Evidence-based indications of platelet-rich plasma therapy

References

• Sim X, Poncz M, Gadue P, et al. Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood. 2016;127(10):1227–1233.
   PubMed Web of Science ®Google Scholar
• Gonzalez AC, Costa TF, Andrade ZA, et al. Wound healing - A literature review. An Bras Dermatol. 2016;91(5):614–620.
   PubMed Web of Science ®Google Scholar
• Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action and classification. Skin Appendage Disord. 2018;4:18–24.
   PubMed Web of Science ®Google Scholar
• Pochini AC, Antonioli E, Bucci DZ, et al. Analysis of cytokine profile and growth factors in platelet-rich plasma obtained by open systems and commercial columns. Einstein (Sao Paulo). 2016;14(3):391–397. .
   PubMed Web of Science ®Google Scholar
• Ramaswamy Reddy SH, Reddy R, Babu N, et al., Stem-cell therapy and platelet-rich plasma in regenerative medicines: a review on pros and cons of the technologies. J Oral Maxillofac Pathol. 22(3): 367–374. 2018.
   PubMedGoogle Scholar
• Farias RJ, da Silva NP, Haddad NF, et al. Platelet-rich plasma obtained with different anticoagulants and their effect on platelet numbers and mesenchymal stromal cells behavior In Vitro. Stem Cells Int. 2016;2016:7414036.
   PubMed Web of Science ®Google Scholar
• Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–167.
   PubMed Web of Science ®Google Scholar
• Periayah MH, Halim AS, Mat Saad AZ. mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res. 2017;11(4):319–327.
   PubMedGoogle Scholar
• Palta S, Saroa R, Palta A. Overview of the coagulation system. Indian J Anaesth. 2014;58(5):515–523.
   PubMedGoogle Scholar
• Masuki H, Okudera T, Watanebe T, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent. 2016;2(1):19. .
   PubMedGoogle Scholar
• Slukvin II. Generation of mature blood cells from pluripotent stem cells. Haematologica. 2010;95(10):1621–1623.
   PubMed Web of Science ®Google Scholar
• Pavlovic V, Ciric M, Jovanovic V, et al. Platelet Rich Plasma: a short overview of certain bioactive components. Open Med (Wars). 2016;11(1):242–247.
   PubMedGoogle Scholar
• Sharda A, Flaumenhaft R. The life cycle of platelet granules. F1000Res. 2018;7:236.
   PubMedGoogle Scholar
• Andia I, Abate M. Platelet-rich plasma: underlying biology and clinical correlates. Regen Med. 2013;8(5):645–658.
   PubMed Web of Science ®Google Scholar
• Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev. 2009;23(4):177–189.
   PubMed Web of Science ®Google Scholar
• Heijnen H. van der Sluijs P. Platelet secretory behaviour: as diverse as the granules … or not? J Thromb Haemost. 2015;13(12):2141–2151.
   PubMed Web of Science ®Google Scholar
• Everts PA, Knape JT, Weibrich G, et al. Platelet-rich plasma and platelet gel: a review. J Extra Corpor Technol. 2006;38(2):174–187.
   PubMedGoogle Scholar
• Li J, Ballim D, Rodriguez M, et al. The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3. J Biol Chem. 2014;289(51):35633–35643. .
   PubMed Web of Science ®Google Scholar
• Ai G, Shao X, Meng M, et al. Epidermal growth factor promotes proliferation and maintains multipotency of continuous cultured adipose stem cells via activating STAT signal pathway in vitro. Medicine (Baltimore). 2017;96(30):e7607. .
   PubMed Web of Science ®Google Scholar
• Shibuya M. Vascular endothelial growth factor (VEGF) and Its Receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer. 2011;2(12):1097–1105.
   PubMedGoogle Scholar
• Brudno Y, Ennett-Shepard AB, Chen RR, et al. Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors. Biomaterials. 2013;34(36):9201–9209.
   PubMed Web of Science ®Google Scholar
• Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22(10):1276–1312.
   PubMed Web of Science ®Google Scholar
• Jain NK, Gulati M. Platelet-rich plasma: a healing virtuoso. Blood Res. 2016;51(1):3–5.
   PubMed Web of Science ®Google Scholar
• Yun YR, Won JE, Jeon E, et al. Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng. 2010;2010:218142.
   PubMedGoogle Scholar
• Cicha I, Goppelt-Struebe M. Connective tissue growth factor: context-dependent functions and mechanisms of regulation. Biofactors. 2009;35(2):200–208.
   PubMed Web of Science ®Google Scholar
• Andia I, Maffulli N. Blood-derived products for tissue repair/regeneration. Int J Mol Sci. 2019;20(18):4581.
   Web of Science ®Google Scholar
• Oudelaar BW, Peerbooms JC, Huis in ‘T Veld R, et al. Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature. Am J Sports Med. 2019;47(2):479–487.
   PubMed Web of Science ®Google Scholar
• Ghasemzadeh M, Hosseini E. Intravascular leukocyte migration through platelet thrombi: directing leukocytes to sites of vascular injury. Thromb Haemost. 2015;113(6):1224–1235.
   PubMed Web of Science ®Google Scholar
• Gato-Calvo L, Magalhaes J, Ruiz-Romero C, et al. Platelet-rich plasma in osteoarthritis treatment: review of current evidence. Ther Adv Chronic Dis. 2019;10:2040622319825567.
   Web of Science ®Google Scholar
• Barbon S, Stocco E, Macchi V, et al. Platelet-rich fibrin scaffolds for cartilage and tendon regenerative medicine: from bench to bedside. Int J Mol Sci. 2019;20(7):1701. .
   Web of Science ®Google Scholar
• Weibrich G, Kleis WK, Hitzler WE, et al. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: a technical report. Int J Oral Maxillofac Implants. 2005;20(1):118–123.
   PubMed Web of Science ®Google Scholar
• Martineau I, Lacoste E, Gagnon G. Effects of calcium and thrombin on growth factor release from platelet concentrates: kinetics and regulation of endothelial cell proliferation. Biomaterials. 2004;25(18):4489–4502.
   PubMed Web of Science ®Google Scholar
• Ghasemzadeh M, Hosseini E. Platelet-leukocyte crosstalk: linking proinflammatory responses to procoagulant state. Thromb Res. 2013;131(3):191–197.
   PubMed Web of Science ®Google Scholar
• Perez AG, Lana JF, Rodrigues AA, et al. Relevant aspects of centrifugation step in the preparation of platelet-rich plasma. ISRN Hematol. 2014;2014:176060.
   PubMedGoogle Scholar
• Kuffler DP. Variables affecting the potential efficacy of PRP in providing chronic pain relief. J Pain Res. 2018;12:109–116.
   PubMed Web of Science ®Google Scholar
• Livshits MA, Khomyakova E, Evtushenko EG, et al. Isolation of exosomes by differential centrifugation: theoretical analysis of a commonly used protocol. Sci Rep. 2015;5:17319.
   PubMed Web of Science ®Google Scholar
• Shin HS, Woo HM, Kang BJ. Optimisation of a double-centrifugation method for preparation of canine platelet-rich plasma. BMC Vet Res. 2017;13(1):198.
   PubMedGoogle Scholar
• Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014;7(4):189–197. .
   PubMedGoogle Scholar
• Crisci A, Marotta G, Licito A, et al. Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report). Diseases. 2018;6(2):30. .
   Google Scholar
• Harrison P. Subcommittee on platelet physiology. The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH. J Thromb Haemost. 2018;16(9):1895–1900.
   PubMed Web of Science ®Google Scholar
• Simonpieri A, Del Corso M, Vervelle A, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13(7):1231–1256. .
   PubMed Web of Science ®Google Scholar
• Franchini M, Cruciani M, Mengoli C, et al. The use of platelet-rich plasma in oral surgery: a systematic review and meta-analysis. Blood Transfus. 2019;17(5):357–367.
   PubMed Web of Science ®Google Scholar
• Mosca MJ, Rodeo SA. Platelet-rich plasma for muscle injuries: game over or time out? Curr Rev Musculoskelet Med. 2015;8(2):145–153.
   PubMed Web of Science ®Google Scholar
• Halpern BC, Chaudhury S, Rodeo SA. The role of platelet-rich plasma in inducing musculoskeletal tissue healing. Hss J. 2012;8(2):137–145.
   PubMedGoogle Scholar
• Cruciani M, Franchini M, Mengoli C, et al. Platelet-rich plasma for sports-related muscle, tendon and ligament injuries: an umbrella review. Blood Transuf. 2019;1:465–478.
   Google Scholar
• Grassi A, Napoli F, Romandini I, et al. Is platelet-rich plasma (prp) effective in the treatment of acute muscle injuries? A systematic review and meta-analysis. Sports Med. 2018;48(4):971–989. .
   PubMed Web of Science ®Google Scholar
• Billesberger LM, Fisher KM, Qadri YJ, et al. Procedural treatments for knee osteoarthritis: a review of current injectable therapies. Pain Res Manag. 2020;2020:3873098.
   PubMed Web of Science ®Google Scholar
• Yang G, Rothrauff BB, Tuan RS. Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm. Birth Defects Res C Embryo Today. 2013;99(3):203–222.
   PubMed Web of Science ®Google Scholar
• Martin JI, Atilano L, Merino J, et al. Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial. J Orthop Surg Res. 2019;14(1):109.
   PubMedGoogle Scholar
• Bosch G, Moleman M, Barneveld A, et al. The effect of platelet-rich plasma on the neovascularization of surgically created equine superficial digital flexor tendon lesions. Scand J Med Sci Sports. 2011;21(4):554–561. .
   PubMed Web of Science ®Google Scholar
• Setayesh K, Villarreal A, Gottschalk A, et al. Treatment of muscle injuries with platelet-rich plasma: a review of the literature. Curr Rev Musculoskelet Med. 2018;11(4):635–642. .
   PubMed Web of Science ®Google Scholar
• Vaquero-Picado A, Barco R, Antuña SA. Lateral epicondylitis of the elbow. EFORT Open Rev. 2017;1(11):391–397.
   PubMed Web of Science ®Google Scholar
• Mishra AK, Skrepnik NV, Edwards SG, et al. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med. 2014;42(2):463–471. .
   PubMed Web of Science ®Google Scholar
• Kwapisz A, Prabhakar S, Compagnoni R, et al. Platelet-rich plasma for elbow pathologies: a descriptive review of current literature. Curr Rev Musculoskelet Med. 2018;11(4):598–606. .
   PubMed Web of Science ®Google Scholar
• Ben-Nafa W, Munro W. The effect of corticosteroid versus platelet-rich plasma injection therapies for the management of lateral epicondylitis: a systematic review. Sicot J. 2018;4:11.
   PubMed Web of Science ®Google Scholar
• Rath E, Schwarzkopf R, Richmond JC. Clinical signs and anatomical correlation of patellar tendinitis. Indian J Orthop. 2010;44(4):435–437.
   PubMed Web of Science ®Google Scholar
• Vetrano M, Castorina A, Vulpiani MC, et al. Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes. Am J Sports Med. 2013;41(4):795–803. .
   PubMed Web of Science ®Google Scholar
• Dragoo JL, Wasterlain AS, Braun HJ, et al. Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med. 2014;42(3):610–618.
   PubMed Web of Science ®Google Scholar
• Krogh TP, Ellingsen T, Christensen R, et al. Ultrasound-guided injection therapy of achilles tendinopathy with platelet-rich plasma or saline: a randomized, blinded, placebo-controlled trial. Am J Sports Med. 2016;44(8):1990–1997. .
   PubMed Web of Science ®Google Scholar
• Boesen AP, Hansen R, Boesen MI, et al. Effect of high-volume injection, platelet-rich plasma, and sham treatment in chronic midportion achilles tendinopathy: a randomized double-blinded prospective study. Am J Sports Med. 2017;45(9):2034–2043. .
   PubMed Web of Science ®Google Scholar
• Rha DW, Park GY, Kim YK, et al. Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial. Clin Rehabil. 2013;27(2):113–122. .
   PubMed Web of Science ®Google Scholar
• Kesikburun S, Tan AK, Yilmaz B, et al. Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med. 2013;41(11):2609–2616. .
   PubMed Web of Science ®Google Scholar
• Shams A, El-Sayed M, Gamal O, et al. Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears. Eur J Orthop Surg Traumatol. 2016;26(8):837–842.
   PubMedGoogle Scholar
• Neufeld SK, Cerrato R. Plantar fasciitis: evaluation and treatment. J Am Acad Orthop Surg. 2008;16(6):338–346.
   PubMed Web of Science ®Google Scholar
• Jain K, Murphy PN, Clough TM. Platelet rich plasma versus corticosteroid injection for plantar fasciitis: a comparative study. Foot (Edinb). 2015;25(4):235–237.
   PubMedGoogle Scholar
• Shetty SH, Dhond A, Arora M, et al. Platelet-rich plasma has better long-term results than corticosteroids or placebo for chronic plantar fasciitis: randomized control trial. J Foot Ankle Surg. 2019;58(1):42–46.
   PubMed Web of Science ®Google Scholar
• O’Connell B, Wragg NM, Wilson SL. The use of PRP injections in the management of knee osteoarthritis. Cell Tissue Res. 2019;376(2):143–152.
   PubMed Web of Science ®Google Scholar
• Shin M, Lee J, Lee S, et al. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg. 2012;38(4):623–630. .
   PubMed Web of Science ®Google Scholar
• Gentile P, Garcovich S, Bielli A, et al. The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial. Stem Cells Transl Med. 2015;4(11):1317–1323. .
   PubMed Web of Science ®Google Scholar
• Gentile P, Garcovich S, Scioli MG, et al. Mechanical and controlled PRP injections in patients affected by androgenetic alopecia. J Vis Exp. 2018;131:e56406.
   Web of Science ®Google Scholar
• Cervelli V, Garcovich S, Bielli A, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709.
   PubMed Web of Science ®Google Scholar
• Owczarczyk-Saczonek A, Krajewska-Włodarczyk M, Kruszewska A, et al. Therapeutic potential of stem cells in follicle regeneration. Stem Cells Int. 2018;2018:1049641.
   PubMed Web of Science ®Google Scholar
• Cervantes J, Perper M, Wong LL, et al. Effectiveness of platelet-rich plasma for androgenetic alopecia: a review of the literature. Skin Appendage Disord. 2018;4(1):1–11. .
   PubMed Web of Science ®Google Scholar
• Gentile P, Scioli MG, Bielli A, et al. Platelet-rich plasma and micrografts enriched with autologous human follicle mesenchymal stem cells improve hair re-growth in androgenetic alopecia. biomolecular pathway analysis and clinical evaluation.. Biomedicines. 2019;7(2):27. .
   PubMed Web of Science ®Google Scholar
• Gentile P, Scioli MG, Bielli A, et al. Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss. Stem Cell Investig. 2017;4:58.
   PubMedGoogle Scholar
• Gentile P. Autologous cellular method using micrografts of human adipose tissue derived follicle stem cells in androgenic alopecia. Int J Mol Sci. 2019;20(14):3446.
   PubMed Web of Science ®Google Scholar
• Giordano S, Romeo M, Lankinen P. Platelet-rich plasma for androgenic alopecia: does it work? Evidence from metaanalysis. J Cosmet Dermatol J. 2017;16(3):374–381.
   PubMed Web of Science ®Google Scholar
• Maria-Angeliki G, Alexandros-Efstratios K, Dimitris R, et al. Platelet-rich plasma as a potential treatment for noncicatricial alopecias. Int J Trichology. 2015;7(2):54–63.
   PubMedGoogle Scholar
• Cervelli V, Lucarini L, Spallone D, et al. Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure. Adv Skin Wound Care. 2011;24(4):176–181. .
   PubMed Web of Science ®Google Scholar
• Nicoli F, Balzani A, Lazzeri D, et al. Severe hidradenitis suppurativa treatment using platelet-rich plasma gel and Hyalomatrix. Int Wound J. 2015;12(3):338–343. .
   PubMed Web of Science ®Google Scholar
• Scioli MG, Bielli A, Gentile P, et al. Combined treatment with platelet-rich plasma and insulin favours chondrogenic and osteogenic differentiation of human adipose-derived stem cells in three-dimensional collagen scaffolds. J Tissue Eng Regen Med. 2017;11(8):2398–2410. .
   PubMed Web of Science ®Google Scholar
• Gentile P, Scioli MG, Bielli A, et al. Concise review: the use of adipose-derived stromal vascular fraction cells and platelet rich plasma in regenerative plastic surgery. Stem Cells. 2017;35(1):117–134. .
   PubMed Web of Science ®Google Scholar
• Azzena B, Mazzoleni F, Abatangelo G, et al. Autologous platelet-rich plasma as an adipocyte in vivo delivery system: case report. Aesthetic Plast Surg. 2008;32(1):155–158. . 159–61
   PubMed Web of Science ®Google Scholar
• Pendsey SP. Understanding diabetic foot. Int J Diabetes Dev Ctries. 2010;30(2):75–79.
   PubMed Web of Science ®Google Scholar
• Del Pino-Sedeño T, Trujillo-Martín MM, Andia I, et al. Platelet-rich plasma for the treatment of diabetic foot ulcers: A meta-analysis. Wound Repair Regen. 2019;27(2):170–182.
   PubMed Web of Science ®Google Scholar
• Gonchar IV, Lipunov AR, Afanasov IM, et al. Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: state of art developments and future prospects. Diabetes Metab Syndr. 2018;12(2):189–194. .
   PubMed Web of Science ®Google Scholar
• Babaei V, Afradi H, Gohardani HZ, et al. Management of chronic diabetic foot ulcers using platelet-rich plasma. J Wound Care. 2017;26(12):784–787. .
   PubMed Web of Science ®Google Scholar
• Maleki-Hajiagha A, Razavi M, Rouholamin S, et al. Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis. J Reprod Immunol. 2020;137:103078.
   PubMed Web of Science ®Google Scholar
• Ramaswamy Reddy SH, Reddy R, Babu NC, et al. Stem-cell therapy and platelet-rich plasma in regenerative medicines: A review on pros and cons of the technologies. J Oral Maxillofac Pathol. 2018;22(3):367–374.
   PubMedGoogle Scholar
• Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg. 2005;16(6):1043–1054.
   PubMed Web of Science ®Google Scholar
• Biehl JK, Russell B. Introduction to stem cell therapy. J Cardiovasc Nurs. 2009;24(2):98–105.
   PubMed Web of Science ®Google Scholar
• Franceschetti T, De Bari C. The potential role of adult stem cells in the management of the rheumatic diseases. Ther Adv Musculoskelet Dis. 2017;9(7):165–179.
   PubMed Web of Science ®Google Scholar
• Choi J, Minn KW, Chang H. The efficacy and safety of platelet-rich plasma and adipose-derived stem cells: an update. Arch Plast Surg. 2012;39(6):585–592.
   PubMedGoogle Scholar
• Zhang ZY, Huang AW, Fan JJ, et al. The potential use of allogeneic platelet-rich plasma for large bone defect treatment: immunogenicity and defect healing efficacy. Cell Transplant. 2013;22(1):175–187. .
   PubMed Web of Science ®Google Scholar
• He M, Guo X, Li T, et al. Comparison of allogeneic platelet-rich plasma with autologous platelet-rich plasma for the treatment of diabetic lower extremity ulcers. Cell Transplant. 2020;29:963689720931428.
   PubMed Web of Science ®Google Scholar
• Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62(4):489–496.
   PubMed Web of Science ®Google Scholar
• Gonshor A. Technique for producing platelet-rich plasma and platelet concentrate: background and process. Int J Periodontics Restorative Dent. 2002;22(6):547–557.
   PubMed Web of Science ®Google Scholar
• Jo CH, Shin JS, Lee SY, et al. ALLOGENEIC PLATELET-RICH PLASMA FOR ROTATOR CUFF REPAIR. Acta Ortop Bras. 2017;25(1):38–43.
   PubMed Web of Science ®Google Scholar
• Rapaport SI, Zivelin A, Minow RA, et al. Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin. Am J Clin Pathol. 1992;97(1):84–91.
   PubMed Web of Science ®Google Scholar
• Zehnder JL, Leung LL. Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin. Blood. 1990;76(10):2011–2016.
   PubMed Web of Science ®Google Scholar
• Christie RJ, Carrington L, Alving B. Postoperative bleeding induced by topical bovine thrombin: report of two cases. Surgery. 1997;121(6):708–710.
   PubMed Web of Science ®Google Scholar
• Dohan Ehrenfest DM, Andia I, Zumstein MA, et al. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3–9. .
   PubMedGoogle Scholar
• Andia I, Maffulli N. Some patients (and some of us) respond better to some biological therapies: the as yet unsolved conundrum. J Orthop Traumatol. 2018;19(1):1. .
   PubMed Web of Science ®Google Scholar