Advances in managing rare acquired bleeding disorders

References

• Hoffman M, Monroe DM. A cell based model of hemostasis. Thromb Haemost. 2001;85:958–965.
   PubMed Web of Science ®Google Scholar
• Smith SA, Travers RJ, Morrissey JH. How it all starts: initiation of the clotting cascade. Crit Rev Biochem Mol Biol. 2015;50:326–336.
   PubMed Web of Science ®Google Scholar
• Ahmed AE. Autoantibodies to coagulation factors and bleeding disorders. Clin Rev Allergy Immunol. 1998;16(3):313–319.
   PubMed Web of Science ®Google Scholar
• Coppola A, Favaloro EJ, Tufano A, et al. Acquired inhibitors of coagulation factors: part I-acquired hemophilia A. Semin Thromb Hemost. 2012;38:433–446.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G, Favaloro EJ. Acquired inhibitors of coagulation factors: part II. Semin Thromb Hemost. 2012;38:447–453.
   PubMed Web of Science ®Google Scholar
• Delgado J, Jimenez-Yuste V, Hernandez-Navarro F, et al. Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors. Br J Haematol. 2003;121:21–35.
   PubMed Web of Science ®Google Scholar
• Cohen AJ, Kessler CM. Acquired inhibitors. Bailleres Clin Haematol. 1996;9:331–354.
   PubMed Web of Science ®Google Scholar
• Franchini M, Gandini G, Di Paolantonio T, et al. Acquired hemophilia A: a concise review. Am J Hematol. 2005;80:55–63.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Acquired hemophilia A. Adv Clin Chem. 2011;54:71–80.
   PubMed Web of Science ®Google Scholar
• Franchini M, Mannucci PM. Acquired haemophilia: a 2013 update. Thromb Haemost. 2013;110:1114–1120.
   PubMed Web of Science ®Google Scholar
• Franchini M, Vaglio S, Marano G, et al. Acquired hemophilia A: a review of recent data and new therapeutic options. Hematology. 2017;22(9):514–520.
   PubMed Web of Science ®Google Scholar
• Green D, Lechner K. A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemost. 1981;45:200–203.
   PubMed Web of Science ®Google Scholar
• Lottenberg R, Kentro TB, Kitchens CS. Acquired hemophilia. A natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Arch Intern Med. 1987;147:1077–1081.
   PubMed Web of Science ®Google Scholar
• Bossi P, Cabane J, Ninet J, et al. Acquired haemophilia due to factor VIII inhibitors in 34 patients. Am J Med. 1998;105:400–408.
   PubMed Web of Science ®Google Scholar
• Yee TT, Pasi KJ, Lilley PA, et al. Factor VIII inhibitors in haemophiliacs: a single-centre experience over 34 years, 1964-97. Br J Haematol. 1999;104:909–914.
   PubMed Web of Science ®Google Scholar
• Yee TT, Taher A, Pasi KJ, et al. A survey of patients with acquired hemophilia in a hemophilia centre over a 28-year period. Clin Lab Haematol. 2000;22:275–278.
   PubMedGoogle Scholar
• Baudo F, de Cataldo F. Acquired factor VIII and IX inhibitors: survey of the Italian Haemophilia Centers (AICE). Register of acquired factor VIII/IX inhibitors. Haematologica. 2002;87:22–28.
   Google Scholar
• Tiede A, Klamroth R, Scharf RE, et al. Prognostic factors for remission of and survival in acquired hemophilia A (AHA): results from the GTH-AH 01/2010 study. Blood. 2015;125(7):1091–1097.
   PubMed Web of Science ®Google Scholar
• Collins P, Hirsch S, Baglin TP, et al. Acquired haemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organisation. Blood. 2007;109:1870–1877.
   PubMed Web of Science ®Google Scholar
• Knoebl P, Marco P, Baudo F, et al. EACH2 registry contributors. Demographic and clinical data in acquired hemophilia A: results from the European acquired hemophilia (EACH2) registry. J Thromb Hemost. 2012;10:622–631.
   Web of Science ®Google Scholar
• Solymoss S. Postpartum acquired factor VIII inhibitors: results of a survey. Am J Haematol. 1998;59:1–4.
   PubMed Web of Science ®Google Scholar
• Franchini M. Postpartum acquired factor VIII inhibitors. Am J Hematol. 2006;81:768–773.
   PubMed Web of Science ®Google Scholar
• Tengborn L, Baudo F, Huth-Kühne A, et al. EACH2 registry contributors. Pregnancy-associated acquired haemophilia A: results from the European Acquired Haemophilia (EACH2) registry. BJOG. 2012;119:1529–1537.
   PubMed Web of Science ®Google Scholar
• Sun B, Xue F, Feng Y, et al. Outcome of CARE: a 6-year national registry of acquired haemophilia A in China. Br J Haematol. 2019;187(5):653–665.
   PubMed Web of Science ®Google Scholar
• Knöbl P. Prevention and management of bleeding episodes in patients with acquired hemophilia A. Drugs. 2018;78(18):1861–1872.
   PubMed Web of Science ®Google Scholar
• Sallah S. Treatment of acquired haemophilia with factor eight inhibitor bypassing activity. Haemophilia. 2004;10:169–173.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Recombinant activated factor VII: mechanisms of action and current indications. Semin Thromb Hemost. 2010;36:485–492.
   PubMed Web of Science ®Google Scholar
• Baudo F, Collins P, Huth-Kühne A, et al. EACH2 registry contributors. Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) registry. Blood. 2012;120:39–46.
   PubMed Web of Science ®Google Scholar
• Tiede A, Amano K, Ma A, et al. The use of recombinant activated factor VII in patients with acquired haemophilia. Blood Rev. 2015;29(Supplement 1):S19–S25.
   PubMedGoogle Scholar
• Tiede A, Worster A. Lessons from a systematic literature review of the effectiveness of recombinant factor VIIa in acquired haemophilia. Ann Hematol. 2018 Oct;97(10):1889–1901.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Acquired factor VIII inhibitors. Blood. 2008;112:250–255.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. The use of desmopressin in acquired haemophilia A: a systematic review. Blood Transfus. 2011;9:377–382.
   PubMed Web of Science ®Google Scholar
• Fosbury E, Drebes A, Riddell A, et al. Review of recombinant anti-haemophilic porcine sequence factor VIII in adults with acquired haemophilia A. Ther Adv Hematol. 2017;8(9):263–272.
   PubMed Web of Science ®Google Scholar
• Mannucci PM, Franchini M. Porcine recombinant factor VIII: an additional weapon to handle anti-factor VIII antibodies. Blood Transfus. 2017;15(4):365–368.
   PubMed Web of Science ®Google Scholar
• Kruse-Jarres R, St-Louis J, Greist A, et al. Efficacy and safety of OBI-1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A. Haemophilia. 2015;21:162–170.
   PubMed Web of Science ®Google Scholar
• Türkantoz H, Königs C, Knöbl P, et al. Cross-reacting inhibitors against recombinant porcine factor VIII in acquired hemophilia A: data from the GTH-AH 01/2010 Study. J Thromb Haemost. 2020;18(1):36–43.
   PubMed Web of Science ®Google Scholar
• Hay CRM, Baglin TP, Collins PW, et al. The diagnosis and management of factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors’ Organization (UKHCDO). Br J Haematol. 2000;111:78–90.
   PubMed Web of Science ®Google Scholar
• Franchini M, Castaman G, Coppola A, et al. on behalf of the AICE working group. Acquired inhibitors of clotting factors: AICE recommendations for diagnosis and management. Blood Transfus. 2015;13:498–513.
   PubMed Web of Science ®Google Scholar
• Collins P, Baudo F, Knoebl P, et al. EACH2 registry collaborators. Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). Blood. 2012;120:47–55.
   PubMed Web of Science ®Google Scholar
• Franchini M, Mannucci PM. Inhibitor eradication with rituximab in haemophilia: where do we stand? Br J Haematol. 2014;165:600–608.
   PubMed Web of Science ®Google Scholar
• Franchini M. Rituximab in the treatment of adult acquired hemophilia A: a systematic review. Crit Rev Oncol Hematol. 2007;63:47–52.
   PubMed Web of Science ®Google Scholar
• Federici AB, Rand JH, Bucciarelli P, et al. Subcommittee on von Willebrand factor. Acquired von Willebrand syndrome: data from an international registry. Thromb Haemost. 2000;84:345–349.
   PubMed Web of Science ®Google Scholar
• Michiels JJ, Michiels JJ, Budde U, et al. Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management. Best Pract Res Clin Haematol. 2001;14:401–436.
   PubMed Web of Science ®Google Scholar
• Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand’s syndrome: a single institution experience. Am J Hematol. 2003;72:243–247.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Recent acquisitions in acquired and congenital von Willebrand disorders. Clin Chim Acta. 2007;377(1–2):62–69.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Acquired von Willebrand syndrome: an update. Am J Hematol. 2007;82(5):368–375.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G, Favaloro EJ. Advances in hematology. Etiology and diagnosis of acquired von Willebrand syndrome. Clin Adv Hematol Oncol. 2010;8(1):20–24.
   PubMedGoogle Scholar
• Budde U, Scheppenheim S, Dittmer R. Treatment of the acquired von Willebrand syndrome. Exp Rev Hematol. 2015;8:799–818.
   PubMed Web of Science ®Google Scholar
• Federici AB, Budde U, Castaman G, et al. Current diagnostic and therapeutic approaches to patients with acquired von Willebrand syndrome: a 2013 update. Semin Thromb Hemost. 2013;39(2):191–201.
   PubMed Web of Science ®Google Scholar
• Kruse-Jarres R. Acquired bleeding disorders in the elderly. Hematology Am Soc Hematol Educ Program. 2015;2015:231–236.
   PubMedGoogle Scholar
• Mohri H, Motomura S, Kanamori H, et al. Clinical significance of inhibitors in acquired von Willebrand syndrome. Blood. 1998;91:3623–3629.
   PubMed Web of Science ®Google Scholar
• Federici AB, Stabile F, Castaman G, et al. Treatment of acquired von Willebrand syndrome in patients with monoclonal gammopathy of uncertain significance: comparison of three different therapeutic approaches. Blood. 1998;92(8):2707–2711.
   PubMed Web of Science ®Google Scholar
• Castaman G, Rodeghiero F, Di Bona E, et al. Clinical effectiveness of desmopressin in a case of acquired von Willebrand’s syndrome associated with benign monoclonal gammopathy. Blut. 1989;58:211–213.
   PubMedGoogle Scholar
• Charlebois J, Rivard GE, St-Louis J. management of acquired von Willebrand syndrome. Transfus Apher Sci. 2018;57:721–723.
   PubMed Web of Science ®Google Scholar
• Meijer K, Peters FT, van der Meer J. Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand’s disease, controlled with recombinant factor VIIa. Blood Coagul Fibrinolysis. 2001;12:211–213.
   PubMed Web of Science ®Google Scholar
• Macik BG, Gabriel DA, White GC 2nd, et al. The use of high-dose intravenous gamma-globulin in acquired von Willebrand syndrome. Arch Pathol Lab Med. 1988;112:143–146.
   PubMed Web of Science ®Google Scholar
• Federici AB, Rossi V, Sacchi E, et al. Are intravenous immunoglobulins really inappropriate in acquired von Willebrand syndrome? Blood Transfus. 2012;10:402–403.
   PubMed Web of Science ®Google Scholar
• Mital A. Acquired von Willebrand syndrome. Adv Clin Exp Med. 2016;25:1337–1344.
   PubMed Web of Science ®Google Scholar
• Tiede A, Rand JH, Budde U, et al. How I treat the acquired von Willebrand syndrome. Blood. 2011;117:6777–6785.
   PubMed Web of Science ®Google Scholar
• Menegatti M, Biguzzi E, Peyvandi F. Management of rare acquired bleeding disorders. Hematology Am Soc Hematol Educ Program. 2019;2019:80–86.
   PubMedGoogle Scholar
• Ortel TL. Clinical and laboratory manifestations of anti-factor V antibodies. J Lab Clin Med. 1999;133:326–334.
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G. Acquired factor V inhibitors: a systematic review. J Thromb Thrombolysis. 2011;31:449–457.
   PubMed Web of Science ®Google Scholar
• Bowman LJ, Anderson CD, Chapman WC. Topical recombinant human thrombin in surgical hemostasis. Semin Thromb Hemost. 2010;36:477–484.
   PubMed Web of Science ®Google Scholar
• Streiff MB, Ness PM. Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure. Transfusion. 2002;42:18–26.
   PubMed Web of Science ®Google Scholar
• Lippi G, Favaloro EJ, Montagnana M, et al. Inherited and acquired factor V deficiency. Blood Coagul Fibrinolysis. 2011;22:160–166.
   PubMed Web of Science ®Google Scholar
• de Raucourt E, Barbier C, Sinda P, et al. High-dose intravenous immunoglobulin treatment in two patients with acquired factor V inhibitors. Am J Hematol. 2003;74:187–190.
   PubMed Web of Science ®Google Scholar
• Bayani N, Rugina M, Haddad-Vergnes L, et al. High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors. Am J Hematol. 2002;71:33–36.
   PubMed Web of Science ®Google Scholar
• Lebrun A, Leroy-Matheron C, Arlet JB, et al. Successful treatment with rituximab in a patient with an acquired factor V inhibitor. Am J Hematol. 2008;83(2):163–164.
   PubMed Web of Science ®Google Scholar
• Chan IS, Ogunsile FJ. An acquired factor X inhibitor: the importance of understanding coagulation. Am J Med. 2017;130(7):e307–8.
   PubMed Web of Science ®Google Scholar
• Patel G, Hari P, Szabo A, et al. Acquired factor X deficiency in light chain (AL) amyloidosis is rare and associated with advanced disease. Hematol Oncol Stem Cell Ther. 2019;12(1):10–14.
   PubMedGoogle Scholar
• Veneri D, Pizzolo G, Bonalumi A, et al. Haemorrhage and amyloidosis. Br J Haematol. 2013;160(6):854.
   PubMed Web of Science ®Google Scholar
• Thompson CA, Kyle R, Gertz M, et al. Systemic AL amyloidosis with acquired factor X deficiency: a study of perioperative bleeding risk and treatment outcomes in 60 patients. Am J Hematol. 2010;85(3):171–173.
   PubMed Web of Science ®Google Scholar
• Goodrick MJ, Prentice AG, Copplestone JA, et al. Acquired factor XI inhibitor in chronic lymphocytic leukaemia. J Clin Pathol. 1992;45(4):352–353.
   PubMed Web of Science ®Google Scholar
• Reece EA, Clyne LP, Romero R, et al. Spontaneous factor XI inhibitors. Seven additional cases and a review of the literature. Arch Intern Med. 1984;144(3):525–529.
   PubMedGoogle Scholar
• Bortoli R, Monticielo OA, Chakr RM, et al. Acquired factor XI inhibitor in systemic lupus erythematosus—case report and literature review. Semin Arthritis Rheum. 2009;39(1):61–65.
   PubMed Web of Science ®Google Scholar
• Luo YY, Zhang GS. Acquired FXIII inhibitor: clinical features, treatment, fibrin structure and epitope determination. Haemophilia. 2011;17:393–398.
   PubMed Web of Science ®Google Scholar
• Ichinose A, Japanese Collaborative Research Group on AH13. Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: A summary of 93 patients. Blood Rev. 2017;31(1):37–45.
   PubMed Web of Science ®Google Scholar
• Yan MTS, Rydz N, Goodyear D, et al. Acquired factor XIII deficiency: A review. Transfus Apher Sci. 2018;57(6):72430.
   Web of Science ®Google Scholar
• Franchini M, Frattini F, Crestani S, et al. Acquired FXIII inhibitors: a systematic review. J Thromb Thrombolysis. 2013;36(1):109–114.
   PubMed Web of Science ®Google Scholar
• Miesbach W. Rituximab in the treatment of factor XIII inhibitor possibly caused by Ciprofloxacin. Thromb Haemost. 2005;93:1001–1003.
   PubMed Web of Science ®Google Scholar
• Boehlen F, Casini A, Chizzolini C, et al. Acquired factor XIII deficiency: a therapeutic challenge. Thromb Haemost. 2013;109:479–487.
   PubMed Web of Science ®Google Scholar
• Gailani D. An IgG inhibitor against coagulation factor XIII: resolution of bleeding after plasma immunoadsorption with staphylococcal protein A. Am J Med. 1992;92:110–112.
   PubMed Web of Science ®Google Scholar
• Franchini M, Mannucci PM. Non-factor replacement therapy for haemophilia: a current update. Blood Transfus. 2018;16(5):457–461.
   PubMed Web of Science ®Google Scholar
• Franchini M, Marano G, Pati I, et al. Emicizumab for the treatment of haemophilia A: a narrative review. Blood Transfus. 2019;17(3):223–228.
   PubMed Web of Science ®Google Scholar
• Franchini M, Marano G, Pati I, et al. Investigational drugs to treat hemophilia. Expert Opin Investig Drugs. 2020;29:295–301.
   PubMed Web of Science ®Google Scholar