21,009
Views
58
CrossRef citations to date
0
Altmetric
Review

Neonatal management and outcome in alloimmune hemolytic disease

, , , , &
Pages 607-616 | Received 25 Nov 2016, Accepted 12 May 2017, Published online: 05 Jun 2017

References

  • de Haas M, Thurik FF, Koelewijn JM, et al. Haemolytic disease of the fetus and newborn. Vox Sang. 2015;109:99–113.
  • Urbaniak SJ, Greiss MA. RhD haemolytic disease of the fetus and the newborn. Blood Rev. 2000;14:44–61.
  • Moise KJ. Fetal anemia due to non-Rhesus-D red-cell alloimmunization. Semin Fetal Neonatal Med. 2008;13:207–214.
  • Bowman J. Thirty-five years of Rh prophylaxis. Transfusion. 2003;43:1661–1666.
  • Koelewijn JM, de Haas M, Vrijkotte TGM, et al. One single dose of 200 microg of antenatal RhIG halves the risk of anti-D immunization and hemolytic disease of the fetus and newborn in the next pregnancy. Transfusion. 2008;48:1721–1729.
  • Bennardello F, Coluzzi S, Curciarello G, et al. Recommendations for the prevention and treatment of haemolytic disease of the foetus and newborn. Blood Transfus. 2015;13:109–134.
  • Illanes S, Soothill P. Management of red cell alloimmunisation in pregnancy: the non-invasive monitoring of the disease. Prenat Diagn. 2010;30:668–673.
  • Fan J, Lee BK, Wikman AT, et al. Associations of Rhesus and non-Rhesus maternal red blood cell alloimmunization with stillbirth and preterm birth. Int J Epidemiol. 2014;43:1123–1131.
  • Bhutani VK, Johnson-Hamerman L. The clinical syndrome of bilirubin-induced neurologic dysfunction. Semin Fetal Neonatal Med. 2015;20:6–13.
  • American Academy of Pediatrics Subcommittee on H. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297–316.
  • Shapiro SM, Bhutani VK, Johnson L. Hyperbilirubinemia and kernicterus. Clin Perinatol. 2006;33:387–410.
  • Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. New Engl J Med. 2008;358:920–928.
  • Stokowski LA. Fundamentals of phototherapy for neonatal jaundice. Adv Neonatal Care. 2011;11:S10–S21.
  • Vreman HJ, Wong RJ, Stevenson DK. Phototherapy: current methods and future directions. Semin Perinatol. 2004;28:326–333.
  • Woodgate P, Jardine LA. Neonatal jaundice: phototherapy. BMJ Clin Evid. 2015;2015:0319.
  • Xiong T, Qu Y, Cambier S, et al. The side effects of phototherapy for neonatal jaundice: what do we know? What should we do? Eur J Pediatr. 2011;170:1247–1255.
  • Newman TB, Wickremasinghe AC, Walsh EM, et al. Retrospective cohort study of phototherapy and childhood cancer in northern California. Pediatrics. 2016;137:e20151354.
  • Wickremasinghe AC, Kuzniewicz MW, Grimes BA, et al. Neonatal phototherapy and infantile cancer. Pediatrics. 2016;137:e20151353.
  • Lai YC, Yew YW. Neonatal blue light phototherapy and melanocytic nevus count in children: a systematic review and meta-analysis of observational studies. Pediatr Dermatol. 2016;33:62–68.
  • Das RR, Naik SS. Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review. Pediatr Allergy Immunol. 2015;26:2–11.
  • Maayan-Metzger A, Yosipovitch G, Hadad E, et al. Transepidermal water loss and skin hydration in preterm infants during phototherapy. Am J Perinatol. 2001;18:393–396.
  • Boo N-Y, Lee H-T. Randomized controlled trial of oral versus intravenous fluid supplementation on serum bilirubin level during phototherapy of term infants with severe hyperbilirubinaemia. J Paediatr Child Health. 2002;38:151–155.
  • Mehta S, Kumar P, Narang A. A randomized controlled trial of fluid supplementation in term neonates with severe hyperbilirubinemia. J Pediatr. 2005;147:781–785.
  • Diamond LK, Allen FH Jr., Thomas WO Jr. Erythroblastosis fetalis. VII. Treatment with exchange transfusion. N Engl J Med. 1951;244:39–49.
  • Murki S, Kumar P. Blood exchange transfusion for infants with severe neonatal hyperbilirubinemia. Semin Perinatol. 2011;35:175–184.
  • Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med. 2001;344:581–590.
  • Chitty HE, Ziegler N, Savoia H, et al. Neonatal exchange transfusions in the 21st century: a single hospital study. J Paediatr Child Health. 2013;49:825–832.
  • Steiner LA, Bizzarro MJ, Ehrenkranz RA, et al. A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality. Pediatrics. 2007;120:27–32.
  • Patra K, Storfer-Isser A, Siner B, et al. Adverse events associated with neonatal exchange transfusion in the 1990s. J Pediatr. 2004;144:626–631.
  • Abbas W, Attia NI, Hassanein SMA. Two-stage single-volume exchange transfusion in severe hemolytic disease of the newborn. J Matern Fetal Neonatal Med. 2012;25:1080–1083.
  • Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev. 2006;4:CD004592.
  • Smits-Wintjens VEHJ, Walther FJ, Rath MEA, et al. Intravenous immunoglobulin in neonates with rhesus hemolytic disease: a randomized controlled trial. Pediatrics. 2011;127:680–686.
  • de Boer IP, Zeestraten ECM, Lopriore E, et al. Pediatric outcome in Rhesus hemolytic disease treated with and without intrauterine transfusion. Am J Obstet Gynecol. 2008;198(1):54.e1–54.e4.
  • Gottstein R, Cooke RW. Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Arch Dis Child Fetal Neonatal Ed. 2003;88:F6–F10.
  • Ballow M. The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders. J Allergy Clin Immunol. 2011;127:315–323; quiz 24–25.
  • Santos MC, Sá C, Gomes SC Jr., et al. The efficacy of the use of intravenous human immunoglobulin in Brazilian newborns with rhesus hemolytic disease: a randomized double-blind trial. Transfusion. 2013;53:777–782.
  • Walsh S, Molloy EJ. Towards evidence based medicine for paediatricians. Is intravenous immunoglobulin superior to exchange transfusion in the management of hyperbilirubinaemia in term neonates? Arch Dis Child. 2009;94:739–741.
  • Figueras-Aloy J, Rodríguez-Miguélez JM, Iriondo-Sanz M, et al. Intravenous immunoglobulin and necrotizing enterocolitis in newborns with hemolytic disease. Pediatrics. 2010;125:139–144.
  • Yang Y, Pan -J-J, Zhou X-G, et al. The effect of immunoglobulin treatment for hemolysis on the incidence of necrotizing enterocolitis - a meta-analysis. Eur Rev Med Pharmacol Sci. 2016;20:3902–3910.
  • Louis D, More K, Oberoi S, et al. Intravenous immunoglobulin in isoimmune haemolytic disease of newborn: an updated systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2014;99:F325–F331.
  • Shahian M, Moslehi MA. Effect of albumin administration prior to exchange transfusion in term neonates with hyperbilirubinemia–a randomized controlled trial. Indian Pediatr. 2010;47:241–244.
  • Dash N, Kumar P, Sundaram V, et al. Pre exchange albumin administration in neonates with hyperbilirubinemia: a randomized controlled trial. Indian Pediatr. 2015;52:763–767.
  • Kaplan M, Wong RJ, Sibley E. Neonatal-perinatal medicine. 9th ed. Cleveland (OH): Mosby; 2011.
  • Yaffe SJ, Levy G, Matsuzawa T, et al. Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital. N Engl J Med. 1966;275:1461–1466.
  • Kaabneh MA, Salama GS, Shakkoury AG, et al. Phenobarbital and phototherapy combination enhances decline of total serum bilirubin and may decrease the need for blood exchange transfusion in newborns with isoimmune hemolytic disease. Clin Med Insights Pediatr. 2015;9:67–72.
  • Trevett TN Jr., Dorman K, Lamvu G, et al. Antenatal maternal administration of phenobarbital for the prevention of exchange transfusion in neonates with hemolytic disease of the fetus and newborn. Am J Obstet Gynecol. 2005;192:478–482.
  • Stevenson DK, Rodgers PA, Vreman HJ. The use of metalloporphyrins for the chemoprevention of neonatal jaundice. Am J Dis Child. 1989;143:353–356.
  • Suresh GK, Martin CL, Soll RF. Metalloporphyrins for treatment of unconjugated hyperbilirubinemia in neonates. Cochrane Database Syst Rev. 2003;2:CD004207.
  • Méndez-Sánchez N, Roldán-Valadez E, Flores MA, et al. Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters. Eur J Clin Invest. 2001;31:773–780.
  • Mishra S, Cheema A, Agarwal R, et al. Oral zinc for the prevention of hyperbilirubinaemia in neonates. Cochrane Database Syst Rev. 2015;7:CD008432.
  • Sharma D, Farahbakhsh N, Sharma P, et al. Role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia: a systematic review of current evidence. J Matern Fetal Neonatal Med. 2016;17:1–10.
  • Fallah R, Islami Z, Lotfi SR. Single dose of 50 mg/kg clofibrate in jaundice of healthy term neonates: randomised clinical trial of efficacy and safety. Indian J Pediatr. 2012;79:194–197.
  • Habibi M, Mahyar A, Ayazi P, et al. The effect of clofibrate on hyperbilirubinemia of term neonates. Acta Med Iran. 2012;50:21–25.
  • Gholitabar M, McGuire H, Rennie J, et al. Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia. Cochrane Database Syst Rev. 2012;12:CD009017.
  • Armanian AM, Barekatain B, Hoseinzadeh M, et al. Prebiotics for the management of hyperbilirubinemia in preterm neonates. J Matern Fetal Neonatal Med. 2016;29:3009–3013.
  • Bisceglia M, Indrio F, Riezzo G, et al. The effect of prebiotics in the management of neonatal hyperbilirubinaemia. Acta Paediatr. 2009;98:1579–1581.
  • Gamsu HR, Mullinger BM, Donnai P, et al. Antenatal administration of betamethasone to prevent respiratory distress syndrome in preterm infants: report of a UK multicentre trial. Br J Obstet Gynaecol. 1989;96:401–410.
  • Porto AM, Coutinho IC, Correia JB, et al. Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial. BMJ. 2011;342:d1696.
  • Al-Alaiyan S, Al Omran A. Late hyporegenerative anemia in neonates with rhesus hemolytic disease. J Perinat Med. 1999;27:112–115.
  • Strand C, Polesky HF. Delayed anemia in erythroblastosis fetalis. Minn Med. 1972;55:439–441.
  • Smits-Wintjens VE, Walther FJ, Lopriore E. Rhesus haemolytic disease of the newborn: postnatal management, associated morbidity and long-term outcome. Semin Fetal Neonatal Med. 2008;13:265–271.
  • Rath ME, Smits-Wintjens VE, Lindenburg IT, et al. Exchange transfusions and top-up transfusions in neonates with Kell haemolytic disease compared to Rh D haemolytic disease. Vox Sang. 2011;100:312–316.
  • Rath ME, Smits-Wintjens VE, Lindenburg I, et al. Top-up transfusions in neonates with Rh hemolytic disease in relation to exchange transfusions. Vox Sang. 2010;99:65–70.
  • Millard DD, Gidding SS, Socol ML, et al. Effects of intravascular, intrauterine transfusion on prenatal and postnatal hemolysis and erythropoiesis in severe fetal isoimmunization. J Pediatr. 1990;117:447–454.
  • Farrar D, Airey R, Law GR, et al. Measuring placental transfusion for term births: weighing babies with cord intact. Bjog. 2011;118:70–75.
  • Garabedian C, Rakza T, Drumez E, et al. Benefits of delayed cord clamping in red blood cell alloimmunization. Pediatrics. 2016;137:e20153236.
  • McAdams RM. Delayed cord clamping in red blood cell alloimmunization: safe, effective, and free? Transl Pediatr. 2016;5:100–103.
  • Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24:105–131.
  • Mainie P. Is there a role for erythropoietin in neonatal medicine? Early Hum Dev. 2008;84:525–532.
  • Zanjani ED, Ascensao JL, McGlave PB, et al. Studies on the liver to kidney switch of erythropoietin production. J Clin Invest. 1981;67:1183–1188.
  • Aher SM, Ohlsson A. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2006;3:CD004865.
  • Nicaise C, Gire C, Casha P, et al. Erythropoietin as treatment for late hyporegenerative anemia in neonates with Rh hemolytic disease after in utero exchange transfusion. Fetal Diagn Ther. 2002;17:22–24.
  • Pessler F, Hart D. Hyporegenerative anemia associated with Rh hemolytic disease: treatment failure of recombinant erythropoietin. J Pediatr Hematol Oncol. 2002;24:689–693.
  • Zuppa AA, Alighieri G, Calabrese V, et al. Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. J Pediatr Hematol Oncol. 2010;32:e95–e101.
  • Ohlsson A, Aher SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2014;4:CD004863.
  • Haiden N, Klebermass K, Cardona F, et al. A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. Pediatrics. 2006;118:180–188.
  • Carnielli VP, Da Riol R, Montini G. Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;79:F44–F48.
  • Berger HM, Lindeman JH, van Zoeren-Grobben D, et al. Iron overload, free radical damage, and rhesus haemolytic disease. Lancet. 1990;335:933–936.
  • Rath ME, Smits-Wintjens VE, Oepkes D, et al. Iron status in infants with alloimmune haemolytic disease in the first three months of life. Vox Sang. 2013;105:328–333.
  • Kling PJ, Schmidt RL, Roberts RA, et al. Serum erythropoietin levels during infancy: associations with erythropoiesis. J Pediatr. 1996;128:791–796.
  • Pathak A, Roth P, Piscitelli J, et al. Effects of vitamin E supplementation during erythropoietin treatment of the anaemia of prematurity. Arch Dis Child Fetal Neonatal Ed. 2003;88:F324–F328.
  • Bousema S, Govaert P, Dudink J, et al. [Kernicterus is preventable but still occurs]. Ned Tijdschr Geneeskd. 2015;159:A8518. Dutch.
  • Hansen TWR. Kernicterus: an international perspective. Semin Neonatol. 2002;7:103–109.
  • Wusthoff CJ, Loe IM. Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes. Semin Fetal Neonatal Med. 2015;20:52–57.
  • Koenig JM, Christensen RD. Neutropenia and thrombocytopenia in infants with Rh hemolytic disease. J Pediatr. 1989;114:625–631.
  • van den Akker ESA, de Haan TR, Lopriore E, et al. Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies. Am J Obstet Gynecol. 2008;199(4):387.e1–387.e4.
  • Rath ME, Smits-Wintjens VE, Oepkes D, et al. Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease. Vox Sang. 2012;102:228–233.
  • Aygun C, Tekinalp G, Gurgey A. Increased fetal iron load in rhesus hemolytic disease. Pediatr Hematol Oncol. 2004;21:329–333.
  • Siddappa AM, Rao R, Long JD, et al. The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology. 2007;92:73–82.
  • Allgood C, Bolisetty S. Severe conjugated hyperbilirubinaemia and neonatal haemolysis. Int J Clin Pract. 2006;60:1513–1514.
  • Dunn PM. Obstructive jaundice and haemolytic disease of the newborn. Arch Dis Child. 1963;38:54–61.
  • Smits-Wintjens VEHJ, Rath MEA, Lindenburg ITM, et al. Cholestasis in neonates with red cell alloimmune hemolytic disease: incidence, risk factors and outcome. Neonatology. 2012;101:306–310.
  • Barker DJ, Osmond C, Golding J, et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298:564–567.
  • Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008;105:17046–17049.
  • Lindenburg ITM, van Klink JM, Smits-Wintjens VEHJ, et al. Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review. Prenat Diagn. 2013;33:815–822.
  • Lindenburg IT, Smits-Wintjens VE, van Klink JM, et al. Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study. Am J Obstet Gynecol. 2012;206(2):141.e1–141.e8.
  • van Klink JMM, Lindenburg ITM, Inklaar MJ, et al. Health-related quality of life and behavioral functioning after intrauterine transfusion for alloimmune anemia. J Pediatr. 2015;167:1130-5.e2.
  • Wallace AH, Dalziel SR, Cowan BR, et al. Long-term cardiovascular outcome following fetal anaemia and intrauterine transfusion: a cohort study. Arch Dis Child. 2017;102(1):40–45.
  • van Klink JMM, van Veen SJ, Smits-Wintjens VEHJ, et al. Immunoglobulins in neonates with Rhesus hemolytic disease of the fetus and newborn: long-term outcome in a randomized trial. Fetal Diagn Ther. 2016;39:209–213.