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REVIEW ARTICLE

Human fetal hepatocyte behavior in dynamic 3D perfusion culture bioreactors

, MD &
Pages 183-192 | Published online: 11 Jul 2009

References

  • Dowling DJ, Mutimer DJ. Artificial liver support in acute liver failure. Eur J Gastroenterol Hepatol 1999; 11: 991–6
  • Gerlach JC. Development of a hybrid liver support system: a review. Int J Artif Organs 1996; 19: 645–54
  • Monga A, Jain SK. Artificial liver support systems. J Assoc Physicians India 1999; 47: 1092–9
  • Monga SP, Hout MS, Baun MJ, Micsenyi A, Muller P, Tummalapalli L, et al. Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors. Am J Pathol 2005; 167: 1279–92
  • Sussman NL, Kelly JH. Improved liver function following treatment with an extracorporeal liver assist device. Artif Organs 1993; 17: 27–30
  • Watanabe FD, Mullon CJ, Hewitt WR, Arkadopoulos N, Kahaku E, Eguchi S, et al. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial.Ann Surg 1997;225:484–91; discussion 491–4
  • Xu AL, Luntz TL, MacDonals JM. Lineage and biology and liver. Principles of tissue engineering2nd ed, RP Lanza, R Langer, J Vacanti. Academic Press, San Diego, CA 1999; 559
  • MacDonald JM, Wolfe SP, Roy-Chowdhury I, Kubota H, Reid LM. Effect of flow configuration and membrane characteristics on membrane fouling in a novel multicoaxial hollow-fiber bioartificial liver. Ann N Y Acad Sci 2001; 944: 334–43
  • Shito M, Kim NH, Baskaran H, Tilles AW, Tompkins RG, Yarmush ML, et al. In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor. Artif Organs 2001; 25: 571–8
  • Gerlach JC, Zeilinger K, Grebe A, Puhl G, Pless G, Sauer I, et al. Recovery of preservation-injured primary human hepatocytes and nonparenchymal cells to tissuelike structures in large-scale bioreactors for liver support: an initial transmission electron microscopy study. J Invest Surg 2003; 16: 83–92
  • Catapano G, Euler M, Gaylor JDS, Gerlach J. Characterization of the distribution of matter in hybrid liver support devices where cells are cultured in a 3-D membrane network or on flat substrata. Int J Artif Organs 2001; 24: 102–9
  • Gerlach JC, Mutig K, Sauer IM, Schrade P, Efimova E, Mieder T, et al. Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study. Transplantation 2003; 76: 781–6
  • Hussain SZ, Sneddon T, Tan X, Micsenyi A, Michalopoulos GK, Monga SP. Wnt impacts growth and differentiation in ex vivo liver development. Exp Cell Res 2004; 292: 157–69
  • Micsenyi A, Tan X, Sneddon T, Luo JH, Michalopoulos GK, Monga SP. Beta-catenin is temporally regulated during normal liver development. Gastroenterology 2004; 126: 1134–46
  • Monga SP, Micsenyi A, Germinaro M, Apte U, Bell A. beta-Catenin regulation during matrigel-induced rat hepatocyte differentiation. Cell Tiss Res 2006; 323: 71–9
  • Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GK. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 2003; 124: 202–16
  • He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 2004; 36: 1117–21
  • Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003; 423: 409–14
  • Watt FM. Epidermal stem cells: markers, patterning and the control of stem cell fate. Philos Trans R Soc Lond B Biol Sci 1998; 353: 831–7
  • Dabeva MD, Shafritz DA. Hepatic stem cells and liver repopulation. Semin Liver Dis 2003; 23: 349–62
  • Monga SP, Tang Y, Candotti F, Rashid A, Wildner O, Mishra B, et al. Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants. Cell Transplant 2001; 10: 81–9
  • Nitou M, Ishikawa K, Shiojiri N. Immunohistochemical analysis of development of desmin-positive hepatic stellate cells in mouse liver. J Anat 2000; 197: 635–46
  • Shafritz DA, Dabeva MD. Liver stem cells and model systems for liver repopulation. J Hepatol 2002; 36: 552–64
  • Sauer IM, Kardassis D, Zeillinger K, Pascher A, Gruenwald A, Pless G, et al. Clinical extracorporeal hybrid liver support—phase I study with primary porcine liver cells. Xenotransplantation 2003; 10: 460–9
  • Sauer IM, Zeilinger K, Obermayer N, Pless G, Grunwald A, Pascher A, et al. Primary human liver cells as source for modular extracorporeal liver support—a preliminary report. Int J Artif Organs 2002; 25: 1001–5
  • Sauer IM, Zeilinger K, Pless G, Kardassis D, Theruvath T, Pascher A, et al. Extracorporeal liver support based on primary human liver cells and albumin dialysis—treatment of a patient with primary graft non-function. J Hepatol 2003; 39: 649–53
  • Zeilinger K, Holland G, Sauer IM, Efimova E, Kardassis D, Obermayer N, et al. Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study. Tissue Eng 2004; 10: 1113–24
  • Zeilinger K, Sauer IM, Pless G, Strobel C, Rudzitis J, Wang A, et al. Three-dimensional co-culture of primary human liver cells in bioreactors for in vitro drug studies: effects of the initial cell quality on the long-term maintenance of hepatocyte-specific functions. Altern Lab Anim 2002; 30: 525–38
  • Gerlach JC, Zeilinger K, Sauer IM, Mieder T, Naumann G, Grunwald A, et al. Extracorporeal liver support: porcine or human cell based systems?. Int J Artif Organs 2002; 25: 1013–8
  • Ader T, Norel R, Levoci L, Rogler LE. Transcriptional profiling implicates TGFbeta/BMP and Notch signaling pathways in ductular differentiation of fetal murine hepatoblasts. Mech Dev 2006; 123: 177–94
  • Blakolmer K, Jaskiewicz K, Dunsford HA, Robson SC. Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver. Hepatology 1995; 21: 1510–6
  • Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, et al. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 1996; 132: 1133–49
  • Fougere-Deschatrette C, Imaizumi-Scherrer T, Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, et al. Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo. Stem Cells 2006; 24: 2098–109
  • Sakai Y, Jiang J, Kojima N, Kinoshita T, Miyajima A. Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotinamide, and dimethyl sulfoxide. Cell Transplant 2002; 11: 435–41
  • Sigal SH, Rajvanshi P, Reid LM, Gupta S. Demonstration of differentiation in hepatocyte progenitor cells using dipeptidyl peptidase IV deficient mutant rats. Cell Mol Biol Res 1995; 41: 39–47
  • Oertel M, Menthena A, Chen YQ, Shafritz DA. Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver. Stem Cells 2006; 24: 2244–51
  • Oertel M, Rosencrantz R, Chen YQ, Thota PN, Sandhu JS, Dabeva MD, et al. Repopulation of rat liver by fetal hepatoblasts and adult hepatocytes transduced ex vivo with lentiviral vectors. Hepatology 2003; 37: 994–1005
  • Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells. Am J Pathol 2001; 159: 1323–34
  • Brennan KR, Brown AM. Wnt proteins in mammary development and cancer. J Mammary Gland Biol Neoplasia 2004; 9: 119–31
  • Pinto D, Clevers H. Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res 2005; 306: 357–63
  • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434: 843–50
  • Tan X, Behari J, Cieply B, Michalopoulos GK, Monga SP. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 2006; 131: 1561–72
  • Sekhon SS, Tan X, Micsenyi A, Bowen WC, Monga SP. Fibroblast growth factor enriches the embryonic liver cultures for hepatic progenitors. Am J Pathol 2004; 164: 2229–40

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