations with physical pain. Proceedings of the National Academy of Sciences, 108(15), 6270–6275. https://doi.org/10.1073/pnas.1102693108
   PubMed Web of Science ®Google Scholar
• Liebowitz, M. R. (1987). Social phobia. Modern Problems in Pharmacopsychiatry, 22, 141–173.
   PubMedGoogle Scholar
• Ma, D. S., Correll, J., & Wittenbrink, B. (2015). The Chicago face database: A free stimulus set of faces and norming data. Behavior Research Methods, 47(4), 1122–1135. https://doi.org/10.3758/s13428-014-0532-5
   PubMed Web of Science ®Google Scholar
• Maslow, A. H. (1981). Motivation and personality. Prabhat Prakashan.
   Google Scholar
• Mischkowski, D., Crocker, J., & Way, B. M. (2016). From painkiller to empathy killer: Acetaminophen (paracetamol) reduces empathy for pain. Social Cognitive and Affective Neuroscience, 11(9), 1345–1353. https://doi.org/10.1093/scan/nsw057
   PubMed Web of Science ®Google Scholar
• Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005). Decision making, the P3, and the locus coeruleus--norepinephrine system. Psychological bulletin,131(4), 510.
   PubMed Web of Science ®Google Scholar
• Pearson, R., Koslov, S., Hamilton, B., Shumake, J., Carver, C. S., & Beevers, C. G. (2018). Acetaminophen enhances the reflective learning process. Social Cognitive and Affective Neuroscience, 13(10), 1029–1035. https://doi.org/10.1093/scan/nsy074
   PubMed Web of Science ®Google Scholar
• Price, D. D. (2000). Psychological and neural mechanisms of the affective dimension of pain. Science, 288(5472), 1769–1772. https://doi.org/10.1126/science.288.5472.1769
   PubMed Web of Science ®Google Scholar
• Quarmley, M. E., Nelson, B. D., Clarkson, T., White, L. K., & Jarcho, J. M. (2019). I knew you weren’t going to like me! neural response to accurately predicting rejection is associated with anxiety and depression. Frontiers in Behavioral Neuroscience, 13, 219. https://doi.org/10.3389/fnbeh.2019.00219
   PubMed Web of Science ®Google Scholar
• Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science, 277(5328), 968–971. https://doi.org/10.1126/science.277.5328.968
   PubMed Web of Science ®Google Scholar
• Randles, D., Kam, J. W., Heine, S. J., Inzlicht, M., & Handy, T. C. (2016). Acetaminophen attenuates error evaluation in cortex. Social Cognitive and Affective Neuroscience, 11(6), 899–906. https://doi.org/10.1093/scan/nsw023
   PubMed Web of Science ®Google Scholar
• Rawlins, M. D., Henderson, D. B., & Hijab, A. R. (1977). Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. European Journal of Clinical Pharmacology, 11(4), 283–286. https://doi.org/10.1007/BF00607678
   PubMed Web of Science ®Google Scholar
• Schlaepfer, T. E., Strain, E. C., Greenberg, B. D., Preston, K. L., Lancaster, E., Bigelow, G. E., & Pearlson, G. D. (1998). Site of opioid action in the human brain: mu and kappa agonists' subjective and cerebral blood flow effects. American Journal of Psychiatry,155(4), 470–473.
   PubMed Web of Science ®Google Scholar
• Slavich, G. M., Shields, G. S., Deal, B. D., Gregory, A., & Toussaint, L. L. (2019). Alleviating social pain: A double-blind, randomized, placebo-controlled trial of forgiveness and acetaminophen. Annals of Behavioral Medicine, 53(12), 1045–1054. https://doi.org/10.1093/abm/kaz015
   PubMed Web of Science ®Google Scholar
• Smith, H. S. (2009). Potential analgesic mechanisms of acetaminophen. Pain Physician, 12(1), 269–280. https://doi.org/10.36076/ppj.2009/12/269
   PubMed Web of Science ®Google Scholar
• Somerville, L. H., Heatherton, T. F., & Kelley, W. M. (2006). Anterior cingulate cortex responds differentially to expectancy violation and social rejection. Nature Neuroscience, 9(8), 1007–1008. https://doi.org/10.1038/nn1728
   PubMed Web of Science ®Google Scholar
• Sun, S., & Yu, R. (2014). The feedback related negativity encodes both social rejection and explicit social expectancy violation. Frontiers in Human Neuroscience, 8, 556. https://doi.org/10.3389/fnhum.2014.00556
   PubMed Web of Science ®Google Scholar
• Toussaint, K., Yang, X. C., Zielinski, M. A., Reigle, K. L., Sacavage, S. D., Nagar, S., & Raffa, R. B. (2010). What do we (not) know about how paracetamol (acetaminophen) works? Journal of Clinical Pharmacy and Therapeutics, 35(6), 617–638. https://doi.org/10.1111/j.1365-2710.2009.01143.x
   PubMed Web of Science ®Google Scholar
• Van Der Molen, M. J., Harrewijn, A., & Westenberg, P. M. (2018). Will they like me? Neural and behavioral responses to social-evaluative peer feedback in socially and non-socially anxious females. Biological Psychology, 135, 18–28. https://doi.org/10.1016/j.biopsycho.2018.02.016
   PubMed Web of Science ®Google Scholar
• Van Der Molen, M. J., Poppelaars, E. S., Van Hartingsveldt, C. T., Harrewijn, A., Gunther Moor, B., & Westenberg, P. M. (2014). Fear of negative evaluation modulates electrocortical and behavioral responses when anticipating social evaluative feedback. Frontiers in Human Neuroscience, 7, 936. https://doi.org/10.3389/fnhum.2013.00936
   PubMed Web of Science ®Google Scholar
• Van Der Veen, F. M., Van Der Molen, M. J., Van Der Molen, M. W., & Franken, I. H. A. (2016). Thumbs up or thumbs down? Effects of neuroticism and depressive symptoms on psychophysiological responses to social evaluation in healthy students. Cognitive, Affective & Behavioral Neuroscience, 16(5), 836–847. https://doi.org/10.3758/s13415-016-0435-2
   PubMed Web of Science ®Google Scholar
• Van Der Veen, F. M., Van Der Molen, M. W., Sahibdin, P. P., & Franken, I. H. (2014). The heart-break of social rejection versus the brain wave of social acceptance. Social Cognitive and Affective Neuroscience, 9(9), 1346–1351. https://doi.org/10.1093/scan/nst120
   PubMed Web of Science ®Google Scholar
• Wager, T. D., Atlas, L. Y., Botvinick, M. M., Chang, L. J., Coghill, R. C., Davis, K. D., Yarkoni, T. (2016). Pain in the ACC? Proceedings of the National Academy of Sciences, 113(18), E2474–E2475. https://doi.org/10.1073/pnas.1600282113
   PubMed Web of Science ®Google Scholar
• Whalen, P. J., Bush, G., McNally, R. J., Wilhelm, S., McInerney, S. C., Jenike, M. A., & Rauch, S. L. (1998). The emotional counting Stroop paradigm: A functional magnetic resonance imaging probe of the anterior cingulate affective division. Biological Psychiatry, 113(18), 1219–1228. https://doi.org/10.1016/S0006-3223(98)00251-0
   Web of Science ®Google Scholar
• Younger, J., Aron, A., Parke, S., Chatterjee, N., & Mackey, S. (2010). Viewing pictures of a romantic partner reduces experimental pain: Involvement of neural reward systems. PloS One, 5(10), 10. https://doi.org/10.1371/journal.pone.0013309
   Web of Science ®Google Scholar